Latest technologies from Johns Hopkins Universityhttp://jhu.technologypublisher.comBe the first to know about the latest inventions and technologies available from Johns Hopkins Universityen-USMon, 18 Jun 2018 23:26:14 GMTFri, 15 Jun 2018 11:36:38 GMT 2018, Johns Hopkins UniversityNovel Quantifiable In Situ Detection of AR-V7 in Metastatic Castration-resistant Prostate Cancer NeedAbout 1 man in 9 will be diagnosed with prostate cancer during his lifetime. When hormonal therapy stops working against prostate cancer, metastatic castrate-resistant prostate cancer (mCRPC) develops. Men affected with CRPC exhibit the spread of cancer to parts of the body beyond the prostate. The cancer is grows and continue to spreads, despite using hormone therapy. As a result, men with this disease require additional treatments such as chemotherapy or targeted therapy to control the growth of the cancer. To identify the development of CRPC, androgen receptor splice variant 7 (AR...Fri, 15 Jun 2018 11:36:38 GMTJHTT-Communications@jhu.edu of Manabodies to the R140Q mutant in IDH2 NeedThe immune system samples and recognizes the intracellular contents of cells (i.e., normal, abnormal, infected and cancer cells) through antigen processing via surface human leukocyte antigens (HLAs) and antigen presentation to T cells via T cell receptors (TCRs), all of which enables the body to distinguish self from non-self proteins. For example, a virally-infected cell would present viral peptides by its surface HLA, triggering T cells to kill that cell.  Similarly, in cancer cells, mutant peptides referred to as MANAs, “Mutation-Associated Neo-Antigens”, can be presented by HLA ...Wed, 13 Jun 2018 13:00:02 GMTJHTT-Communications@jhu.edu, high-resolution measurement of telomeres in archival tissue specimens for use in personalized medicine, 15 May 2018 05:21:45 GMTJHTT-Communications@jhu.edu Alterations Related to Anti-EGFR Therapeutic Response Need:Colorectal cancer is the third most common cancer worldwide, with 1.2 million patients diagnosed annually. In late-stage colorectal cancer, the most commonly used targeted therapies are monoclonal antibodies, which prevent epidermal growth factor receptor (EGFR) activation. Several studies have identified alterations in KRAS and other genes as likely mechanisms of primary and secondary resistance to anti-EGFR antibody therapy. Despite these efforts, additional mechanisms of resistance to EGFR blockade are thought to be present in colorectal cancer and little is known about determina...Sat, 05 May 2018 13:57:02 GMTJHTT-Communications@jhu.edu Cells Upregulate Angiopoietin-like 4 To Promote Vascular Permeability in Ischemic Retinal Disease NeedIn proliferative diabetic retinopathy (PDR), the most vision-threatening consequence of diabetic eye disease, is retinal ischemia leading to increased expression of angiogenic factors that promote neovascularization. Although therapies targeting the potent angiogenic mediator vascular endothelial growth factor (VEGF) have been remarkably successful for the treatment of diabetic macular edema, this approach has not proven sufficient to prevent the development of retinal neovascularization, implicating additional angiogenic factor(s) in PDR pathogenesis. Technology OverviewJohns Hopkin...Mon, 30 Apr 2018 07:57:14 GMTJHTT-Communications@jhu.edu Molecular Method for the Detection of Mycobacterium Tuberculosis, 20 Apr 2018 10:35:58 GMTJHTT-Communications@jhu.edu to achieve enhanced delivery to the bladder, 20 Apr 2018 05:57:28 GMTJHTT-Communications@jhu.edu Antibacterials Against D,D- and L,D-Transpeptidases needb-lactam antibacterial agents target peptidoglycan biosynthesis and are used for treatment of infection, but have been ineffective in treatment of Tuberculosis (TB). This lack of activity has been attributed to the presence of b-lactamase and limited penetration of the thick mycolate coat. Thus, new generation of antibacterial agents to treat TB, a disease that causes more deaths worldwide than any other infectious disease, are urgently needed. Technology overviewJohns Hopkins researchers have identified novel b-lactam antibacterials that contain a bicyclic penem core. The current an...Mon, 16 Apr 2018 06:08:49 GMTJHTT-Communications@jhu.edu Treatment or Prevention of Heterotopic Ossification, 29 Mar 2018 06:12:20 GMTJHTT-Communications@jhu.edu Biosensor CaspaseTracker rtTA, 28 Mar 2018 10:17:19 GMTJHTT-Communications@jhu.edu of lung cells from cigarette smoke, a primary insult causing chronic obstructive pulmonary disease (COPD) and other lung diseases, and ability to increase airway surface hydration and maintain ciliary function. NeedChronic obstructive pulmonary disease (COPD) is predicted to become the third leading cause of death globally by 2030, with cigarette smoke being a major cause. Despite the prevalence of COPD there has been very little progress in developing therapeutic strategy in past 20 years. Thus, mechanistic studies for therapeutic targets for treating COPD and other lung diseases is urgently needed. Technology OverviewJohns Hopkins researchers have identified novel genes that protect lung cells from toxic insults such as cigarette smoke using a novel platform based upon Dictyostelium discoideu...Mon, 05 Mar 2018 07:19:50 GMTJHTT-Communications@jhu.edu Device for Magnetic Stimulation of the Vestibular System NeedVestibular disorders (dizziness, vertigo, imbalance) are ubiquitous problems in clinical medicine. They account for many millions of visits to physicians and therapists every year, and often produce prolonged physical and psychological disability leading to a loss of economic productivity and a high risk of falls and injuries. Like many other neurological disorder (such as stroke or trauma) treatment depends on exercise regimens, which for vestibular disorders must stimulate the labyrinth to promote recovery. Unfortunately, these physical therapy programs commonly lack scientific rat...Sat, 03 Mar 2018 00:00:55 GMTJHTT-Communications@jhu.edu Mepron for Malaria Prophylaxis NeedDespite significant research and clinical efforts, malaria continues as a substantial health problem in over 90 countries.  According to the WHO World Malaria Report, in 2016 there were 216 million cases of malaria worldwide with an estimated 429,000 deaths.  Malaria also poses a serious health threat to tens of millions of nonimmune travellers who visit malaria endemic areas every year.  With the current lack of a clinically proven vaccine, preventing malaria is dependent upon chemoprophylaxis.  Chemoprophylaxis requires repeated and extended drug dosing, and lack of adherence to da...Fri, 02 Mar 2018 10:39:08 GMTJHTT-Communications@jhu.edu Fusion Protein to Enhance Anti-Tumor Immunity and Antigen-specific T-cell Cytotoxicity Need: Active immunotherapy, such as anti-PD-1/PD-L1 and anti-CTLA-4 checkpoint blockage, involves the administration of molecules to mobilize host immune cells to recognize and kill tumors. Proper presentation of tumor antigens through antigen presenting cells is a prerequisite to elicit a potent immune response. Current strategies enhance antigen presentation by boosting conventional CD11b+ dendritic cells. While these are potent in antigen presentation, they perform subpar cross presentation. FMS-like tyrosine kinase 3 Ligand (Flt3L) is believed to expand CD8a+, CD103+, and Plasmacytoi...Fri, 02 Mar 2018 10:35:35 GMTJHTT-Communications@jhu.edu Stem Cells and Monoclonal Antibodies (MY-10) Stem Cells and Monoclonal Antibodies (MY-10) Case Number C02182 ABSTRACT Monoclonal antibodies that recognize a stage-specific antigen on immature human marrow cells. These antibodies are useful in methods of isolating cell suspensions from human blood and marrow that can be employed in bone marrow transplantation. Cell suspensions containing human pluripotent lympho-hematopoietic stem cells are also provided, as well as therapeutic methods employing the cell suspensions. PUBLICATION Civin, C.I., Strauss, L.C., Brovall, C., Fackler, M.J., Schwartz, J.F., Shaper, J.H. Antigenic ...Fri, 23 Feb 2018 00:02:10 GMTJHTT-Communications@jhu.edu of PCR Fragments with Short Homology Arms for Genome Editing NeedThe RNA-guided DNA endonuclease, Cas9, has emerged as a powerful new tool for genome engineering. Cas9 creates targeted ‘double-strand breaks’ (DSBs) in the genome. Knock-in of specific mutations (precision genome editing) requires ‘homology-directed repair’ (HDR) of the DSB by synthetic donor DNAs containing the desired edits, but HDR has shown considerable variability in efficiency. Guidelines which improve HDR design and integration success would help move forward the field of genome editing. Technology OverviewHopkins researchers developed a novel method for genome editing in mam...Mon, 19 Feb 2018 12:39:49 GMTJHTT-Communications@jhu.edu monoclonal antibody inhibitors targeting potassium channel KCNK9 Need:KCNK9 is one of 15 mammalian subtypes in the highly conserved family of two-pore domain potassium channels (K2P). Under physiological conditions, KCNK9 is primarily expressed in the brain where it serves to maintain cellular membrane potentials. However, overexpression of KCNK9 has been detected in breast, lung, skin, and other cancers, and is thought to contribute to malignancy by promoting cell survival and resistance to hypoxia and potentially serve as a cell surface tumor-associated antigen. In breast and lung cancer patients, high KCNK9 expression correlated with reduced overal...Sun, 11 Feb 2018 17:49:28 GMTJHTT-Communications@jhu.edu Response Biomarker Panel for Diagnosis of Lyme Disease, 05 Feb 2018 11:39:49 GMTJHTT-Communications@jhu.edu Combination of Carbapenem and Avibactam for Treatment of Bacterial Infections NEEDMultidrug-resistant (MDR) pathogens, e.g. Mycobacterium tuberculosis (TB) are a growing threat with significant economic ramifications. In particular, TB is one of the top 10 causes of death worldwide, with an estimated 10.4 million people infected, globally. An estimated 1.8 million deaths are attributable to TB. MDR-TB is TB that does not respond to the 2 most powerful anti-TB drugs, and approximately 500,000 people developed MDR-TB in 2015. Globally, only 52% of MDR-TB patients are successfully treated, demanding new approaches to combating this pathogen. This specific case is par...Mon, 05 Feb 2018 09:21:15 GMTJHTT-Communications@jhu.edu Closure Device/Modification Closure Device/ModificationJHU REF: C13048  Invention Novelty: An endoscopic wound closure device for treating luminal tears in the gastrointestinal (GI) tract that mechanically joins the perforated would, conferring an appreciably better seal than existing endoscopically implanted sutures.   Value Proposition: As luminal perforations cause seepage of GI fluids, which can be caustic or rich in bacteria, the perforations damage surrounding tissue through erosion or bacterial infection and are associated with high degrees of mortality and morbidity.  The disclosed device mechanicall...Fri, 02 Feb 2018 08:08:33 GMTJHTT-Communications@jhu.edu detection is key to reducing cancer deaths. JHU investigators have developed a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1,005 patients with non-metastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types. The sensitivities ranged from 69% to 98% for the detection of five cancer types (ovary, liver, stomach, pa...Fri, 26 Jan 2018 00:00:40 GMTJHTT-Communications@jhu.edu AND PROGNOSIS OF LUNG CANCER and tools are provided for detecting and predicting lung cancer. The methods and tools are based on epigenetic modification due to methylation of genes in lung cancer or pre-lung cancer. The tools can be assembled into kits or can be used seperately. Genes found to be epigentically silenced in association with lung cancer include ACSL6, ALS2CL, APC2, ART-S1, BEX1, BMP7, BNIP3, CBR3, CD248, CD44, CHD5, DLK1, DPYSL4, DSC2, EDNRB, EPB41L3, EPHB6, ERBB3, FBLN2, FBN2, FOXL2, GNAS, GSTP1, HS3ST2, HPN, IGFBP7, IRF7, JAM3, LOX, LY6D, LY6K, MACF1, MCAM, NCBP1, NEFH, NID2, PCDHB15, PCDHGA12, PFK...Fri, 19 Jan 2018 00:00:30 GMTJHTT-Communications@jhu.edu  TC-1/A2 cell lineCASE NUMBER:    C04953TECHNOLOGYJHU Scientists characterized the ability of DNA-encoding calreticulin linked to DNA-encoding E7 antigen to generate HLA-A2-restricted E7-specific CD8+ T-cell responses in HLA-A2 (AAD) transgenic mice, as well as antitumor effects against an E7+ HLA-A2+ tumor cell line, TC-1/A2.TECHNICAL DETAILSScientists at JHU transduced TC-1, an established E7-expressing tumor cell line, with a retrovirus encoding the HLA-A2 (AAD) molecule. The expression of HLA-A2 in the TC-1/A2 cells was confirmed by flow cytometry analysis using an antibody against ...Wed, 10 Jan 2018 11:14:01 GMTJHTT-Communications@jhu.edu versatile method to fabricate giant vesicles that can encapsulate a range of membrane-bound proteins, luminal proteins, and cell lysates under physiologically relevant conditions NeedCreating artificial vesicular systems that can mimic natural cells continues to be a challenge in the fields of synthetic biology as well as gene and drug delivery. This class of artificial systems serve as a powerful platform for both studying biology in a minimal, controlled system and moreover can be used as biocompatible vehicles to deliver various biological and chemical materials in a cellular environment. Currently, giant vesicles can be fabricated with geometry, membrane lamellarity, and lipid compositions to mimic real cells; however, encapsulating biological materials insid...Wed, 10 Jan 2018 06:16:37 GMTJHTT-Communications@jhu.edu Tunable Biomaterials for Tissue Engineering: Independent Control on Mechanics, Adhesion and Chemistry NeedAdult Stem Cells hold great promise in tissue engineering because of their proliferative capacity and ability to differentiate into several phenotypes, and ultimately build new tissues. However, to enable translation of stem celll therapies and tissue-enginggering techniques, there is a significant need to generate materials that can be used to study fundamentals in biology and modulate or enhance differentiation. Poly(ethylene glycol) (PEG)-based hydrogels are frequently utilized to encapsulate cells in a 3D environment. Unfortunately, PEG based biomaterials lack functionality to in...Wed, 10 Jan 2018 05:01:32 GMTJHTT-Communications@jhu.edu Healing Compositions Comprising Biocompatible Cellulose Hydrogel Membranes and Methods of Use Thereof NeedCorneal lacerations are a common type of eye injury. These can occur in varying degrees of severity, and in many cases the wound is non-self-sealing. This type of injury requires significant intervention including sutures and, in some cases, many layers of grafts. During the course of treatment patients are required to wear bandages that can obstruct vision and prevent an injured individual from completing essential tasks. Thus, there is a need for an ocular bandage with healing capabilities that is high in transparency and strength. Technology OverviewJohns Hopkins University resear...Tue, 09 Jan 2018 07:49:21 GMTJHTT-Communications@jhu.edu Duplexes for the Strand-specific Detection and Quantification of Rare Mutations NeedOne of the most important opportunities in the future of the fight against cancer is the detection of cancer-related genetic mutations in the blood or bodily fluids at early stages of cancer, at the early stages of recurrence, or to become aware of changing cancer genetics during a treatment course. Studies have shown that blood, saliva, pap smear, or pancreatic cyst fluid samples can be used to detect circulating tumor DNA (ctDNA) at early-mid stages of cancer progression. However, most approaches to analyzing the DNA samples depend on sequencing instruments with relatively high err...Fri, 05 Jan 2018 13:18:19 GMTJHTT-Communications@jhu.edu Treating or Preventing Enthesopathy, 05 Jan 2018 13:17:27 GMTJHTT-Communications@jhu.edu for Treatment of Brain Injury in the Presence of Anesthesia Need:Brain injury (e.g. traumatic brain injury) is a devastating health problem in the US and beyond. Often, anesthesia is used during the acute and chronic phase of the treatment. Thus far, there is no treatment taking advantage of the direct effects of anesthesia on a patient to administer therapy for brain injury. Technology Overview:Johns Hopkins researchers develop a novel method of delivering neuroprotective agents to the brain in the presence of an anesthetic used commonly following brain injury. The invention is based on the finding that in the presence of anesthesia, glial cells...Fri, 05 Jan 2018 13:16:42 GMTJHTT-Communications@jhu.edu Therapeutic Target for Neural Regeneration, Stroke and Anti-depressants needCurrent anti-depressants in the market have various limitations including lack of broad-spectrum drugs, unexpected side effects, toxicity and low efficacy for certain patients. New generation of anti-depressants based on most recent biomedical discoveries concerning depression are urgently needed. Technology overviewJohns Hopkins researchers have identified novel function of Gadd45b in regulating chromatin and epigenetic DNA methylation levels of promoters for specific types of neuronal genes, including those essential for neuronal plasticity and cell survival. Gadd45b is a member of...Fri, 05 Jan 2018 12:49:01 GMTJHTT-Communications@jhu.edu Constrained Peptides for Targeting the Prostate Specific Membrane Antigen Disulfide Constrained Peptides for Targeting the Prostate Specific Membrane Antigen Technical Details: Utilizing a standard phage display methodology, we have screened a hepta-peptide disulfide bridge constrained phage display library for binding to the prostate specific membrane antigen (PSMA). PSMA is a prostate specific cell surface marker which is up regulated in aggressive prostate cancer and is considered one of the best cell surface targets for prostate cancer currently available. A variety of peptide ligands were generated and found to bind to PSMA with varying affinities. ...Fri, 05 Jan 2018 12:35:18 GMTJHTT-Communications@jhu.edu (Po), 05 Jan 2018 12:31:31 GMTJHTT-Communications@jhu.edu of AKT2/NF?B/Lipocalin-2 Signaling Axis for the Treatment of Dry Age-related Macular Degeneration (AMD) NEED        The dry type of age-related macular degeneration (AMD) affects approximately 80-90% of individuals with AMD. Its cause is unknown, it usually progress more slowly than the wet type and at this time, there is no proven medical treatment or cure.  There is one surgical implant that can help some people gain more functional vision. There are also some unproven treatments such as acupuncture, microcurrent stimulation and rheopheresis. Hence, there is great need for therapeutic agents. PROBLEM SOLVED Johns Hopkins researchers have identified the specific signaling axis both in ...Fri, 05 Jan 2018 00:03:21 GMTJHTT-Communications@jhu.edu Heterotopic Ossification with the Development of a Novel Bone Healing System Using Muscle Derived Cells (MDSCs), Bone Induction Agents, and Scaffolds bone healing, angiogenesis promoting and/or vasculogenesis performing system and methods of use thereof are provided, that employ a unique three-principled regenerative healing strategy of muscle-derived cells (e.g., fibroblast-depleted muscle derived stem cells (MDScs)), a bone induction agent (e.g., including ex vivo progenitor cell expansion with early osteo-induction), and a structurally robust scaffold (e.g., a collagen scaffold) support to achieve bone regeneration, angiogenesis promotion and/or vasculogenesis performance, thereby overcoming previous limitations in regenerative healing...Fri, 05 Jan 2018 00:03:19 GMTJHTT-Communications@jhu.edu Inhibitors in Immunotherapy NeedTumors have the ability to interfere with the adaptive immune response by recruiting myeloid-derived suppressor cells (MDSCs), blocking antigen-presenting dendritic cell (DC) function and altering normal T-cell signal transduction and function. Such immunosuppressive mechanisms allow tumor cells to avoid immune recognition and eradication.  The use of phosphodiesterase-5 (PDE5) inhibitors (sildenafil, tadalafil, and vardenafil; currently used to treat erectile dysfunction) are proposed as modulators of MDSC function to restore antitumor immune response.  Technology OverviewExtensive ...Fri, 05 Jan 2018 00:03:13 GMTJHTT-Communications@jhu.edu Flox Mouse Line OverviewJHU researchers generated the GDF11 flox mouse line by inserting a loxP site upstream of exon 2 and a floxed neo cassette downstream of exon 3. Cre mediated recombination was then used to remove the neo cassette leaving exons 2 and 3 floxed (Molecular Image Detail).   Detailed Technology OverviewMyostatin (Mstn) and growth/differentiation factor 11 (Gdf11) play important roles in growth and differentiation. Mstn is predominantly expressed in developing and adult skeletal muscle, while Gdf11 allows differentiation between anterior and posterior (A/P) axial mesoderm identity. In a ...Fri, 15 Dec 2017 11:18:44 GMTJHTT-Communications@jhu.edu of the Most Common Gene for Bardet-Biedl Syndrome NeedCurrently nine BBS(1-9) genes have been discovered and they account for only 40-50% of all mutations that result in BBS. This technology comprises of BBS10, a novel BBS gene whose mutational involvement in the disease makes it an attractive diagnostic and therapeutic target. Other advantages include: Diagnostic test applications in pre-natal and antenatal screeningBBS10 encodes a previously unknown, rapidly evolving vertebrate-specific chaperonin-like proteinBBS10 mutations are found across various ethnic groupsPotential applications in prominent therapeutic areas of familial obesit...Fri, 15 Dec 2017 10:57:54 GMTJHTT-Communications@jhu.edu Pancreatic Ductal Adenocarcinomas have Detectable Telomere Fusions and their Detection in Pancreatic Cyst Fluids Predicts the Grade of Dysplasia of Intraductal Papillary Mucinous Neoplasms Need Physicians must determine whether patients with cystic tumors of the pancreas will be operated on or receive further imaging and monitoring.  Biomarkers that can inform the physician of the state of progression of the tumor, as well as predict the neoplastic nature of the cyst, would be valuable for determining treatment course. Specifically, the authors would like to reduce the number of patients undergoing unneeded surgical resections, as this procedure has high morbidity. Market size can be inferred by the fact that up to 25% of the US population over the age of 70 likely harbors...Fri, 15 Dec 2017 10:29:08 GMTJHTT-Communications@jhu.edu conditional knockout mice NeedThe miR-143/145 microRNA cluster has been implicated in colon cancer and other epithelial tumors, but investigation of its role in pathogenesis requires a research tool in which miR-143/145 expression can be modulated in specific cell types. Technology OverviewJohns Hopkins researchers generated a conditional knockout allele for the miR-143/145 cluster that has been used to develop transgenic mice. miR-143/145 conditional knockout mice have been generated, leading to an initial validating study on the effect of miR-143/145 deletion specifically in epithelial cells of the gastrointest...Fri, 10 Nov 2017 11:51:15 GMTJHTT-Communications@jhu.edu Cell Signature in Biliary Atresia NeedBiliary atresia is a pediatric disease that is difficult to diagnose. Surgical intervention is sometimes capable of correcting the disorder, but undiagnosed and subsequently untreated infants will likely die of liver failure within the first three months after birth. While infants suffering from the disorder are born and jaundiced, it is not immediately clear whether this is benign self-limited jaundice) which is of no consequence to the child) or if this is the life-threatening disease, biliary atresia. This invention may provide a method for more accurately and quickly identifying ...Fri, 10 Nov 2017 11:50:50 GMTJHTT-Communications@jhu.edu Modifiers of Marfan Syndrome and Related Conditions NeedMarfan syndrome (MFS) is a systemic connective tissue disorder with autosomal dominant inheritance, caused by mutations in the FBN1 gene. Clinical manifestations involve the ocular, skeletal, and cardiovascular systems with a broad phenotypic continuum with an expectation of severe and rapidly progressive disease in multiple organ systems, with the major cause of mortality resulting from aortic root dilatation, dissection and rupture. With proper management, the life expectancy of someone with MFS approximates that of the general population, however, there remains a need for methods ...Fri, 10 Nov 2017 11:50:09 GMTJHTT-Communications@jhu.edu Blood Based Test to Predict for Response to Immune Checkpoint Inhibitors: Plasma Tumor DNA Assays for Micro-satellite Instability and Mutational Load on preliminary evidence, we believe that increased mutational burden occurs in patients with metastatic disease after therapy with certain chemotherapies. Based on current paradigms, this would expose a vulnerability to immune checkpoint inhibitor therapies. Thus, we propose two blood tests to determine 1) if micro-satellite instability is present afterseveral chemotherapy treatments and 2) if increased mutational burden could be detected as a predictive marker for sensitivity to immune checkpoint therapies. These tests could allow for selecting only those patients with the highest likel...Fri, 10 Nov 2017 11:48:21 GMTJHTT-Communications@jhu.edu - The Highly Extensible Resources for Modeling Event Driven Supply Chains NeedSupply chains include a series of steps when transporting products from manufacturers to patients. The supply chain management market will exceed $13 billion in software revenue by the end of 2017 and is expected to exceed $19 billion by 2021. HERMES (Highly Extensible Resource for Modeling Supply-chains) represents the flow of products from the manufacturer to the patient. Managing the safety and quality is vital to ensure the appropriate delivery of products and to mitigate risks. HERMES provides the user with a computational framework for modeling and optimizing supply chains.   T...Fri, 10 Nov 2017 11:47:52 GMTJHTT-Communications@jhu.edu A Computational Platform for Rational Intervention Development and Portfolio Management NeedComputational modeling can serve as the virtual library to assist funders, policy-makers, and disease control officials in evaluating the potential value of disease control interventions. In 2010, it cost nearly $1.4 trillion for cardiovascular disease and diabetes globally. The U.S. potential annual savings on healthcare costs is estimated to reach $303 billion by 2023 if preventative evidence-based approaches are used. Decision makers currently rely on spreadsheets, such as Microsoft Excel, and must complete additional analyses and explore various financial models. Using predictive...Fri, 10 Nov 2017 11:47:31 GMTJHTT-Communications@jhu.edu Imaging and Radiotherapeutics Agents Targeting Carbonic Anhydrase IX NeedDuring early stages of tumorigenesis, rapidly differentiating tumor cells create regions of hypoxic activity where metabolic demands surpass the local vascular oxygen supply. The lactic acid generated from the resulting hypoxia can trigger expression of carbonic anhydrase IX (CA IX), a gene responsible for pH maintenance that provides a mechanism for the rapidly expanding tumor to survive the local toxic region. The onset of tumor acidosis, a corresponding low pH, and upregulation of CA IX are all important biomarkers of the acceleration of tumor progression. This progression of CA I...Fri, 10 Nov 2017 11:44:01 GMTJHTT-Communications@jhu.edu Selective Inhibitor of Histone Demethylase LSD1 NEED: Lysine-specific demethylase 1 (LSD1) is an epigenetic enzyme that oxidatively cleaves methyl groups from monomethyl and dimethyl Lys4 of histone H3 (H3K4Me1, H3K4Me2) and can contribute to gene silencing. This study describes the design and synthesis of analogs of a monoamine oxidase antidepressant, and their LSD1 inhibitory properties. Treatment of two cancer cell lines, LNCaP and H460 with the compound conferred a reduction in proliferation rate, and the compound showed additive to synergistic effects on cell growth when used in combination with two out of five HDAC inhibitors te...Mon, 16 Oct 2017 12:23:26 GMTJHTT-Communications@jhu.edu as a Sensitizing Agent for Cancer Chemotherapy and Radiation Therapy NEED: Ionizing radiation (IR) is a useful modality to treat multiple types of cancers that exerts its effect by causing DNA damage, in particular DNA double strand breaks (DSBs).Yet, tumor cells often present radiation protective phenotypes which can lead to IR treatment failure. Existing approaches to sensitize cancer cells to IR use RNA interference (RNAi) agents such as siRNA or shRNA. Here, for the first time specific microRNA (miRNA) is utilized as a means to sensitize cancer cells to radiation or chemotherapy. Improves cancer therapeutic response to radiation or chemotherapyThe id...Thu, 05 Oct 2017 23:59:30 GMTJHTT-Communications@jhu.edu Switches and Methods for Making and Using the Same Involving the Circular Permutation of DNA Details: The invention provides molecular switches which couple external signals to functionality and to methods of making and using the same. The switches according to the invention can be used, for example, to regulate gene transcription, target drug delivery to specific cells, transport drugs intracellularly, control drug release, provide conditionally active proteins, perform metabolic engineering, create molecular sensors, and modulate cell signaling pathways. Libraries comprising the switches and expression vectors and host cells for expressing the switches are also provided. T...Fri, 22 Sep 2017 11:44:57 GMTJHTT-Communications@jhu.edu of Computing Low Oxygen Delivery during Cardiac Surgery on Cardiopulmonary Bypass OverviewThis technology involves a novel algorithm to quantify low oxygen delivery by taking into account not only the depth of oxygen delivery below certain predefined thresholds, but also the time spent below those given thresholds. JHU researchers have preliminary data that assessing oxygen delivery in this manner is associated with release of a neurological injury biomarker.Fri, 22 Sep 2017 06:06:58 GMTJHTT-Communications@jhu.edu<![CDATA[Library of llustrations Created by Artist Mike Linkinhoker While He Worked in the Division of Gastroenterology & Hepatology, Created for the Sole Use of the Johns Hopkins Division of Gastroenterology & Hepatology Website]]> OverviewThis technology are GI illustrations for use by the JHU division of Gastroenterology and Hepatology website. Fri, 22 Sep 2017 06:06:20 GMTJHTT-Communications@jhu.edu, 22 Sep 2017 06:05:07 GMTJHTT-Communications@jhu.edu Phenotyping Reveals Robust Determination to Cellular Biological Age OverviewJHU researchers have developed a platform to determine the cellular biological age of individuals based on quantifiable functional outputs of their cells. Using a comprehensive approach, of high-throughput single cell technologies to measure biochemical and biophysical properties of cells, we have further developed a generalized linear model that robustly and reproducibly combines various cellular features to predict age.Fri, 22 Sep 2017 06:04:30 GMTJHTT-Communications@jhu.edu Involvement Menu Implementation Toolkit NeedThere is an unmet need of tools that encourage family members to play an active role in caring for patients. There is a current trend towards involving family members in the care of patients in hospital settings. This tool is a menu of choices relating to patient care that family members can participate in. This menu provides a physical tool as opposed to a solely behavioral tool. Technology OverviewJohns Hopkins researchers have developed a ‘menu’. This ‘menu’ is a laminated list of tasks that is placed in the room of ICU patients. These tasks are related to patient care and provide...Fri, 22 Sep 2017 06:03:01 GMTJHTT-Communications@jhu.edu of a novel grading system for prostate cancer NeedThe current prostate cancer grading system was developed between 1966 and 1974 by Donald Gleason and the Veterans Administration Cooperative Urologic Research Group. The system assigns histological patterns 1 through 5 with a Gleason score derived from adding the most and 2nd most common patterns. Scores range from 2 (well-differentiated) to 10 (undifferentiated). Over the subsequent 40 years, histological and clinical diagnosis of prostate cancer along with its treatment has evolved, leading to revisions of the Gleason system first codified in 2005 and more recently in 2014. The cur...Fri, 22 Sep 2017 06:02:37 GMTJHTT-Communications@jhu.edu History of US (Book 6/Book 2/Book 3) OverviewThe following six titles are included in this agreement: -A History of US, Book 6: A Common Core Teaching Guide (War, Terrible War)-A History of US, Book 6: A Common Core Student Discussion Guide (War, Terrible War)-A History of US, Book 2: A Common Core Teaching Guide (Making Thirteen Colonies) -A History of US, Book 2:  A Common Core Student Discussion Guide (Making Thirteen Colonies) -A History of US, Book 3: A Common Core Teaching Guide (From Colonies to Country)-A History of US, Book 3:  Common Core Student Discussion Guide (From Colonies to Country)Fri, 22 Sep 2017 06:02:18 GMTJHTT-Communications@jhu.edu Electronic Textbook for a Complete Data Science Curriculum OverviewThis textbook consists of videos, assessments, and lecture notes for the 9 courses in the Johns Hopkins Data Science Specialization (JHU DSS). The material is in electronic form and consists of text files, HTML files, and video files (mp4 and raw files). Fri, 22 Sep 2017 06:02:13 GMTJHTT-Communications@jhu.edu Checklists OverviewThis technology consists of layered integrated smart checklists as cognitive tools to improve care in the ICU. These smart checklists will pull and push information to EHRs and provide advisory prompts and reminders to prescribers for specific evidence based therapies and goals so as to close the quality gap and ensure all patients receive the therapies they should. This software will also act as a communication tool to nursing, respiratory therapy and other ICU staff.  All prompts and reminders will be advisory, the clinician will always have the final decision whether to e...Fri, 22 Sep 2017 06:01:46 GMTJHTT-Communications@jhu.edu of Covariance Sequential Correlation Maps using Spectral Derivatives and Multiplication of Resulting Covariance Matrices OverviewThe technology consists of a computer script that produces 3D sequential correlation maps involving amide protons and nitrogens from conventional pairs of triple-resonance nuclear magnetic resonance (NMR) spectra. The maps combine the information provided otherwise separately by all spectra. Derivation (gradient) is performed in the dimension subject to covariance prior to calculating the covariance.Fri, 22 Sep 2017 06:01:02 GMTJHTT-Communications@jhu.edu Kindergarten Readiness Assessment (KRA) Application OverviewThe Kindergarten Readiness Assessment (KRA) Application is a software solution to support teachers in administering direct performance and selected response assessment items to Kindergarten and Pre-K students as part of the K-Ready project in Maryland and Ohio. Initially developed for delivery on iOS 6+ tablet devices, the application will also be ported to Android and desktop PC/Mac platforms. The application requires authentication with an external cloud-hosted database, as well as continuous connection to the Internet in order for the assessment results to be recorded in ...Fri, 22 Sep 2017 06:00:44 GMTJHTT-Communications@jhu.edu for Military Acuity Model for Multidisciplinary Cancer Clinics OverviewJHU researchers have assisted ProcessProxy in developing Multi-Disciplinary Cancer (MDC) differentiated processes and fungible tasks that can be packaged for sale to other clinics that desire to become Multidisciplinary in practice. This will require reviewing the features before final implementation of their process into ProcessProxys standard MAM-Healthcare Smartgrid framework.Fri, 22 Sep 2017 06:00:28 GMTJHTT-Communications@jhu.edu Electret Transducer with Controlled Restoring Force for Microphones and Energy Harvesting NeedThe traditional push-pull headphones and loudspeakers currently only generate limited amounts of power due to their small size. The limiting factor in the power output for these devices is the amount of movement of the diaphragm and the charge level of the electret. While the power generated by the current push-pull system is sufficient for commercial headphones and loudspeakers, it is insufficient for devices that need to operate at high temperatures and underwater. Technology OverviewTwo new mono-charged push-pull (PP) electrict transducers are proposed where the resonance frequenc...Fri, 22 Sep 2017 06:00:14 GMTJHTT-Communications@jhu.edu of CUSP game OverviewThe Comprehensive Unit-based Safety Program (CUSP) is a 5-step program to improve local safety culture and has been linked to improvements in clinical care.  A CUSP workshop has been designed to train teams in the CUSP model.  