Myelin Protein Zero (MPZ)-targeting Compounds and Uses Thereof

Unmet Need Peripheral nerve injuries require optimally timed intervention to maximize functional recovery and minimize permanent nerve death and negative impacts to quality of life. Current treatment plans rely primarily on monitoring for spontaneous healing or an indication that there must be surgical intervention, an approach that hinges on accurate...

Combined MAPK and NAMPT Inhibition: Greater Efficacy in Axonal Degeneration

Value Proposition - Demonstrates synergistic effect of targeting two biochemical pathways. - Offers possible disease-modifying therapy for degenerative diseases of the axons. - Possible treatment to minimize damage from acute brain injury. Unmet Need - Degeneration of axons is a hallmark feature of various neurological conditions. Deterioration of...

3D Shell MEAs for Electrically Active Organoids

Value Proposition ·        3D shell MEAs is a novel platform for encapsulation, electrical stimulation, and recording of organoids ·        Electrophysiological measurements of electrically active 3D organoids.  ·        Relevant to brain development, neurological disorders, drug screening; neuromorphic computing and brain-machine interfaces; and...

Novel Triazole Compounds to Treat Nav1.6-related Brain Disorders

Unmet Need Abnormal behavior of sodium (Nav) channels is linked to a variety of epilepsy syndromes, movement disorders, and neuropathic pain. While researchers continue to elucidate the roles of different Nav channel isoforms within a variety of neurological disorders, current therapeutics influence numerous Nav channel isoforms, resulting in off-target...

Pirt-GCaMP3 Mice

Invention novelty: Primary sensory neurons in the DRG play essential role in initiating somatosensory such as pain, itch, and touch by directly sensing various sensory stimuli like mechanical, chemical, and thermal stimuli. Dysfunction of these neurons often leads to various pathological conditions including chronic pain and itch. Currently, no one...

Ethoxyquin and Derivatives for Treatment of Peripheral Neuropathies and Other Neurodegenerative Disorders

Peripheral neuropathies are a group of neurodegenerative disorders affecting the peripheral nerves. Currently there is no effective therapy that prevents nerve degeneration except in cases of autoimmune peripheral neuropathies. Wehave now identified a compound, ethoxyquin (EQ), that prevents nerve degeneration in chemotherapy-induced peripheral neuropathy...

Medical Device for Treatment of Ulnar Neuropathy

C04545: Medical Device for Treatment of Ulnar Neuropathy Value Proposition: Key Benefits • Stand alone device for treating ulnar neuropathy • Affordable • Safe • Easy to wear Technical Details: UlnarGuardTM is a non-invasive medical device used for treating pain and disability due to ulnar neuropathy. It is designed to worn under clothing...