The Applications of CUSP game is 1/2 of this overall workshop training.Fri, 22 Sep 2017 06:00:05 GMTJHTT-Communications@jhu.edu Involvement Menu NeedThere is an unmet need of tools that encourage family members to play an active role in caring for patients. There is a current trend towards involving family members in the care of patients in hospital settings. This tool is a menu of choices relating to patient care that family members can participate in. This menu provides a physical tool as opposed to a solely behavioral tool. Technology OverviewJohns Hopkins researchers have developed a ‘menu’. This ‘menu’ is a laminated list of tasks that is placed in the room of ICU patients. These tasks are related to patient care and provide...Fri, 22 Sep 2017 05:55:05 GMTJHTT-Communications@jhu.edu an Interactive, Personalized Safety Decision Smart Phone Application to Prevent and Respond to Intimate Partner Violence in College Women OverviewThis technology is a personalized safety decision application for access through smart phones targeting college women. The safety decision-making process (e.g., knowing the advantages and disadvantages of the relationship, having enough information to make a safety decision, helping a friend in an abusive relationship) will increase safety-seeking behaviors which in turn will increase healthy relationships and decrease exposure to IPV and ultimately improve health and safety outcomes for college women.Fri, 22 Sep 2017 05:54:55 GMTJHTT-Communications@jhu.edu Expressing P. Falciparum Aldolase Isolate 3D7 NeedApproximately 214 million malaria cases were recorded in 2015 with 438,000 people dying from this disease. The majority of these deaths result from a failure to diagnose and treat malaria before the onset of severe disease, at which point, even with proper treatment a 20% mortality rate may be expected. Microscopy is the current gold standard for diagnosing malaria followed by PCR assays, but both require specialized equipment and trained personnel. Rapid diagnostic tests (RDTs) are becoming the most accessible format of malaria diagnostic testing in clinical point of contact setting...Fri, 22 Sep 2017 05:45:04 GMTJHTT-Communications@jhu.edu Compensated Analytical Image Reconstruction analytical dynamic computed tomography (CT) image reconstruction algorithm that can estimate and utilize information about the time-dependent motion vector field at any point of moving tissue or the sampleValue Proposition:Two major problems associated with the current CT imaging technique are imaging radiation overdoses and insufficient temporal resolution. This invention is an analytical algorithm which enables reconstruction of motion compensated images of moving objects. This largely improves motion artifact and blurred spatial resolution induced by the motion of the object whil...Fri, 22 Sep 2017 05:44:21 GMTJHTT-Communications@jhu.edu NeedThere is increasing evidence supporting that ?loss of function? of metastasis suppressor genes plays an important role in cancer metastases. To help identify metastasis suppressor genes on human chromosomes, Johns Hopkins researchers have transferred individual human chromosomes into metastatic rat prostate cancer cells. Technology OverviewTo identify metastasis suppressor genes on human chromosomes, Johns Hopkins researchers transferred individual human chromosomes (7, 8, 10, 11, 12 or 17) into highly metastatic Dunning R-3327 rat prostate cancer cells by microcell-mediated chromoso...Fri, 22 Sep 2017 05:36:57 GMTJHTT-Communications@jhu.edu Monitor OverviewJHU researchers are developing a hydration monitor based on a spectroscopic measurement of skin. This has the potential to measure a hydration index correlating with system physiological hydration levels, as well as extra-cellular vs intra-cellular water content. This technology is amenable to translation in wearable health monitors, as well as medical devices for susceptible patients such as those with congestive heart failure.Fri, 15 Sep 2017 23:59:58 GMTJHTT-Communications@jhu.edu Asthma Book OverviewAsthma is one of the most common chronic childhood diseases. Unfortunately, it continues to be a major public health concern and leads to high rates of hospitalizations and emergency department visits. “My Asthma Book” is a coloring book for children in order to provide them with age appropriate health education. The book covers evidence based prevention strategies including identification of environmental factors and correct use of medications.Fri, 15 Sep 2017 23:59:52 GMTJHTT-Communications@jhu.edu Pathway of complement assay to diagnose atypical HUS and other disorders of complement activation hemolytic uremic syndrome (aHUS) is a rare microangiopathic hemolytic anemia (MAHA) that often leads to renal failure, stroke and premature death(1). In most cases the disease is caused by genetic mutation in one of more than 6 genes that leads to increased activation of the alternative pathway of complement. Currently there is no good diagnostic assay for aHUS; thus, the disease is often confused with other MAHAs such as thombotic thrombocytopenic purpura (TTP), malignant hypertension, pre-eclampsia, disseminated intravascular coagulation, and catastrophic anticardiolipid syndrome. M...Tue, 05 Sep 2017 04:48:34 GMTJHTT-Communications@jhu.edu Activation by PARP Inhibitor Elongates Telomere NOVELTY This invention is a new assay termed ADDIT (Addition of de novo initiated telomeres) that can rapidly identify effectors of telomere length, even if the regulators are essential genes and a method of regulating telomere length with a PARP inhibitor. VALUE PROPOSITION The researchers developed an in vivo telomere elongation assay where telomerase repeat addition can be monitored over 48 hours. Several analytical procedures for the quantification of telomerase activity, methods for detecting telomerase activity, as well as for identifying compounds that regulate or affect te...Thu, 24 Aug 2017 05:53:13 GMTJHTT-Communications@jhu.edu Co-Treatment with anti-HDAC6 for Adult Onset Polycystic Kidney Disease NEED: Adult-onset polycystic kidney disease (ADPKD) is one of the most prevalent, potentially lethal, monogenic human disorders. Disease progression causes fluid filled cysts to grow in the kidneys, which can lead to declining kidney function and eventually kidney failure. More than 50% of patients afflicted with ADPKD eventually develop end stage kidney disease and require dialysis or kidney transplantation. Here, inventors identified a novel target when modulated in combination with inhibition of histone deacetylase 6 (HDAC6) shows potent activity to treat renal diseases, such as ADPKD...Fri, 18 Aug 2017 08:57:58 GMTJHTT-Communications@jhu.edu of AHR Agonists to Prevent or Treat NEC in Premature Infants NEED: Necrotizing enterocolitis (NEC) is the leading cause of death from gastrointestinal disease in premature infants. The main risk factors for the development of NEC are prematurity, bacterial colonization and administration of formula feeds, which in the setting of an abnormal microbiome lead to enhanced signaling via toll like receptor 4 (TLR4), ultimately causing rapid progression from mucosal injury, bacterial translocation, systemic sepsis and then death within 24 hours. Inventors discovered that aryl hydrocarbon receptor (AHR) plays a protective role in a mouse model for NEC, an...Mon, 14 Aug 2017 05:41:58 GMTJHTT-Communications@jhu.edu Therapeutic for Erectile Dysfunction NEED: Erectile dysfunction (ED) affects around 52% of U.S. men due to a wide variety of causes. Standard treatment for ED patients comprises of PDE5 inhibitors (e.g., Viagra) administration, which restores function for only 40% of all patients. As such, there is a significant need for preventing and treating erectile dysfunction of any etiology including post-surgery, diabetes, cardiovascular disease, and other metabolic disturbances. TECHNICAL OVERVIEW: The disclosed invention employs an injected, naturally-produced biological molecule to initiate stem cell recruitment and allow nerve r...Fri, 11 Aug 2017 12:22:30 GMTJHTT-Communications@jhu.edu forms of artemisinins inhibit cytomegalovirus (CMV) replication in vitro and in vivo NOVELTY: This technology involves the use of a derivative of artemisinin as a new therapy for Cytomegalovirus (CMV) infection. VALUE PROPOSITION: CMV infection is recognized as a cause of morbidity and mortality, especially in immunocompromised individuals. CMV is also the most common viral infection in solid organ transplant recipients. Several anti-viral drugs such as ganciclovir, valganciclovir, foscarnet, and cidofovir are used for treating CMV infection, but lack efficacy . The malaria drug, artemisinin and its derivatives show anti-viral activity, suggesting that it could be de...Fri, 11 Aug 2017 11:36:01 GMTJHTT-Communications@jhu.edu Risk Assessment NeedWith 9.9 million new cases each year, more than 47 million people worldwide have dementia. To detect dementia, questionnaires and cognitive screening tests are administered. Physicians diagnose dementia based on medical history, in-person examinations, brain imaging and blood tests. The global societal cost of dementia in 2015 was estimated at $818 billion. Since no treatment exists for most forms of dementia, early diagnosis is crucial to optimize its management. Technology OverviewThe Dementia Risk Assessment (DRA) is an online tool to determine the risk of dementia based on a nove...Tue, 08 Aug 2017 11:32:43 GMTJHTT-Communications@jhu.edu CRISPR-based yeast two-hybrid system for investigating RNA-protein interaction Need: DNA-sequencing technology has led to the development of many powerful techniques, such as RIP-seq and CLIP-seq, which can be used to identify many RNAs bound by a protein of interest, however, few protocols exist for identifying the proteins bound to a particular RNA. Most available techniques involve RNA pull-down followed by protein identification via mass spectrometry, which requires highly specific, robust biochemical enrichment and is prone to non-biological associations of molecules that can occur between cell lysis and affinity purification. Because so many biologically and ...Thu, 27 Jul 2017 09:44:42 GMTJHTT-Communications@jhu.edu for Optimizing Radiation Beam Intensity Profile Shape Using Dual Multiple Aperture Devices NeedX-ray computed tomography has found widespread clinical utility; however, increasing concerns about the risks associated with ionizing radiation have driven the search for exposure reduction strategies. This invention explores hardware-based dose reduction methods.Technology OverviewThe invention is a Multiple Aperture Device (MAD), which is a novel x-ray beam modulator that uses binary filtration on a fine scale to spatially modulate an x-ray beam. Stage of DevelopmentPrototypePublicationsDesign of dual multiple aperture devices for dynamical fluence field modulated CTThu, 29 Jun 2017 12:50:14 GMTJHTT-Communications@jhu.edu Cell Death by Hyperactivation of Motility Networks Novelty:This technology is based on the discovery that hyper-activation of cellular motility networks can sensitize cancer cells to stressor to induce cell death. This is a novel method for the induction of cell death in cancers with mutations in motility pathways. Value Proposition:Therapeutic initiatives focused on single targets may fail to adequately address the highly complex and adaptable nature of cancers. Both government and industry-funded review articles point to an increased focus on cell or systems-based screens which reflect a mechanism of action for exploitation, rather...Fri, 16 Jun 2017 12:23:09 GMTJHTT-Communications@jhu.edu - Anti-Tmem100 Antibody Novelty: The Johns Hopkins researchers have developed rabbit polyclonal antibody specifically against Tmem100 that is suitable is suitable for immunohistochemical staining of tissue sections and western blot to detect Tmem100 protein level. Value Proposition: Tmem100 is a 134-amino acid, two-transmembrane protein highly conserved in vertebrates (Moon et al., 2010) and is identified as a candidate for the modulation of the TRPA1-V1 complex in the nociceptive pathway in the dorsal root ganglion (DRG) (Weng et al., 2015). Tmem100 has been shown to be involved in processes such as renal ...Tue, 13 Jun 2017 11:35:17 GMTJHTT-Communications@jhu.edu - Pirt-Cre Mice novelty: JHU researchers have generated generated Pirt-Cre mice in which Cre recombinase is expressed specifically in all primary sensory neurons in dorsal root ganglion (DRG) under the control of Pirt promoter. Value Proposition:Primary sensory neurons in dorsal root ganglion (DRG) play essential role in initiating, transmitting, and modulating pain and itch signals from the periphery. Pirt is a modulator of several TRP channels. Strikingly, Pirt is expressed specifically in all primary sensory neurons in the DRG and not in any CNS neurons. Dysfunction of DRG neurons often leads to ...Tue, 13 Jun 2017 11:30:57 GMTJHTT-Communications@jhu.edu High mobility group a1 (Hmga1) gene enhances organoid formation, intestinal stem cell self-renewal and expands the epithelial niche cell compartment in transgenic mice by amplifying Wnt signaling. NEED: High mobility group A1 (Hmga1) chromatin remodeling proteins are enriched in intestinal stem cells (ISCs), although its function in these settings had been poorly understood. Prior studies show that Hmga1 causes hyperproliferation, aberrant crypt formation, and polyposis in transgenic mice.TECHNICAL DETAILS: Johns Hopkins researchers demonstrate that Hmga1 amplifies Wnt/β-catenin signaling to enhance self-renewal and expand the ISC compartment.  Genes encoding Wnt agonist receptors and downstream Wnt effectors. Surprisingly, Hmga1 also “builds” an ISC niche by directly up-regulatin...Mon, 12 Jun 2017 08:39:33 GMTJHTT-Communications@jhu.edu Mutations in Human Breast Cancer Cells                                                  ESR1 mutations in human breast cancer cells CASE NUMBER C13950 ABSTRACT Newly discovered mutations in the estrogen receptor alpha gene, ESR1, are thought to predict for resistance to certain endocrine therapies in breast cancers that express hormone receptors. FEATURES Johns Hopkins researchers used AAV gene targeting to introduce wild type (controls), Y537S and D538G ESR1 mutations into the human breast cancer cell line MCF-7. STAGE OF DEVELOPMENT Tangible material DISEASE INDICATION Breast Cancer ...Tue, 30 May 2017 11:48:32 GMTJHTT-Communications@jhu.edu CTRP3 as Protein Therapeutics for Non-alcoholic Fatty Liver Disease (NAFLD) fatty liver disease (NAFLD), a major cause of liver dysfunction, is characterized by intrahepatic triacylglycerol (TAG) overaccumulation resulting from excess dietary lipids and de novo fatty acid synthesis. NAFLD is closely linked to insulin resistance and uncontrolled gluconeogenesis and, hence, is often associated with obesity. Yet, while NAFLD is a reversible condition, to date, therapeutic options are limited. Hence, this invention describes a novel role of C1q/TNF-related protein (CTRP)-3 in the direct regulation of liver lipid metabolism, unraveling CTRP3 as a valuable new...Fri, 19 May 2017 05:46:35 GMTJHTT-Communications@jhu.edu database to detect biologically important single nucleotide variants of cancer exomes are currently being sequenced, yielding millions of non-synonymous single nucleotide variants (SNVs) of possible relevance to disease etiology. Here, we provide a software toolkit to prioritize SNVs based on their predicted contribution to tumorigenesis. It includes a database of precomputed, predictive features covering all positions in the annotated human exome and can be used either stand-alone or as part of a larger variant discovery pipeline.Availability and Implementation: MySQL database, source code and binaries freely available for academic/government use at ...Fri, 19 May 2017 05:42:32 GMTJHTT-Communications@jhu.edu High-throughput Annotation of Somatic Mutations (CHASM) sequencing of cancer genomes has uncovered thousands of DNA alterations, but the functional relevance of the majority of these mutations to tumorigenesis is unknown. We have developed a computational method, called Cancer-specific High-throughput Annotation of Somatic Mutations (CHASM), to identify and prioritize those missense mutations most likely to generate functional changes that enhance tumor cell proliferation. The method has high sensitivity and specificity when discriminating between known driver missense mutations and randomly generated missense mutations (area under rece...Fri, 19 May 2017 05:40:40 GMTJHTT-Communications@jhu.edu Mendelian Inheritance In Man (OMIM TM Database) NeedToday, the genetic base for each major Mendelian disease is know and a medical professional can make a diagnosis based on the presence of a specific defective gene. In addition, a patient’s DNA can also be tested to reveal if (s)he is predisposed to a disease. Using gene therapy, medical professionals can correct a genetic defect by introducing a non-defective gene to a patient’s cells. Currently, there is a need for an easily accessible database to catalogue so much genetic information. The current invention is a portal to the overwhelming amount of genetic information currently ava...Fri, 19 May 2017 05:27:26 GMTJHTT-Communications@jhu.edu Layer-by-Layer Approach to Co-deliver DNA and siRNA Via AuNPs Gold Nanoparticles for Gene TherapyNovelty: This technology is a bioreducible/biodegradable polymer coated gold nanoparticle (AuNP) for the co-delivery of siRNA and DNA for targeted gene therapy.Value Proposition: There is a current unmet medical need for methods to safely and efficaciously deliver nucleic acids to cells and tissues for gene therapy. Approaches involving the use of viral vectors or polymeric vectors are limited by either their immunogenicity or lack of efficacy. The invention addresses these concerns and provides efficacious delivery of nucleic acids for targeted gene ...Tue, 09 May 2017 07:52:55 GMTJHTT-Communications@jhu.edu - New, Simple and Quick Test to Diagnose, Predict, and Prevent Brain Disorders Using Non-invasive Nasal Brush and Single-Cell Analysis novelty: This technology is the first clinical assay to measure biological markers that reflect symptom severity and drug efficacy for mental disorders, such as depression and schizophrenia. This tool is useful for not only diagnosing such disorders, but also predicting them before onset, choosing the best treatments for individual patients, and monitoring treatment efficacy. Value proposition: This tool aims to improve diagnosis, monitoring, and treatment selection for brain disorders, and prevent disease onset in vulnerable individuals. It will also allow screening of druggable com...Mon, 08 May 2017 06:32:55 GMTJHTT-Communications@jhu.edu Resonance Method for Imaging Molecular Binding with Enhanced Sensitivity Need: The binding affinity of a drug for its target is perhaps the most essential parameter when assessing drug efficacy, however it is often calculated in vitro within purified systems, which do not accurately represent patient-specific kinetics. More recently, strategies have been developed for chemically labeling compounds and their targets, either fluorescently, radioactively, or metallically, allowing for better assessment of target binding in cells and animals. Chemical labeling of compounds or targets, however, creates a costly technological barrier and safety considerations for t...Fri, 05 May 2017 07:41:19 GMTJHTT-Communications@jhu.edu Tau Mouse Lines that Faithfully Recapitulate Alzheimer’s Disease-like Pathologies Proposition: Effective therapy for Alzheimer?s disease (AD), the most common form of dementia and a devastating illness for the elderly, remains a great unmet need. For translational research and preclinical drug development, animal models that faithfully mimic the cardinal pathological features of AD are critical. A major limitation of current mouse models is the lack of progressive AD-like neuropathology, especially the severe age-dependent neuronal loss in their brains. In an effort to produce an improved model of the disease, we generated and characterized new mouse models that condi...Thu, 04 May 2017 10:09:46 GMTJHTT-Communications@jhu.edu and Fungal Volatiles NeedIncreasingly, invasive mold infections have been recognized in people who are immune compromised by genetic conditions, aging, other infections (e.g. HIV) and modern medicine (e.g. transplantation). Moreover, increasing evidence points to the role of these organisms as causes of environmental toxicities and industrial spoilage. An over-abundance of mold products- especially the organic metabolites that are secreted during the asexual reproduction phase- have been associated with food spoilage, industrial contaminations, and the medical syndrome characterized by respiratory complaints...Fri, 28 Apr 2017 05:55:21 GMTJHTT-Communications@jhu.edu;KA.3 (human keratinocyte-iPSC) Details: Described are induced pluripotent stem cells (iPSC) generated from keratinocytes. Keratinocytes were plucked and cultured from human hair and reprogrammed using non-viral, non-integrating methods. The resulting iPSCs contain no evidence of integrated pluripotency transgenes.  Associated Publication: PLoS One. 2012;7(8):e42838.Fri, 21 Apr 2017 11:15:15 GMTJHTT-Communications@jhu.edu SCADA Systems with Abstract State Need:Supervisory control and data acquisition (SCADA) manufacturers are considering moving SCADA systems to cloud-like settings to obtain cost, scalability, and fault-tolerance benefits.  In such settings, a few large cloud SCADA providers could manage SCADA systems for many individual utility companies.  While this can lower utility companies’ costs, simplify their management, and potentially offer new features and services, it raises critical security and confidentiality issues.Technical Overview:Our idea is to leverage the benefits of the cloud without revealing sensitive information ...Fri, 21 Apr 2017 04:36:44 GMTJHTT-Communications@jhu.edu, 21 Apr 2017 04:34:31 GMTJHTT-Communications@jhu.edu Patient-Specific Modeling of the Heart for Risk Stratification of Ventricular Arrhythmia in Patients with Hypertrophic Cardiomyopathy (HCM) via Image-Based Computational Simulations NeedHyperthrophic cardiomyopathy (HCM), predominantly an asymptomatic disease, frequently leads to sudden cardiac death resulting from ventricular arrhythmias, i.e. abnormal uncoordinated heart rhythms, particularly among young patients. For patients at high risk for sudden cardiac death, mortality is reduced by the prophylactic insertion of implantable cardioverter defibrillators (ICDs). Approaches to identify which HCM patients at risk for arrhythmia and thus need an ICD have been attempted with little success, and overall, there is no contemporary means for determining whether a patie...Thu, 20 Apr 2017 06:31:55 GMTJHTT-Communications@jhu.edu Questionnaire and Performance Tests to Assess Visual Abilities in Ultra-low Vision Need:   Ultra-low vision (ULV) is defined as levels of vision that are so limited that an individual cannot even recognize shapes, but may be able to see movement, direction of a light source, or tell night from day.  Standard vision tests such as letter charts are of no use to measure the visual abilities of these individuals, and until recently few if any tools were available to test them.  Due to emerging new treatments such as gene therapy, electronic retinal implants, and stem cell technology, and in view of the likelihood that individuals with ULV will be the participants of choice...Thu, 20 Apr 2017 06:31:48 GMTJHTT-Communications@jhu.edu Machine Learning Approach to Beamforming NeedGiven their ability to aid in real-time navigation of our complex anatomy, ultrasound and photoacoustic images are popular options for image guidance during surgery. However, noise in these images complicate surgical procedures, particularly noise caused by reflection and reverberation artifacts from highly echogenic structures, which often appear as true signals. If unidentifiable as noise rather than true signals, these artifacts cause irreversible damage to surrounding structures such as nerves and major blood vessels, leading to complications such as paralysis and patient death. ...Thu, 20 Apr 2017 06:31:44 GMTJHTT-Communications@jhu.edu is a mobile app that measures 3 different parameters of gait - balance, speed and endurance by instructing patients on self-administering 3 specific clinically validated tests of gait and balance. It fulfills the promise of personalized medicine by enabling patients to monitor their own gait and balance. Novelty: The measures in the mobile application track three critical domains of mobility unlike any other application on the market The measures selected have already been validated in multiple large scale clinical trials and are standard of care in neurologic and geriatric practi...Thu, 20 Apr 2017 06:31:33 GMTJHTT-Communications@jhu.edu Linked Data Graph Tool NeedThe publishing industry has expanded over the last few years with the increased digital presence.  With that, there has been an increase need to identify tools that can help navigate use of citations, the number of articles read, and the number of articles that may be accessed.ApplicationJHU researchers constructed a tool to link together objects (articles, data, software) in a set of graphs that support citations, navigation and discovery.  The tool includes a protocol for aggregating objects and a set of APIs for creating, querying and updating such objects as well. Stage of Develo...Thu, 20 Apr 2017 06:31:33 GMTJHTT-Communications@jhu.edu A Patient-Centered Ambulatory Regional Anesthesia Program Need: With a focus on shortening hospital stays and creating greater patient satisfaction, hospitals have begun to build out their outpatient surgery programs. With that focus, hospitals have emphasized regional anesthesia as a means to better pain control, less nausea and vomiting and decreased length of stay in the hospital. Such surgery centers are now focusing on the best ways to build out their anesthesia programs.   Technical Overview: The myBlock regional anesthesia program, delivers to surgery centers an all-inclusive program that is patient-centered, safe and efficient. Inc...Thu, 20 Apr 2017 06:31:30 GMTJHTT-Communications@jhu.edu Platform for Bacterial Identification and Antimicrobial Susceptibility Test NeedFor managing dangerous infections, clinicians need to know what bacteria strain(s) is/are causing the infections, the bacterial loads, and the antibiotic resistance profile of the bacteria.  Without knowing this vital information in a timely manner, it is impossible to begin using narrow-spectrum antibiotics that can effectively treat the patients. Importantly, these 3 aspects are all important, knowing one aspect earlier does not help.Technology OverviewOur technology falls into the in-vitro microbiological diagnostics market. This market constantly needs rapid, accurate, and automa...Thu, 20 Apr 2017 06:31:21 GMTJHTT-Communications@jhu.edu Screening and Brief Intervention: A Self-Paced Online Program for Nurses Need:Nurses, like other professionals, require education on screening patients for alcohol abuse and coaching for brief alcohol interventions. Without the proper tools in hand, nurses may miss an opportunity to identify and intervene at a pivotal point in a patients stay.    Technical Overview:                 Faculty at Johns Hopkins University and University of Pittsburgh have collaborated in creating 13 self-paced online educational modules to educate nursing staff and other populations on alcohol screening and intervention techniques. Videos, questions and assessment tools are includ...Thu, 20 Apr 2017 06:31:19 GMTJHTT-Communications@jhu.edu Ultrasound Transmission Element (CUTE) Catheter NeedApproximately 48.5 million couples are infertile worldwide. In the US, more than one million couples seek infertility treatment each year, and spend more than $3 billion in pursuit of babies. Unfortunately, current infertility treatments, including artificial insemination and embryo transfer approaches, can’t offer both an effective and economic solution. Obviously, there is a clear clinical need to increase fertilization success rate in a non-invasive and easy-to-perform approach, while reducing the overall time/cost and the hormone intake. From literature and from our center’s expe...Thu, 20 Apr 2017 06:31:16 GMTJHTT-Communications@jhu.edu and Database-guided Antimicrobial Peptide Evolution Need Antimicrobial peptides (AMPs) are typically amphiphilic peptides that have selectively to target and kill bacteria at low micromolar concentrations, often without harming mammalian cells and are thus an excellent candidate for drug development.Technology OverviewThe  new methodology combines molecular dynamic simulations and database-guided high-throughput screening to rationally design membrane-active peptides.  This methodology is able to design a range of structural and functional properties such as pore size and selectively targeting membranes with specific lipid compositions, e...Thu, 20 Apr 2017 06:30:59 GMTJHTT-Communications@jhu.edu Prevention 360 (IP 360) Need: Infection prevention is a major and growing concern in the healthcare  industry, particularly in light of the emergence of methicillin-resistant Staphylococcus aureus (“MRSA”).    Technology Overview: The IP 360TM, also known as an Infection Prevention 360, is a suite of applications that manages and delivers infection prevention data in real time. It is a web-based tool that allows infection prevention experts and auditors to enter and manage data, provide insights to set infection prevention strategies, monitor risk areas, improve quality of patient care, and ultimately pr...Thu, 20 Apr 2017 06:30:49 GMTJHTT-Communications@jhu.edu (Infection Prevention 360) HH Module Need: Infection prevention is a major and growing concern in the healthcare  industry, particularly in light of the emergence of methicillin-resistant Staphylococcus aureus (“MRSA”).    Technology Overview: The IP 360TM, also known as an Infection Prevention 360, is a suite of applications that manages and delivers infection prevention data in real time. It is a web-based tool that allows infection prevention experts and auditors to enter and manage data, provide insights to set infection prevention strategies, monitor risk areas, improve quality of patient care, and ultimately pr...Thu, 20 Apr 2017 06:30:49 GMTJHTT-Communications@jhu.edu for Rhomboid Proteases invention describes a method for creating novel, inhibitors of desired bacterial rhomboid proteases (RhP), and applies this method to produce potent antibiotics.  The value proposition is very high providing a means of identifying and creating novel, specific bacterial Rhp inhibitors (antibiotics) with a novel mechanism of action to prevent/overcome drug resistance.Thu, 20 Apr 2017 06:30:42 GMTJHTT-Communications@jhu.edu Medication Response using Wearables for Parkinson's Disease NeedKey challenges for treating Parkinson’s Disease are patient-to-patient variability of disease progression, the large temporal fluctuations in symptoms, and the unpredictable patient response during treatment. These challenges are currently addressed during clinic visits when physicians optimize treatment. Unfortunately these clinic visits are infrequent and do not provide sufficient relevant data to properly assess the immediate effects of most neuromodulatory treatment options. More frequent measurements of disease progression will allow clinicians to assess and titrate treatment on...Thu, 20 Apr 2017 06:30:40 GMTJHTT-Communications@jhu.edu Patient Mobility in the ICU using a Novel Non-Invasive Sensor NeedPatient mobilization is a critical variable that can predict future physical impairments and the ultimate length of stay for intensive care unit (ICU) patients. Measuring patient mobilization requires a clinical staff member to monitor a video feed of multiple patients in an ICU ward and make subjective distinctions on their level of mobility. This is a costly and time consuming process that distracts key clinical staff from other areas of patient care.Technical DescriptionThis disclosure describes the Non-Invasive Mobility Sensor (NIMS) technology that provides automated identificat...Thu, 20 Apr 2017 06:30:40 GMTJHTT-Communications@jhu.edu 3D and Plexin D1 as New Therapeutic Targets for Pancreatic Cancer Treatment Need: Most patients with pancreatic ductal adenocarcinoma (PDA) present with metastatic disease at the time of diagnosis or will recur with metastases after surgical treatment. Technology Overview: Semaphorin-plexin signaling mediates the migration of neuronal axons during development and of blood vessels during angiogenesis. The expression of the gene encoding semaphorin 3D (Sema3D) is increased in PDA tumors. Sema3D from PDA cells coimmunoprecipitated with the co-receptor plexin D1 (PlxnD1) on PDA cells. Mouse PDA cells in which SEMA3D was knocked down exhibited decreased invasive and ...Thu, 20 Apr 2017 06:30:39 GMTJHTT-Communications@jhu.edu Center of Motion Robot NeedImage-guided interventions (IGI) may be performed based on pre-acquired images, but using the imager at the time of the intervention to directly guide the procedure improves accuracy.  Compatibility of robotic devices with the imaging has been a challenging engineering task, especially with magnetic resonance (MR) environment. Technology OverviewThis novel invention is a development of a new robotic system for direct image-guided interventions. The manipulator uses our previously reported Pneumatic Step Motor actuation and is entirely made of electrically nonconductive, nonmetallic, ...Thu, 20 Apr 2017 06:30:35 GMTJHTT-Communications@jhu.edu for Automated Measurement of Spatial-cognitive Abilities, 20 Apr 2017 06:30:31 GMTJHTT-Communications@jhu.edu Hyperspectral Sensing Reliably Identifies Colorectal Cancer in Intraoperative Colon Specimens Need: Surgical management of colorectal cancer relies on accurate intraoperative identification of tumor and resection to negative margins. Hyperspectral (HS) imaging is a passive, non-ionizing diagnostic method that has garnered increased interest for its ability to detect multiple tumor types and even neoplastic biomarkers. We sought to explore the ability to use HS spectroscopy for transluminal identification of tumor specimens during surgical resection of colorectal cancers.Technology Overview:  The accuracy of HS measurements to identify colorectal cancer was high during both transl...Thu, 20 Apr 2017 06:30:23 GMTJHTT-Communications@jhu.edu Networks of Excitatory Projection Neurons and Inhibitory Interneurons for Studying Human Cortical Neurotoxicity  Unmet Need:  Translating neuroprotective treatments from discovery in cell and animal models to the clinic has proven challenging. To reduce the gap between basic studies of neurotoxicity and neuroprotection and clinically relevant therapies, JHU scientists developed a human cortical neuron culture system from human embryonic stem cells or human inducible pluripotent stem cells that generated both excitatory and inhibitory neuronal networks resembling the composition of the human cortex.Technical Details: This cell culture methodology uses timed administration of retinoic acid to neural prec...Thu, 20 Apr 2017 06:30:20 GMTJHTT-Communications@jhu.edu A database of ADP-ribosylated proteins NeedPharmaceutical companies are conducting clinical trials for PARP inhibitors to treat cancer patients.  There is currently only one drug approved in this class, but there is a need for continued and improved knowledge of PARP substrates. Technology OverviewJHU researchers created a database that curates the last 30 years of literature on ADP-ribosylation and over 5000 substrates in humans, mouse and rate as well as other organisms.  The information can provide additional support and guidance to pharmaceutical companies working in this space.Stage of DevelopmentThe database is availabl...Thu, 20 Apr 2017 06:30:08 GMTJHTT-Communications@jhu.edu iPSCs, 20 Apr 2017 06:29:50 GMTJHTT-Communications@jhu.edu Ablation Lesion Assessment System Need: Catheter-based cardiac Radio frequency (RF) ablation has become a common treatment for arrhythmias such as atrial fibrillation or ventricular tachycardia. Cardiac ablation requires contiguous transmural lesions to be made between anatomical boundaries.  Incomplete ablations are thought to result in a 40-50% recurrence rate in patients undergoing cardiac ablation for treatment of atrial fibrillation. Currently, assessment of lesion effectiveness is conducted by indirect measures. Real-time assessment of tissue depth and transmural lesion formation would allow the operator to adjust ...Thu, 20 Apr 2017 06:29:46 GMTJHTT-Communications@jhu.edu Drug Delivery System to Enable Targeted Ultrasound-gated Release of Neuromodulatory Agents, noninvasive neuromodulation of the brain of an otherwise awake subject could revolutionize both basic and clinical neuroscience. Towards this goal, the JHU scientists have developed nanoparticles that allow noninvasive uncaging of a neuromodulatory drug upon the application of focused ultrasound. These nanoparticles are composed of biodegradable and biocompatible constituents and are activated using sonication parameters that are readily achievable by current clinical transcranial focused ultrasound systems. These particles are potent enough that their activation can silence seizures...Thu, 20 Apr 2017 06:29:38 GMTJHTT-Communications@jhu.edu Ratio Modulation Need: Electronic or capacitive communication is necessary for the control and operation of a large number of electronics, mechanical devices, computing devices, etc. However, the existing protocols can require large amounts of code, and require a synchronization source for the timing of the signal.Technical Details: JHU inventor has designed a system and method for data communication. It is advantageous because it does not require synchronization to physically modulate a digital signal across a medium. There are two major advantages to using this method. It is very lightweight code with ...Thu, 20 Apr 2017 06:29:35 GMTJHTT-Communications@jhu.edu A Protein Bioconjugation Method with Exquisite N-terminal Specificity Need:The use of proteins and peptides for therapeutic applications are often compromised by low biological stability, high renal clearance, and non-optimal bio-distribution.  Chemical attachment of poly-(ethylene glycol) (PEGylation) is often considered the most effective way to improve these pharmacologic properties by increasing circulation half-life and reducing both the immunogenicity of proteins and protease mediated degradation.  However, random conjugation results in heterogeneous derivatives with undefined composition and can substantially lower the bioactivity of the modified pr...Thu, 20 Apr 2017 06:29:16 GMTJHTT-Communications@jhu.edu Dense Cu Nanowires for Low-overpotential CO2 Reduction Need:  CO2 emissions from power generation is one of the primary sources of global warming, and the electrochemical reduction of these emissions is a promising solution for this problem.  However, there are few if any catalysts with sufficient activity and selectivity to make this technology commercially feasible. Technical Overview:  Our new catalysts are made using a two-step synthesis of highly dense Cu nanowires as advanced electrocatalysts for CO2 reduction. CuO nanowires were first grown by oxidation of Cu mesh in air and then reduced by either annealing in the presence of hydrogen...Thu, 20 Apr 2017 06:29:10 GMTJHTT-Communications@jhu.edu Desiccant Heat Exchanger Cartridge for a Portable Cooling System field of technology is evaporative cooling using a desiccant (such as silica gel or molecular sieve). Evaporative cooling using desiccants normally involves passing air through beads of desiccant to dry out the air. The desiccant beads remove water from the air by a process called adsorption. The dry air can then be used in systems that cool through evaporation (especially useful for cooling sweaty humans). It is a very effective method of cooling, however the adsorption process is exothermic and the desiccant beads heat up as a result. This results in the dry output airheating up as well....Thu, 20 Apr 2017 06:29:08 GMTJHTT-Communications@jhu.edu Mapping Data 38 North DPRK Digital Atlas, built originally on Google Earth, contains the largest, most comprehensive geospatial dataset of North Korea to date, identifying general locations such cities, roads, bridges, and railways, as well as more specific data such as schools, hospitals, military facilities, factories, mines and more. This proprietary database has been collected and compiled by Curtis Melvin, a Senior Fellow at the US-Korea Institute at SAIS, over the past decade, and offered exclusively through USKI. A small portion of the dataset was converted into a custom-built, interactive sea...Thu, 20 Apr 2017 06:29:07 GMTJHTT-Communications@jhu.edu of Tumor-Specific DNA in Saliva and Blood, 20 Apr 2017 06:28:42 GMTJHTT-Communications@jhu.edu in situ Hybridization for highly multiplexed RNA analysis of fixed tissue specimens Need: Formalin fixed and paraffin embedded (FFPE) tissues are the most common form of patient specimens analyzed by pathologists. This standard practice of preserving clinical samples, however, dramatically damages the RNA content of these valuable specimens. RNA molecules provide important information about which genes are being expressed in a tissue, and whether or not there may be an ongoing infection. Current approaches to FFPE RNA analysis rely on RNA purification followed by reverse transcription (RT), processes that can reduce the sensitivity of downstream analyses and/or introduc...Thu, 20 Apr 2017 06:28:28 GMTJHTT-Communications@jhu.edu Micro-fabricated Device for the Analysis of Mechanical and Chemical Properties of Complex Mechanically Controlled Tissue Constructs need:  There is a need to bridge the gap between simplistic in-vitro studies and expensive, complex in-vivo studies to obtain meaningful pre-clinical data from a representative cellular environment and. One promising method is to use 3D cell cultures, or organ-chips, that reconstitute various functionalities of human organs in a microenvironment. These platforms allow extensive control on the cellular microenvironment while recapitulating important physiologic conditions. These platforms can be used to study mechanisms and new treatments for diseases such as asthma and brain cancer. The ...Thu, 20 Apr 2017 06:28:07 GMTJHTT-Communications@jhu.edu Needle System for Central Venous Access need: Invasive temporary pacemakers are most commonly inserted via a transvenous approach, where access to the femoral, internal jugular or subclavian vein is gained, and the lead is directed into the heart. In an emergency situation, often the jugular vein is the quickest route. When accessing the jugular vein, potential perforation of the carotid artery must be prevented. In order to mitigate these risks, a need exists for a hybrid needle system to help with safe access, placement, and verification into the jugular vein when imaging is not available   JHU engineers have invented a Hybr...Thu, 20 Apr 2017 06:27:59 GMTJHTT-Communications@jhu.edu design and process for developing tissue-engineered organs with hollow structures is a commonly used biomaterial for tissue engineering applications given its compositional proximity to physiological tissues. Despite much progress in recent years, clinical application of collagen-based scaffolds has been limited by constraints in its biomanufacturing process. Recently, the JHU scientists developed an innovative process to manufacture seamless and biomechanically tunable collagen scaffolds with unprecedented flexibilities of incorporating a variety of design features in both longitudinal and radial or cross-sectional directions relevant to genitourinary and gastroin...Thu, 20 Apr 2017 06:27:58 GMTJHTT-Communications@jhu.edu<![CDATA[Maryland EXCELS Quality Finder: A Mobile App Designed to Help Maryland Families & Professionals Find High-Quality Early Childhood and School-Age Programs Across the State]]> Need:Identifying a convenient and safe childcare program with high quality levels is very challenging. There are a wide range of childcare and school-age programs within a short distance from family homes, workplaces or routes of travel. How should parents select which program in their area is appropriate for their children.  Technical Overview:                 Faculty members in the Center for Technology and Education at Johns Hopkins University, in conjunction with the Maryland State Department of Education have developed Maryland EXCELS, a voluntary Quality Rating and Improvement Syst...Thu, 20 Apr 2017 06:25:18 GMTJHTT-Communications@jhu.edu and Interferences with Healthcare - Incident Reporting Form NeedThere is a need to collect information about attacks or interferences involving health care personnel, patients, health care facilities or health care transports.  This information is important to report so that we have a better understanding of the problems that health care personnel and patients suffer, and who is responsible. Technology OverviewProvided is an incident reporting form for reporting attacks and interferences with health care personnel, patients, health care facilities or health care transports. Stage of DevelopmentIncident reporting form developed. Publications Thu, 20 Apr 2017 06:24:22 GMTJHTT-Communications@jhu.edu Education Modules for Ophthalmology in Eyemaginations, Inc.'s Education Software - Module 4 Nerve Fiber Layer Evaluation Need:The Interactive Skills Transfer System (ISTS) is a new education approach to medical information that maximizes the effectiveness of learning, rather than serving as an encyclopedic data storage repository, as do traditional textbooks.Technology Overview:  Unlike lecture format, the interactive nature of ISTS brings each student into the process of learning at their own speed and permits evidence-based evaluation of what has been learned. Textbooks contain differential diagnosis lists that fail to duplicate the intellectual thining process needed to solve clinical problems. ISTS sim...Thu, 20 Apr 2017 06:15:08 GMTJHTT-Communications@jhu.edu Education Modules for Ophthalmology in Eyemaginations, Inc.'s Education Software - Module 3 Visual Field Evaluation Need:The Interactive Skills Transfer System (ISTS) is a new education approach to medical information that maximizes the effectiveness of learning, rather than serving as an encyclopedic data storage repository, as do traditional textbooks.Technology Overview:  Unlike lecture format, the interactive nature of ISTS brings each student into the process of learning at their own speed and permits evidence-based evaluation of what has been learned. Textbooks contain differential diagnosis lists that fail to duplicate the intellectual thining process needed to solve clinical problems. ISTS sim...Thu, 20 Apr 2017 06:15:07 GMTJHTT-Communications@jhu.edu Education Modules for Ophthalmology in Eyemaginations, Inc.'s Education Software - Module 2 Optic Disc Evaluation Need:The Interactive Skills Transfer System (ISTS) is a new education approach to medical information that maximizes the effectiveness of learning, rather than serving as an encyclopedic data storage repository, as do traditional textbooks.Technology Overview:  Unlike lecture format, the interactive nature of ISTS brings each student into the process of learning at their own speed and permits evidence-based evaluation of what has been learned. Textbooks contain differential diagnosis lists that fail to duplicate the intellectual thining process needed to solve clinical problems. ISTS sim...Thu, 20 Apr 2017 06:15:07 GMTJHTT-Communications@jhu.edu Hopkins Diabetes Management Program NeedThe medical management of glycemic control in hospitalized patients with diabetes mellitus is sub-optimal. Many problems have been identified, which include lack of knowledge by health care providers regarding names and pharmacological action of commercially available insulin preparations and oral hypoglycemic agents, mistiming of blood glucose measurements and insulin administration, non-standardized algorithms for the identification and treatment of hypoglycemia and severe hyperglycemia and poor counseling regarding outpatient management of blood sugars.  In addition, the length of...Thu, 20 Apr 2017 06:08:32 GMTJHTT-Communications@jhu.edu to Peptidylarginine Deiminase 2 Protect Against Joint and Lung Damage in Rheumatoid Arthritis Need:  Rheumatoid Arthritis is a complex and clinically heterogeneous disease which presents a recognized challenge for diagnosis and prediction of future severity. Peptidylarginine deiminase (PAD) enzyme family members are known to be central players in the pathology of Rheumatoid Arthritis (RA). There is a need for precise biomarkers to identify clinically unique disease subgroups in order to help direct treatment plans.  In a subset of patients with RA, autoantibodies that activate some of these PAD enzymes have been identified. These antibodies are associated with severe joint and lu...Fri, 14 Apr 2017 03:28:24 GMTJHTT-Communications@jhu.edu of LAG3 as the a-synuclein Neuronal Transmission Receptor, 07 Apr 2017 05:17:33 GMTJHTT-Communications@jhu.edu of PARIS Prevents Dopaminergic Neurodegeneration in Models of Parkinson’s Disease, 07 Apr 2017 05:17:33 GMTJHTT-Communications@jhu.edu Eye Drop Technology with Enhanced Hyaluronic Acid Retention and Delivery to Ocular Tissues present invention provides biomaterial compositions that can immobilize HA to the ocular surfaces through an HABpep and transmembrane mucins and collagen of ocular tissues can act as anchoring sites. These biomaterial compositions provide prolonged HA binding and retention in both ex vivo and in vivo animal models. HA eye drop solutions with these the inventive biomaterials can prolong the biological and physical benefits to the ocular surface and potentially be more effective in treating eye disorders including dry eye than standard HA-eye drop presently available. Methods of making and u...Fri, 07 Apr 2017 05:17:27 GMTJHTT-Communications@jhu.edu of Tumor Seeding during Needle Biopsy by Chemotherapeutic-Releasing Gelatin Sticks Need: Needle biopsy is an indispensable diagnostic tool in obtaining tumor tissue for diagnostic examination. Tumor cell seeding in the needle track during percutaneous needle biopsies has been reported for various types of cancers. The mechanical force of the biopsy both directly displaces the malignant cells and causes bleeding and fluid movement that can further disseminate cells. Technology Overview: To prevent the risk of tumor cell seeding during biopsy, we developed a gelatin stick loaded with chemotherapeutics such as doxorubicin (DXR) that was inserted into the biopsy canal. The...Thu, 06 Apr 2017 08:52:45 GMTJHTT-Communications@jhu.edu Plasmid NEEDThe androgen receptor (AR) is a widely expressed ligand-activated transcription factor which mediates androgen signaling by binding to androgen response elements (AREs) in normal tissue and prostate cancer (PCa). Within tumors, the amount of AR plays a crucial role in determining cell growth, resistance to therapy and progression to fatal castrate recurrent PCa in which prostate cells appear to become independent of androgenic steroids. Despite the pivotal role of the AR in male development and fertility and all stages of PCa development, the mechanisms governing AR expression remain...Mon, 03 Apr 2017 07:02:34 GMTJHTT-Communications@jhu.edu Human Schwann Cell Line NEEDSchwann cells (SCs) play an important role in the pathogenesis of peripheral nerve diseases. However, use of primary human SCs (hSCs) for in vitro models is limited because these cells are difficult to prepare and maintain in high yield and purity under common cell culture conditions.FEATURESTo circumvent this obstacle, the inventor immortalized primary human fetal SCs using the SV40 large T-antigen and human telomerase reverse transcriptase expression vectors. After cloning, selection, and purification, they evaluated several immortalized SC lines for their ability to express extrac...Mon, 03 Apr 2017 06:17:36 GMTJHTT-Communications@jhu.edu H-2 Db Restricted E7 Peptide (aa 49-57)-specific CD8+ T Cell Line NEEDHuman papillomaviruses, particularly HPV-16, are associated with most cervical cancers and their precursors. E7 is an oncogenic HPV protein that is expressed in most HPV-positive cervical carcinomas and plays an important role in the initiation and maintenance of cellular transformation. Accordingly, vaccines targeting the E7 protein appear to be a promising approach to prevent and/or treat HPV-associated cervical malignancies.FEATURESJohns Hopkins researchers have generated the HPV-16 E7-specific CD8+ T cell line by vaccinating six week old female C57BL/6 (H-2Db) mice with 107 p.f.u...Mon, 03 Apr 2017 05:56:28 GMTJHTT-Communications@jhu.edu Overdose Education Computerized Intervention computerized intervention is designed to inform patients about the risks associated with opioids, behaviors that increase the risk of overdose, and methods to respond to an overdose. On average, patients complete this intervention in 18 minutes and it has been associated preliminarily with  increased knowledge in 3 domains (opioids, opioid overdose, opioid overdose response knowledge). The intervention is currently hosted in the online survey manager Qualtrics.Fri, 31 Mar 2017 04:08:03 GMTJHTT-Communications@jhu.edu Staph-Enterotoxin B Receptor researchers have discovered that a glycoshphingolipid, digalactosylceramide serves as a receptor for Staph-Enterotoxin B Receptor (SEB) and have developed a recptor based immunoassay to detect nmole level of this toxin in blood.  A rapid, simple, and inexpensive sandwich enzyme-linked receptor based immunodot assay detects pathogens or pathogenic products in test samples using receptors for a characteristic component of the pathogen. This assay is widely applicable because it is highly specific, it does not require special equipment, and the results can be obtained within a few h...Thu, 30 Mar 2017 11:17:32 GMTJHTT-Communications@jhu.edu Quantitative Determination of Nucleoside Analogue Drugs in Genomic DNA or RNA Need:Hematologic and epithelial malignancies have been shown to progress by epigenetically silencing genes that code for tumor suppressors, cell cycle regulators or proteins involved in cell-cell interaction. Gene suppression occurs through promoter methylation and modification of histones. Drugs which are able to manipulate promoter methylation and histone modification include DNA methyltransferases (DNMT), as well as inhibitors such as DAC and 5AC. To be effective, these drugs must be incorporated into genomic DNA and RNA. There are, however, multiple factors which affect the degree to...Fri, 24 Mar 2017 13:27:06 GMTJHTT-Communications@jhu.edu Anastasis Biosensor (Split version) NOVELTYThis technology involves a biosensor that is able to label and track cells in vitro and in vivo that have reversed apoptosis (Anastasis, Greek for “rising to life”) after they experienced mitochondrial outer membrane permeabilization (MOMP) and caspase-3 activation, the 2 most recognized hallmarks of apoptosis at execution stage.  This biosensor can be used to identify regulator of anastasis (therapeutic targets), and screening for drugs that can promote or suppress reversal of apoptosis.  Value Proposition:This invention is a biosensor that track anastasis, the phenomenon in ...Fri, 24 Mar 2017 06:36:59 GMTJHTT-Communications@jhu.edu Shell Guide Wire Introducer current invention, a clamshell wire introducer (the clamshell), addresses the deficiencies of currently available introducers.  The device is similar in shape to standard wire introducers, but is split along the ventral surface of the long axis. The device is then used in the same manner as any other wire introducer.  After wire insertion, the device is withdrawn from the hemostatic valve and manual pressure released, allowing the clamshell to open, permitting the device to be retrieved off the wire in a friction-free fashion.Tue, 21 Mar 2017 12:53:16 GMTJHTT-Communications@jhu.edu Utilization as Decision Tools for Personalized Cancer Drug Regimens present invention includes methods for identifying chemotherapy treatments specifically suited for each cancer patient. The methods include obtaining a biopsy from the cancer patient; establishing a cancer culture from the biopsy; mixing the cancer culture with a matrix forming mini cancers.  The mini cancers are then used to screen chemotherapy agents by identifying those agents that completely stop mini cancer growth, inhibit mini cancer growth, and/or  inhibit invasion of the mini cancers in a surrounding extracellular matrix. Since the mini cancers are derived from the patient, only th...Tue, 21 Mar 2017 12:53:11 GMTJHTT-Communications@jhu.edu Thermal Spray Coatings are several well-known industrial spray deposition processes to fabricate coatings on various substrates. However, it is challenging to produce high quality coatings, i.e. coatings that have low porosity, low oxide content, low surface roughness, high hardness, and high bond strength. This invention is  fully-dense, nanostructured coatings with tunable feature size, phase composition, and superior mechanical properties, produced by heat-treatment of thermal spray coatings with specified compositional characteristics.Tue, 21 Mar 2017 12:53:00 GMTJHTT-Communications@jhu.edu Steerable Drill for Minimally-invasive Surgery conventional core decompression of osteonecrosis, surgeons cannot successfully reach the whole area of the femoral head due to the rigidity of the instruments currently used. To address this issue, this invention is a steerable drill using a continuum dexterous manipulator (CDM) and flexible cutting tool passing through the lumen of the CDM. Effective curved-drilling parameters, as well as drilling trajectory. Moreover, the invention can perform S-shape drilling as well as multiple-branch drilling.Tue, 21 Mar 2017 12:52:54 GMTJHTT-Communications@jhu.edu Patient-Specific Modeling of the Heart for Risk Stratification for Ventricular Arrhythmia in Patients with Repaired Tetralogy of Fallot (TOF) via Image-Based Computational Simulations JHU inventors previous invention (C11304) provides a non-invasive method to identify the optimal ablation sites for infarct-related ventricular tachycardia (VT) by using 3D electrophysiological heart simulations with a model reconstructed from the patient?s late gadolinium-enhanced (LGE) MRI image. In this application, the inventors extend that methodology to patients with Tetralogy of Fallot (TOF), the most common form of cyanotic congenital heart disease. TOF hearts are quite unique in terms of their geometry, scar profile, and etiology of arrhythmia.  In the TOF cohort, 43% of patients ...Tue, 21 Mar 2017 12:52:41 GMTJHTT-Communications@jhu.edu Stiffness Steerable Cutter (Drilling, milling, etc) Using Low Melting Point Alloys new type of cable-driven continuum manipulator (CM) is presented, in which the stiffness of the device along its body length can be controlled using the thermomechanical properties of a phase changing alloy. The liquid phase of the alloy is used for achieving high dexterity and the solid phase for high stiffness. Joule heating and water cooling is used for transitioning the phase changing alloybetween stiff and compliant states. Single-segment and two-segment working prototypes of the CM are demonstrated. The mechanical and thermodynamic features of these prototypes are discussed and their p...Tue, 21 Mar 2017 12:51:32 GMTJHTT-Communications@jhu.edu quantification of rare mutation by Bottleneck Sequencing NeedThe underlying mechanisms of aging, carcinogenesis, and neurodegeneration involve the buildup of stochastic somatic cell mutations. Understanding the temporal and spatial properties of these mutations can lead to a more mechanistic understanding of human disease progression and the design of genetic-level therapeutics. No simple method of high-throughput genetic screening of somatic point mutations currently exists with sufficient sensitivity to identify these rare mutations. Most modern techniques use single cell genomic sequencing, which can detect these rare mutations genome-wide ...Tue, 21 Mar 2017 12:51:07 GMTJHTT-Communications@jhu.edu Balloon Shunt is a novel, patented treatment platform that functions to alter cerebrospinal fluid (CSF) flow, increase cerebral blood flow (CBF), and modulate the intracranial pressure (ICP) wave through natural cardiac-induced dynamics.  CADENCE can be visualized as an intra-aortic balloon pump for the brain and therefore functionally very distinct from a CSF shunt.  For patients with hydrocephalus, the current method of passive shunting drains CSF and reduces ICP, but it does not directly address CBF. CADENCE’s ability to alter CSF flow, increase CBF, and modulate ICP addresses clinical unmet need...Tue, 21 Mar 2017 12:50:51 GMTJHTT-Communications@jhu.edu for Sustained Release of a Carbonic Anhydrase Inhibitor (CAI) from Biodegradable Polymeric Microparticles is a leading cause of irreversible blindness that affects over 60 million people worldwide.  Traditional therapies aim to reduce intraocular pressure and include topical eye drop formulations, laser treatments, and incisional surgeries. Eye drop treatment is effective, but limited by drop toxicity, poor bioavailability of medication, and poor patient adherence.  Johns Hopkins inventors have developed a novel sustained delivery system for CAI for the treatment of glaucoma.Tue, 21 Mar 2017 12:50:44 GMTJHTT-Communications@jhu.edu Tool for Establishing Minimal Families of Cold-formed Steel Sections for Production invention is a new algorithm that produces a family of minimal weight cold-formed steel lipped channels with the smallest number of individual cross-sections (family size) that are still capable of covering the current engineering design demands as commonly found in light steel framing. The algorithms shows that a new family of shapes with only 12 sections can achieve the same or better performance as the 108 sections commercially available in the United States.The developed family of shapes provides a direct demonstration of the potential for optimization to improve cold-formed steel manu...Tue, 21 Mar 2017 12:50:01 GMTJHTT-Communications@jhu.edu Antagonist in the Treatment of Acute and Chronic Cardiac Disease present invention provides p75NTR antagonists that can improve cardiac function under acute and chronic cardiac conditions via administration of an effective amount to a subject in need thereof.  The amino acid sequences of these novel p75NTR antagonists have been identified and incorporated into a patent application providing future patent protection for commercial products derived therefrom.  The p75NTR antagonists have been shown to increase contractility in a population of cardiac cells and as a treatment for specific types of heart disease.Tue, 21 Mar 2017 12:49:37 GMTJHTT-Communications@jhu.edu of Actin Crosslinking Proteins for the Development of Anti-Cancer Therapeutics detection of pancreatic ductal adenocarcinoma is essential for patients to have a chance for survival.  The inventors have identified proteins that are significantly upregulated in pancreatic ductal adenocarcinoma while related paralogs are not.  Targets have been  identified and used to screen small molecule modulators to Identify therapeutic agents for cancer.Metastatic disease is responsible for the majority of cancer-related deaths, and as cells undergo transformation from healthy to metastasis, the cell’s biomechanical machinery undergoes dramatic shifts in composition.  The invento...Tue, 21 Mar 2017 12:49:25 GMTJHTT-Communications@jhu.edu Bone Extracellular Matrix Scaffold bone particulates are mixed with polycaprolactone (PCL) or another thermoplastic material. The material, when heated above a specific temperature, becomes a viscous liquid PCL suspension with bone particulates that can be extruded from an extrusion-based three-dimensional printer. This allows for the construction of anatomically shaped, porous, and patient-matched scaffolds with innate bioactivity that can be used to regenerate bone.This technology is the development of anatomically-shaped, porous scaffolds comprised primarily of bone extracellular matrix.  The gross geometry ca...Tue, 21 Mar 2017 12:48:40 GMTJHTT-Communications@jhu.edu and Ion Channel Pathway Cell Model for Testing Psychiatric Therapeutics, 17 Mar 2017 12:20:07 GMTJHTT-Communications@jhu.edu Method and Apparatus for Data Triaging Using Visual Saliency Model with ‘360˚ View’ (fish-eye view) Camera NeedN/ATechnology OverviewThe invention is a visual saliency system, which can be used as a frontend co-processor for information triaging, compression and analysis in various computer vision tasks. Saliency is the distinct subjective perceptual quality which makes some objects of the environment stand out from their neighbours and immediately grab the observer’s attention. We use a biologically plausible proto-object based visual saliency model to identify regions of interest for both visualization and efficient analysis. The system is also extended to videos and incorporates motion asp...Fri, 17 Mar 2017 06:00:14 GMTJHTT-Communications@jhu.edu App: Empowering Decisions for a Safe Path Forward NeedSafety planning is a widely advocated intervention to prevent and respond to intimate partner violence (IPV), yet the vast majority of survivors never access safety services in formal settings, such as health care clinics. The challenge is to increase women’s access to safety planning by integrating evidence based tools that make use of appropriate technology.Technology OverviewThe Hopkins myPlan team originally developed the safety decision aid for use as an internet-based resource in 2005.  As technology has advanced, the team has continued to develop, adapt and evaluate the safety...Fri, 17 Mar 2017 06:00:05 GMTJHTT-Communications@jhu.edu of a stable Nav1.9 (Scn11a) cell line NeedChronic pain management is primarily achieved through the effective use of opioid derived therapeutics.  Although efficacious, these drugs are also associated with adverse events of addiction, confusion and sedation. In large part, these side effects result from an inability to selectively screen for drugs that target the established pain-sensing voltage-gated sodium (Nav) channel isoform Nav1.9 (gene name: Scn11a) found in sensory dorsal root ganglion (DRG) neurons and the enteric nervous system.  The ability to express this channel in heterologous systems is necessary prerequisite ...Fri, 17 Mar 2017 06:00:04 GMTJHTT-Communications@jhu.edu Morale Project NeedTurnover in hospital medicine exceeds 14%, almost double of physicians in general. Recruitment costs of one new hospitalist can range from $20,000 to $120,000. Losing a single hospitalist can equal a loss of $500,000 when the costs of on-boarding and ramp up are included. Low employee morale has been associated with decreased productivity, increased absenteeism, increased turnover, and decreased patient satisfaction. In addition to its financial impact, departures due to low morale can be sudden and devastating, leading to loss of team cohesiveness, increased work burden on the remai...Fri, 17 Mar 2017 06:00:00 GMTJHTT-Communications@jhu.edu Insulin-loaded Nanoparticle and the Method for Preparing Thereof Need:Repeated injections of insulin is the standard of care for treating Type 1 diabetes, and essential for control and management of Type 2 diabetes. Drawbacks of this treatment include poor patient compliance, discomfort, and an impaired lifestyle, and hypoglycemia. Oral administration of insulin, if successful, could deliver insulin such that it mimics the natural process of insulin metabolism, avoiding the hypoglycemia and discomfort associated with injections. Therefore, there is an unmet need to overcome the challenges associated with oral delivery of insulin, including, insulin de...Fri, 17 Mar 2017 05:59:58 GMTJHTT-Communications@jhu.edu and VectorEYES – A System for Insect Surveillance and Tracking that Provides Actionable Insect Population Data to Public Health Administrators NeedCurrently, mosquito surveillance methods are costly in terms of human resources and not easily scalable. The invention is a low-cost solution that provides real-time mosquito surveillance data to health administrators, communities and individuals.Technology OverviewThe invention consists of two parts: VectorEyes; and VectorWeb.  VectorEYES, which are existing, evidence-based, ovitraps with one simple modification: the addition of low-cost, reprogrammed, camera-phone technology, which converts ovitraps into cloud connected surveillance sensors that transmit images of inside the trap t...Fri, 17 Mar 2017 05:59:56 GMTJHTT-Communications@jhu.edu Novel Data Streaming Natural Language Parser System NeedExtracting important information from electronic health record (EHR) database systems is an important part of data analytics in clinical settings. Performing this operation quickly is computationally expensive in a real-time setting.  Technology Overview  This software is a novel natural language processing analytic platform that performs the identification and extraction of different words, sentences, phrases and ontologies to quickly visualize the key features of any medical record. The system uses an unsupervised count sketch method that can determine the relationship between stru...Fri, 17 Mar 2017 05:59:49 GMTJHTT-Communications@jhu.edu of stable mouse neuroblastoma N2a cells that express either wild-type human APP695 N2a APP695wt or human APP695swe N2a APP695swe, 17 Mar 2017 05:59:46 GMTJHTT-Communications@jhu.edu – A novel sensitive, specific, scalable and simple method to identify functional anti-tumor T cell responses Need With the growth of cancer immunotherapy dependent on enhancing anti-tumor T cell responses, it has become important to rapidly, sensitively and specifically assess functional anti-tumor T cell responses, specifically via liquid biopsy.   Such biomarkers can define which patients will respond to a given immunotherapy and who might require additional therapies.  ELISPOT currently is used for this purpose, however ELISPOT lacks sensitivity and only assays cytokine production.  Technology OverviewThe technology is a novel, sensitive, specific, and scalable method to evaluate candidate t...Fri, 17 Mar 2017 05:59:45 GMTJHTT-Communications@jhu.edu of New Monoclonal Antibodies Recognizing Human Prostate-specific Membrane Antigen (PSMA) Need Prostate-specific membrane antigen (PSMA, also known as GCPII) is a validated target for prostate cancer imaging and therapy.  Macromolecular reagents, most notably monoclonal antibodies (mAbs), offer a viable alternative to small-molecule PSMA ligands for imaging and therapy.  However existing anti-PSMA antibodies have several drawbacks, including limited commercial availability, poorly defined epitopes, and lack of data on cross-reactivity towards GCPII paralogs and orthologs.Technology OverviewThe technology includes four novel murine monoclonal antibodies (mAbs) that recognize h...Fri, 17 Mar 2017 05:59:34 GMTJHTT-Communications@jhu.edu Calibration for Cone Beam CT using Line Fiducials NeedTraditional BB-based geometric calibration methods for cone-beam CT (CBCT) rely significantly on foreknowledge of the scan trajectory shape. This is a hindrance to the implementation of variable trajectory CBCT systems, normally requiring a dedicated calibration phantom or algorithm for every scan orbit of interest. A more flexible method of calibration is proposed here that accommodates various orbit types – including strongly noncircular trajectories – without software or phantom redesign.Technical DetailsThe proposed method uses a calibration phantom consisting of multiple radio-o...Fri, 17 Mar 2017 05:59:32 GMTJHTT-Communications@jhu.edu app (working title: Moms Talk Shots) Need:  Educational and Communication tools for obstetric patients. Technology Overview: Moms Talk Shots is an interactive, educational app for computers, tablets and smartphones. The app is intended for pregnant obstetric patients and their close friends and family, as well as their obstetric providers. For patients, the app will survey their knowledge, attitudes and beliefs regarding maternal and infant vaccinations, and based on their answers will then deliver individually tailored information about vaccinations via educational videos. For providers, the app will provide written resour...Fri, 17 Mar 2017 05:59:31 GMTJHTT-Communications@jhu.edu of HPV-16 H-2 Kb-restricted E6 Peptide (aa 48-57)-specific CD8+ T Cell Line The HPV-16 E6-specific CD8+ T cell line is generated by vaccinating six to eight week old female C57BL/6 (H2-Kb) mice with 2ug of pcDNA3-CRT/E6 using a helium-driven gene gun. Mice received two boosts with the same regimen 1 and 2 weeks later. The resulted splenocytes were harvested, stimulated with irradiated TC-1 tumor cells in the presence of murine IL-2 (20U/ml) for eight weeks, and sorted for E6-specificity and CD8 expression. The resulted E6-specific CD8+ T cell recognizes the HPV-E6 epitope (amino acid 48-57).   FEATURES The resulted E6-specific CD8+ T cell recognizes the HP...Fri, 17 Mar 2017 05:59:31 GMTJHTT-Communications@jhu.edu HPV-16 H-2 Kb Restricted E7 Peptide (aa 49-57)-specific CD8+ T Cell (E7T-LUC) Line Need:A significant challenge in determining the response to Adoptive T cell Transfer (ACT) therapy is the difficulty in assessing the trafficking of antigen specific T cells as well as the therapeutic effect against tumors in vivo without killing the mice. Understanding of the trafficking of antigen-specific CD8+ T cells in vivo will provide insight about how our immune system controls infectious diseases and cancers.Technology Overview:Johns Hopkins researcher, TC Wu has developed the E7T-LUC cell line by infecting a HPV-16 E7-specific CD8+ T cell line with retrovirus that contains a pl...Fri, 17 Mar 2017 05:59:30 GMTJHTT-Communications@jhu.edu of Small Molecule Inhibitors of Neutral Sphingomyelinase 2 (nSMase2) for the Treatment of Neurodegenerative Diseases NeedIn the brain, neutral sphingomyelinase 2 (nSMase2) is expressed in neurons and increased activity and expression of this enzyme has been associated with pro-inflammatory conditions observed in Alzheimer’s disease, multiple sclerosis and human immunodeficiency virus (HIV-1) patients. Inhibition of human nSMase2 may preserve neuronal function by preventing increases in ceramide, and/or blocking exosome production and as a consequence decreasing cell death.  A number of nSMase inhibitors have been identified, but these compounds have molecular characteristics that make them poor drug ca...Fri, 17 Mar 2017 05:59:29 GMTJHTT-Communications@jhu.edu Compass: A Mobile Health Platform for Collecting Longitudinal Circadian Behavior Data on those at Risk or Already Diagnosed with Metabolic Syndrome needCircadian rhythms drive much of our health, but are not well understood.Technology OverviewJohns Hopkins researchers developed a mobile health platform for collecting longitudinal circadian behavior data on those at risk or already diagnosed with Metabolic Syndrome. The mobile health software stack includes an Apple ResearchKit App, an Apple Watch App, an Android App, an Amazon Echo/Alexa Skill and a cloudbased web service for collecting, and organizing health metrics and circadian behavior patterns. The platform, both in its individual components and through the combination of compo...Fri, 17 Mar 2017 05:59:28 GMTJHTT-Communications@jhu.edu New Index Utilizing Myocardial Scar and Myocardial Interstitial Fibrosis Volume to Assess Left Ventricular Function Need:  Assessing the condition of the heart after a heart attack in key to determining effective treatment for heart muscle damage, and to predict future heart failure. Monitoring the function of the left ventricle of the heart is an important way to diagnose cardiac function after heart attack. In current methods, physicians examine elements of heart function such as blood ejection fraction to make clinical diagnoses and predictions. Left ventricle ejection fraction (LVEF) is the most prevalent variable used to evaluate global function of the left ventricle. However, significant myocard...Fri, 17 Mar 2017 05:59:27 GMTJHTT-Communications@jhu.edu Human Heavy Chain Ferritin Nanocages and Their Uses for Therapeutic and Diagnostic Delivery Need:Localized delivery of chemotherapeutics to the lung via inhalation provides a straightforward method of directly targeting lung cancers. However, due to the presence of multiple delivery barriers, the effectiveness of the        approach has been limited. Here, we disclose an invention of a novel inhalable drug delivery platform capable of overcoming multiple barriers simultaneously following inhalation.Technology Overview:The newly designed system is composed of human heavy chain ferritin proteins and polyethylene glycol (PEG) polymers, which individually provide intrinsic tumor ta...Fri, 17 Mar 2017 05:59:26 GMTJHTT-Communications@jhu.edu Gradient Hydrogels to Study and Screen Potential Cancer Therapeutics needHypoxia is a critical factor in the progression and metastasis of many cancers. Frequently, oxygen gradients develop in tumors as they grow beyond their vascular supply leading to heterogeneous areas of oxygen depletion.Technology OverviewJohns Hopkins researchers have created a gradient hydrogel (collagen and gelatin) and observed that hypoxic gradients guide cancer cell motility and matrix remodeling through HIF1α activation.  They further found that in the hypoxic gradient, individual cells migrate more quickly, across longer distances, and in the direction of increasing oxygen te...Fri, 17 Mar 2017 05:59:21 GMTJHTT-Communications@jhu.edu Compressed Sensing CMOS Image Sensor with Pixel-wise Coded Exposure (PCE) Need: This technology allows for independent control of exposure time during pixel integration whereby the image sensor can sample a high frame rate video at a low framerate.   Technology OverviewThrough modulating pixel exposure, a video is compressed into a single image for storage and transmission. The video is recovered from the image using compressed sensing techniques. This method allows for video compression prior to sampling. Further, in this architecture, the pixels have the ability to be exposed over multiple frames, thereby increasing video SNR as more light can be integrated ...Fri, 17 Mar 2017 05:59:18 GMTJHTT-Communications@jhu.edu (Game Enhancing Augmented Reality) - A lower limb alternative control interface for computers NeedFor current gaming systems, computers, and other electronics, the controller is adapted for use by the users hands.  There are limited solutions available to provide more sensitive, robust controllers for those needing to use their lower limbs to control an electronic device.Technical DescriptionJHU researchers have created a device, partnered with novel software, that transfers dexterous control of computers from the hands to the feet.  The device features an innovative sensor design provides high sensitivity and robust usability.  A Graphic User Interfaces allow for significant use...Fri, 17 Mar 2017 05:59:11 GMTJHTT-Communications@jhu.edu of C1q/TNF-related Protein-1 (CTRP1) to Treat Fatty Liver Disease (steatosis) NeedObesity is a leading preventable cause of death worldwide, and it is associated with a number of comorbidities, including Non-alcoholic Fatty Liver Disease (NAFLD).  Fatty liver is the accumulation of triglycerides and other fats in the liver cells.  The amount of fatty acid in the liver depends on the balance between the processes of delivery and removal. In some patients, fatty liver may be accompanied by hepatic inflammation and liver cell death (steatohepatitis). Potential pathophysiologic mechanisms for fatty liver include the following: decreased mitochondrial fatty acid beta-o...Fri, 17 Mar 2017 05:59:08 GMTJHTT-Communications@jhu.edu in vivo screening platform for chemical and genetic modulators of Apoliporpotein-B Need: Rapid and sensitive screening platform to develop diagnostic tests for metabolic diseases.Technology Overview: Elevated serum Apolipoprotein-B (ApoB) may represent a unifying risk factor underlying many of the world?s most prevalent metabolic diseases. ApoB levels independently predict incidence of diabetes, metabolic syndrome, and cardiovascular disease even after adjusting for confounding variables Elevated serum Apolipoprotein-B (ApoB) may represent a unifying risk factor underlying many of the world?s most prevalent metabolic diseases. ApoB levels independently predict incidenc...Fri, 17 Mar 2017 05:59:05 GMTJHTT-Communications@jhu.edu Endoscope Design for Three-dimensional Surgical Guidance NeedAlthough stereoscopy has been commercially developed and has found wide acceptance through the US and Europe, it requires extensive and potentially cost-prohibitive computational hardware and also potentially limited for imaging featureless surfaces. Technology OverviewThis technology is a simple and cost-effective 3-D endoscope based on structured illumination technique. The system is calibrated and validated for quantitative depth measurement in both static and dynamic samples. The demonstrated setup affirms the feasibility for depth qantization and assisting medical diagnostic dec...Fri, 17 Mar 2017 05:59:02 GMTJHTT-Communications@jhu.edu Patient-centered Personalized Preventive Services for Patients with Diabetes and Other Co-morbidities Need Personalized preventative care services will enable providers to realize short term gains with payers experiencing long term revenue boosts. This platform is designed to provide personalized preventative services for patients with diabetes and other comorbidities. The current disease management platforms on the market concentrate on the providers’ perspective. Dr. Elham Hatef is focused on providing patients’ perspective in managing their own chronic conditions.   Technology Overview Researchers at Johns Hopkins have developed a website that provides a comprehensive list of pati...Fri, 17 Mar 2017 05:59:01 GMTJHTT-Communications@jhu.edu Particles for the Conversion of Inhibitory Signals to Co-stimulatory Signals for Enhanced Immune-mediated Tumor Cell Killing Need:One of the largest obstacles to overcome in cancer immunotherapy is the suppressive actions of the tumor microenvironment. Combination therapies that activate an immune response as well as block inhibitory pathways have potential in creating a prolonged and effective anti-tumor response. Technology Overview:Johns Hopkins researchers develop an immunoswitch nanoparticle that combines an inhibitory checkpoint signal, PD-L1, in the tumor microenvironment with a co-stimulatory, 4-1BB, signal to T cells for efficient stimulation. By combining antibodies against both molecules on a single...Fri, 17 Mar 2017 05:58:55 GMTJHTT-Communications@jhu.edu Oscillatory Atherectomy Device Incorporating a Novel Burr Design and Torque Limiting System for the Safer Treatment of Advanced Coronary Artery Disease NeedCardiovascular disease is the leadind cause of death globally and the most significant cost contributor to the health care system. When coronary plaques become heavily calcified - which is typical in older patients with long-standing coronary disease and those with co-morbidities such as chronic kidney disease - the compliance of the vessel is reduced to a point at which angioplasty is no longer effective. Currently, these heavily calcified stenosis are treated with an aggressive intervention known as coronary athrectomy, which partially ablates and modifies the compliance of the ath...Fri, 17 Mar 2017 05:58:55 GMTJHTT-Communications@jhu.edu Emergency Cricothyrotomy Assist Device (Trade Name CricSpike™ ) need:  The technology is an emergency airway device. Technology Overview:  This technology is a handheld cricothyotomy assist device that ensures breathing tube placement into the trachea, reducing the risk of accidental placement into the surrounding tissue or puncture into the esophagus. The device can also function as a self-contained breathing device itself if a separate breathing tube is not available. The device includes two main components:  a large breakaway handle; and an intertracheal tip that can remain in the neck until a long-term airway is developed. The technology works to...Fri, 17 Mar 2017 05:58:53 GMTJHTT-Communications@jhu.edu Insulator-Based High Efficiency Switching of Magnetic Unit, Method and Application Need: The invention meets the need for improved magnetic random access memory, racetrack memory, and spin logic devices.  The present state of the art of electrical current by spin-orbital torque (SOT) consists of a single heavy metal layer (e.g., W or Ta) in contact with a ferromagnetic layer, which acquires perpendicular magnetic moment suitable for high-density storage. An electrical current passing through the heavy metal layer with enough current density will enable SOT switching of the magnetic moment. This required current density is typically greater than 107 A/cm2, which is clos...Fri, 17 Mar 2017 05:58:53 GMTJHTT-Communications@jhu.edu Signatures of Estrogen and Progesterone Receptor Pathways Predict the Prognosis of Colorectal Cancer Currently adjuvant chemotherapy in CRC is universally recommended for stage III but still controversial in stage II. Conventional clinical and pathologic risk factors are insufficient to identify patients with stage II CRC who carry a high recurrent risk and require adjuvant therapy. This study demonstrated that the gene signature of ER pathway was able to well predict the recurrent risk of stage II CRC patient, suggesting the potential application of this signature as a novel marker to help refine risk assessment for patients with early-stage CRC. 2. The gene signatures of ER and PR pathwa...Fri, 17 Mar 2017 05:58:52 GMTJHTT-Communications@jhu.edu for Network Attack Resilient Intrusion Tolerant SCADA Need:Today?s SCADA (supervisory control and data acquisition)systems use fault-tolerance techniques to remain available even when parts of the system fail. The systems can be restored after a few hours of downtime during a non-critical time, a tolerance that is considered acceptable today.However, as malicious attacks become more prevalent, SCADA systems need to be more resilient and responsive to both benign failures and malicious attacks. For example, a sophisticated attacker can take down a primary control center at a critical moment purposefully, causing system downtime at the worst ...Fri, 17 Mar 2017 05:58:46 GMTJHTT-Communications@jhu.edu support for cone-beam computed tomography NeedNewer imaging systems based on cone-beam CT (CBCT) introduces an additional design criterion for the head holder that has not been previously addressed. This invention results in a radiographic profile that avoids a well-known image artifact (shading and streaks in CBCT images commonly referred to as a “cone-beam artifact”).Technology OverviewThis invention concerns a design of patient head holder that differs from designs commonly used in x-ray computed tomography (CT) to support the patient head’s head during the scan. Conventional head holders are well-suited for CT scanning syste...Fri, 17 Mar 2017 05:58:39 GMTJHTT-Communications@jhu.edu for automated read-across of chemical safety NeedModern information technologies have made big data available in safety sciences, i.e. extremely large data sets that may be analyzed only computationally to reveal patterns, trends, and associations.  There are a number of approaches to compile these data sets, but in all current approaches there are challenges in how to make sense of these data.Technical Details JHU researchers have created a new web-based tool called REACH-across, which particularly is focused on information and details related to chemical safety.  The database and its structure was devised based on intrapolation o...Fri, 17 Mar 2017 05:58:37 GMTJHTT-Communications@jhu.edu ANTI-FUNGAL INHIBITORS NeedIndividuals with impaired immunity, including those with advanced HIV infection, organ transplants, and on immunosuppressive regimens are susceptible to major fungal pathogens, such as Cryptococcus neoformans and Candida albicans.  Cryptococcus neoformans is particularly problematic for AIDS patients.  Over a million people worldwide suffer life-threatening infections with this fungus and as many as 600,000 die each year in Africa alone.  Fluconazole is the most commonly prescribed antifungal medication, but side effects of its use include vomiting, diarrhea, rash, and increased live...Fri, 17 Mar 2017 05:58:34 GMTJHTT-Communications@jhu.edu of Fast Imaging of NMR Parameters with Variably-accelerated Sensitivity Encoding (vSENSE) Need: Long scan times due to its requirement that multiple saturation-offset image frames be acquired is the underlying reason that widespread clinical use of chemical exchange saturation transfer (CEST) imaging is hampered. Technology Overview: The invention is a novel method that fully samples one CEST saturation frame, then undersamples the other frames variably. The fully-sampled frame, in conjunction with newly proposed incoherence absorption and artifact suppression strategies, improves the accuracy of sensitivity maps and permits higher acceleration factors for the other undersamp...Fri, 17 Mar 2017 05:58:34 GMTJHTT-Communications@jhu.edu AND METHODS FOR MAGNETIC ISOLATION AND ANALYSIS OF RARE CELLS NeedNumerous devices and methods have been developed to try and isolate circulating tumor cells in a reproducible and efficient manner. To date, the majority of work has been performed utilizing the CellSearch test, which is the only FDA-approved device. However, the CellSearch test is limited by the associated expense and not being able to be used at point-of-care (POC). A POC, easy to use device is still needed in the cancer field.Technology OverviewThe closest “Lab on a Chip” cell isolation device with Immiscible Filtration Assisted by Surface Tension (IFAST), has been reported from t...Fri, 17 Mar 2017 05:58:31 GMTJHTT-Communications@jhu.edu potentiometric wearable sweat sensor Need:The current method for measurement of chloride ion concentration in sweat in CF patients involves a visit to a clinic to collect a relatively large volume of sweat that can be analyzed by a conventional electrochemical reference electrode.  In this invention, we describe a wearable sensor to reliably measure the concentration of chloride ions in sweat. The device geometry and materials are selected to minimize transport and hence enable accurate measurements over extended time periods.Technical Overview:Sweat is a non-invasively accessed bio-fluid that contains information on health...Fri, 17 Mar 2017 05:58:30 GMTJHTT-Communications@jhu.edu Imaging and Radiotherapeutics Agents Targeting Carbonic Anhydrase IX (second generation), 17 Mar 2017 05:58:28 GMTJHTT-Communications@jhu.edu Estimation of Patient Attributes based on MRI Brain Atlases invention describes a novel way for diagnostic estimation of the patient attributes based on a unique atlas-based information-retrieval technology. The use of MRI atlases facilitate automated image segmentation and region-of-interest based feature analysis. The recent development of multi-atlas techniques, in particular, offers superior segmentation accuracy. In previous atlas-based approaches, segmentation is usually the single end-goal. We realized that the multi-atlas repository provides not only the pre-segmented labels for segmentation, but also a knowledge database associated with v...Fri, 17 Mar 2017 05:58:25 GMTJHTT-Communications@jhu.edu of Novel Prostate Cancer Cell Lines that Employ the Alternative Lengthening of Telomeres (ALT) Telomere Maintenance Mechanism NeedInstead of telomerase, approximately 10% of cancers maintain telomeres via a DNA template dependent mechanism called Alternative Lengthening of Telomeres (ALT).   The ALT pathway is dependent on homologous recombination and tightly linked to recurrent cancer-associated somatic inactivating mutations of ATRX or DAXX, genes encoding chromatin remodeling proteins. This translates to 1.4 million new cases and 820,000 cancer deaths globally due to ALT mediated cellular immortalization.  In addition, therapies targeting telomerase may cause cancer cells to activate the ALT pathway, further...Fri, 17 Mar 2017 05:58:24 GMTJHTT-Communications@jhu.edu breast cancer cell lines derived from transgenic HuHER2 mouse model NeedPreclinical evaluation of therapeutic agents against metastatic breast cancer require cell lines and animal models that recapitulate clinical metastatic breast cancer.Technology OverviewResearchers at Johns Hopkins University extracted primary mammary gland tumors, purified the epithelial breast cancer cells over a number of passages, and established 7 different HuHER-2 cell lines. These lines show all the hallmarks of highly aggressive, metastatic breast cancer and are being used to establish a left cardiac ventricle injection model of widespread HER-2/neu positive metastatic breast...Fri, 17 Mar 2017 05:58:23 GMTJHTT-Communications@jhu.edu Prevention App is a smartphone app designed to help patients attending fall prevention clinic. Fall Prevention App was developed to help coordinate care of patients coming to the Hopkins Fall Prevention Clinic with the PMR Department. The app does not collect any patient information and does not communicate this information to anyone else. It is designed to substitute many of the handouts that we would normally give to our patients. That is to say, the exercise, recommendations, fall calendar handouts are not embedded in the app to patients don’t lose it. It also gives information about patient’s fall ...Fri, 17 Mar 2017 05:58:22 GMTJHTT-Communications@jhu.edu Application for Persons at Risk of HIV NeedThere remains a need for new and improved initiatives to identify and successfully engage and retain those people who may be at high risk of HIV infection or are infected with HIV.Technical DetailsJHU researchers have designed a patient facing linkage, adherence and retention based application to support HIV prevention.  The application serves as a source of information for both caregivers and patients and incorporates novel algorithms to help facilitate better and more inter-connected care.Stage of DevelopmentPrototypeFri, 17 Mar 2017 05:58:21 GMTJHTT-Communications@jhu.edu[18F]FNDP for PET Imaging of Soluble Epoxide Hydrolase (sEH) Need Soluble epoxide hydrolase (sEH) inhibitors have been shown to effectively increase the levels of epoxyeicosatrienoic acids and reduce the levels of dihydroxyeicosatrienoic acids, which may be translated to therapeutic potentials for multiple disease indications. sEH inhibitors show great promise for the treatment of  hypertension, diabetes, stroke, dyslipidemia, pain, immunological disorders, eye diseases, neurological diseases and other indications.  sEH imaging could prove useful for drug development and patient selection strategies.Technology OverviewThe technology provides a sen...Fri, 17 Mar 2017 05:58:20 GMTJHTT-Communications@jhu.edu Cells novelty: JHU researchers have generated PS120/FLAG-NF2 cells with human WTNHE3 expression (no TAG), stable human R799C mutant NHE3 expression (no tag), and with stable rabbit WT NHE3 expression (no tag).  Value Proposition: NHE null fibroblasts expression in different species and polymorphisms of NHE3 to be used for functional studies. R799C is a mutant that occurs in a significant percent of certain world populations and has been identified in the NHE3 gene. JHU researchers have generated PS120/FLAG-NF2 cells with NHE3 expression.  Technical Details:Cell Lines, Cell Culture, and Tra...Fri, 17 Mar 2017 05:58:18 GMTJHTT-Communications@jhu.edu Multi-platform Biomarker Approach to Reduce False Positives in Lung Cancer Screening recently completed National Lung Screening Trial (NLST) demonstrated a 20% mortality reduction in low-dose CT (LDCT) screening as compared to chest radiography among smokers at high risk for lung cancer. This finding has led to Medicare coverage of LDCT for lung cancer screening. However, this mortality reduction is weighted against the harm from a high false positive (FP) rate with over 95% of LDCT positive nodules not resulting in a lung cancer diagnosis. CT images with identified pulmonary nodule(s) can be grouped into three categories: (1) images with all nodules having a high certaint...Fri, 17 Mar 2017 05:58:15 GMTJHTT-Communications@jhu.edu PET Metabolic Tumor Volume: Method for Identifying the Optimum Segmentation Method for Human Solid Tumors Need:The use of quantitative metrics derived from PET images to help make clinical decisions, has shown tremendous promise. Examples of such metrics include standardized uptake value (SUV), total lesion glycolysis, and metabolic tumor volume. Quantitative FDG-PET imaging has been shown to separate responders from nonresponders early in a treatment regimen. Such stratification allows clinical trials to achieve statistically significant decisions in shorter duration with fewer subjects. Further, on an individual patient level, the stratification of a non-responding patient prevents continu...Fri, 17 Mar 2017 05:58:10 GMTJHTT-Communications@jhu.edu, Purification, Reconstitution and Functional Characterization of a Human Zinc Transporter ZnT8 NeedThe escalating type-2 diabetes (T2D) epidemic is a major global health concern.  Genes affecting risk for T2D include the zinc transporter gene ZnT8.  There exist a need for better production, purification, reconstitution and functional characterization of the human ZnT8, and improved methods for detection and treatment of T2D.Technology OverviewThe present invention provides methods of identifying drugs for the treatment or prevention of diabetes by measuring the activity of the human zinc transporter ZnT8 and pharmaceutical compositions thereof.  Human ZnT8 was over-expressed in a ...Fri, 17 Mar 2017 05:58:09 GMTJHTT-Communications@jhu.edu Activin Signaling Activity in Combination with Immunomodulation to Alter Regulatory T cell-mediated Immune Regulation in order to Treat Cancer Need In the context of the tumor microenvironment, immunosuppressive regulatory T (Treg) cells can hinder anti-tumor immune responses and immunotherapies.  Agents that inhibit Treg function could greatly enhance the patients? own anti-tumor immune response, and enhance the effectiveness of existing immunotherapies.Technology OverviewThis technology includes a new target, Activin signaling, for cancer immunotherapy.  Stage of Development  Data in a melanoma, mouse xenograft model show that ablation of Activin signaling supresses tumor growth and enhances the effects of certain cell-based ...Fri, 17 Mar 2017 05:58:05 GMTJHTT-Communications@jhu.edu Therapy to block Cancer Metastasis and Progression need:  Oncology and cancer therapeutics need new targets and new multimodal therapeutics to treat or prevent tumor metastasis and progression.  Technology Overview:  The technology identifies an upregulated level of two interleukins that can be used as a diagnostic and prognostic tools for metastatic disease and as a therapeutic target.  First, Interleukin 6 and Interleukin 8 have been identified to play important roles in tumor progression and metastasis. The synergistic mechanism between the two interleukins promotes cancer cell migration in metastatic cell lines through a pathway that...Fri, 17 Mar 2017 05:58:04 GMTJHTT-Communications@jhu.edu and Methods for Preparation of Composite Polymer Coatings on Medical Implants, and their Use for Co-delivery of Multiple Antimicrobial Agents invention describes biodegradable nanofiber-film composite that forms a conformal coating on medical devices for local, sustained release of multiple antibiotics following implantation. This composite coating comprises of one or more sets of biodegradable polymer fibers embedded in a biodegradable polymer film whereas both the nanofibers and films carry one or more antibiotics, and the loading and release profile of the antibiotics are tunable independently. This invention also describes the process for preparing this composite coating by electrospinning method followed by post spinning a...Fri, 17 Mar 2017 05:58:00 GMTJHTT-Communications@jhu.edu Application of TRPM7 Blockers to Treat Sleep Apnea and Hypertension in Obesity Need: Obesity is a growing epidemic in the U.S. and leads to cardiovascular morbidity and mortality acting via multiple mechanisms including hypertension and obstructive sleep apnea. High levels of leptin have been associated with both conditions. However, the mechanism by which leptin enhances sympathetic activity is unclear.  Leptin receptors (LEPRs) are expressed in the carotid bodies, the most important arterial chemoreceptors for the cardiovascular-respiratory chemoreflex. However, the mechanism of leptin in CB is unknown. High levels of leptin may increase the CB chemoreflex leadin...Fri, 17 Mar 2017 05:57:53 GMTJHTT-Communications@jhu.edu Anisotropic Polymeric Particles with Naturally Derived Cell Membranes for Enhanced Drug Delivery Need:Although biomimetic polymeric particles have been used for drug delivery, these particles have not been able to mimic the natural cell in terms of size, shape, mechanical properties, and surface features. This invention is a biomimetic particle platform that can be used to simulate natural cells found throughout the body.  Technology Overview:Johns Hopkins researchers combined multiple aspects of normal cell physiology to create a truly mimetic particle that can be used for enhanced drug delivery. The core particle consists of polymeric construct similar to other biomimetic platform...Fri, 17 Mar 2017 05:57:52 GMTJHTT-Communications@jhu.edu for Deformable 3D-2D Registration Using Multiple Locally Rigid Registrations Need 3D preoperative imaging (e.g., CT, MRI, PET) provides the basis for many forms of surgical planning and intraoperative guidance. During the surgical planning stage, clinicians may define geometric annotations (points, contours, shapes, etc.) in the preoperative 3D images, such as outlining of relevant anatomical structures and identification of desired placement/trajectory of surgical hardware. These annotations can be incorporated into the surgical process using various algorithms for rigid/deformable registration (aligning physical coordinate systems to create a “mapping” from one...Fri, 17 Mar 2017 05:57:51 GMTJHTT-Communications@jhu.edu Talking Eye Need:Currently, low-vision aids for the visually impaired focus mainly on maximizing remaining vision and fall into one of three broad categories: 1) optical devices, such as magnifying lenses, telescopes and spectacles 2) tablet devices that enable text magnification, and 3) non-optical devices, such as braille keyboards for computer access.  Individuals who are visually impaired typically require a number of these devices to perform the various activities of daily life.  While low vision aids have traditionally sought to improve reading ability or Internet access, there is now an emerg...Fri, 17 Mar 2017 05:57:49 GMTJHTT-Communications@jhu.edu, 17 Mar 2017 05:57:46 GMTJHTT-Communications@jhu.edu Type 1 Receptor Autoantibody in Wound Healing Need:Chronic wounds are among the most common, painful, debilitating and costly conditions in diabetics and in older adults, and are an important portal for bacterial infections that often lead to amputations, sepsis and mortality. In diabetic and aging skin, chronic inflammation commonly accompanies poor wound healing and increases the risk for chronic non healing wounds.  In diabetic and aged skin, the angiotensin system is dysregulated with aberrant angiotensin AT1 receptors (AT1R) signaling that increases inflammatory burden leading to thinning of epidermis, degeneration of collagen,...Fri, 17 Mar 2017 05:57:45 GMTJHTT-Communications@jhu.edu Coatings with High Molecular Weight Poly(ethylene glycol) Allow Nanoparticles to Diffuse through Mucus Need:Mucus traps many pathogens preventing them from reaching and infecting the underlying cells and tissues, as well as preventing particulates from reaching the epithelial surface if they are larger than, and/or adhere to the mucus mesh, which can decrease drug delivery efficiency. Many nanoparticle (NP) formulations are designed to be mucoadhesive, but Johns Hopkins researchers have shown that adhesion to mucus leads to limited distribution over vaginal, lung, and colorectal tissues. In contrast, NPs densely coated with non-mucoadhesive hydrophilic polymers, such as PEG, are able to p...Fri, 17 Mar 2017 05:57:44 GMTJHTT-Communications@jhu.edu Method to Guide Treatment of Heart Rhythm Disorders need:Catheter ablation is the standard of care to treat heart rhythm disorder, such as atrial fibrillation. Catheter ablation is performed uniformly in the same way in all patients, but success rate is marginal at around 60%. This computational method is novel because it provides personalized assessment based on biological signals of each patient and identifies optimal targets of catheter ablation. Personalized catheter ablation is expected to improve the success rate.Problem Solved:A human heart consists of a network of approximately five billion cardiomyocytes, connected by a lattice-l...Fri, 17 Mar 2017 05:57:39 GMTJHTT-Communications@jhu.edu Cancer Detection by Single-molecule Imaging of Nucleocytoplasmic Tumor-specific Proteins in the Peripheral Circulation report a platform technology for the ultra-sensitive detection and digital quantification of proteins. Our technology?which we term SMAC, for single-molecule analysis and counting?integrates microfluidics with single-molecule imaging. With SMAC, we discover the potential for nucleocytoplasmic proteins to serve as a novel class of exquisitely tumor-specific biomarkers for early cancer detection and diagnosis. As proof-of-principle, we demonstrate in multiple preclinical models that SMAC can identify early-stage cancer with 100% specificity and sensitivity.Fri, 17 Mar 2017 05:57:37 GMTJHTT-Communications@jhu.edu Health Analytics and Software for Estimating the Etiology of Infection and Predicting Susceptibility to Treatment, 17 Mar 2017 05:57:36 GMTJHTT-Communications@jhu.edu Radiomics Integration System (IRIS): A novel combined informatics and radiomics method for integration of many types of data for classification into different groups for improved visualization patent provides new methods for a novel informatics method for the integration of different variables or ontologies using an advanced unsupervised machine learning method which will be used to visualize factors not visible to the human observer. These factors can be unknown characteristics between imaging datasets and other factors which will provide insights into the structure of the data. We have termed this invention, the Informatics Radiomics Integration System (IRIS), For example, using clinical data and radiological images, we can determine the relationship between, the structure, ...Fri, 17 Mar 2017 05:57:35 GMTJHTT-Communications@jhu.edu Apple Watch Seizure App and Seizure Detector using Responsivity Testing NeedOver 2.5 million people are living with epilepsy in the United States. There is a need to better understand epilepsy and to develop new methods for monitoring and managing the disease. Technology OverviewJohns Hopkins EpiWatch™ is an app for Apple Watch™ and research study. EpiWatch helps manage epilepsy by tracking seizures and possible triggers, medications and side effects. This information can be viewed by users at any time, and a dashboard lets users share a summary of the data with their doctor or caregiver. With EpiWatch, it is possible to send a message to family members or c...Fri, 17 Mar 2017 05:57:35 GMTJHTT-Communications@jhu.edu Miniaturized Triaxial Force Sensor with Independent Axial and Transverse Force Sensing Need Lack of force sensing is one of the most formidable technical challenges in retinal microsurgery. Incorporating high sensitivity force sensing into the ophthalmic tools has thepotential to provide the surgeon useful force feedback and to enable safe robotic assistance.  Forces exerted in retinal microsurgery are generally well below the human sensory threshold.  75% of forces applied during in vitro retinal manipulation in porcine cadaver eyes are less than 7.5 mN, and only 19% of the events at this force level can be felt by the surgeons.  Large forces are undesired and can potenti...Fri, 17 Mar 2017 05:57:34 GMTJHTT-Communications@jhu.edu Health—The Opentable of Health Care, 17 Mar 2017 05:57:33 GMTJHTT-Communications@jhu.edu Electronic Stethoscope “Programmable Electronic Stethoscope” offers hardware/software solutions for improved digital auscultation in non-ideal settings and follow-up clinical aid. Current methods for analysis of lung sounds suffer from low noise tolerance. Commercial stethoscopes mainly address low/stationary noise; most are unable to adapt to abrupt, natural-sound contaminations that limit the clinical value of the chest sounds. This invention bridges the gap between true need and commercial availability. Highly adaptable to unknown clinical settings, this invention addresses the above limitations; subsequent a...Fri, 17 Mar 2017 05:57:32 GMTJHTT-Communications@jhu.edu of Additional Anti-Persister Activity against Borrelia burgdorferi from an FDA Drug Library disease is a leading vector borne disease in the US. Although the majority of Lyme patients can be cured with standard 2-4 week antibiotic treatment, 10-20% of patients continue to suffer from prolonged post-treatment Lyme disease syndrome (PTLDS). While the cause for this is unclear, persisting organisms not killed by current Lyme antibiotics may be involved. In our previous study, we screened an FDA drug library and reported 27 top hits that showed high activity against Borrelia persisters. In this study, we present the results of additional 113 active hits that have higher activity aga...Fri, 17 Mar 2017 05:57:31 GMTJHTT-Communications@jhu.edu of Persistence in Borrelia burgdorferi: Implications for Improved Intervention present invention relates to compositions and methods for treating and diagnosing Lyme disease. More particularly, the present invention relates to methods and compositions for treating Lyme disease based, in part, on genes whose expression is differentially modulated in antibiotic resistant strains of Borrelia burgdorferi.Fri, 17 Mar 2017 05:57:30 GMTJHTT-Communications@jhu.edu Decision Support MDR-TB Application have conceptualized and designed a clinical decision support application for MDR-TB. This application will assist clinicians (doctors, nurses, pharmacists) with the following types of information: a) standardized regimens; b) weight-based dosing; c) drug-drug interactions; d) side effect monitoring; e) symptom management; f) adherence to care.Fri, 17 Mar 2017 05:57:29 GMTJHTT-Communications@jhu.edu Johns Hopkins MDR-TB Training Program DetailsJohns Hopkins Researchers have developed a program that focuses on principles of adult learning theory to include didactic sessions, large group case studies, case-based small group exercises, educational materials and clinical support documents.  Sessions include power point slides with speaker notes.   Paper-based clinical decision support tools have been developed to facilitate learning. Stage of DevelopmentIn useFri, 17 Mar 2017 05:57:28 GMTJHTT-Communications@jhu.edu of magnetic bead-based multiplex immunoassays of serum biomarkers for the early detection of pancreatic cancer, 17 Mar 2017 05:57:28 GMTJHTT-Communications@jhu.edu for Estimating Permeability of Fractured Rock Formations from Induced Slow Fluid Pressure Waves present invention relates generally to geophysical exploration. The invention relates to a method for estimating the permeability of fractured rock formations from the analysis of a slow fluid pressure wave, which is generated by pressurization of a borehole. Wave propagation in the rock is recorded with TFITM although other imaging or pressure monitoring techniques could be used. Poroelastic theory is then employed to estimate the permeability from the measured wave speed.Fri, 17 Mar 2017 05:57:26 GMTJHTT-Communications@jhu.edu of Tumor-Derived DNA in Cerebrospinal Fluid of Patients with Primary Tumors of the Brain and Spinal Cord DNA shed by cancer cells has been shown to be a rich source of putative tumor-specific biomarkers. As cell-free DNA from brain and spinal cord tumors cannot usually be detected in the blood, we studied whether the cerebrospinal fluid (CSF) that bathes the CNS is enriched for tumor DNA, here termed CSF-tDNA. We analyzed 35 primary CNS malignancies and found at least one mutation in each tumor using targeted or genome-wide sequencing. These results suggest that CSF-tDNA could be useful for the management of patients with primary tumors of the brain or spinal cord.Fri, 17 Mar 2017 05:57:25 GMTJHTT-Communications@jhu.edu Device and Method to Treat Esophageal Disorders needAn effective yet convenient method to treat esophageal disorders does not exist.  For example, there is pressing need for non-invasive therapeutic options for patients with Barrett’s esophagus which progresses to low-grade dysplasia or high grade dysplasia.  Technology OverviewJohns Hopkins researchers developed devices and methods to administer treatments to the distal esophagus (for disorders such as esophageal cancer, dysplasia, achalasia and others) in an easy, patient-directed, point of care fashion.   Stage of DevelopmentPreliminary data available.Fri, 17 Mar 2017 05:57:22 GMTJHTT-Communications@jhu.edu Mutations in GNAQ Sensitive to Antibiotic; Novel Molecular Pathway and Treatment Target for Capillary Malformations and Related Syndromes unexpected observation while working on developing cell models for these vascular abnormalities generated the following idea: Cells with the capillary malformation/ Sturge-Weber syndrome mutation may be more sensitive to an antibiotic than normal cells. This suggests a particular cell molecular pathway may be signaling abnormally in these cells with the mutation. We propose to determine whether blood vessels cells with this mutation grow less well with this antibiotic and to investigate changes in this pathway in cells and in human tissue.Fri, 17 Mar 2017 05:57:22 GMTJHTT-Communications@jhu.edu Method to Improve Nanoparticle Distribution Within the Brain Interstitium by Enabling their Escape from Perivascular Spaces Hopkins inventors have developed a combination strategy that improves the overall homogeneity and volume of distribution of an administered nanoparticle when infused into the brain. This strategy comprises 1) developing a non-adhesive nanoparticle and 2) administering this nanoparticle in a hyperosmolar solution into the brain using convection enhanced delivery (CED). We demonstrate that a 60 nm, non-adhesive nanoparticle administered into the striatum via CED in a 3% hyperosmolar solution achieves higher and more homogeneous volumes of distribution throughout the brain interstitium. Thi...Fri, 17 Mar 2017 05:57:21 GMTJHTT-Communications@jhu.edu CTRP5 Action to Improve Insulin Resistance Associated with Obesity and Type 2 Diabetes NeedObesity is a leading preventable cause of death worldwide, with increasing rates in adults and children. In 2014, 600 million adults (13%) and 42 million children under the age of five were obese.  Obesity is associated with a number of comorbidities, the most common of which is metabolic syndrome, a combination of medical disorders which includes: diabetes mellitus type 2, high blood pressure, high blood cholesterol, and high triglyceride levels.  Authorities view it as one of the most serious public health problems of the 21st century.  Unfortunately, few targets have been identifi...Fri, 17 Mar 2017 05:57:20 GMTJHTT-Communications@jhu.edu Antagonists for the Treatment of Cognitive Deficits, including NeuroAIDs glutamine antagonists have been shown to have anti-cancer activities in multiple preclinical and clinical studies. However the toxicity of the glutamine antagonists at doses necessary for their anticancer effects have hampered their clinical development. Herein we describe a completely novel use for the glutamine antagonists. Using a prototype glutamine antagonist, we show for the first time, at doses significantly less that that used for its anticancer efficacy, that it can selectively abrogate cognitive deficits in the EcoHIV model of neuroAIDs. We show supporting PK and biomarker da...Fri, 17 Mar 2017 05:57:17 GMTJHTT-Communications@jhu.edu Generation of Sentence-Based Descriptors from Images, 17 Mar 2017 05:57:17 GMTJHTT-Communications@jhu.edu and Assessment of Outcomes Data from Patients in Various Addiction Treatment Facilities is a method of assessing outcomes in patients completing various treatment settings, with a particular emphasis on substance and alcohol abuse, though may expand to include other outcomes (eg, mental health, medical improvements) in the future. The project will combine publically available questionnaires to assess a broad domain of outcomes, including drug use but also quality of life metrics, to assess the value of treatment and allow for comparison across treatment modalities and settings.Fri, 17 Mar 2017 05:57:16 GMTJHTT-Communications@jhu.edu of Promoter Methylation of CCND2, CCNA1, and CALCA Genes in Urine Samples for Early Detection and Monitoring of Low Grade Papillary Urothelial Cell Carcinoma Patients Need:Urothelial cell carcinoma (UCC) constitutes over 90% of bladder cancers in the Western world, non-muscle invasive UCC being the most common and treated by trans-urethral resection of bladder tumor (TURBT) with or without Bacillus Calmette-Guerin (BCG), the main intravesical immunotherapy for treating early-stage bladder cancer.  20% of patients will be cured while 70% will recur at least once every 5 years, and the remaining will progress to muscle-invasive disease with poor prognosis. Since, conventional approaches (computed tomography, urine cytology, histopathology, or tumor-node...Fri, 17 Mar 2017 05:57:13 GMTJHTT-Communications@jhu.edu Sacral Nerve Stimulation for Inflammation Need:About 5%-7% of general population in Western society is affected by immune-mediated inflammatory diseases that include, but not limited to, ankylosing spondylitis, psoriasis, psoriatic arthritis, rheumatoid arthritis, and inflammatory bowel disease (IBD) (includes Crohn?s disease and ulcerative colitis). The prevalence of inflammatory diseases is even higher in the veterans? population due to frequent exposures to stress.  Although these diseases have different epidemiologies and pathophysiologies, they have one thing in common: an imbalance in inflammatory cytokines.  Further, a ch...Fri, 17 Mar 2017 05:57:08 GMTJHTT-Communications@jhu.edu Early Learning Assessment (ELA) Application, 17 Mar 2017 05:57:05 GMTJHTT-Communications@jhu.edu Membrane Antigen Targeted Plasmon-enhanced Raman Spectroscopy Reporters for Molecular Imaging of Prostate Cancer Need:Non-invasive assessment of tumor burden and cancer-selective treatment in prostate cancer. This approach is will allow visualization in real-time of the distribution and action of therapeutic agents in vivo by transducing the presence of PSMA at the tissue level to characteristic Raman spectral patterns. This nanoplex platform, therefore, directly enables the real-time imaging of prostate tumor (critical in surgical margin definition) while inhibiting the growth of prostate tumor cells.Technical Overview:We have designed and engineered a nanoplex containing surface enhanced Raman sp...Fri, 17 Mar 2017 05:57:05 GMTJHTT-Communications@jhu.edu of Adult Heart Muscle from Human Pluripotent Stem Cells Need:Pluripotent stem cells (PSCs) are capable of becoming all types of patients’ body cells and thus, provide unprecedented opportunities for disease modeling and personalized medicine. With the capability, current cardiac regenerative medicine focuses on utilizing PSCs for modeling heart disease and cell-based interventions of cardiac repair. However, PSC derived cardiomyocytes exhibit fetal-like characteristics, and the immaturity remains a key impediment for their therapeutic applications. Technical Overview:This invention describes a platform to generate adult cardiomyocytes from hu...Fri, 17 Mar 2017 05:57:00 GMTJHTT-Communications@jhu.edu of Spatially-encoded NMR Parameters from Arbitrarily-shaped Compartments an Linear Algebraic Modeling is a new method to accelerate the acquisition of NMR and MRI measurements that are spatially localized to arbitrarily shaped compartments, many-fold. If compartment-average indices can suffice, SLAM can speed-up clinical or animal studies by up to scores-fold, and generate quantitatively equivalent results to compartment average measures obtain by conventional (FT) MRI methods. SLAM’s ability to yield MRI measures within scan times of a minute or so, should facilitate its application in many clinical settings where scan time is at a premium.Fri, 17 Mar 2017 05:56:57 GMTJHTT-Communications@jhu.edu Scaffolds for Corneal Reconstruction present invention relates to methods for treating a corneal disease such as, for example, corneal blindness, or the refractive power of a cornea by generating a vitrified decellularized corneal inlay.Due to donor shortages, corneal blindness remains a significant clinical challenge, although corneal transplantation has a high success. Developing new corneal substitutes which have ideal characteristics, including transparency, proper concave shape, biocompatibility and good integration with host tissue becomes essential to address these challenges of current therapeutic strategies. JHU inve...Fri, 17 Mar 2017 05:56:54 GMTJHTT-Communications@jhu.edu A Novel Orthosis to Mitigate Scissoring Gait in CP Patients Need: Cerebral Palsy is a group of serious movement disorders that affects the lives of thousands of patients each day by limiting their mobility and fine motor control. A common form of Cerebral Palsy called spastic diplegia significantly impedes a patient’s ability to walk normally because the knees and thighs can cross over each other in a scissor-like movement. This scissoring-gait can cause instability and difficulty in walking and standing. Currently, there are few methods or devices to treat scissoring-gait and those that do exist are cumbersome, uncomfortable, and relatively inef...Fri, 17 Mar 2017 05:56:53 GMTJHTT-Communications@jhu.edu Detection of Circulating Breast Tumor Antigen and Epigenetic Markers using Plasmon-enhanced Raman Spectroscopic Assay NeedBreast cancer is the second leading cause of cancer-related mortality with an estimated 40,610 deaths for women in 2017. In the United States, the average chance of a women developing breast cancer is 1 in 8 and early breast cancer screening and detection is key in the treatment. One method of early diagnosis is through surface?enhanced Raman spectroscopy (SERS). Raman spectroscopy can detect changes in molecular structure and composition, such as carbohydrate, lipids, proteins, and nucleic acids changes during early tumor diagnosis. Using SERS, indicators of breast cancer progressio...Fri, 17 Mar 2017 05:56:52 GMTJHTT-Communications@jhu.edu = TB – Track/Link/Cure have designed a set of m-health applications that rapidly identify, link, engage persons into TB care. Currently, reporting processes for TB are delayed and often require the healthcare worker to sift through multiple piles of paperwork. With this set of applications, a primary health care nurse or doctor can see the results in real-time directly on the application. Staff can then contact the patient and link them to TB care. The ordering clinician can then see that the patient has TB and they will be treating the patient or rifampicin resistant TB and if the case has been linked to a...Fri, 17 Mar 2017 05:56:49 GMTJHTT-Communications@jhu.edu Method to Identify Variation in Physician Outcomes, Practice Patterns, and Costs product provide insurers, hospitals, other medical facilities, and patients with data-driven analytics about physician outcomes, practice patterns, and costs. This method is based on the theory that access to information is the key to the best quality and highest value care. The analytics on physician performance are based on national standards (e.g., Centers for Medicare and Medicaid Services), specialty guidance (e.g., American College of Physicians guidelines), as well as customized metrics designed by researchers at the Johns Hopkins Schools of Medicine and Public Health. The big-data...Fri, 17 Mar 2017 05:56:47 GMTJHTT-Communications@jhu.edu Microport Unmet Need:  Intravenous, intraarterial, and intraventricular (brain) access is a challenge in the research industry.Technology Overview:  Unmet Need:  Intravenous, Intraarterial, and Intraventricular (brain) access can be challenging in animal models.  The microport has a flexible tubing catheter.  At the end of the catheter, we have created a valve system so that fluid can exit but cannot backwash into the catheter.  This will minimize the risk of having a blood clot form within the catheter.  This will eliminate the need for a heparin flush.  In addition, the catheter has miniature anchors...Fri, 17 Mar 2017 05:56:47 GMTJHTT-Communications@jhu.edu Vascular Network Assembly from Diabetic Patient-derived Induced Pluripotent Stem Cells diabetics, hyperglycemia results in deficient endothelial progenitors and cells, leading to cardiovascular complications. We aim to engineer three-dimensional (3D) vascular networks in synthetic hydrogels from type-1 diabetes (T1D) patient-derived human induced pluripotent stem cells (hiPSCs), thus serving as a transformative autologous vascular therapy for diabetic patients.Fri, 17 Mar 2017 05:56:43 GMTJHTT-Communications@jhu.edu CCL19 after Completion of Therapy for Acute Lyme Disease Identifies Patients at Risk for Development of Post-treatment Lyme Disease Syndrome Who Will Benefit from Further Antibiotic Therapy chemokine CCL19 has been identified in acute pre-treatment samples from patients with Lyme disease and distinguishes acutely infected patients from controls. In addition we have demonstrated that a subset of patient continue to have elevated levels of CCL19 for up to 6-12 months post-treatment. In addition, the measurement of an elevated CCL19 immediately after the completion of antibiotic therapy identifies those at high risk of having persistent symptoms. This high risk population is a candidate for further antibiotic therapy to prevent the development of long term complications of PTLDS...Fri, 17 Mar 2017 05:56:41 GMTJHTT-Communications@jhu.edu"Prescription Strength App" Modular Library System and Repository Hopkins Global mobile Health Initiative (JHU-GmI) would like to develop a foundation for a modular system called the JHU Prescription Strength App Backbone. This system would offer standards and validation to host in-house custom modules and incorporate devices from participating partners. These modules would then be hosted within a shared library accessed by providers who would prescribe an appropriate selection of modules to a patient at the point of care. The patient would then download a customized “app”, comprised of the selected modules, working together seamlessly using a common ...Fri, 17 Mar 2017 05:56:40 GMTJHTT-Communications@jhu.edu Memory Particles for Biomedical Uses NEED Many diseases in the human body are best treated using drug delivery in which a triggered release of extracellular therapeutics or a triggered shape change of intracellular therapeutics mediates the delivery of drugs. However, these therapeutics should only be released under specific circumstances and locations to have the maximum impact with the smallest possibility of unintended adverse effects. Thus, there is a need to develop an effective way of targeting these therapeutics such that they are released or change shape under certain circumstances only. In addition, cellular uptak...Fri, 17 Mar 2017 05:56:39 GMTJHTT-Communications@jhu.edu Lattice Weaves with Tailored Damping Properties Need Vibrations that occur within high speed rotary devices, such as turbines, can lead to excessive wear, fatigue, or failure.  As a result, technologies to reduce vibrations within these components may result in substantial savings. Although polymeric materials typically offer excellent damping properties, they are not feasible in high temperature environments and there is a substantial need for non-polymeric materials that can dampen vibrations at high operating temperatures without the use of a damping fluid.Technology Overview                  Cu and NiCr metallic lattice materials ...Fri, 17 Mar 2017 05:56:37 GMTJHTT-Communications@jhu.edu CS Tag: A More Sensitive and Specific Protein Tag tags are short linear sequences that are added onto proteins in order to facilitate their detection. The most commonly used tags are FLAG, Myc, HA and His ). Tagging proteins has two primary uses. The first is for protein expression in heterologous systemsand the second use is in localization studies. . We and others have found that antibodies to these tags usually give satisfactory results but do not have the sensitivity and specificity to make for a smooth work flow. Indeed most investigators use multiple copies of the tag to enhance specificity and sensitivity. Nonetheless, even w...Fri, 17 Mar 2017 05:56:35 GMTJHTT-Communications@jhu.edu dose and risk prediction during target and critical structure delineation for radiotherapy, 17 Mar 2017 05:56:35 GMTJHTT-Communications@jhu.edu Biopsy Plan Optimization NeedAn estimated 233,00 new cases of prostate cancer were diagnosed in the US alone.  Studies have shown it is necessary to treat many men to prevent one death from prostate cancer.  However, the current method of biopsy often misses relevant tumors.  Accordingly, there is a need for more specific prostate screening test and more reliable prostate diagnosis at biopsy.Technology OveriewJohns Hopkins faculty member, Dr. Dan Stoianovici, has developed a method for optimizing a biopsy plan to improve cancer diagnosis.  In particular, a capsule (cylinder with hemispherical ends) shaped volume...Fri, 17 Mar 2017 05:56:34 GMTJHTT-Communications@jhu.edu Health Support Intervention for Hepatitis C Linkage to Care and Hepatitis C Treatment Adherence Support have designed an e-health application that documents and supports community based hepatitis C linkage to care and treatment for patients diagnosed with hepatitis C (HCV). There are an estimated 3.2 million Americans in the United States infected with HCV. Only about 6% of individuals have been cured of their hepatitis C infections. The major prognosticator of HCV cure is treatment adherence for the short period of 3-6 months. The high cost of current HCV therapies justifies increased adherence support to ensure successful completion of treatment. We propose an electronic mobile system tha...Fri, 17 Mar 2017 05:56:33 GMTJHTT-Communications@jhu.edu Sperm DNA Methylation as a Predictive Marker of Autism Risk Need:Autism spectrum disorder (ASD), is a complex neurodevelopmental disorder that refers to a range of conditions characterized by challenges with behavior including social skills, communication, and repetitive behaviors, all of which have ranges and severities that are patient specific.  Currently, there are no medical tests such as a scan or in vitro diagnostic blood test that can be used to quickly and easily diagnose ASD. The diagnosis process involves in depth patient observation, interviews, and a series of cognitive tests. Technical Overview:JHU researchers have identified specif...Fri, 17 Mar 2017 05:56:33 GMTJHTT-Communications@jhu.edu Dexterous Manipulator for Therapeutic and Diagnostic Procedures in the Clinical Setting where Tool Access is Limited Need: Next-generation surgical tools.Technology Overview:  The technology is a dexterous manipulator less than 1 mm in diameter and 3 mm in length. It can be used as a procedural platform that can access narrow, tight, constrained or otherwise inaccessible spaces in the body in order to provide high dexterity that permits: the performance of diagnostic or therapeutic interventions including but not limited to drug delivery, biopsy, deployment of of other tools, positioning of active or passive secondary tools, and the performance of procedures that are made possible, safer or less inva...Fri, 17 Mar 2017 05:56:32 GMTJHTT-Communications@jhu.edu, a Statistical Method to Identify Genomic Copy Number Variation (CNV) using High-density DNA Methylation Arrays and epigenetic alterations have been implicated in carcinogenesis and integrated analyses of these have provided new insights into the mechanisms of cancer development. We developed Epicopy, a statistical method to identify copy number variation (CNV) using high-density Illumina 450K methylation arrays. Using Epicopy, we studied the instances where CNV information can be reliably measured and provided guidelines to confidently identify CNVs. Using paired SNP and methylation arrays from TCGA, we showed that Epicopy provides a robust method to obtain both copy number and methylation info...Fri, 17 Mar 2017 05:56:30 GMTJHTT-Communications@jhu.edu Gene GULP1 as a Functional Tumor Suppressor in Urothelial Carcinoma Novelty:The technology identifies a novel biomarker to detect the presence of bladder cancer via a urine test. The technology could be coupled with existing urine-based cancer tests to improve sensitivity as a diagnostic or to test drug efficacy.  Value Proposition:Bladder cancer (BC) is the 6th most common cancer in the US, with approximately 72,000 new cases reported annually. BC is currently diagnosed using cystoscopy and cytology in patients with symptoms, such as hematuria (blood in the urine). However, due to the high recurrence rate, long-term follow-ups are necessary. The cos...Fri, 17 Mar 2017 05:56:30 GMTJHTT-Communications@jhu.edu (Variant Effect Scoring Tool) (Variant Effect Scoring Tool) is a machine learning method that predicts the pathogenicity of missense and insertion/deletion variants observed through genome sequencing, allowing them to be prioritized in subsequent functional studies.Fri, 17 Mar 2017 05:56:29 GMTJHTT-Communications@jhu.edu – UPDATE Need In the new ?post-genome? era of personalized medicine, many variants critical to disease susceptibilities and drug sensitivities will be identified and increased numbers of people will undergo genetic testing. The Karchin group is developing algorithms and tools to facilitate this process. These models are being applied to cancer genomics, unclassified variants in Mendelian disease genes, and complex disease genetics. Technology OverviewCHASM AND VESTA machine learning method that predicts the functional significance of somatic missense mutations observed in the genomes of cancer c...Fri, 17 Mar 2017 05:56:29 GMTJHTT-Communications@jhu.edu Preclinical Comparative Study of 68Ga-Labeled DOTA, NOTA and HBED-CC Chelated PSMA-targeted Radiotracers cancer is the leading cancer in the U.S. population and the second leading cause of cancer death in men. Therapy for locally advanced disease remains contentious and an increasing number of disparate options are available. We have been engaged in the development of new, high-sensitivity, low molecular weight imaging agents for prostate cancer using the prostate-specific membrane antigen (PSMA) as a target. PSMA is a marker for androgen-independent disease that is also expressed on solid (nonprostate) tumor neovasculature. Previously, the inventors synthesized a variety of PSMA inhibit...Fri, 17 Mar 2017 05:56:27 GMTJHTT-Communications@jhu.edu cell sensitization to TRAIL therapy using PEGylated long-acting TRAIL combined with a tumor-homing nanoparticle TRAIL sensitizer NEED: Recombinant human tumor necrosis factor (TNF)-related apoptosis inducing ligand (hrTRAIL) and its agonistic antibodies have been under intense focus as crucial molecularly-targeted antitumor biologics due to their ability to selectively induce death receptor (DR)-mediated apoptosis in cancer cells while sparing healthy tissue. Yet, natural TRAIL resistance and the extremely short half-life of rhTRAIL have impeded clinical translation. Disclosed herein is a series of long-acting PEGylated TRAIL (TRAILPEG) with enhanced stability and half-life, and their use in combination with a tum...Fri, 17 Mar 2017 05:56:18 GMTJHTT-Communications@jhu.edu of poly(β-amino ester)-co-polyethylene glycol (PEG-PBAE-PEG) polymer for gene and drug delivery vectors are widely investigated due to their ability to safely and effectively deliver exogenous genes and potentially cure diseases of genetic origin. Much portion of the ongoing research in the field is also dedicated to further optimize the existing vectors for in vivo applications. This work describes new compositions of matter of polyethylene glycol (PEG) - poly(ß-amino ester) (PBAE) co-polymers through a novel synthesis scheme. DNA , siRNA , and other cargos associate with a blend of PEGylated PBAE and unmodified PBAE to form stable particles for drug and gene delivery. PEGylat...Fri, 17 Mar 2017 05:56:10 GMTJHTT-Communications@jhu.edu Optimization Software for Linear Elastic Continuum Solid Mechanics problem this Topological Optimization Software seeks to address is a problem which humanity has grappled with ever since our ancestors began to make tools - design optimization. This goes beyond the mere shape of an item but can also include what materials the item will be made out of. This optimization process is known as topology. The Topological Optimization Software is specifically related to the SIMP branch of topology. The SIMP process seeks to design a shape from the the ground up by iteration. This also allowed scientists to take into account material strength when designing an obj...Fri, 17 Mar 2017 05:56:06 GMTJHTT-Communications@jhu.edu Beacon System for Industrial Machine Safety technology is a Bluetooth sensing system for use on construction machinery as well as individual hardhats. A set of Bluetooth sensors are placed on a particular construction machine and all workers in the area wear hardhats with additional sensors. The sensors on the machine sense any workers that are nearbye by way of their Bluetooth hardhat sensors. Inside the machine, there is a iOS device which displays any nearby hardhat sensors as blips at the appropriate location and direction from the machine.Fri, 17 Mar 2017 05:56:05 GMTJHTT-Communications@jhu.edu Experimental Epigenetic Analysis Unmasks Dietary Targets and Genetic Liability for Diabetic Phenotypes a functional approach to investigate the epigenetics of type 2 diabetes (T2D), we combine three lines of evidence?diet-induced epigenetic dysregulation in mouse, epigenetic conservation in humans, and T2D clinical risk evidence?to identify genes implicated in T2D pathogenesis through epigenetic mechanisms related to obesity. Beginning with dietary manipulation of genetically homogeneous mice, we identify differentially DNA-methylated genomic regions. We then replicate these results in adipose samples from lean and obese patients pre and post-Roux-en-Y gastric bypass, identifying regions ...Fri, 17 Mar 2017 05:56:04 GMTJHTT-Communications@jhu.edu Computational Solution to Accelerating Spatial Searches on the Surface of the Earth, Sky or any Sphere NeedModern information technologies have made big data available in a variety of sciences, i.e. extremely large data sets that may be analyzed only computationally to reveal patterns, trends, and associations.  There are a number of approaches to compile these data sets, but in all current approaches there are challenges in how to make sense of these data.Technology DetailsJHU researchers have created a computational solution to accelerate searches related to astronomy and other sciences, navigating the significant amounts of data associated with these sciences.   The solution comprises ...Fri, 17 Mar 2017 05:56:03 GMTJHTT-Communications@jhu.edu Virtual Intervention Laboratory to Prevent Stroke fibrillation (AF), the most common human arrhythmia, is a marker of an increased risk of embolic stroke. However, recent studies suggest that AF may not be mechanistically responsible for the stroke events. An alternative explanation for the mechanism of intracardiac thrombosis and stroke in patients with AF is structural remodeling of the left atrium (LA). However, a mechanistic link between LA structural remodeling and intracardiac thrombosis is unclear, because there is no clinically feasible methodology to evaluate the complex relationship between these two phenomena in individual p...Fri, 17 Mar 2017 05:56:01 GMTJHTT-Communications@jhu.edu Methods and Devices Enabling Multiphoton Imaging with Improved Signal-to-Noise Ratio report the development of a single-fiber based scanning device (termed as endomicroscope) and system capable of performing high-resolution optical imaging of biological tissues with multiphoton excitation. The imaging device is fiber-optically based and is flexible with a small footprint (~2 mm in diameter), and the entire imaging system is compact and portable. The technology can serve as (1) a transformative clinical tool for performing multiphoton imaging of internal organs that are not possible with a standard microscope; and (2) a research tool with flexibility and dramatically reduce...Fri, 17 Mar 2017 05:56:00 GMTJHTT-Communications@jhu.edu Compressive Ultrahigh-speed Continuous Imager Using Spectrally-structured Ultrafast Laser Pulses invention uses chirped processing and electro-optic modulation in optical fiber components to encode unique pseudorandom binary patterns at an ultra-high rate onto the spectra of broadband mode-locked laser pulses. Each laser pulse receives a unique spectral pattern and then serves as an ultrashort burst of structured illumination of an object inside a 1- or 2-D spatial disperser. The output energy of each pulse after striking the object is recorded with a photodetector and digitizer and an image is reconstructed using Compressed Sensing recovery from only a few percent of the number of s...Fri, 17 Mar 2017 05:55:58 GMTJHTT-Communications@jhu.edu for Tracker Registration from Radiographic Projection Need A variety of intraoperative 2D radiographic imaging systems are currently used in interventional radiology, surgery, and radiation therapy.  Surgical navigation offers an accompanying method for image-guidance, in which surgical tools are tracked in real-time via the use of dedicated markers attached to the tools.  A common problem when using such navigation systems, is gradual degradation of tracker registration (to a pre-/intra-operative 3D image), often due to intra-procedure patient motion to surgical manipulation of tissue.              Conventional registration methods in clin...Fri, 17 Mar 2017 05:55:57 GMTJHTT-Communications@jhu.edu Administration of Glutamate Carboxypeptidase (GCP-II) Inhibitors for Enhanced Brain Delivery have developed a novel method to enhance the penetrance of multiple GCPII inhibitors which were developed by the inventor and Dr. Pomper at JHU. This method demonstrated improved brain penetrance in rodents. The penetrance of a specific GCPII inhibitor showed significant brain penetrance in non-human primates and inhibited GCPII activity in the brain in rodents.Fri, 17 Mar 2017 05:55:56 GMTJHTT-Communications@jhu.edu Methods to Count Corneal Subbasal Nerves NeedAlthough emerging non-invasive techniques for corneal nerve assessments are increasingly being utilized to diagnose and monitor peripheral neuropathies, robust automated methods to measure nerves in the corneal subbasal plexus have not been developed.Technology OverviewTo automate nerve counts in the cornea, a custom algorithm was developed specifically to quantify nerve fibers in corneal subbasal plexus images in whole mount specimens immunostained for the pan-axonal marker ?III tubulin. This novel counting method will be applicable to corneal whole mounts and for images obtained in...Fri, 17 Mar 2017 05:55:56 GMTJHTT-Communications@jhu.edu Biodegradable CCP:SA Polymers for the Treatment of Malignant Glioma, 17 Mar 2017 05:55:55 GMTJHTT-Communications@jhu.edu App (Hemorrhage Risk Stratification) App: The app is a calculator for mobile phones, tablets, and other electronic devices such as computers. It allows the user to input patient: age, renal function, and size of stroke. It then provides an estimation of the probability of hemorrhagic transformation during a patients’ hospitalization. The HeRS score is a prospectively validated equation based on continuous variables of age, renal function, and stroke size. The equation is complex and cannot be performed easily or quickly with paper or with an ordinary calculator. Determining the probability of hemorrhagic transformation of a...Fri, 17 Mar 2017 05:55:54 GMTJHTT-Communications@jhu.edu Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH): A Novel Anticancer Therapeutic for Solid Malignancies Need: One of the hallmarks of cancer cells is metabolic reprogramming for faster metabolism and cell growth. For example, increased glycolysis has long been known to be part of cancer cells? biochemical adaptation. One of the key enzymes of glycolysis is glyceraldehyde-3-phosphate dehydrogenase (GAPDH) which catalyzes the first step of energy rich/ redox molecule producing reaction. There is a great need in the art to identify potential therapeutic strategies and compositions that target energy metabolism in the treatment of cancer.The present invention provides a method for inhibiting o...Fri, 17 Mar 2017 05:55:54 GMTJHTT-Communications@jhu.edu Novel Peptide for the Transcellular Delivery of Therapeutics, Imaging Agents, Biopharmaceuticals, siRNA, Genes, and other Molecular Cargos Across Endothelial Biological Barriers, 17 Mar 2017 05:55:52 GMTJHTT-Communications@jhu.edu 7-Amino-5-thio-thiazolo[4,5-d]pyrimidines for Fractalkine Receptor (CX3CR1) PET Imaging groups worldwide have endeavored to detect and quantify microglial activiation with imaging in order to understand a variety of neuropsychiatric diseases, ranging from HIV dementia to schizophrenia all of which have a prominent neuroinflammatory component. Within the central nervous system (CNS), fractalkine receptor, a.k.a., CX3CR1, is the only known microglia-specific target indicated in neuroinflammation, and it happens to be a readily accessible receptor. In the periphery, CX3CR1 also plays important roles in inflammatory diseases, cell migration and adhesion. The CX3CR1 specific Low...Fri, 17 Mar 2017 05:55:50 GMTJHTT-Communications@jhu.edu of Novel Quantitation to Medical Imaging for Cancer Outcome Prediction researchers have proposed a range of novel algorithms to quantify tumor uptake in medical imaging to enable significantly enhanced outcome prediction in cancer patients. This work enables a novel combination of volume and uptake information in tumors, including the ability to quantify heterogeneous tumors by utilizing image processing techniques as well as novel metric formulation to enable quantitation of tumor uptake. It arrives at quantitative values that comprehensively summarize key features of tumor uptake in medical imaging, enabling application to outcome prediction.Fri, 17 Mar 2017 05:55:49 GMTJHTT-Communications@jhu.edu Intracerebral Hemorrhage Prediction Employing logistic Regression and Features Extracted from CT (PItcHPERFECT) invention is a novel method for automatically detecting intracerebral hemorrhage (ICH) in cross-sectional X-ray computed tomography (CT) studies. PItcHPERFECT creates voxel-level predictors derived from the CT image and produces voxel-level probability maps of the brain that quantifies the likelihood that each voxel is ICH. Binary lesion segmentations are created from these probability maps using a validated population-level threshold. PItcHPERFECT was derived on a large number of patients with ICH, under multiple imaging centers and scanning parameters.Fri, 17 Mar 2017 05:55:47 GMTJHTT-Communications@jhu.edu of AGX/UAP Inhibitors to Inhibit Flux through the Hexosamine Biosynthetic Pathway (HBP) novelty: This technology involves small molecule inhibitors of UDP-N-acetylgalactosamine pyrophosphorylase (AGX/UAP) to normalize aberrant glycosylation in the hexosamine biosynthetic pathway (HBP).  This novel strategy simultaneously suppresses multiple complex human diseases that include cancer and diabetes. Value proposition: Instead of using highly efficient oxidative phosphorylation found in most healthy cells, cancer cells instead primarily ferment glucose for energy production. This property ? known as the Warburg effect ?results in cancer cells using orders of magnitude more ...Fri, 17 Mar 2017 05:55:46 GMTJHTT-Communications@jhu.edu Method and Use of Highly Stable Biodegradable Gene Vector Platforms Capable of Overcoming Various Biological Barriers researchers have formulated compact, colloidally stable gene carriers that have a dense surface coverage of hydrophilic and neutrally charged PEG. These gene vectors stably retain their physicochemical characteristics over at least a week in aqueous solution and are highly stable in physiological solutions. Moreover, they demonstrate the ability to penetrate physiological barriers such as airway mucus and brain tissue/tumor allowing for widespread distribution and high level transgene expression in vivo. These advantages provide the opportunity to expand this highly efficient, tailorable...Fri, 17 Mar 2017 05:55:45 GMTJHTT-Communications@jhu.edu Universal Memory Operated by Electric Currents Need  Modern computer rely on a hierarchy of several storage devices. Universal memory combines the advantages of the multiple storage devices and possesses non-volatility, high speed, ultra density, and infinite durability.  Skymions can be used for universal memory, because of their small size, stability, individual creation and annihilation, and facile movement by low currents.Technology Overview:                                The inventors have developed a universal memory in which data is carried by skyrmion, a topological magnetic structure. In the invention, data writing, deletin...Fri, 17 Mar 2017 05:55:43 GMTJHTT-Communications@jhu.edu for shunting fluid between two compartments within human body Need: Ascites (fluid in the peritoneal cavity) can form in patients with some cancer types or cirrhosis of the liver. Current methods to remove the fluid are long term solutions such as dietary changes, diuretic drugs or a clinical procedure called paracentesis to remove the fluid. Paracentesis is an invasive procedure which removes ascites fluid using a large pump.  Some patients are unresponsive to therapeutic methods and develop refractory ascites. Such patients usually require recurrent large-volume paracentesis and multiple hospital admissions. Many patients seek emergency treatment...Fri, 17 Mar 2017 05:55:43 GMTJHTT-Communications@jhu.edu Elimination in Phase-Encoded Analog-Photonic Links using a Four-Wave Mixing Comb Source minimization is a crucial goal for analog optical links as high distortion reduces the spurious free dynamic range. We have devised a method for canceling distortions by exploiting the phase relationship between lines on an optical comb generator. We have demonstrated elimination of even order distortions and third order distortion and this method has a clear path toward eliminating the fifth order distortion and beyond.Fri, 17 Mar 2017 05:55:42 GMTJHTT-Communications@jhu.edu Optical Display Based on Chemical Release from Printed Porous Voxels describe the concept of utilizing precisely patterned and chemically loaded three-dimensional porous containers akin to “chemical voxels” to enable dynamic visual patterns via spatial and temporal control of both local and global chemical release. Using numerical simulations and experiments, we show how variations in porosity, volume, shape and relative positioning of the chemical voxels can be used to control the types of images that are formed with control in both space and time. We generate moving images via controlled chemical release from an array of voxels to create an animation of a ...Fri, 17 Mar 2017 05:55:40 GMTJHTT-Communications@jhu.edu Echo Fishing Lure and more fishing hobbyists use boat sonar to detect fishes and underwater structure. These sonars operate on the same principle as medical ultrasonography systems. They fire ultrasound pulses and receive the echo signal. Based on the signal time-of-flight (TOF) and phase, the image is reconstructed. These sonars work at a frequency between 100k to 400kHz (compared to MHz for medical ultrasound), and capable to provide underwater ultrasound images with a refresh rate of few Hertz. Large fish, fish schools, and other large underwater objects can show up in the ultrasound image. However, fi...Fri, 17 Mar 2017 05:55:37 GMTJHTT-Communications@jhu.edu Egress and Invasion Inhibitors and Their Use as Antiparasitical Agents emergence of drug resistance by P. falciparum, necessitates the development of novel antimalarials to stay one step ahead of the rapidly evolving parasite. We are working to identify compounds that can disrupt the parasites key pathways. In this project, we are targeting the parasites invasion and egress pathway to prevent proliferation. The parasite employs an actomyosin motor as part of a larger invasion machinery complex known as the glideosome to invade target cells. A key component of the invasion machinery is a tetrameric complex of Aldolase that connects the motor to the cytoplasmic...Fri, 17 Mar 2017 05:55:35 GMTJHTT-Communications@jhu.edu Modification of Human Adipose-derived Mesenchymal Stem Cells for Brain Cancer and Other Neurological Diseases, 17 Mar 2017 05:55:34 GMTJHTT-Communications@jhu.edu Algorithm for Denoising of Lung Sound Recordings from a Digital Stethoscope software algorithm is proposed to enhance the quality of lung (body) sounds recorded using a digital stethoscope mounted with an external microphone. The algorithm operates by removing unwanted noise interferences such as background talk, patient crying, room noises, etc. A team of clinical experts evaluated and confirmed that the quality of the lung sound processed through this algorithm is noticeably improved relative to the original non-processed signal.Fri, 17 Mar 2017 05:55:34 GMTJHTT-Communications@jhu.edu liver nuclear receptors as a treatment for Wilsons disease disease is a hepato-neurologic disorder caused by mutations in the gene ATP7B and accumulation of copper in tissues, predominantly in the liver. The disease is lethal, unless treated. Current life-long treatment involves copper chelation or copper replacement using Zn. Both procedures alleviate major symptoms but side effects are frequent and neurologic deterioration is often observed. Using Atp7b-/- mice (an animal model for Wilson disease), we demonstrated that treatment of these animals (via addition to the diet) with a specific compound markedly improves their liver function amelio...Fri, 17 Mar 2017 05:55:33 GMTJHTT-Communications@jhu.edu<![CDATA[The HEARS (Hearing health care Equality through Accessible Research & Solutions) Intervention, Training Materials and Process of Delivering Community-based Hearing Care]]> Need:Currently, hearing care is primarily delivered through audiologists, hearing aid dispensers and otolaryngologists. The only community-based aspect of hearing care currently is occasional hearing screening. The HEARS intervention is a first-in-kind approach to providing a combination of hearing screening, education, counseling and amplification delivered in the community utilizing lay health advisors and community health workers. Associated training, education and counseling materials (documents, graphics and mobile applications) are additional contributions.Technical Overview:   The...Fri, 17 Mar 2017 05:55:32 GMTJHTT-Communications@jhu.edu Nanoprobe-enabled Capture and Early Detection of Microbial Pathogens invention presents the development of a novel sensing strategy for early detection of food- and water-borne microbial pathogens. Our strategy is enabled by a multifunctional nanoprobe built upon plasmonic-magnetic heterodimer nanoparticles, which are biofunctionlized with antibodies, peptides, proteins, and/or oligonucleotides via bioconugation and crosslinking. This multifunctional nanoprobe is used to recognize and label microbial pathogens in a flowing stream carrying filtered food or water analytes. To achieve ultralow detection limit (Fri, 17 Mar 2017 05:55:31 GMTJHTT-Communications@jhu.edu Intraocular Lens Calculation "Super Formula" IOL calculation formulas are currently available. Individual formulas have been demonstrated to work best with certain input variables. For example, a particular formula works better with shorter eyes and a particular formula may work better in longer eyes. Further, there are adjustments to these formulas that have been used to obtain better results. The current work will graphically pick and choose the parts of each formula that have either been proven or believed to be the most accurate and combine this into one overall formula. This combined or super formula can be adjusted or...Fri, 17 Mar 2017 05:55:30 GMTJHTT-Communications@jhu.edu dual-use optical tomographic imaging system for pre-clinical research as an independent instrument or on-board other instruments optical imaging, including both bioluminescence and fluorescence imaging, is an important modality for pre-clinical research. At present, all molecular optical imaging systems operates as stand-alone systems. It would be very powerful to integrate the operation of a molecular optical imaging system with other pre-clinical research systems to provide complementary molecular information. Our invention pertains to a dual-use optical tomographic imaging system that can operate for efficient stand-alone applications, and can also be docked robotically on-board another imaging or irradiati...Fri, 17 Mar 2017 05:55:29 GMTJHTT-Communications@jhu.edu Toxins and their Use as Pharmacological Modulators of GABAa Receptors, 17 Mar 2017 05:55:27 GMTJHTT-Communications@jhu.edu to Determine Risk of Developing PTSD after Stressful Events stress disorder (PTSD) is recognized by the Department of Defense, the Department of Veterans Affairs, and the National Institute of Mental Health as a major medical issue for both deployed and returning U.S. troops. HPA axis alterations in PTSD individuals have been implicated in the past and various biomarkers such as SKA2 have been demonstrated to be important for other HPA axis related phenomenon leading to psychiatric phenotypes such as suicide. The current invention is a method for determining which individuals are at risk to developing PTSD after exposure to stressful eve...Fri, 17 Mar 2017 05:55:26 GMTJHTT-Communications@jhu.edu for Cervicovaginal Secretion Transplants to Restore Healthy Vaginal Microbiota, 17 Mar 2017 05:55:22 GMTJHTT-Communications@jhu.edu malaria parasite biomarkers in human saliva and the development of a non-invasive malaria rapid diagnostic test (RDT) falciparum sexual stage gametocyte parasites do not cause disease but are critical for transmission of the malaria parasite through the mosquito vector from one human to another. To date, no simple point of care diagnostic to identify gametocyte carriers and individuals with sub-microscopic asexual stage parasitemia exists. Current RDTs do not have enough sensitivity to identify such carriers. PCR is the only commonly used method for identifying but it is costly and cannot be done in a rural health clinic in malaria endemic regions throughout the world. Current RDTs use blood as the...Fri, 17 Mar 2017 05:55:21 GMTJHTT-Communications@jhu.edu in Aggressive Prostate Cancer Patients glycosylation is one of the most common forms of protein modifications. Each glycoprotein can be glycosylated at different glycosites and each glycosite may be modified by different glycans. This structural heterogeneity provides additional signatures for each glycoprotein in physiological and pathological processes and could serve as markers for disease development. However, the structural heterogeneity also complicates the studies of structure-function relationships of glycoproteins. To rapidly identify and quantify the protein glycosylation from complex biological and clinical and ...Fri, 17 Mar 2017 05:55:21 GMTJHTT-Communications@jhu.edu Johns Hopkins Pathology Flashcard App Johns Hopkins Pathology Flashcard App is a mobile application for iOS devices, including iPad, iPhone and iPod Touch. The app implements a mechanism for the creation, management, organization, sharing, and review of image-based flashcards. The primary intent of this app is for medical education in the field of pathology, however it is also suitable for use in other areas of medical and non-medical education.1. The app provides a mechanism for creating image-based flashcards from either photos on the mobile device or directly using the devices camera.  As such, the app is uniquely suited fo...Fri, 17 Mar 2017 05:55:19 GMTJHTT-Communications@jhu.edu of Me-LOVARs claim a Multi-echo Parametric VARiation Saturation (MePaVARS) sequence, which places multiple image readouts in between a series of saturation pulses. with the saturation pulse parameters varied which allows the generation of CEST contrast maps with patterns of signal loss encoded into the images for better discrimination between various CEST imaging agents according to these patterns produced by variation of saturation conditions. The saturation parameter changes include, but are not limited to, saturation power (B1), length (tsat), number of pulses, shape of saturation pulses, amplitude o...Fri, 17 Mar 2017 05:55:19 GMTJHTT-Communications@jhu.edu Synthetic Aperture Ultrasound Imaging of ultrasound (US) image is determined by transmission frequency and aperture size of transducer. Synthetic aperture (SA) is a technique to improve resolution by synthetizing received signals and extend the aperture size for reconstruction.Fri, 17 Mar 2017 05:55:18 GMTJHTT-Communications@jhu.edu of an in vitro Model of Metastatic Cancer Need: Metastasis is by far the main cause of cancer lethality; the majority of cancer death from solid tumors are due to metastatic cancer spread from the tumor to other sites in the body. Key features of metastatic cascade are invasion, migration, and epithelial-mesenchymal transition (EMT). There are models of cancer cell metastasis but they omit such initial steps of metastatic cascade so potential molecular targets may also be missed. Lack of an in vitro model of metastasis is a major impediment in understanding its biology and identification of potential therapeutic targets.Technol...Fri, 17 Mar 2017 05:55:17 GMTJHTT-Communications@jhu.edu Synthetic Brain Penetrating Gene Vectors central nervous system (CNS), as a target for gene therapy, presents multiple practical advantages for intervention [1]. The existence of numerous genetic targets that can alter the natural history of CNS diseases renders gene therapy an attractive approach for the development of novel treatments [2]. Viral gene delivery, though relatively efficient, has been limited by immunogenicity, low packaging capacity and difficulties in manufacture and scale-up [2, 3]. Non-viral gene vectors offer an attractive alternate strategy for gene delivery, but diffuse and homogeneous transgene delivery in...Fri, 17 Mar 2017 05:55:14 GMTJHTT-Communications@jhu.edu Osler Guide (app) needCurrently, paper reference books exist for guiding clinical decisions, but there is no app available for this purpose. Technology OverviewThe residents of Johns Hopkins Internal Medicine department have composed a paper guide for the last 16 years to diagnose and treat the most common diseases and conditions encountered on a daily basis.  The Osler Guide app provides an interactive platform for viewing this content and includes references to the original research data as well as embedded videos with guides to diagnosis.Stage of DevelopmentA mobile and tablet app is available for Appl...Fri, 17 Mar 2017 05:55:13 GMTJHTT-Communications@jhu.edu Deflection Shape Sensor and Method of Use for Dexterous Continuum Manipulators present invention generally relates to dexterous continuum manipulator (DCM) shape sensing and, more particularly, to large deflection shape sensing for DCM. DCMs have found a variety of applications in robotic surgery in general and, specifically, in minimally-invasive surgery (MIS). These DCMs typically assist surgeon in diagnosis and/or operating in constrained environments. For many surgical applications, the DCMs may need to operate with curvatures much larger than the current shape sensing methods can detect. This inventions describes a specific embodiment for shape sensing technique...Fri, 17 Mar 2017 05:55:10 GMTJHTT-Communications@jhu.edu Application Suite (Comprised of 3 individual apps - EMCAPS 2.0, SurgeApp, FluCast) PACER app suite is a series of tools available for free on PACER’s website that are meant to be used for research and educational purposes. The apps are: FluCast - a forecasting tool for predicting seasonal influenza at the hospital level, EMCAPS 2.0 - a mass casualty morbidity and mortality planning tool for 11 different National Planning scenarios , and Surge - an application that assists hospital planners in predicting bed availability in the wake of a disaster. The goal is to get these applications easily into the hands of local, state and national emergency planners, hospital emer...Fri, 17 Mar 2017 05:55:08 GMTJHTT-Communications@jhu.edu Prior Knowledge About a Needle Artifact and Position for Increasing Temporal Resolution in Real-time MR Imaging Using Iterative Imaging Strategies such as Compressed Sensing technology relates to a system and method for tracking a moving needle or other object while it is being inserted into biological tissue, using improved magnetic resonance imaging (MRI) techniques that can provide sufficiently high resolution images in real time to precisely guide the needle placement.  Fri, 17 Mar 2017 05:55:01 GMTJHTT-Communications@jhu.edu Additive Manufacturing NeedDespite the rapid advance of additive manufacturing technologies in recent years, methods to fully encase objects withmultilayer, thick features are still undeveloped.Technology OverviewJohns Hopkins faculty member, Dr. Gregory Chirikjian, along with colleagues from JHU and Applied Physics Lab, have developed conformal printing around objects. As opposed to current conformal approaches that either deposit a single layer of material or require large amounts of sacrificial support material, this invention (through two novel, separate layering approaches) fully defines multiple layers f...Fri, 17 Mar 2017 05:55:00 GMTJHTT-Communications@jhu.edu of Autophagy in Cancer Lines is an unmet need for selective and specific autophagy inhibitors in cancer research and cancer drug development. Many cancer types rely on autophagy, whereby the cell degrades unnecessary or damaged cellular components, to maintain homeostasis of the cell, particularly in the hypoxic environment of rapidly proliferating tumors. Autophagy pathways have come under increasing scrutiny and numerous proteins have been identified. One such autophagocytic protein is LC3-II, part of the LC3/Atg3 autophagocytic pathway. As an indicator of its significance in the growth of cancer cells, LC3-II is ...Fri, 17 Mar 2017 05:54:56 GMTJHTT-Communications@jhu.edu Patient Self-Management Program is a behavioral program that improves patient self-management and adherence. DECIDE, an acronym for Decision-making Education for Choices In Diabetes Everyday, is a structured, 9-module program that uses problem-solving skill training for managing chronic conditions. Patients use a problem-based approach to identifying and managing barriers and challenges that impede optimal self-care and adherence behaviors. The program was originally developed to treat high risk diabetes patients with multiple comorbidities. It has proven effective in improving health behaviors and disease control se...Fri, 17 Mar 2017 05:54:53 GMTJHTT-Communications@jhu.edu Rigid Body Optical Tracking System and Method virtual rigid body optical tracking system includes a virtual rigid body generator for projecting a virtual rigid body, wherein the virtual rigid body forms a pattern of light on a surface. The virtual rigid body optical tracking system includes an optical detection system for detecting the pattern of light, and a data processing system in communication with the optical detection system. The data processing system is configured to determine a position of the virtual rigid body generator based on the detected pattern of light.Fri, 17 Mar 2017 05:54:53 GMTJHTT-Communications@jhu.edu Triazole Conjugated Ureas membrane antigen (PSMA) is a type II integral membrane protein expressed on the surface of prostate tumors, particularly in castrate-resistant, advanced and metastatic disease. PSMA is also expressed in neovascular endothelium of most solid tumors, such as lung, colon, pancreatic, renal carcinoma and skin melanoma, but not in normal vasculature, which makes it an excellent target for imaging and targeted therapy of these cancers. Here we describe a series of PSMA-targeted radiolabeled triazole conjugated ureas developed through click chemistry.Fri, 17 Mar 2017 05:54:51 GMTJHTT-Communications@jhu.edu Projection Geometry for Volumetric Image Reconstruction propose a novel method for enabling volumetric image reconstruction from unknown projection geometry of tomographic imaging systems, including CT, cone-beam CT (CBCT), and tomosynthesis systems. The invention enables image reconstruction in cases where it was not previously possible (e.g., custom-designed trajectories on robotic C-arms, or systems using uncalibrated geometries), and more broadly offers improved image quality (e.g., improved spatial resolution and reduced streak artifact) and robustness to patient motion (e.g., inherent compensation for rigid motion) in a manner that does no...Fri, 17 Mar 2017 05:54:49 GMTJHTT-Communications@jhu.edu of Hyperbarically Loaded Polymeric Materials for Biomedical Applications NeedTherapeutic gas delivery remains one of the greatest challenges in tissue engineering. Consequently many technologies and approaches have been developed but all lackeffective ways to deliver sufficient therapeutic gas, such as oxygen, to targeted regions within deeper tissue. This invention introduces a means of delivering therapeutic gases in a controlled and sustained manner involving the hyperbaric loading of gas into microtanks and the subsequent controlled release of the gas from these biodegradable micro-scale vessels. Additional advantages include:  1. Allows up to one month...Fri, 17 Mar 2017 05:54:43 GMTJHTT-Communications@jhu.edu Microfabricated Multiple Actuation Device for Mechanical Conditioning of 3D Microtissues have recently demonstrated an approach that enables mechanical stimulation of microtissues via magnetic actuation of magnetic microspheres bonded to one of the cantilevers in each device (ALL THREE ZHAO REFS). This has notably allowed measurement of the mechanical stiffness of such constructs, and hence analysis of the relative contribution of cells and matrix to relevant mechanical properties, and also (ZHAOADVMAT) investigations of he role of boundary conditions and mechanical constraints on tissue formation (ZHAOBIOMAT). While these results to date have demonstrated the potential of m...Fri, 17 Mar 2017 05:54:42 GMTJHTT-Communications@jhu.edu Targeted Radiohalogenated Ureas for Cancer Radiotherapy cancer is the leading cancer in the U.S. population and the second leading cause of cancer death in men. Therapy for locally advanced disease remains contentious and an increasing number of disparate options are available. We have been engaged in the development of new, high-sensitivity, low molecular weight imaging agents for prostate cancer using the prostate-specific membrane antigen (PSMA) as a target. PSMA is a marker for androgen-independent disease that is also expressed on solid (nonprostate) tumor neovasculature. We have synthesized a variety of novel, high affinity inhib...Fri, 17 Mar 2017 05:54:41 GMTJHTT-Communications@jhu.edu for Stereo Reconstruction from Monoscopic Endoscope Images system enables reconstruction of 3d images from monoscopic endoscopes with a working channel. The system is inexpensive and could easily be made disposable. Clinical applications in include taking precise, minimally invasive measurements of structures inside the body, such as the airway, sinus, and digestive tract.Fri, 17 Mar 2017 05:54:37 GMTJHTT-Communications@jhu.edu Nanofiber Hydrogels for Local Treatment of Brain-related Diseases have developed a novel type of therapeutic agent-containing liquids that comprise self-assembling peptide nanofibers and physically encapsulated and chemically bound medicinal compounds, capable of transforming into a gel form upon contact with body fluids. The resulting gel can gradually release the incorporated therapeutic agents in a controlled manner over a long period of time. This platform technology allows for effective incorporation of various kinds of therapeutic agents for improved treatments of brain-related diseases through local delivery.Fri, 17 Mar 2017 05:54:37 GMTJHTT-Communications@jhu.edu Activity Peptides (diagnostics) ability to convert transient stimuli from the extracellular environment into long-term changes in neuronal function is central to an animal’s capacity to adapt and learn from its environment. This is mediated through sensory organs, which transduce physical and chemical stimuli into precise patterns of neuronal activity that elicit specific change in the structure and function of the nervous system. Work from many laboratories over the past few decades on the mechanisms that underlie these activity-dependent changes in the nervous system has highlighted the significant role that protein tr...Fri, 17 Mar 2017 05:54:34 GMTJHTT-Communications@jhu.edu Brazing with Thermite Redox Foils Need The invention offers an improved and more efficienct means for bonding dissimilar materials.  Reactive self-propagating multilayer foils can be used as local heat sources for joining materials without heating either component significantly  (as only the region near the interface is heated). This is useful for joining dissimilar materials without pre-wetting components with solder or coating them with inert metal layers such as Au or Ag.    Technology OverviewThe invention comprises a novel reactive composite foil, including metallic fuel particles, oxidizer particles, and a diluent,...Fri, 17 Mar 2017 05:54:33 GMTJHTT-Communications@jhu.edu Mechanism with Enhanced Torsional Stiffness NeedThis invention pertains to an improvement in the Robotic ENT Microsurgery System (REMS).  The REMS robot uses a delta mechanism to provide translational degrees of freedom.  Though the delta mechanism offers a lot of advantages, particularly in reducing the weight of the robot has to move, it also suffers from weak torsional stiffness. Technical DetailsJohns Hopkins faculty member and medical robotics pioneer, Dr. Russell Taylor, has developed an improved feature of a delta mechanism used in industrial robots.  The delta mechanism is a common parallel design for industrial robots, ho...Fri, 17 Mar 2017 05:54:31 GMTJHTT-Communications@jhu.edu Align newly invented DNA alignment algorithm combined and fine tuned with recent advances in GPU technology resulted in a 40x 50 x speed increase and better quality results. Bundled with appropriate HW+SW environment, one Compute Align appliance is expected to provide the same speed of data processing capability as the highest speed input data provider, the industry leading DNA Aligner platform, the Illumina HiSeq X 10 cluster.Fri, 17 Mar 2017 05:54:28 GMTJHTT-Communications@jhu.edu Cup Need: Cerebral Palsy (CP) is a group of serious movement disorders that limits the mobility and fine motor control of thousands of patients each day.  Patients often have difficulties drinking independently because of dysfunctions in both their oral motor control and their gross motor control. Risk of choking or spilling the liquid is very high. Thus, there is a need to control the amount of liquid consumed in one drinking motion and minimize the effects of their gross-motor dysfunctions, while allowing for individual customization for each patient’s needs and limitations.Technology Over...Fri, 17 Mar 2017 05:54:26 GMTJHTT-Communications@jhu.edu Spinal Probe Incorporating an Electromechanical System for Detection and Prevention of Breaches During Surgery Need: Next generation orthopedic surgical tools, particularly for spinal fusion.Technology Overview: The AccuSpine is a self-contained solution which transforms spinal fixation, enabling safe and accurate pedicle screw placement across a broad range of patients. At the core of our invention is an electromechanical system that measures the different forces and torques being applied to the probe over the course of an operation scientific principle behind the AccuSpine is based on density differences in the vertebrae. In our studies of human vertebral anatomy, we identified a significant de...Fri, 17 Mar 2017 05:54:25 GMTJHTT-Communications@jhu.edu for Treating Refractory Seizures Using a Novel Therapeutic Approach invention provides novel pharmaceutical interventions that convert phenobarbital (PB)-resistant seizures into phenobarbital responsive seizures in neonates. We have shown that unlike in adult brains, expression of a transport protein in the neonatal brain is much lower and undergoes further down-regulation following an ischemic insult, which is one of the most common cause of neonatal seizures. Since it is the activity of this transport protein on neuronal cell membranes that help reduce the intracellular Cl concentrations; we proposed that enhancing its activity in an injured/seizing neon...Fri, 17 Mar 2017 05:54:24 GMTJHTT-Communications@jhu.edu Acid-based Polymeric CEST Contrast Agents for Molecular Imaging of Prostate-specific Membrane Antigen have discovered that a salicylic acid (SA) analog when grafted on a polymeric platform is able to produce significantly enhanced contrast in MR images detectable through chemical exchange saturation transfer (CEST). That SA modified polymeric platform (SA PolyCEST), has been further modified with Glu-Lysine urea, an inhibitor of Prostate-specific membrane antigen (PSMA), a cell surface protein that is over expressed in most prostate cancers, including hormone-refractory and metastatic disease and tumor neovasculature. The PSMA targeted SA PolyCEST retains it high CEST contrast sensitivity ...Fri, 17 Mar 2017 05:54:16 GMTJHTT-Communications@jhu.edu Intraarterial Catheter-based Method for Predicting Territory of Local Blood Brain Barrier Opening Need: The blood-brain barrier (BBB) is a major hurdle to therapeutic agents reaching the brain. Osmolar agents can be used to create openings in the BBB, but this technique is clinically limited because of wide variability in the size and location of the resulting openings. JHU inventors have developed a system and highly controlled procedure to meet the significant unmet need of predictable creation of therapeutically effective BBB openings order to administer effective and localized treatment.• Predictable procedure provides added control and reproducibility of BBB openings opening cre...Fri, 17 Mar 2017 05:54:08 GMTJHTT-Communications@jhu.edu Restricted GABA Positive Allosteric Modulators for the Treatment of Irritable Bowel Syndrome and other Ailments of the Peripheral Nervous System pathogenesis of irritable bowel syndrome is associated with hyperexcitability of neurons, affecting both extrinsic (spinal) and intrinsic (enteric) nerves leading to chronic visceral hypersensitivity and altered motility, respectively. We have discovered a novel class of molecules that can provide a beneficial effect for irritable bowel syndrome, and potentially other diseases of the peripheral nervous system.Fri, 17 Mar 2017 05:54:01 GMTJHTT-Communications@jhu.edu implementing algorithms for monolingual alignment developed a software package for performing monolingual alignment -- the task of aligning parallel sentences in the same language. It contains two parts: a Markov model for token-based alignment and a semi-Markov model for phrase-based alignment. The algorithm has implication in the application of recognizing textual entailment and question answering.Fri, 17 Mar 2017 05:53:58 GMTJHTT-Communications@jhu.edu Enhancement of the T-cell Armamentarium as an Anti-cancer Therapy, 17 Mar 2017 05:53:44 GMTJHTT-Communications@jhu.edu African Diaspora Power Chip, 17 Mar 2017 05:53:42 GMTJHTT-Communications@jhu.edu Tailored Vaccine Risk Communication Module is a tremendous need to provide parents and the broader population accurate information about the risks and benefits of vaccines to include content that addresses their issues of interest and in a manner that is suitable for them. This product captures individual demographics and vaccine attitudes, beliefs and intended behavior and provides an informational intervention that is algorithmically tailored to address issues of interest to the user, at an appropriate educational level, from individuals with similar cultural groups, and including personalized information about the user.Fri, 17 Mar 2017 05:53:39 GMTJHTT-Communications@jhu.edu Enema for Pre-exposure Prophylaxis of HIV Infection for those at Risk of HIV Infection via Receptive Anal Intercourse propose a single dose tenofovir enema to protect from an exposure to HIV via receptive anal intercourse (pre-exposure prophylaxis - PrEP). Tenofovir-containing regimens have been proven effective by the oral route using daily dosing regimens to prevent HIV infection for men and women at risk of HIV infection via sexual exposure. This approach is significantly limited by the poor adherence in some research settings and the requirement for daily dosing to achieve and sustain protective concentrations. We believe we will demonstrate that a single enema will provide sufficient concentrations to...Fri, 17 Mar 2017 05:53:38 GMTJHTT-Communications@jhu.edu comprehensive post-processing toolbox for magnetic resonance based peripheral vascular imaging artery disease (PAD) is an important public health concern particularly among the elderly. Although measures such as ankle-brachial index and segmental pressures have been used to characterize disease severity, new magnetic resonance based imaging techniques allow us to assess subclinical vascular function and morphology. Here, we describe the design of a comprehensive post-processing toolbox for assessment of peripheral vascular disease from magnetic resonance imaging. While there are commercially available toolboxes that perform one or more of the assessments - none of them involv...Fri, 17 Mar 2017 05:53:36 GMTJHTT-Communications@jhu.edu High-Affinity α7-nAChR Pet Radiotracers for Non-Invasive Diagnostic Imaging of Neurological Disorders Need: Cerebral neuronal nicotinic cholinergic receptors (nAChRs) are ligand-gated ion channels composed of α and β subunits that can assemble in multiple combinations of pentameric structures. The α7-nAChR subtype has been associated with the pathophysiology of a variety of neurological disorders, including schizophrenia and Alzheimer’s disease; yet, to date efforts to generate ligands to image α7-nAChR have been unsuccessful with existing tracers lacking specificity. Here, inventors developed the first high-specific uptake PET imaging tracer for α7-nAChR with excellent imaging propertie...Fri, 17 Mar 2017 05:53:35 GMTJHTT-Communications@jhu.edu and Apparatus for Selective Treatment Inside Body Lumen present invention teaches a method and device to electrically modulate the function of nerves that control sympathetic and parasympathetic activity in the human body. In one embodiment of the method, neural ganglia that regulate sympathetic activity of the adrenal and renal tissue can be stimulated or damaged to accentuate or attenuate function. Methods to regulate sympathetic activity via intravascular lumen and an apparatus that achieves this method are described.Fri, 17 Mar 2017 05:53:29 GMTJHTT-Communications@jhu.edu Scaffolds and Multifunctional Intermediates for Imaging PSMA prostate-specific membrane antigen (PSMA) is increasingly recognized as an important target for cancer imaging and therapy. Current PSMA inhibitors based on a urea scaffold have shown good results for imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT) in human subjects. The urea scaffold has certain limitations, including undesired renal uptake and other non-specific (non-tumor) binding. Twenty seven new urea-based scaffolds were synthesized and studied with respect to their binding affinity to PSMA. Two high affinity compounds were su...Fri, 17 Mar 2017 05:53:22 GMTJHTT-Communications@jhu.edu An Analytical Database and Website for Personalized Medicine and Data Sharing in Radiation Oncology Oncospace database aggregates treatment planning and clinical information about prior patients facilitating analysis and extraction of knowledge from prior courses of care. The goal is to use the knowledge to influence clinical decisions, quality and safety of care for new patients. This is accomplished through easy to use web based interfaces designed to support clinical decision making.Fri, 17 Mar 2017 05:53:18 GMTJHTT-Communications@jhu.edu Web Application Infrastructure and Implementation is a three-tiered application that is able to store, analyze, visualize and return annotations for time-series data in a Software-as-a-Service manner. This provides researchers with access to a robust time-series toolset without the need for installing the software locally. The interface itself works via a web browser, so the toolset can be accessed from anywhere with an internet connection.Fri, 17 Mar 2017 05:53:01 GMTJHTT-Communications@jhu.edu Apparatus and Method for the AX=XB Calibration Problem AX=XB sensor calibration problem is frequently encountered in the fields of robotics and computer vision. In this problem A,X, and B are each homogeneous transformations (i.e., elements of the special Euclidean group, SE(3)) with A and B given from sensor measurements, and X unknown. AX = XB is one of the most common mathematical formulations used in robot-sensor calibration problems. It can be found in a variety of applications including camera calibration, Cartesian robot hand calibration, robot eye-to-hand calibration [1], aerial vehicle sensor calibration [2] and image guided therapy (...Fri, 17 Mar 2017 05:53:00 GMTJHTT-Communications@jhu.edu Hydrogels, low oxygen tension, plays a pivotal role during development, regeneration, and cancer. However, nobody has stimulated hypoxia in a 3D microenvironment. Here, we developed a fundamental technology to create hydrogel materials that can serve as 3D hypoxic microenvironments. The HI hydrogels are formed via oxygen consumption in a laccase-mediated crosslinking reaction with biodegradability, cytocompatibility, and tunable mechanical properties. Oxygen levels and gradients within the HI hydrogels can be accurately controlled and precisely predicted. We demonstrate that HI hydrogels guide ...Fri, 17 Mar 2017 05:52:58 GMTJHTT-Communications@jhu.edu Mass Spectrometry-based Atlas of the Normal Human Proteome of biomarkers or therapeutic targets for human diseases requires comparison of proteomes of disease tissues with normal cells/tissues. However, a baseline of normal human proteome is not available. Mass spectrometry enables sampling of cells/tissues to provide a catalog of proteins expressed along with their relative abundance. To generate an atlas of normal human proteome, we carried out in-depth high resolution mass spectrometry-based profiling of 30 different human normal samples including 17 adult tissues, 7 fetal tissues and 6 purified primary hematopoietic cells. This resu...Fri, 17 Mar 2017 05:52:54 GMTJHTT-Communications@jhu.edu estimation of tissue types and linear attenuation coefficients for computed tomography invention concerns a method to jointly estimate tissue types and linear attenuation coefficients of the objects from x-ray projections. The current methods use two separate steps: first to estimate linear attenuation coefficients, then tissue types. Jointly estimating the two types of information offers a lot of technical and clinical merits.Fri, 17 Mar 2017 05:52:53 GMTJHTT-Communications@jhu.edu Fibrin Microfibers for Microvasculature Development in vitro model system that guides the development of microvasculature, recapitulating the detailed organization of both its cellular and a-cellular components is established. Use of electrostretched fibrin microfibers enables both endothelial layer organization and co-culture of supporting perivascular (mural) cells such as vascular smooth muscle cells and pericytes. The fiber curvature affects the circumferential deposition of endothelial-produced ECM independently of cellular organization and induces deposition of higher quantities of vascular ECM proteins. Further, a luminal multicellula...Fri, 17 Mar 2017 05:52:48 GMTJHTT-Communications@jhu.edu Both Magnitude and Direction of Transverse Motion with Optical Coherence Tomography method is developed for transverse motion tracking using optical coherence tomography (OCT) and this method allows to obtain both direction and magnitude of motion. The proposed motion tracking method involves scanning the OCT beam circularly and processing the obtained three dimensional data with novel algorithms.Fri, 17 Mar 2017 05:52:46 GMTJHTT-Communications@jhu.edu wraps and sheaths to minimize inflammation and scarring invention describes a novel semi-permeable nanofiber construct in the form of a wrap or sheath that can prevent inflammatory scarring at primary nerve or vessel repair site. The wrap/sheath consists of a nanofiber mesh with thickness ranging from 50 to 500 m and pore size of less than 10 m, and can be used in the form of a sheet wrapping around or as a tubular sheath covering the connection between two segments of a tubular tissue such as a nerve or a blood vessel. The wrap is composed of randomly oriented nanofibers (100 nm to 2 m in diameter) prepared by electrospinning from biocompatib...Fri, 17 Mar 2017 05:52:44 GMTJHTT-Communications@jhu.edu Acid Binding Polymer System Transforms Tissue and Biomaterial Surfaces introduce a transformational biomaterial approach to engineering lubrication at the tissue surface that can be applied in a single application. Articular cartilage explants were modified with a synthetic peptide-polymer system designed to non-covalently bind HA to the tissue surface and work synergistically with HA in the local fluid environment. Lubrication properties of chemically-modified tissue surfaces with bound HA were similar to those of native tissue bathed in HA lubricant. Biomaterials-mediated strategies that locally concentrate HA and create a self-healing coating of biologic...Fri, 17 Mar 2017 05:52:37 GMTJHTT-Communications@jhu.edu of Induced Neural Crest from Human Postnatal Fibroblasts Need: Human, functional iNC stem cells that can be used for perpherial nervous system and other stem cell therapies. Technology Overview: Collectively, by employing a single genetic factor and multiple environmental cues, functional iNC were derived from postnatal fibroblasts of healthy donors and patients. Considering limited availability of human neural crest and its relevance to numerous diseases in neural crest lineages, these direct and defined iNC derivation holds immediate and broad impact. In particular, identification of a cell surface marker can be immediately applicable to ski...Fri, 17 Mar 2017 05:52:35 GMTJHTT-Communications@jhu.edu Spectrum Chemoprotective Activities of Exemstane Against Cancer and Other Chronic Diseases: Synergism with Sulforaphane control the growth and development of the majority of breast cancers, the most prevalent malignancies of women in the developed world. Exemestane, a synthetic steroid commonly used clinically to prevent, delay progression of, and treat breast cancer, was designed to inhibit estrogen biosynthesis by aromatase. We have made the unexpected observation that exemestane also has widespread protective activities unrelated to blocking estrogens. Thus, exemestane is potently anti-inflammatory and antioxidant and can thereby protect against development of cancer and chronic degenerative diseas...Fri, 17 Mar 2017 05:52:33 GMTJHTT-Communications@jhu.edu delivery of antigenic CTL peptide to tumor loci by Annexin V renders tumor cells susceptible to adaptive CD8+ cell immunity immunotherapy represents a promising methodology to control tumors because it can stimulate the immune system to specifically target and eliminate tumor cells. To overcome the challenge of immune tolerance, which is common to immunotherapy, we generated a novel chimeric protein to selectively coat tumor cells with a foreign immunogenic CD8+ T cell (CTL) peptide(s) recognized by preexisting immunity so that immune tolerance could be bypassed and preexisting immunity could control tumors. In the current study, we exploited the fact that tumor cells undergo significant apoptotic ...Fri, 17 Mar 2017 05:52:32 GMTJHTT-Communications@jhu.edu Inhibitors of DNA Polymerase (Beta) library of small molecules whose structure are based upon that of a DNA lesion produced by potent antitumor agents that inactivates DNA polymerase was synthesized and shown to irreversibly inhibit the enzyme. One such molecule was shown to be active in DU145 cell (prostate cancer cells) lysates and to be cytotoxic to the same cells. A pro-inhibitor potentiates the cytotoxicity of methyl methanesulfonate (MMS) in DU145 cells ~3-fold. This molecule exemplifies a general approach for inhibiting DNA repair enzymes.Fri, 17 Mar 2017 05:52:23 GMTJHTT-Communications@jhu.edu density, 17 Mar 2017 05:52:13 GMTJHTT-Communications@jhu.edu and Method For Blood Brain Permeability Imaging (BBPI) Using Dynamic Susceptibility Contrast Magnetic Resonance Imaging Susceptibility Contrast (DSC) Magnetic Resonance Imaging (MRI) is a commonly used imaging technique for looking at blood flow in the brain. When there is damage to the blood-brain barrier (BBB) the recorded signal is altered. I have developed a technique to record the changes in the recorded signal caused by damage to the BBB which is independent of the changes in signal caused by blood flow. This enables us to measure damage to the BBB and opens up new ways to characterize a variety of disease states and potentially track or predict treatment response. I have validated this techni...Fri, 17 Mar 2017 05:52:05 GMTJHTT-Communications@jhu.edu B-mode (GB) Surface Imaging ultrasound imaging is widely used in the medical diagnostic area. Currently the dominant method for 3D ultrasound image acquisition is using wobbler scanning probe. In these probes, a 1-D array is used to generate 2D B-mode images. The array is driven by a motor, mechanically scanning along the lateral direction. As a result, a series of b-mode slices can be acquired to form the 3D image. As a replacement of wobbler probe, 2D array, also called matrix array, becomes commercially available recently. It is composed of a much larger number of transducer elements which is permutated as a 2D arr...Fri, 17 Mar 2017 05:52:02 GMTJHTT-Communications@jhu.edu Time Ultrasound Thermal Dose Monitoring System for Tumor Ablation Therapy this invention we propose a high accuracy real time ultrasound thermal dose monitoring system for tumor ablation therapy. In the tumor ablation operation, applicator guidance and ablation process monitoring are crucial, especially when the operation requires high accuracy. However, due to the low contrast between ablated and untreated tissue in the B mode image, conventional ultrasound imaging is usually not effective for the monitoring. Other imaging modalities include CT and MRI can be incorporated with the ablation therapy and provide effective image guidance and monitoring, however, the...Fri, 17 Mar 2017 05:52:01 GMTJHTT-Communications@jhu.edu Shared Decision Making for the Treatment of Depression and Suicidality, 17 Mar 2017 05:52:01 GMTJHTT-Communications@jhu.edu of a Clostridium Novyi-NT Based Therapy to Treat and Potentially Eliminate Human Chordoma use of c. novyi-NT has been previously reported for the treatment of cancer 1-8 and now we have shown that a variation of this approach works particularly well for chordoma, a neoplasm growing from remnants of the notochord. We wish to add these additional findings to existing I.P. for this approach. In our work we have shown that c.novyi-NT when given by intratumoral injection to a human xenograft model of chordoma, germinates rapidly and will eventually eliminate the tumor with no long term signs of tumor recurrence.Fri, 17 Mar 2017 05:51:55 GMTJHTT-Communications@jhu.edu (Important Information About Me) with neurodevelopmental disabilities (NDD) often have complex medical and surgical histories and long term care needs. Challenges in expressive communication coupled with time constraints often impede our ability to individualize care. Important Information About Me is an individualized patient health organizational tool for children with NDD. It facilitates communication of medical and unique personal information to health providers, rehabilitative specialists and caregivers. It is a user-friendly tool to organize personal and medical information of children with developmental dis...Fri, 17 Mar 2017 05:51:50 GMTJHTT-Communications@jhu.edu Highly Accurate Fundus Classification Method and Apparatus for Grading of the Advance of Age Related Macular Degeneration method of detecting, and classifying severity of, a retinal disease using retinal images includes at least one of receiving, retrieving or generating reference data that includes information concerning occurrences of key image features for each of a plurality of retinal disease and disease severity conditions; receiving a retinal image of an individual; processing the retinal image of the individual to identify occurrences of each of a plurality of distinguishable image features throughout at least a region of interest of the retinal image; identifying which ones of the identified occurrence...Fri, 17 Mar 2017 05:51:49 GMTJHTT-Communications@jhu.edu Serum Albumin-PSA proaerolysin Prodrug NEEDThe current standards of care for prostate cancer (Pca) include hormonal therapy, radiation therapy, surgery, chemotherapy, and combinational therapy. However, these treatments often have side effects that affect the quality of life of the Pca patients. Hence, there is an urgent need for developing better target-based therapies. This technology is a novel therapeutic that exploits the cytotoxic effects of a bacterial toxin, aerolysin, engineered to specifically target prostate tumor cells. Other advantages of this technology include: • Enhanced targeting to tumor site using a natura...Fri, 17 Mar 2017 05:51:37 GMTJHTT-Communications@jhu.edu Mouse Monoclonal Antibody Against Human LINE-1 ORF1p Novelty:Johns Hopkins researchers have developed a monoclonal antibody against the cancer-associated protein LINE-1 ORF1p.  Technical Overview:There is great unmet need for a method of easily and broadly screening for cancer. Biomarkers, one of the major tools used in cancer screening, are usually specific for one cancer type, making testing for a host of biomarkers unwieldy and impractical.  The inventors have found that LINE-1 ORF1p expression is associated with a number of cancers including lymphoma and colon, renal cell, hepatocellular, lung, breast, pancreatic, and biliary tract...Fri, 17 Mar 2017 05:51:31 GMTJHTT-Communications@jhu.edu Computational Flow Dynamics Based Method for Estimating Thromboembolic Risk in Patients with Myocardial Infarction present a unique method for quantitative assessment and estimation of thromboembolic risk in patients recovering from myocardial infarction. The method takes cardiac imaging data (CT, echo, CMR) from a patient and constructs a time]dependent geometric model of the left]ventricle (LV) from this data. This model is then subjected to computational fluid dynamic (CFD) analysis and the CFD analysis generates a variety of metrics that correlate with the risk of LV thrombus formation. The risk predicted by the CFD analysis can used to determine the course of treatment for the patient.Fri, 17 Mar 2017 05:51:30 GMTJHTT-Communications@jhu.edu Septal Aneurysm Transseptal Access System (ASATAS) Sheath Designs in a Transseptal Access SystemJHU REF: C12321  Invention Novelty: This technology comprises of a novel sheath design and a transseptal access system for performing transseptal punctures during invasive cardiac procedures.   Value Proposition: Transseptal punctures are required to be performed in various invasive cardiac procedures. While they are accompanied by a number of complications, they are most difficult in patients with atrial septal aneurysm. Because the septal wall in these patients is extremely pliable there is a huge risk of cardiac wall perforation during in...Fri, 17 Mar 2017 05:51:27 GMTJHTT-Communications@jhu.edu Integrator: A Bioinformatics Pipeline to Integrate and Interpret Multi Omics Data major bottleneck of proteomics is no longer the ability to generate data, but the correct analysis of proteomics data, and mining as much information from it as possible. This new software allows us to rapidly analyze data generated by mass spectrometry in an extensive maner using advanced charge state determination of MS spectra, search spectra using multiple search engines, data recombination, advanced protein redundancy removal, unique post-process quatitation and iterative search methods to solve this problem. We can typically expand the number of proteins identified by a factor o...Fri, 17 Mar 2017 05:51:00 GMTJHTT-Communications@jhu.edu Visual procedure checklist and information content site for image guided procedures. is a website concept seeking to provide a visual checklist for interventional radioloigsts and other physicians performing image guided procedures. Each prcedure performed will have a static content page (e.g, IVC filter placement procedure overview, steps, indications, contraindications), a dynamic content page (i.e., video and image rich checklist for the procedure with bullet points at each step) and a link to a web-simulation page (this would bea potential partnership with Mentice).Fri, 17 Mar 2017 05:50:54 GMTJHTT-Communications@jhu.edu Time-domain Spectroscopic Ellipsometer invention involves a new instrumentation and calibration procedure for terahertz time-domain spectroscopic ellipsometry (THz-TDSE). The invented spectroscopic ellipsometer measures the complex (i.e. real and imaginary) spectral information, for instance complex dielectric function, with absolute numerical values in THz range. The technique uses polarization information of a probing terahertz light rather than its field intensity as used in the current competing technology. The ellipsometer can accurately characterize many material systems such as metals, thick or highly doped semiconductor...Fri, 17 Mar 2017 05:50:38 GMTJHTT-Communications@jhu.edu pulse pileup effects compensation method for photon counting detectors (PCDs) NeedPhoton counting x-ray detectors (PCSD) can potentially boost the usefulness of clinical x-ray computed tomography (CT) scanners by efficiently measuring x-ray spectrum information, i.e., improved contrast-to-noise ratio in images, reduced radiation dose, and improved material decomposition.  A major hindrance to their adoption in the clinical setting is their limited speed.Technology OverviewJohns Hopkins faculty member, Dr. Ken Taguchi, has developed software using Photon counting x-ray detectors having increased speed.  Pulse pileup effects (PPEs) distort spectrum and decrease coun...Fri, 17 Mar 2017 05:50:34 GMTJHTT-Communications@jhu.edu pileup effects (PPE) models of recorded spectrum for photon counting detector (PCD) processing of photon counting X-Ray CT sinogramsJHU REF: [C12151]  Invention novelty: New and more efficient methods of compensating for image distorting effects in photon counting X-Ray CT.   Value Proposition Traditional CT suffers from some major limitations: low contrast between different tissues and high dosages required for a clean image. Photon counting X-Ray (PCXD) CT systems avoid these limitations. However, the raw data from photon counting X-Ray CT suffers from pulse pileup and spectral response effects which distort and occlude the true data. This invention provides me...Fri, 17 Mar 2017 05:50:34 GMTJHTT-Communications@jhu.edu of a Website and statistical methodology to determine an individual patient's risk of complication and death from a surgical procedure or medical treatment NeedPatients are looking for more personalized risk assessments before opting to undergo elective surgery. This website assures a patient’s full understanding of the surgery while providing a more accurate, individualized, risk calculation for the patient. Patients, medical professionals, and insurance providers can access the system through a website. Technology Overview  General statistics do not factor in personal medical history, and therefore patients are not well informed of the procedure which in turns brings the quality of consent into question. This website provides a way to giv...Fri, 17 Mar 2017 05:50:01 GMTJHTT-Communications@jhu.edu Treatment Response Prediction using clinical parameters and advanced unsupervised machine learning: the contribution scattergram. early diagnosis of cancer is necessary to facilitate the clinical management of patients, and machine learning (ML) algorithms can identify and model the progression and treatment of cancerous conditions. As a result, there is a growing trend in the application of ML methods in cancer research, and considerable activity in the integration of different types of data for the treatment of breast cancer (Kourou et al.). However, there are few computer-aided diagnostic systems that integrate MRI and other imaging modalities to visualize the data. Therefore, researchers have developed ML systems...Fri, 17 Mar 2017 05:49:57 GMTJHTT-Communications@jhu.edu of ARID1B Translocations in Neuroblastomas are tumors of peripheral sympathetic neurons and are the most common solid tumor in children. We performed whole-genome sequencing (6 cases), exome sequencing (16 cases), genome-wide rearrangement analyses (32 cases), and targeted analyses of specific genomic loci (40 cases) using massively parallel sequencing to determine the genetic basis for neuroblastoma. On average, each tumor had 19 somatic alterations in coding genes (range, 3-70). Chromosomal deletions and sequence alterations of chromatin remodeling genes, ARID1A and ARID1B, were identified in 8 of 71 neuroblastomas (11...Fri, 17 Mar 2017 05:49:03 GMTJHTT-Communications@jhu.edu Blood Perfusion and Collection System present invention is a complete system for the collection of stem cells found within the umbilical cord and placenta vasculature. A strategy of the system is the use of perfusion in order to recover a larger yield of residual cells than what is currently recoverable. The invention is composed of three primary components: a hand-held sterile access (SA) component, a portable tray-container, and a perfusion pump device. The SA component clamps onto the umbilical cord at the time of delivery to accurately and sterilely access the vein and arteries for the purposes of perfusing the vasculature...Fri, 17 Mar 2017 05:49:01 GMTJHTT-Communications@jhu.edu'Hyper-Precise' Spherical Volumetric Sampler of Volumetric Data: A Technique for System Independent Measurements of PET and Other Quantitative Volumetric Data (with special case variant implementation of a 'Hyper-Accurate' Spherical Sampler)., 17 Mar 2017 05:48:45 GMTJHTT-Communications@jhu.edu Active Chelators (MACs) as Chemotherapueutic Agents for Treatment of Human African Trypanosomiasis (HAT) Activated Chelators (MACs) are proprietary neuroprotective drugs [D-PHARM LTD; Rehovot Isreal] that modulate cell membrane metal ion homeostasis by adopting an inactive conformation outside only in the lipid environment of cell membranes. In this environment, the drugs are able to unable to bind metal ions at their elevated non-physiological concentrations, which results in a drug with excellent tolerability. DP-b99, a BAPTA-based lipophilic MAC of calcium, zinc and copper has been safely used in humans (1, 2) and is currently in phase III clinical trails trials for treatment of acute...Fri, 17 Mar 2017 05:48:35 GMTJHTT-Communications@jhu.edu pn-junction design for photovoltaics and sensors not requiring top transparent or patterned electrodes invention describes utilizing particular semiconducting materials metallic surface states to provide electrical conduction on the surface of a pn-junction. The invention allows for collection of charges from electron-hole pair separation processes in photovoltaics and sensors without requiring the use of transparent or patterned electrical contacts.Fri, 17 Mar 2017 05:48:33 GMTJHTT-Communications@jhu.edu for telerobotic surgery combined teleoperative-cooperative controllable robotic system includes a robotic actuator assembly, a control system adapted to communicate with the robotic actuator assembly, and a teleoperation unit adapted to communicate with the control system. The control system is configured to control at least a first portion of the robotic actuator assembly in response to at least one of a force or a torque applied to at least a second portion of the robotic actuator assembly by a first user for cooperative control. The control system is further configured to control at least a third portion of the ...Fri, 17 Mar 2017 05:48:29 GMTJHTT-Communications@jhu.edu network-based analysis for identification of: individual selective pressures, high-probability evolutionary trajectories and critical positions for genetic adaptation assembled a large database of publicly available clinical and experimental â-lactamase mutants that have recently evolved under antibiotic pressure. From this database we identified pairs of co-occurring mutations as a way to map functional interactions. These interactions were modeled as an undirected network of mutated residue positions, in which link weights are proportional to the number of co-occurrence events, normalized relative to their individual occurrence. This network representation of putative functional interactions has a modular topology and that each module is associated wit...Fri, 17 Mar 2017 05:47:07 GMTJHTT-Communications@jhu.edu of GCPII Enzymatic Activity in Human Skin Biopsies as a Clinical Biomarker have identified a unique tissue preparation and enzymatic assay conditions to quatitatively monitor glutamate carboxypeptidase II (OCPII) activity in human skin biopsy samples. This assay can be utilzed as a phanacodynamic (PD) marker in the clinical development of novel GCPII inhibitors. This new assay is a significant improvement over GCPII biomarker assays previously described. Older methods necessitated the collection of CSF and nerve samples, biomatrices diffcult to obtain in clinical studies. Older methods also employed complex spectrometr analyses and provided only indirect measures ...Fri, 17 Mar 2017 05:46:55 GMTJHTT-Communications@jhu.edu Dehydrogenase Activity Distinguishes Leukemia Stem Cells from Normal Hematopoietic Stem Cells in Acute Myeloid Leukemia the methods of the present invention, intermediate (int) levels of aldehyde dehydrogenase (ALDH) activity reliably distinguished leukemic CD34+CD38? cells capable of engrafting immunodeficient mice, from residual normal hematopoietic stem cells that exhibited relatively higher ALDH activity. Minimal residual disease (MRD) detected during complete remission was enriched for the CD34+CD38?ALDHint leukemic cells, and the presence of these cells after therapy highly correlated with subsequent clinical relapse. The methods of the present invention can distinguish normal from leukemic CD34+CD3...Fri, 17 Mar 2017 05:46:26 GMTJHTT-Communications@jhu.edu and Molecular Biomarkers for Common Diseases, 17 Mar 2017 05:46:20 GMTJHTT-Communications@jhu.edu sequences of ovarian clear cell carcinomas Clear Cell Carcinoma (OCCC) is an aggressive cancer that is generally resistant to therapy. To gain novel insights into the genetic origin of this tumor type, we determined the exomic sequences of eight tumors after immunoaffinity purification of neoplastic cells. Through comparison to normal cells from the same patients, we identified four genes that were mutated in at least two tumors. Two of these were known to play a role in this tumor type (PIK3CA and KRAS) and two were novel: the serine/threonine phosphatase gene PPP2R1A and the chromatin remodeling gene ARID1A. Recurrent missens...Fri, 17 Mar 2017 05:46:18 GMTJHTT-Communications@jhu.edu Microrheology as a CFTR Outcome Measure inventors have discovered that sputum microrheology can be used as a outcome measure for CFTR or other ion channel function in human subjects and cultured airway cells. The technology depends on a novel particle tracking of microrheology, a method that is able to precisely measure the viscosity, elasticity, and mesh pore size of the test material (in this case sputum or airway culture mucus) by examining a trackable movement of various sized nano particle tracers. Because the inventors hypothesize that cystic fibrosis transmembrane conductance regulator (CFTR) chloride and bicarbonate tr...Fri, 17 Mar 2017 05:45:44 GMTJHTT-Communications@jhu.edu of Acute Liver Injury and Hepatic Failure by Mobilization of Bone Marrow Derived Stem Cells Need: Acute Liver Failure (ALF), typically due to drug poisoning or viral hepatitis, accounts for around 10,000 deaths per year in the United States. Treatment options are severely limited: supportive observation in the hopes of spontaneous recovery or liver transplant. Liver transplant is an imperfect solution for these patients with extraordinary resource utilization and inferior outcomes. Medical treatments to improve rates of spontaneous recovery are badly needed. It is known that under some circumstances bone marrow derived hematopoietic stem cells (HSCs) can participate in migratio...Fri, 17 Mar 2017 05:45:40 GMTJHTT-Communications@jhu.edu of Diagnosis and Progression in Cervical Cancer smears and HPV infection tests do not distinguish between lesions that will progress to an invasive carcinoma and those that will not. JHU researchers aimed to identify epigenetic biomarkers for diagnosis and progression monitoring of premalignant lesions in cervical cancer. Hypermethylated genes were identified as potential biomarkers after validation by MSP, including GGTLA4 and ZNF516. The methylation frequency for these two genes was higher in tumor: GGTLA4 (100%) and ZNF516 (96%); than in normal samples: GGTLA4 (12%) and ZNF516 (16%). The methylation status of GGTLA4 showed a progress...Fri, 17 Mar 2017 05:45:36 GMTJHTT-Communications@jhu.edu Microarray Platforms Uncover Novel Hypermethylated Genes in an Oral Squamous Cell Carcinoma Case-control Study: A Phase 1 Pre-clinical Biomarker Development Study successfully demonstrated that unbiased genome-wide methylation arrays paired with publicly available expression data identify panels of relevant hypermethylated genes in primary OSCC. MCAM, KIF1a, EDNRB and CALCA were identified as hypermethylated in OSSC tumor tissue, when compared to normal tissue. These results should be validated in a Phase II Biomarker Development Study.Fri, 17 Mar 2017 05:45:35 GMTJHTT-Communications@jhu.edu of [125I]iodoDPA-713: A New Probe for Imaging Inflammation is becoming an increasingly important target for imaging, particularly in the context of central nervous system disease. Imaging agents are also being sought to study autoimmune disease and the inflammatory arthritides, the cardiovascular system and cancer. For nearly 20 years, the standard radiopharmaceutical for imaging inflammation has been the isoquinoline [11C]PK11195, a ligand for translocator protein (TSPO), a.k.a. the peripheral benzodiazepine receptor (PBR), which is upregulated in activated glial and immune cells. But [11C]PK11195 tends to demonstrate significant non-spe...Fri, 17 Mar 2017 05:45:34 GMTJHTT-Communications@jhu.edu Image-guided Navigation and Intervention Systems Using Cooperative Sets of Local Sensors BeeSpaceMouse is an enabling technology for the tracking of ultrasound probes and other imaging devices. Combining ultrasound imaging with image analysis algorithms, probe-mounted cameras, and very low-cost, independent optical-inertial sensors, it is possible to reconstruct the position and trajectory of the device and possible tools or other objects by incrementally tracking their current motion. This opens up several possible application scenarios that previously required expensive, imprecise, or impractical hardware setups. Examples are the generation of freehand three-dimensional ultr...Fri, 17 Mar 2017 05:45:14 GMTJHTT-Communications@jhu.edu Novel methodology for arrhythmia risk stratification by assessing qt interval instability studies have demonstrated that beat-to-beat instability in QT interval, which is the global manifestation of instability in ventricular repolarization dynamics, predicts propensity to arrhythmias. However, a robust methodology to assess QT interval instability and thus predict propensity to arrhythmia in a patient-specific manner is currently lacking. This invention describes a new methodology for assessing QT interval instability. We propose a novel and radically different approach that is based on engineering methods used frequently in other engineering fields, but never applied to ...Fri, 17 Mar 2017 05:45:03 GMTJHTT-Communications@jhu.edu Gene Mutations Identify Susceptibility to DNA Damaging Agents demonstrate that the presence of a mutation in the PALB2 gene confers dramatic susceptibility to DNA damaging agents. This suggests a new test that can be used to predict response to this class of agents. Based on previous reports of the response of cancers with BRCA2 mutations to PARP inhibitors, we also predict that cancers with PALB2 gene mutations should also be sensitive to PARP inhibitors.Fri, 17 Mar 2017 05:44:59 GMTJHTT-Communications@jhu.edu Smooth-walled Feedhorn with Sub 30 dB Cross-polarization over a 30% Bandwidth feed horns offer excellent beam symmetry, main beam efficiency, and cross-polar response over wide bandwidths, but can be challenging to fabricate. An easier-to-manufacture smooth-walled feed is explored that approximates these properties over a finite bandwidth. The design, optimization and measurement of a monotonically-profiled, smooth-walled scalar feedhorn with a diffraction-limited ~14 degree FWHM is presented. The feed was demonstrated to have low cross polarization (Fri, 17 Mar 2017 05:44:55 GMTJHTT-Communications@jhu.edu alterations in pancreatic carcinomas are currently few therapeutic options for patients with pancreatic cancers and new insights into the pathogenesis of this lethal disease are urgently needed. To this end, we performed a comprehensive analysis of the genes altered in 24 pancreatic tumors. First, we determined the sequences of 23,781 transcripts, representing 20,583 protein-encoding genes, in DNA from these tumors. Second, we searched for homozygous deletions and amplifications using microarrays querying ˜one million single nucleotide polymorphisms in each sample. Third, we analyzed the transcriptomes of the same samples u...Fri, 17 Mar 2017 05:43:27 GMTJHTT-Communications@jhu.edu Education Modules for Ophthalmology in Eyemaginations, Inc.'s Education Software Need:The Interactive Skills Transfer System (ISTS) is a new education approach to medical information that maximizes the effectiveness of learning, rather than serving as an encyclopedic data storage repository, as do traditional textbooks.Technology Overview:  Unlike lecture format, the interactive nature of ISTS brings each student into the process of learning at their own speed and permits evidence-based evaluation of what has been learned. Textbooks contain differential diagnosis lists that fail to duplicate the intellectual thining process needed to solve clinical problems. ISTS sim...Fri, 17 Mar 2017 05:43:10 GMTJHTT-Communications@jhu.edu Therapy to Treat Gemcitabine-Resistant Cancers Need: Gemcitabine resistance is a widespread problem. A large proportion of cancer patients end up receiving gemcitabine at some point of their care (as is approved in lung, pancreatic, breast and ovarian cancer), and although efficacious in a third of the cases, most do not respond, and even those who respond eventually develop resistance. Plk1 is a key step in cell cycle progression, and there is preclinical evidence suggesting that after cytotoxic damage cells are particularly sensitive to Plk1 inhibition. Here we provide in vitro and in vivo evidence of that hypothesis. With this com...Fri, 17 Mar 2017 05:43:04 GMTJHTT-Communications@jhu.edu of Cardiovascular Function by Multi-modality Speckle Tracking, speckle tracking was introduced as a new method for assessment of myocardial deformation from conventional echocardiographic recordings.1-4 Speckles are natual acoustic makers visible in ultrasound images that can be tracked automatically frame by frame throughout the cardiac cycle. However, due to need of high image quality and the restricted acoustic access to the hear, the speckle tracking method is stil not implemented in the clinic. As a par of our collaboration with Toshiba we are curently validating their new speckle tracking algorithm for 2- and 3-dimensional echocardiography...Fri, 17 Mar 2017 05:42:51 GMTJHTT-Communications@jhu.edu Fitting Calculation For Diffusion Tensor Imaging tensor imaging is a new MRI modality that is becoming an important technique to assess various types of brain diseases. However, this technique has one weakness; its extreme sensitivity to patient motions. The image is often corrupted by patient motions as small as cardiac pulsation of the brain. Even though this problem is ameliorated by employment of rapid imaging, we often find corrupted images are included in the scans, which leads to substantial errors in tensor calculation. Currently, one of the best methods is to visually inspect all the raw images and remove corrupted images ...Fri, 17 Mar 2017 05:38:46 GMTJHTT-Communications@jhu.edu "smart" nanogels as carriers for hydrophobic drugs present invention involves a biocompatible nanogel composition for the delivery of hydrophobic substances that are not readily soluble in organic solvents. These nanogels have been designed to contain hydrophobic cores which encapsulate the insoluble molecules, and a hydrophilic shell which allows long term systemic circulation. The nanogels constitute discrete particles that are less than 100 nm in size. The compositions are non-toxic and non-antigenic, and are suitable for systemic administration by injectable, oral, ophthalmic, or pulmonary means. Furthermore, the surface of the nano...Fri, 17 Mar 2017 05:38:35 GMTJHTT-Communications@jhu.edu MR-eye: Methods and Devices for Local MRI present invention is a novel method to lock the MRI frame-of-reference to an internal device, where the RF excitation is confined to the immediate region surrounding the probe. Two dimensions are encoded using cylindrical encoding or conventional read/phase encoding. The third dimension is resolved along the body of the probe using one or more modification methods to provide optimum slice selection. These methods and devices provide real-time MRI scanning from the view-point of the probe. Problem Solved/Background Magnetic Resonance Imaging systems typically use surface coils to ima...Fri, 17 Mar 2017 05:38:05 GMTJHTT-Communications@jhu.edu of Bio-electrical Rhythms Via a Novel Engineering Approach cellular electrical rhythms govern numerous biological processes from the autonomous beating of the heart, to respiratory rhythms and insulin secretion. For instance, abnormal pacing in the heart leads to various forms of electrical disorders that necessitate conventional pharmacologic interventions and implantation of costly electronic devices that are associated with various side effects and expenses. Similarly, spontaneous electrical discharges in damaged neurons underlie neuropathic pain but limited useful therapy is available. JHU researchers have conceived of a novel meth...Fri, 17 Mar 2017 05:36:41 GMTJHTT-Communications@jhu.edu Approach for Tackling Cancer Chemoresistance current cancer treatment regime of surgery, radiotherapy and chemotherapy can fail due to multidrug resistant cancer cells. Cancer cells resist therapy through high expression levels of multidrug resistance proteins (MDRs) such as P-glycoprotein MDR1, MRP1, MRP2, and the ABC half transporter ABCG2, that act as molecular pumps to remove chemotherapy drugs from the interior of the cell. Cutting edge research at JHU has now led to the novel discovery that Nuclear factor E2p45-related factor (NRF2, a well-researched bzip transcription factor) is the master regulator for the MDR genes. Biswal...Fri, 17 Mar 2017 05:36:28 GMTJHTT-Communications@jhu.edu<![CDATA[C04341 & C04342 - Small molecule modulators of Wnt and Hedgehog pathways]]> Need:Wnt and Hedgehog are important signaling pathways involved in cellular proliferation and differentiation.  Both pathways have been shown to play roles in the development, growth and migration of different types of cancer, including colorectal, prostate, lung, breast, and brain cancer.  Therefore, cancer researchers hope that modulators /inhibitors of these pathways could be used to treat a wide range of malignancies. Drugs targeting the hedgehog pathway, such as Vismodegib, have been approved by the FDA to treat basal cell carcinoma. A variety of Wnt modulators are being clinical te...Fri, 17 Mar 2017 05:35:59 GMTJHTT-Communications@jhu.edu[11C]MCG For Imaging NAALADase/PSMA present invention relates to compounds particularly asymmetric urea compounds which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express NAALADase and/or PSMA. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled compounds of the invention, particularly tissues, organs, or tumors which express NAALADase and/or PSMA to which the compounds of the invention have an affinity.Fri, 17 Mar 2017 05:34:47 GMTJHTT-Communications@jhu.edu Diploidy to Haploidy for Genetic Diagnosis of mutations associated with hereditary diseases is complicated by the diploid nature of mammalian cells. Mutations present in one allele are often masked by the wild-type sequence of the other allele. Individual alleles can be isolated from every chromosome within somatic cell hybrids generated from a single fusion. Nucleic acids from the hybrids can be analyzed for mutations in an unambiguous manner. This approach was used to detect two cancer-causing mutations that had previously defied genetic diagnosis. One of the families studied, Warthin Family G, was the first kindred with a ...Fri, 17 Mar 2017 05:33:14 GMTJHTT-Communications@jhu.edu APC Mutation Associated with Familial Colorectal Cancer the 160,000 new cases of colorectal cancer (CRC) diagnosed each year in the U.S., at least 15% have a hereditary component. Two well-defined syndromes, Familial Adenomatous Polyposis (FAP) and Hereditary Non-Polyposis Colorectal Cancer (HNPCC), account for up to 5% of the familial cases. Truncating APC mutations are responsible for FAP, and defective mismatch repair genes cause HNPCC. However, the genes responsible for the majority of the familial cases are unknown. There is a need in the art for additional tools and information for identifying familial cancer genes.Fri, 17 Mar 2017 05:32:02 GMTJHTT-Communications@jhu.edu Silicon on Sapphire Chips integrated electronic-optoelectronic module comprising: an ultrathin silicon-on-sapphire composite substrate; at least one electronic device fabricated in the ultrathin silicon; and at least one optoelectronic device bonded to the ultrathin silicon-on-sapphire composite substrate and in electrical communication with the at least one electronic device fabricated in the ultrathin silicon layer. For example, VCSELs and photodetectors are integrated with CMOS electronic circuitry to provide useful modules for electro-optical interconnects for computing and switching systems.Fri, 17 Mar 2017 05:30:26 GMTJHTT-Communications@jhu.edu, Label-Free Biomolecular Detection at Electrically displaced Liquid Interfaces Using Interfacial Electrokinetic Transduction (IET) Need: The diagnostic detection assay market increasingly includes lab-on-a-chip assays and point of care tests.  Currently detection and diagnostics assays often have recognized limitations such as inadequate specificity and sensitivity, as well as the risk of inaccuracy through false positive results. There is a tremendous need in the field for an antigen detection assay which is quick, accurate and very sensitive. Microfluidic biosensors offer the opportunity to create point of care assays with less sample and far less reagent consumption than traditional methods.  Technology Overview:...Fri, 17 Mar 2017 05:14:57 GMTJHTT-Communications@jhu.edu Potential of Tumor DNA from Ovarian Cyst Fluid invention is related to the area of DNA analysis. In particular, it relates to analysis of genes in clinical samples. According to one aspect of the invention a method is provided in which ovarian cyst fluid is tested for mutations in a panel of genes frequently mutated in ovarian neoplasms.Fri, 17 Mar 2017 05:14:56 GMTJHTT-Communications@jhu.edu Cancer to Long-acting TRAIL Receptor Agonists with Kinase Inhibitors NEED: TNF-related apoptosis-inducing ligand (TRAIL) receptor agonists (TRAs, e.g. recombinant TRAIL variant, antibodies) selectively induce death receptor (DR)-mediated apoptosis in cancer cells while sparing normal tissue and can therefore serve as a targeted anti-cancer agent. Yet, most primary cells are TRAIL resistant. To address tumor heterogeneity, the use of TRAIL sensitizers has been contemplated as a way to overcome TRAIL resistance and effectively treat TRAIL-resistant primary tumors. Here we introduce a cell-based screening method to identify kinase inhibitors (KIs) as TRAIL s...Fri, 17 Mar 2017 05:14:56 GMTJHTT-Communications@jhu.edu Activity Peptides (therapeutics) ability to convert transient stimuli from the extracellular environment into long-term changes in neuronal function is central to an animal’s capacity to adapt and learn from its environment. This is mediated through sensory organs, which transduce physical and chemical stimuli into precise patterns of neuronal activity that elicit specific change in the structure and function of the nervous system. Work from many laboratories over the past few decades on the mechanisms that underlie these activity-dependent changes in the nervous system has highlighted the significant role that protein tr...Fri, 17 Mar 2017 05:14:53 GMTJHTT-Communications@jhu.edu, Allogeneic Cell Therapy of Cancer present invention describes methods of preparing a cell composition for treating cancer in a human being by obtaining lymphocytes from a partially or fully HLA-matched healthy donor, activating and expanding T cells reactive to tumor neoantigens (i.e. new epitopes resulting from somatic mutations in the cancer cell), and enriching for tumor-specific T cells that are not reactive against non-tumor tissue of the cancer patient. Methods of treating human cancer with such tumor-specific, non-alloreactive T cells are also described.Fri, 17 Mar 2017 05:14:53 GMTJHTT-Communications@jhu.edu of Alzheimer's and other Diseases of Cognitionß peptide, generated by sequential processing of amyloid precursor protein (APP) by ? APP cleavage enzyme1 (BACE1) and g-secretase, increases with neuronal activity. Here, we report an activity-dependent mechanism that normally inhibits BACE1 activity and is disrupted in Alzheimer?s disease (AD). Neuronal pentraxin 2 (NPTX2) is an immediate early gene and member of a family of synaptic proteins that bind BACE1 on the cell surface, and limit its activation in endosomes. Deletion of NPTX genes increases Aß and plaque in a mouse model of AD. In human postmortem brain of subjects with AD, NPTX2 i...Fri, 17 Mar 2017 05:14:49 GMTJHTT-Communications@jhu.edu Pill Dispenser to Control Prescription Drug Abuse/Misuse NEED: Prescription drug abuse is a growing problem with ~15,000 deaths yearly according to the Centers for Disease Control (CDC). There is great need for devices that help reduce the amount of overdose deaths, yet, existing products are not completely tamper proof, costly and cumbersome. Hence, inventors engineered a personalized, tamper-resistant pill dispenser that aims to control access to and use of prescription opioids by releasing drugs only in timed intervals to defined authorized users.   Tamper-proof device avoids unauthorized access to medicationsPersonalized dispenser uses bio...Fri, 10 Mar 2017 13:05:37 GMTJHTT-Communications@jhu.edu Mouse Model for Acute Myeloid Leukemia (AML) Need: Constitutive activation of FMS-like tyrosine kinase 3 (FLT3) by internal tandem duplication (ITD) mutations is one of the most common molecular alterations known in acute myeloid leukemia (AML). To investigate the role FLT3/ITD mutations play in the development of leukemia, we generated a FLT3/ITD knock-in mouse model by inserting an ITD mutation into the juxtamembrane domain of murine Flt3 genomic DNA. The FLT3/ITD knock-in may serve as an ideal model for:  (1) studying in vivo the roles FLT3/ITD mutations play in the development and maintenance of leukemia; (2) understanding the ...Fri, 10 Mar 2017 11:51:10 GMTJHTT-Communications@jhu.edu for Generating Synthetic Aperture Ultrasound Images during Needle Placement NeedThe device, EchoSpine, aims to improve the efficacy of lumbar punctures. EchoSpine has the potential to save hospital administration hundreds of millions of dollars per year by reducing the complications stemming from blind lumbar punctures.​Technology OverviewThe device is the first to market with the concept of using photoacoustic imaging at the tip of a needle to guide deep tissue punctures. Piezoelectric crystals are used to construct an Aline signal in the path of the needle to identify the distance and type of tissue ahead, essentially acting as a “studfinder”. By allowing the ...Fri, 10 Mar 2017 07:04:02 GMTJHTT-Communications@jhu.edu pH-sensitive protein switches we show that a single charge buried in a hydrophobic environment in a protein can stabilize a partially folded protein. This suggests a strategy that will greatly facilitate the study of structural and thermodynamic properties of protein folding intermediates, and also suggests how buried ionizable groups can be used to engineer artificial pH sensing domains in proteins.Thu, 09 Mar 2017 07:47:15 GMTJHTT-Communications@jhu.edu Imaging of Mucus Penetrating Particles for Intravaginal Therapy Need:Mucus-penetrating particles (MPP) have shown strong potential for local drug and gene delivery at the mucosae, including the female reproductive tract, gastrointestinal tract, the airways, and the eyes. However, it remains difficult to evaluate the therapeutic advantages of the MPP in vivo in a non-invasive and real-time manner.Technology Overview:Johns Hopkins researchers developed mucus-penetrating liposomes, a new platform of MPP that can effectively encapsulate contrast agents or therapeutics and bypass the adhesive mucus barrier for efficient mucosal delivery. Using Chemical Ex...Wed, 08 Mar 2017 05:26:13 GMTJHTT-Communications@jhu.edu SmartInstrument Series (PSI Series): Peabody SmartGuitar, Peabody SmartViolin, Peabody SmartViola, Peabody SmartCello Need: Repetitive motion injuries to the musculoskeletal and nervous systems  are among the most common injuries in the U. S.  They are a significant problem for professional musicians, student-musicians as well as amateur instrumentalists related to their many hours of practice and performance.   Millions of musicians in the U.S. have significant pain in their arms, hands and necks from playing a string instrument, such as the guitar. Some of issues are related non-optimal positioning of the hands and the use of excessive force on the instrument strings. There is a need for a device a...Fri, 03 Mar 2017 08:50:01 GMTJHTT-Communications@jhu.edu Lines of Induced Pluripotent Stem Cells (iPSCs) Derived from Members of an American Family with, and without DISC1 Mutations Associated with Schizophrenia and Depression Novelty: These tangible materials are induced Pluripotent Stem Cells (iPSCs) derived from members with or without DISC1 (Disrupted in schizophrenia 1) mutations in an American family associated with schizophrenia.  Value Proposition:Mutations in DISC1 have been shown to predispose individuals to the development of psychiatric illnesses such as schizophrenia.  This technology provides tangible materials in form of cell lines derived from human with or without DISC1 mutation to screen for drugs against schizophrenia and other psychiatric disorders.  Technical Details: Johns Hopkins Uni...Fri, 03 Mar 2017 08:49:46 GMTJHTT-Communications@jhu.edu Slit Endotracheal Tube: patent pending endotracheal tube comprising a flexible hollow tube with a spiral slit traversing a substantial length of the tube. The slit has edges that separate to create an opening by which the tube may be spiral wound onto a medical device, such as a fiber optic bronchoscope, that is in use in a pharynx passage. The angle of the slit is preferably in the range of 30-60 degrees.Fri, 24 Feb 2017 08:16:11 GMTJHTT-Communications@jhu.edu biocompatible wireless monitoring device for the prevention of pressure ulcers NOVELTY The Mercury Patch is the first low-cost, wireless wound care product that provides both a monitoring and therapeutic function to help prevent pressure ulcer development within a hospital setting. VALUE PROPOSITION Existing pressure monitoring devices focus on expensive mattress overlay systems, which are cost-prohibitive and impractical for hospitals to implement as a preventative measure. The Mercury Patch is the first pressure monitoring platform that can be worn and provide crucial data about high-risk areas on a patient. The Mercury Patch is comprised of two main comp...Fri, 24 Feb 2017 08:16:11 GMTJHTT-Communications@jhu.edu the Epileptogenic Zone using Network Fragility Theory NOVELTY The current invention is a novel algorithm to identify brain regions associated with drug resistant epilepsy. VALUE PROPOSITION Epilepsy affects about 50 million people worldwide and approximately 40% of all individuals with epilepsy have intractable seizures, which cannot completely be controlled by medical therapy. The annual cost of assessing and treating patients with Medically Refractory Epilepsy (MRE) ranges from $3-4 billion in the US. 80% of these costs are accounted by patients whose seizures are not adequately controlled by anti-epileptic drugs. The main treatme...Fri, 24 Feb 2017 08:16:08 GMTJHTT-Communications@jhu.edu Treatment Strategies of Cancer based on RNA Polymerase I Inhibition NEED Dysregulation of ribosomal RNA (rRNA) synthesis is a hallmark of cancer. It results from oncogenic drive and loss of tumor suppressor activities that lead to uncontrolled transcription by RNA polymerase I (Pol I).  Despite its key role in cancer, there are few therapies available that target Pol I. Therefore, inhibitors of Pol 1 transcription may provide a novel approach for the treatment of cancer. TECHNICAL DESCRIPTION Johns Hopkins researchers synthesized novel analogues of a known Pol I inhibitor which displayed anticancer effects in vitro and in vivo. The derivatives inhibit...Fri, 24 Feb 2017 08:15:41 GMTJHTT-Communications@jhu.edu and Apparatus for Impedance-Based Monitoring of Minimally-Invasive Tumor Treatment  DETAILS Multiple catheters equipped with at least two electrodes are positioned within the volume of a tumor to be treated. Each catheter creates a weak electric field in its near surroundings at a unique frequency. Combining the measurements from each catheter results in an impedance map of the tumor volume. During treatment, the catheters monitor changes to the tissue caused by the treatment and display the changes to the interventionalist. Specifically, changes to relative water content, cell packing density, and several other factors affect the impedance.Fri, 24 Feb 2017 08:15:37 GMTJHTT-Communications@jhu.edu Bioreactor with a Non-Static Cell Pouch NEED Heart failure after myocardial infarction (MI) is a common and morbid condition that affects millions worldwide.  While there are multiple therapies that help the heart adapt and compensate for the damage incurred in an MI, there remains no method by which injured heart muscle may be repaired or replaced.  Stem cell therapy shows great promise to regenerate and repair damaged heart tissue, and thereby prevent heart failure, although the effects in clinical trials to date are modest.  Reasons for the modest effects include: a) current delivery methods, which result in poor retention...Fri, 24 Feb 2017 08:15:35 GMTJHTT-Communications@jhu.edu Line Microarray of Seven NCI60 Cell Lines       Cell Line Microarray of Commonly used Cancer Cell Lines CASE NUMBER:       C14193 UNMET NEEDAn emerging concern in the field of cancer pathology is the reliability and reproducibility of immunohistochemical (IHC), in situ hybridization (ISH), and fluorescence in situ hybridization (FISH) methods to evaluate gene expression and genome alterations in tissues specimens. A tool that could be used to standardize the parameters of IHC or ISH for specific molecular targets would thus be very valuable for biomarker discovery and validation. PROBLEM SOLVEDTo address this problem, Researche...Fri, 24 Feb 2017 08:15:27 GMTJHTT-Communications@jhu.edu and Methods for Genetic Modification of Cells Having Cosmetic Function to Enhance Cosmetic Appearance are methods and compositions to genetically modify substantially intact cells having cosmetic function to enhance the cosmetic appearance in mammals so as to enhance and/or maintain a biochemical and/or physiological process that has a positive effect on cosmetic appearance. The methods and compositions may provide cosmetic benefits such as reduced skin sagging, increased skin thickness, reduced wrinkles, increased skin thickness and collagen content, increased skin tone and elasticity, increased skin hydration, and improved skin texture and color.Fri, 24 Feb 2017 08:15:16 GMTJHTT-Communications@jhu.edu and Intranasal Delivery of Fospropofol NOVELTY This invention provides for novel formulations and delivery methods of the propofol prodrug, fospropofol, allowing for its use in additional indications beyond anesthesia, including migraine, analgesia, and emesis treatment. VALUE PROPOSITION Propofol and its water soluble prodrug, fospropofol, are short-acting anesthetics used for general anesthesia. Propofol has shown efficacy in a number of additional indications, including migraine, analgesia, and emesis. However, current intravenous formulations of propofol and fospropofol do not allow for their exploration and use i...Fri, 24 Feb 2017 08:15:15 GMTJHTT-Communications@jhu.edu time measurement of pedicle screw pull-out force NOVELTY This technology can measure the tensile forces applied to the pedicle screw and provide real time feedback before reaching screw pull-out force. VALUE PROPOSITION Pedicle screw fixation is the most common method used to achieve spinal fusion for surgical treatment of spine deformity. Pedicle screws are used at each vertebral segment to instrument the spine and reduce the deformity by connecting the screws to rods. Large forces are placed on the screws while reducing the spinal deformity potentially leading to instrumentation failure as screw loosening, and screw pullout. ...Fri, 24 Feb 2017 08:14:55 GMTJHTT-Communications@jhu.edu human neural stem cells to model brain tumors researchers developed a new method to generate genetically accurate models of rare tumors, and a companion computational methodology to find therapeutic interventions that target them. They validated their human neural stem cell model of MYC-driven Group 3 medulloblastoma and showed that CDK4/6 inhibitors are active against this subgroup. Their results suggest that palbociclib is a potential effective treatment for poor-prognosis MYC-driven Group 3 medulloblastoma tumors in carefully selected patients. TECHNICAL DESCRIPTIONJHU researchers used human stem and progenitor cells to dev...Fri, 24 Feb 2017 08:14:52 GMTJHTT-Communications@jhu.edu Anucleate Cellular and Extracellular Vesicles as a Novel Biologics Delivery Platform NEED Biologic therapeutics, specifically antibodies, have demonstrated tremendous potential for treatment of a wide range of cancer types. Antibodies are designed to possess a strong affinity for a particular target, a very desirable characteristic for a drug. However, antibodies must be administered multiple times by injection, due to their relatively short half-lives. Patients must see a doctor for injection every 1-2 weeks for the course of the treatment. There is therefore an unmet need for a delivery platform that increases the half-life of antibodies in order to drastically reduce...Fri, 24 Feb 2017 08:14:50 GMTJHTT-Communications@jhu.edu PACS – an automated and intelligent PACS system Super PACS - An Automated and Intelligent PACS SystemUNMET NEEDThe standard techniques for many orthopedic surgical operations often become a high risk, expensive procedure that rely on the ability of a surgeon to mentally reconstruct computed tomography (CT) images and co-register these images with the patient’s 3-D anatomy intraoperatively. This typically requires multiple X-ray images at several orientations of the CT mounted C-arm; subjecting the patient to significant radiation exposure, extended time under anesthesia, and increased operating room costs.TECHNICAL DESCRIPTIONAn inte...Fri, 24 Feb 2017 08:14:49 GMTJHTT-Communications@jhu.edu Invasive Focused Ultrasound (MIFUS) for Brain NEED Clinical HIFU procedures are typically image-guided to permit treatment planning and targeting before applying a therapeutic or ablative level of ultrasound energy. When MRI is used for guidance, the technique is called Magnetic Resonance-guided Focused Ultrasound (MrgFU). In HIFU therapy, ultrasound beams are focused on diseased tissue, and due to the significant energy deposition at the focus, temperature within the tissue rises to 65° to 85°C, destroying the diseased tissue by coagulation necrosis. PROBLEM SOLVED Most brain surgeries involving deep tumor resections are done u...Fri, 24 Feb 2017 08:14:27 GMTJHTT-Communications@jhu.edu Immuno Desorption Assay (MeLIDA) Immuno Desorption Assay (MeLIDA)CASE NUMBER:   C13929ABSTRACTThe use of transition metal-labeled antibodies has enabled the contemporary detection of tens of antigens per samples by mass-cytometry. In short, the combination of a flow cytometer with a mass spectrometer allows measuring the levels of the transition metals, as reporters for the quantity of antigens detected with specific antibodies. This revolutionary approach combined the sensitivity and specificity of antibody-based detection with the selectivity and quantitative capabilities of mass spectrometry. In fact, contrary...Fri, 24 Feb 2017 08:14:27 GMTJHTT-Communications@jhu.edu acid nanoglues and hydrogels for corneal applications, and treating ocular disorders present invention describes a tailorable, multifunctional and photocrosslinkable dendrimer-hyaluronic acid based nanoglue compositions that seals corneal incisions and simultaneously releases antibiotic/steroids to address infections/inflammation and accelerate corneal wound healing.Fri, 24 Feb 2017 08:14:19 GMTJHTT-Communications@jhu.edu degradable glaucoma stent for controlled intraocular pressure reduction NEED There are a number of parameters that affect the electrospinning process including polymer, solvent, polymer: solvent ratio, flow rate, voltage, distance to collector, collector type and speed, and needle size.5 Typical electrospinning setups allow for the manufacture of aligned or random fiber mats composed of nano- or micro-fibers. These setups usually do not have precise control of each of the parameters that affect the process, and also do not allow for simple interchange of collector types. And while several modifications have been made to the needle, spinneret, and spraying p...Fri, 24 Feb 2017 08:14:18 GMTJHTT-Communications@jhu.edu, High Strength, Absorbable Sutures Capable of Controlled Drug Release NEED There are a number of parameters that affect the electrospinning process including polymer, solvent, polymer: solvent ratio, flow rate, voltage, distance to collector, collector type and speed, and needle size.5 Typical electrospinning setups allow for the manufacture of aligned or random fiber mats composed of nano- or micro-fibers. These setups usually do not have precise control of each of the parameters that affect the process, and also do not allow for simple interchange of collector types. And while several modifications have been made to the needle, spinneret, and spraying p...Fri, 24 Feb 2017 08:14:16 GMTJHTT-Communications@jhu.edu, Scalable System for the Manufacture of Electrospun Fibers and Devices NEED There are a number of parameters that affect the electrospinning process including polymer, solvent, polymer: solvent ratio, flow rate, voltage, distance to collector, collector type and speed, and needle size.5 Typical electrospinning setups allow for the manufacture of aligned or random fiber mats composed of nano- or micro-fibers. These setups usually do not have precise control of each of the parameters that affect the process, and also do not allow for simple interchange of collector types. And while several modifications have been made to the needle, spinneret, and spraying p...Fri, 24 Feb 2017 08:14:16 GMTJHTT-Communications@jhu.edu diftitox (Ontak®) and Methods of Making diftitox (Ontak®) was approved by the FDA in 1999 for the treatment of cutaneous T cell lymphoma (CTCL).  It was put on clinical hold by the FDA in 2011 because of heterogeneity in the formulation (aggregates) and impurities stemming from the production and purification of the protein drug from E. coli inclusion bodies.  We disclose a method to produce aggregate-free monomeric denileukin diftitox, a simplified method to overexpress aggregate-free monomeric denileukin diftitox, and a novel use of denileukin diftitox as a host-directed therapy for tuberculosis.Fri, 24 Feb 2017 08:14:09 GMTJHTT-Communications@jhu.edu and Method for Aligning Non-overlapping Cone-beam Computed Tomography Volumes Using Vision-based Tracking or Depth Cameras System and Method for Aligning Non-overlapping Cone-beam Computed Tomography Volumes Using Vision-based Tracking or Depth CamerasUNMET NEEDThe standard techniques for many orthopedic surgical operations often become a high risk, expensive procedure that rely on the ability of a surgeon to mentally reconstruct computed tomography (CT) images and co-register these images with the patient’s 3-D anatomy intraoperatively. This typically requires multiple X-ray images at several orientations of the CT mounted C-arm; subjecting the patient to significant radiation exposure, extended time under...Fri, 24 Feb 2017 08:14:00 GMTJHTT-Communications@jhu.edu Hook and Catheter Designs for Gastrointestinal Perforation Closure NOVELTY This technology is a new device that allows for acquiring tissue and foreign bodies or closing openings in bodily tissue. VALUE PROPOSTITION Perforation is a potentially serious complication of diagnostic and therapeutic gastrointestinal endoscopy. Closure of any perforation endoscopically is preferable to avoid surgical intervention which requires abdominal incision with its associated morbidity and mortality. Available endoscopic closure devices such as endoclips and endoscopic suturing do not reliably allow full-thickness closure because the serosal layers of the gastro...Fri, 24 Feb 2017 08:13:32 GMTJHTT-Communications@jhu.edu mouse model of pseudoxanthoma elasticum (PXE); floxed Abcc6 allele Conditional mouse model of pseudoxanthoma elasticum (PXE); floxed Abcc6 alleleCASE NUMBER: C13613 ABSTRACTUsing ES-cells, JHU researchers generated a PXE conditional mouse model (floxed Abcc6 allele).  When bred to a CMV-cre mouse, this mouse develops robust calcification in the vibrissae (snout of the mouse).  They use this mouse model to test drugs that will inhibit calcification in vivo.  While PXE is a rare genetic condition, the researchers believe that the calcification in this mouse model relates to more common forms of vascular calcification.  In fact, the drugs they use in this...Fri, 24 Feb 2017 08:13:10 GMTJHTT-Communications@jhu.edu prescription Writer Program NEED Prescription errors represent one of the most serious but often preventable types of common medical errors. Children are more vulnerable than adults to these errors due to their shortened window between therapeutic and toxic effect. A 2009 study at Johns Hopkins Children’s Center found that 257 out of 314 (82%) of examined prescriptions contained at least 1 error. Nine prescriptions (2.9%) had the potential to cause significant medical injury.  Medication errors can occur during writing, transcribing, dispensing, administering, and monitoring; but studies show that 68-75% of errors...Fri, 24 Feb 2017 08:13:02 GMTJHTT-Communications@jhu.edu Fluoride Prenatal Dietary Supplement NOVELTYJHU researchers have developed a novel prenatal dietary supplement containing 3 mg of fluoride and a unique composition of a prenatal vitamin.  VALUE PROPOSITIONAlthough the Institute of Medicine has indicated 3mg of fluoride as adequate intake for pregnant women since 1997, there is no existing prenatal vitamin on the market with this dose of fluoride. In fact, prenatal vitamins do not contain fluoride at all. Fluoride is an important nutrition supplement that may affect dentition as well as immediately impact maternal health and, through its effects on microbiome, may decrea...Fri, 24 Feb 2017 08:13:01 GMTJHTT-Communications@jhu.edu and Device to Modulate Cardiac and Pulmonary Autonomic Control NEED Autonomic control and sympathovagal balance controls both systemic and pulmonary arterial pressures. Cardiac sympathetic nerves have been implicated in the pathophysiology of heart failure and arrhythmias. Over 22 million people worldwide suffer from congestive heart failure. While pacemakers send electrical signals through nerves to restore cardiac function, they are painful and require major surgery to place. Surgical and interventional treatments to increase ventricular function, such as coronary artery bypass and stenting, valve repair/replacement, left ventricular volume reduc...Fri, 24 Feb 2017 08:12:59 GMTJHTT-Communications@jhu.edu–Machine Co-Learning: Subconscious Data Exploration NOVELTY This technology alters the relationship dynamic between human and computer in Big Data exploration. Not only does it facilitate easier communication between user and computer but it raises the computer to a more equal partner in the relationship. VALUE PROPOSITION This technology seeks to radically alter how analysts interact with data. It seeks to leverage the most evolved aspects of human intuition and pair it with the relentless thoroughness of modern computing/machine learning. While it builds off of a core computing system which automatically adjusts data feeds to ma...Fri, 24 Feb 2017 08:12:40 GMTJHTT-Communications@jhu.edu Self-assembly of a Peptide-MHC Dynamic Anchor for Antigen-specific Immune Modulation NEED: Tumor-specific T cells almost universally suffer from a poor capacity to recognize tumor antigen due to intricate mechanisms of central and peripheral immune tolerance. Hence, there is great need for improved methods for enhancing immune responses to diseases, such as cancer and infections. Disclosed herein is a fusion protein platform that utilizes annexin V to tether MHCs expressing a target antigen to antigen-specific T cells, thereby enabling an enhanced antigen-specific T-cell response, independent of immune tolerance.   TECHNICAL DETAILS: The disclosure features compounds com...Fri, 24 Feb 2017 08:12:25 GMTJHTT-Communications@jhu.edu for telomere length regulators (ADDIT Addition of de novo initiated telomeres) NOVELTY This invention is a new assay termed ADDIT (Addition of de novo initiated telomeres) that can rapidly identify effectors of telomere length, even if the regulators are essential genes and a method of regulating telomere length with a PARP inhibitor. VALUE PROPOSITION The researchers developed an in vivo telomere elongation assay where telomerase repeat addition can be monitored over 48 hours. Several analytical procedures for the quantification of telomerase activity, methods for detecting telomerase activity, as well as for identifying compounds that regulate or affect te...Fri, 24 Feb 2017 08:12:12 GMTJHTT-Communications@jhu.edu "Radiator" EGS for Extracting Geothermal Energy embodiment in accordance with the present invention includes an EGS configured to allow the commercial production of electrical energy. One criteria of an EGS according to the present invention is that the temperature and volume of the fluids extracted are sufficiently high and large enough as to allow the commercial production of electrical energy. The system is able to operate for at least N years before the extracted fluid falls below the minimum temperature needed for energy production. Additionally, fractures are separated from each other by a sufficiently large volume of rock (Vcrit) ...Fri, 24 Feb 2017 08:12:06 GMTJHTT-Communications@jhu.edu of Metastatic Cancers Resistant to Immune Checkpoint Blockade by Suppression of Myeloid Derived Cells with Epigenetic Modulators or PI3K Inhibitors responses have been observed in patients treated with checkpoint inhibitory anti-PD-1 or anti-CTLA-4 antibodies. However, immunotherapy against poorly immunogenic cancers remains a challenge. Treatment with both anti-PD-1 and anti-CTLA-4 antibodies were unable to eradicate large, modestly immunogenic CT26 tumors or metastatic 4T1 tumors. However, co-treatment with epigenetic modulating drugs and checkpoint inhibitors markedly improved treatment outcomes, curing more than 80% of them. Functional studies revealed that the primary targets of the epigenetic modulators were myeloid-deriv...Fri, 24 Feb 2017 08:12:06 GMTJHTT-Communications@jhu.edu of a Novel AIF3 Isoform of a novel AIF3 isoformCASE NUMBERC13339 ABSTRACTApoptosis-inducing factor (AIF) is a bifunctional flavoprotein with a vital function in bioenergetics within mitochondria and a lethal function in cell death when it moves to the nucleus. We identified a novel AIF isoform AIF3 in mouse brain by 5? RACE. AIF3 lacks exons 2 and 3, which contain a hydrophobic mitochondrial inner membrane sorting signal. When we removed floxed AIF exon 3 in the forebrain postnatally, AIF3 is induced in mouse brain. Our preliminary data indicate that AIF3 might play an important role in neurodegen...Fri, 24 Feb 2017 08:12:04 GMTJHTT-Communications@jhu.edu Nanobodies and Derivatives to Study Structure and Function of Wilson Disease Protein (Copper Transporter ATP7B) in vitro and in Cells NEEDAn emerging concern in the field of cancer pathology is the reliability and reproducibility of immunohistochemical (IHC), in situ hybridization (ISH), and fluorescence in situ hybridization (FISH) methods to evaluate gene expression and genome alterations in tissues specimens. A tool that could be used to standardize the parameters of IHC or ISH for specific molecular targets would thus be very valuable for biomarker discovery and validation. PROBLEM SOLVEDNanobodies are single chain antibodies that can be used for fundamental and clinical research.  We have produced, purified, and c...Fri, 24 Feb 2017 08:12:04 GMTJHTT-Communications@jhu.edu AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF A HIV INFECTION NEEDAntiretroviral therapy is the current standard treatment for HIV-1. It prevents all new infection events, depleting the pool of infected cells. However, ART is not curative. HIV-1 persists in the genomes of long-living cells, causing the virus to resurge almost immediately when ART is discontinued.TECHNICAL DETAILSFor the first time, Johns Hopkins researchers have shown that the vast majority of latently infected CD4 T cells in HIV-1 infected patients contain immune escape mutations in dominant CD8 T cell epitopes.  This unexpected finding complicates the design of a therapeutic CD8 ...Fri, 24 Feb 2017 08:11:50 GMTJHTT-Communications@jhu.edu Rabbit Polyclonal Antibodies Specific for S113 and S117 Phosphorylated Sam68 (Src-associated substrate in mitosis of 68 kDa), an RNA-binding Protein with Multi-functions in the Cell polyclonal antibodies specific for S113 and S117 phosphorylated Sam68 (Src-Associated substrate in Mitosis of 68 kDa) CASE NUMBERC13182 ABSTRACTAn rabbit polyclonal antibodies specific for S113 and S117 phosphorylated Sam68 generated and affinity purified using the peptide NH2-CAEKD(Sp)LDP(Sp)FTH-COOH by Primm (Cambridge, MA). FEATURESThe research recent study (Fu K. et al. Nature Communications, 2013) demonstrated that Sam68 is a novel substrate of IKKalpha kinase, and during T cell receptor engagement-induced activation signaling, Sam68 was phosphorylated by IKKalpha at S113 and ...Fri, 24 Feb 2017 08:11:48 GMTJHTT-Communications@jhu.edu Flox Mouse Line researcher  generated mice carrying a targeted deletion of the Tll2 gene. The construct was generated which a LoxP site and a LoxP/neo cassette which were introduced into introns 6 and 7, respectively. Following homologous recombination in embryonic stem cells and transfer of the targeted cells into blastocysts, several chimeric mice were obtained that transmitted the targeted allele through the germline. Offspring from the chimeric mice were then mated with EIIa-cre transgenic mice to generate mice in which exon 7 had been completely deleted.FEATURESMice homozygous for the deletio...Fri, 24 Feb 2017 08:11:38 GMTJHTT-Communications@jhu.edu to Accelerate Resolution of Acute Lung Inflammation, 24 Feb 2017 08:11:31 GMTJHTT-Communications@jhu.edu Flox Mouse Line genetically engineered mouse line carries a floxed allele for TII1, which encodes a metalloprotease involved in regulating myostatin and GDF-11 activity. The line may be useful for developing drugs capable of modulating the activities of myostatin and/or GDF-11, for example for enhancing muscle growth and regeneration. TII1 is also involved in regulating collagen formation, so this line may also be useful for drug development to combat fibrosis.FEATURESThe novel animal model provides new opportunities for in-depth analyses of in vivo roles of BMP1-like proteinases in bone and othe...Fri, 24 Feb 2017 08:11:29 GMTJHTT-Communications@jhu.edu Flox Mouse Line genetically engineered mouse line carries a floxed allele for Bmpl, which encodes a metalloprotease involved in regulating myostatin and GDF-11 activity. The line may be useful for developing drugs capable of modulating the activities of myostatin and/or GDF-11, for example for enhancing muscle growth and regeneration. Bmp1 is also involved in regulating collagen formation, so this line may also be useful for drug development to combat fibrosis.FEATURESThe novel animal model provides new opportunities for in-depth analyses of in vivo roles of BMP1-like proteinases in bone and othe...Fri, 24 Feb 2017 08:11:10 GMTJHTT-Communications@jhu.edu Improved Formulation of Mebendazole and Drug Combination to Improve Anti-cancer Activity NEEDGlioblastoma multiforme (GBM) is the most common and aggressive brain cancer, and despite treatment advances, patient prognosis remains poor.TECHNICAL DESCRIPTIONJHU researchers demonstrated that a customized and particular formulation of mebendazole improves its pharmacokinetics and anticancer efficacy in preclinical testing for brain cancer.  The bioavailability of oral administered mebendazole is enhanced with the improved formulation in particular for intracranial tumors. They show that the anticancer efficacy of our formulation of mebendezole is superior to three different marke...Fri, 24 Feb 2017 08:11:06 GMTJHTT-Communications@jhu.edu Derivation and Prospective Isolation of Fusion-competent Myoblasts from Disease-specific Human iPSCs derivation and prospective isolation of fusion-competent myoblasts from disease-specific human iPSCs CASE NUMBERC13338 UNMET NEEDDuchenne muscular dystrophy (DMD) is a debilitating muscular disorder that is present in 1 in 3,500 males and results in a reduced lifespan. One major relevant problem is the lack of an inexpensive cellular DMD model, a major hurdle for DMD research. DMD myoblasts are the muscle cells that are essential for modelling the disease for both basic research as well as drug screening. DMD myoblasts are either obtained from patients (which is expensive) or creat...Fri, 24 Feb 2017 08:11:04 GMTJHTT-Communications@jhu.edu diode-like device for fluids present invention is directed to an improved fluid diode using topology optimization with Finite Element Method (FEM). Topology optimization as a flexible optimization method has been extended to the fluid field. For given boundary conditions and constraints, it distributes a specific amount of pores (or remove materials to get channel) in the design domain to minimize/maximize an objective function. In this design, inlet and outlet ports are aligned and inflow and outflow are in the same direction. The present invention features an intricate network of fluid channels having optimized flui...Fri, 24 Feb 2017 08:10:49 GMTJHTT-Communications@jhu.edu 3-kinase (alpha) Expression Vectors at Johns Hopkins University have developed a set of plasmids that express recombinant P110a/niP85a heterodimer providing the means to purify large quantities of a fusion protein containing the full length phosphatidylinositol 3 kinase alpha (P110?) in complex with residues 322-600 of the regulatory subunit p85.  The fusion protein has an amino-terminal tag for purification.FEATURESThe recombinant heterodimers expressed using these plasmids can be used in in vitro assays and structural biology experiments. These plasmids provide an active and stable PI3Ka enzyme wild type or...Fri, 24 Feb 2017 08:10:45 GMTJHTT-Communications@jhu.edu Motorized Micro-forceps and Method of Use in Microsurgery micromanipulation system includes a micromanipulator that includes a handpiece, and a micromanipulation tool that includes a tool shaft and is operatively connected to the handpiece. The micromanipulator further includes an actuator assembly connected to the micromanipulation tool to provide manual control of the micromanipulation tool, and a force sensing system comprising a force sensor attached to the tool shaft. The force sensing system is configured to provide an output signal that indicates a force imposed on the tool shaft. The micromanipulation system also includes a processor that i...Fri, 24 Feb 2017 08:10:43 GMTJHTT-Communications@jhu.edu Organ-specific Metastatic Human Breast Cancer Cell Lines organ-specific metastatic human breast cancer cell lines CASE NUMBERC13010 ABSTRACTA history of clinical observations has demonstrated that breast cancer metastases are capable of sustained deadly growth in several vital organs, such as, lung, brain, and liver as well as bone/marrow, ovaries, adrenals, lymph nodes, and skin.  In order to study the biology and treatment options of organ-specific breast cancer metastases, we have generated unique organ-specific human metastatic breast cancer cell lines.  Obtaining these cell lines directly from organ-of-origin explants maintained imp...Fri, 24 Feb 2017 08:10:42 GMTJHTT-Communications@jhu.edu Technologies for Robot Assisted Ultrasound Tomography: System Setup and Calibration NOVELTY We are proposing a robot-assisted ultrasound tomography system that can offer soft tissue tomographic imaging, and deeper or faster scan of the anatomy. This system consists of a robot-held ultrasound probe which tracks the position of another freehand probe, trying to align with it. Fri, 24 Feb 2017 08:10:33 GMTJHTT-Communications@jhu.edu Csp_P as a versatile anti-malaria and anti-dengue mosquito-based transmission blocking agent and dengue virus, the causative agents of the two most devastating vector-borne diseases, malaria and dengue, are transmitted by the two most important mosquito vectors, Anophele gambiae and Aedes aegypti, respectively. Chromobacterium (Csp_P) can effectively colonize the midgut of An. gambiae and Ae. aegypti mosquitoes when introduced through an artificial nectar meal. Csp_P exposure blocks Plasmodium falciparum and dengue virus infection in the mosquito gut, thereby representing a disease transmission blocking agent. The entomopathogenic and anti-pathogen properties of Csp_P rende...Fri, 24 Feb 2017 08:10:31 GMTJHTT-Communications@jhu.edu for Improved Distribution of in situ Gelling Agents on Mucosal Epithelia Novel Method for Drug Delivery and STI PreventionJHU REF: C12945  Invention Novelty: A novel method that uses a hypotonic thermosensitive gelling drug delivery system to confine drugs to epithelial surfaces. The technology also uses gelling agents at low concentrations to reduce susceptibility to sexually transmitted infection (STI).   Value Proposition: Thermosensitive in situ gelling agents undergo gel to solution transitions during increases in temperatures making them ideal for long term drug release. However, these agents are limited by their critical gel concentration (CGC)—the min...Fri, 24 Feb 2017 08:10:29 GMTJHTT-Communications@jhu.edu (mouse) Stable Cell Line (mouse) Stable Cell Line CASE NUMBERC12936 ABSTRACTThe Kir2.1 channel (KCNJ2) is a member of inwardly-rectifying potassium channels, expressing two transmembrane-spanning segments, flanking a conserved pore region. Inward rectifier K+ channels pass prominent inward currents, and mediate the cardiac inwardly-rectifying potassium current (IK1), while outward currents are largely blocked. FEATURESKir2.1 expression is stable and efficient in this cell line.Cell line is established by standard protocols using pcDNA3.1. HEK 293 stable cell lines expressing Kir2.1 STAGE OF DEVELOPMENTTang...Fri, 24 Feb 2017 08:10:26 GMTJHTT-Communications@jhu.edu based automated treatment planning and evaluation for radiotherapy from stored knowledge base Radiation Therapy using an Analytic Database of Previously Treated Patients JHU REF: C12931  Invention Novelty This technology has the potential to mitigate the risk of radiation therapy while also reducing the time and cost of dosimetry.  Risk is mitigated by employing an overlap histogram and a novel algorithm that links current patient target structure / Organs at Risk (OAR) to successful treatment plans of historic patients.  The technology makes use of historical patient data to deliver the lowest possible effective target dose to target sites.  Furthermore, the software cal...Fri, 24 Feb 2017 08:10:24 GMTJHTT-Communications@jhu.edu and Methods to Decrease Obesity-related Hepatic Fat Accumulation and Serum Glucose acid (VPA) is a widely prescribed anticonvulsant for the treatment of epilepsy. Here we demonstrate that VPA is a novel activator of AMP-activated protein kinase (AMPK), a key regulator of cellular metabolism, using primary mouse and human hepatocytes. A cytochrome P450 inhibitor blocked the VPA-stimulated phosphorylation of AMPK in these cell lines, suggesting a requirement for biotransformation of VPA. In line with this, treatment of hepatocytes with metabolites of VPA resulted in increased phosphorylation of AMPK/ACC as compared with VPA. Treatment of ob/ob mice with VPA for 14 day...Fri, 24 Feb 2017 08:10:22 GMTJHTT-Communications@jhu.edu Initiative for Doctoral Education, 24 Feb 2017 08:10:21 GMTJHTT-Communications@jhu.edu Damping System to some embodiments of the present invention, a cooperatively-controlled robot includes a robotic actuator assembly comprising a tool holder and a force sensor. The cooperatively-controlled robot further includes a control system adapted to communicate with the robotic actuator assembly and the force sensor, and an actuator in communication with the control system and mechanically coupled to a tool. The force sensor is configured to detect a vibrational force applied on the tool and send a signal to the control system based on the vibrational force. The control system is configured t...Fri, 24 Feb 2017 08:10:20 GMTJHTT-Communications@jhu.edu Older Patient-companion Pre-consultation Checklist Checklist for Geriatric Patients and their CompanionsJHU REF: C12909  Invention Novelty: A novel checklist designed to elucidate patient problems for geriatric patients and their non-paid companions during visits to a medical clinic waiting room   Value Proposition: Family members have been the predominant providers of long-term care to the elderly. . In a study of over 12,000 Medicare beneficiaries in 2004, over 38% of beneficiaries were accompanied to routine medical visits. When companions were present, the engagement with task assistance was very strong, and it was accompanied by...Fri, 24 Feb 2017 08:10:19 GMTJHTT-Communications@jhu.edu Sugar Transporters as Druggable Targets for T2DM Intestinal Cell Models for Obesity-related Diabetes Research JHU REF: [C12898]  Invention Novelty: Adult intestinal stem cell culture models derived from patients with obesity related Type 2 Diabetes Mellitus (T2DM) to be used to identify therapeutic targets and study role of abnormal sugar channels.   Value Proposition: Gastric bypass surgery (GBS) is currently the only effective treatment that leads to rapid resolution of T2DM and therefore has led to a significant increase in the demand for other non-surgical therapeutics treatments. There is currently no non-surgical therapeutics t...Fri, 24 Feb 2017 08:10:16 GMTJHTT-Communications@jhu.edu, Synthesis and Structure-activity Relationships of Pyridoquinazolinecarboxamides as RNA Polymerase I Inhibitors invention describes a set of novel small molecules that inhibit RNA polymerase I. RNA polymerase I (Pol I) governs the transcription of ribosomal RNAs, which are needed for building and function of the ribosomes. These ribosynthetic activities are greatly increased in cancer cells, and Pol I transcription rate is commonly deregulated in human cancers. The small molecules described here inhibit Pol I and cause degradation of RPA194, the catalytic subunit driving the Pol I activity. The molecules inhibit the growth of cancer cells and hold promise as new anticancer agents.Fri, 24 Feb 2017 08:10:15 GMTJHTT-Communications@jhu.edu Education and Assessment Center (PEAC); An Education and Learner Assessment Platform Physician Education and Assessment (PEAC) ToolJHU REF: C12887  Invention Novelty: A novel method of providing didactic information in the form of medical education for residents and healthcare professionals, as well as evaluating both learners and teachers.   Value Proposition: Internet-delivered continuing medical education (online CME) is an innovation that offers many advantages to physicians, including a low-cost and often superior medical education to students and professionals. In 2008, online continuing medical education (CME) was around 8% of all the CME consumed, but it is ex...Fri, 24 Feb 2017 08:10:14 GMTJHTT-Communications@jhu.edu North ( is a website offering original analysis and research guides and tools regarding events in and around North Korea. North (  a website reflects a real North Korea JHU REF: C12884  Invention Novelty: 38 North ( devotes to reflecting a real North Korea to both seasoned observers and general audiences by offering them the best possible analysis and research tools.   Value Proposition: North Korea has been in the throes of change for decades. Those changes have important implications for not only the Korean peninsula, but also the East Asia, and even international community. However, too often analysis of the North Korea affairs is permeated by inexperience, littered wi...Fri, 24 Feb 2017 08:10:13 GMTJHTT-Communications@jhu.edu of Fission and Fusion Operations for High Throughput Generation of Combinatorial Droplets research in digital microfluidics has burgeoned as droplets can function as miniaturized reactors in biological and chemical applications. Droplet microfluidic platforms boast the ability to generate many reactions within short time periods. However, most droplet platforms digitize samples into discrete droplets and are limited to the analysis of single samples under homogeneous probe conditions. Such platforms are incapable of addressing the needs of next generation applications which require large libraries of samples and probes. Examples include SNP analysis for crop improvement and ...Fri, 24 Feb 2017 08:10:07 GMTJHTT-Communications@jhu.edu Encapsulation Increases the Bioavailability and Efficacy of D-PDMP in Interfering with Atherosclerosis and Cardiac Hypertrophy in apoE-/- Transgenic Mice, 24 Feb 2017 08:10:07 GMTJHTT-Communications@jhu.edu and Morphometric Analysis of Digitized Handwriting Tracings and Morphometric Analysis of HandwritingJHU REF: C12847  Invention Novelty: A novel method of analyzing the kinematic features and letter form of digitized handwriting tracings.   Value Proposition: Conditions such as Autism, Attention Deficit Hyperactivity Disorder can affect handwriting styles; identifying these differences early on can be beneficial in assessing the progression of the condition. Existing technologies for handwriting analysis perform only kinematic analyses, without addressing the letter form, which is a crucial handwriting characteristic.   Technical Details: ...Fri, 24 Feb 2017 08:09:59 GMTJHTT-Communications@jhu.edu self-folding tools for single cell capture and manipulation Micro – Grippers for Single Cell AnalysisJHU REF: [C12843]  Invention Novelty: Biocompatible, self- folding micro- grippers able to capture and manipulate a single cell activated by desired environmental stimulus for both in vivo and in vitro analysis   Value Proposition:  Scientists and engineers are consistently seeking improved tools for exploring the behavior of individual cells, but current biopsy tools collect samples too large and heterogeneous (mixed) misrepresenting the unique nature of a single cell. This technology is a completely tetherless, biocompatible micro-grip...Fri, 24 Feb 2017 08:09:58 GMTJHTT-Communications@jhu.edu Optic Distal Sensor Controlled Surgical Blade, 24 Feb 2017 08:09:55 GMTJHTT-Communications@jhu.edu Yeast with Hygromycin Marker at LEU2 Ubiquitin Expressed Yeast Strain at LEU2 JHU REF: [C12803]Invention Novelty: A genetically engineered single ubiquitin expressed Yeast strain at (leucine) LEU2 to serve as an in vivo model for the discovery of ubiquitin linkage roles in subcellular signal pathways  Value Proposition: Unique Polyubiquitination (polyUb) linkage combinations serve essential roles in several nondegradation pathways that dictate substrate fate within the cell, but due to insufficient in vivo models and ubiquitin?s dynamic nature, little is known about ubiquitin linkage dependent pathways. This technology is a si...Fri, 24 Feb 2017 08:09:48 GMTJHTT-Communications@jhu.edu, a Software Tool for Collection, Storage and Analysis of Standardized Phenotypic and Genomic Information, an Interactive Online Phenotype Analytical ToolJHU REF: [C12798]  Invention Novelty: A novel interactive online software that provides an in-depth analysis of individual case phenotypic, genomic information, and clinical test results within a comprehensive easy to use, searchable database.   Value Proposition: There is significant growth in the development of software and database management for genetic diseases for the purpose of improving treatment for human diseases. The major hurdle remains in the efficient organization, analysis and interpretation of the data. PhenoDB is an int...Fri, 24 Feb 2017 08:09:47 GMTJHTT-Communications@jhu.edu of a Long Non-coding Kcna2 Antisense RNA and its Role in Neuropathic Pain present invention relates to the field of neurology. More specifically, the present invention provides methods and composition useful for treating neuropathic pain. In a specific embodiment, the present invention provides a recombinant Kcna2 sense fragment. In another embodiment, the present invention provides a method of treating neuropathic pain comprising the step of administering a composition comprising a recombinant Kcna2 sense fragment. Fri, 24 Feb 2017 08:09:43 GMTJHTT-Communications@jhu.edu of Myosin II for Modulating Cell Mechanics Novel Panel of Myosin II Activators for Disease Therapy and Tissue EngineeringNovelty:A panel of myosin II activators developed to treat disease and useful for tissue engineering in regenerative medicine.Value Proposition:Changes in cellular mechanics due to impaired activity of myosin II, a motor protein essential for cell division, motility, and rigidity, is associated with numerous diseases, including myopathies, heart failure, and cancer. This technology provides a panel of small molecule myosin II activators that strongly stimulate the cellular contractile system, valuable as prom...Fri, 24 Feb 2017 08:09:41 GMTJHTT-Communications@jhu.edu Optic Distal Sensor Controlled Drug Injector NOVELTY Motion-compensated high-precision drug injector using a fiber optic distal sensor to monitor, in real time, the relative position between the injector tip and the tissue.  The linear motion controls the injector tip position based on the sensor input to compensate for the unwanted tissue and hand motions for precise control of the injection depth. VALUE PROPOSITION We describe a motion-controlled drug injector integrated with a common–path swept source optical coherence tomography (CP-SSOCT) based fiber distal sensor.  The injector is connected to a linear motion motor t...Fri, 24 Feb 2017 08:09:35 GMTJHTT-Communications@jhu.edu as pure spin current generators and detectors is a spintronics device. The spintronics device can include a ferromagnetic metal layer, a positive electrode disposed on a first surface portion of the ferromagnetic metal layer, and a negative electrode disposed on a second surface portion of the ferromagnetic metal.Fri, 24 Feb 2017 08:09:29 GMTJHTT-Communications@jhu.edu Hexosamine Reagents for Improved Quality Recombinant Glycoprotein Production Need: Glycosylation has a major impact on recombinant glycoproteins with important implications for increasing therapeutic use of these compounds. Various approaches are being developed to afford scientists and engineers more control over the type, location, and amount of sugar added to the protein. One technique involves adding sugar reagents to a tissue culture media to stimulate flux through a desired sugar modification pathway. While promising in theory, to date, sugar-based agents have been limited because they are either poorly transported across the lipid membrane or else cause to...Fri, 24 Feb 2017 08:09:23 GMTJHTT-Communications@jhu.edu Microscope Attachment for High Resolution Laser Labeling of Microscopic Glass Slides and Histological Sections Situ Marking of Microscope Slides with Laser Aided InstrumentationJHU REF: [C12707]  Invention novelty: This invention is a system that could permanently mark the microscope slide with an optical laser.   Value Proposition The technology can be commercialized as a microscope that could microscope slides could be in situ marked with laser. Currently there is no similar product in market. Advantages of the invention include: ·         Controllable spot size ·         Permanently marked ·         High resolution   Technical Details Johns Hopkins researchers have been working on devel...Fri, 24 Feb 2017 08:09:23 GMTJHTT-Communications@jhu.edu feature recognition of Anatomical Images based on Atlas grid (GAIA) Image Search EngineJHU REF: C12700  Invention novelty: This technology is an image-based search engine specifically for medical anatomical images   Value Proposition: Rising healthcare costs and the increasing demand for healthcare services have effected a significant transformation in the field of healthcare image management software over the last decade. The major features of post-processing include workflow tasks such as image processing, image reconstruction, computer-aided detection, three-dimensional (3D) view generation, and quality control. This technology is a method for im...Fri, 24 Feb 2017 08:09:20 GMTJHTT-Communications@jhu.edu Phase Extraction of Global Peptides, Glycopeptides, and Glycans Using Chemical Immobilization in a Tip throughput analysis of proteins, glycoproteins, and glycans is important for characterizing tissues or body fluids to gain biological and pathological insights. This could lead to the insight in understand the disease development and identification of disease-associated proteins as disease diagnostics or therapeutics. The application of proteomic, glycoproteomic, and glycomic methods to the analysis of disease associated changes in variable human samples will require the analysis of larger sample numbers reproducibly, in order to facilitate statistical validation of the data. Therefore, i...Fri, 24 Feb 2017 08:09:18 GMTJHTT-Communications@jhu.edu A Database for a High Resolution Map of Phosphorylation Networks in Humans for a High Resolution Map of Phosphorylation Networks in HumansJHU REF: [C12682]  Invention noveltyA high resolution map of a protein modification, phosphorylation, in humans   Value Proposition Protein phosphorylation, mediated by protein kinases, is one of the essential regulatory mechanisms in eukaryotes. Biochemical analysis of kinase-substrate relationships (KSRs) using purified protein components in a global manner that is built upon direct KSRs is lacking in higher eukaryotes such as humans. Advantages of this technology include: ·         provides associated computational...Fri, 24 Feb 2017 08:09:15 GMTJHTT-Communications@jhu.edu Method to Analyze Human Anatomy from Multiple Granularity Levels CAD Algorithm for MR TechnologyJHU REF: [C12675]  Invention Novelty: An enhanced medical imaging computer-assisted detection (CAD) algorithm for Magnetic Resonance (MR) technology able to analyze multiple levels of detail- based on anatomical region for improved visual range and image quality.   Value Proposition: MRI is increasingly becoming the imaging modality of choice due to the superior image quality and non-use of radiation; however as the push for earlier disease diagnosis and amount of image data that needs to be viewed increases, it is becoming difficult for physicians to ...Fri, 24 Feb 2017 08:09:13 GMTJHTT-Communications@jhu.edu 'n' Read, 24 Feb 2017 08:09:12 GMTJHTT-Communications@jhu.edu Imaging Toolbox for Guiding Cardiac Resynchronization Therapy Implantation from Patient-Specific Computed Tomography and Body Surface Potential Mapping Data Cardiac Resynchronization Therapy ImplantationJHU REF: C12672Invention novelty: This method is for evaluating cardiac properties from Computed Tomography (CT) scan combined with Body Surface Potential Mapping (BSPM). Value Proposition:Heart failure is a major public health problem in the United States that affects 5 million people and contributes to an increasing number of hospitalizations and deaths. Advances in techniques delivered during cardiac resynchronization therapy (CRT) have provided non-pharmacological options for patients with moderate to severe heart failure. However, the ...Fri, 24 Feb 2017 08:09:12 GMTJHTT-Communications@jhu.edu Glucocerebrosidase from a Fungus, Cheatomium Globosum, 24 Feb 2017 08:09:10 GMTJHTT-Communications@jhu.edu Signature of Aristolochic Acid Exposure for Environmental Carcinogen for Bladder CancerJHU REF: [C12638]  Invention novelty: a comprehensive panel of biomarkers for aristolochic acid, an environmental carcinogen for urothelial carcinoma, the most common form of bladder cancer   Value Proposition Early detection is usually critical for the successful treatment of cancer, therefore there is a constant market need to develop novel biomarkers for diagnosis and prognosis of cancers. Aristolochic acid (AA) has been used for medicinal purposes for more than 2,000 years, but there are profound nephrotoxicity and carcinogenicit...Fri, 24 Feb 2017 08:09:01 GMTJHTT-Communications@jhu.edu tissue shaver Shaving Device for Spinal Bone ImplantsJHU REF: C12626  Invention novelty: This invention is a novel method of removing tissue attached to bone allografts and autografts by saving time, increasing accuracy and improving safety to the user.   Value Proposition: Spinal fusion surgery is an aggressively growing market, with over 600,000 fusion surgeries performed in the U.S. annually. One component of the surgery is the decellularization (tissue extraction) of bone grafts that are used in the surgery. Currently nurses or technicians either manually remove the tissue from the bone, or th...Fri, 24 Feb 2017 08:08:58 GMTJHTT-Communications@jhu.edu Tissue Assay for Active Surveillance of Prostate Cancer Patients Tissue Assay for Active Surveillance of Prostate Cancer PatientsJHU REF: [C12614]Invention novelty: novel biomarker-based predictor for the early detection of a highly aggressive prostate cancerValue PropositionOther than skin cancer, prostate cancer is the most common cancer in American men. The American Cancer Society estimates about 240,000 new cases of prostate cancer will be diagnosed in the US, and about 30,000 men in the US will die of prostate cancer in 2013.  Widespread prostate specific antigen (PSA) -based screening is believed to have contributed to the decrease in prosta...Fri, 24 Feb 2017 08:08:55 GMTJHTT-Communications@jhu.edu of Calculating Radiation Dose to Circulating Blood Cells Including Lymphocytes to Calculate Radiation Dose to Circulating BloodJHU REF: 12610Invention Novelty: This technology is a method for calculating radiation dose received by circulating blood during external beam radiotherapy. Value Proposition:Severe treatment-related lymphopenia (TRL) occurs in 40% of glioblastoma patients despite minimal radiation (RT) doses to bone marrow or nodal sites. In glioblastoma, TRL is associated with decreased survival and is thought to be the result of an overdose of radiation to the circulating blood. Calculating radiation dose to circulating blood is challenging and is affec...Fri, 24 Feb 2017 08:08:54 GMTJHTT-Communications@jhu.edu Release Assays for Diagnosis of Invasive Fungal Infections invasive fungal infections that are problematic to humans are those that are difficult to diagnose. This is particularly true when fungal antigens are hard to detect and/or culture does not reveal the cause of infection. We have developed assays to detect infection with pathogenic fungi by measuring release of interferon-gamma by the infected host upon cell exposure to specific microbial antigens.Fri, 24 Feb 2017 08:08:53 GMTJHTT-Communications@jhu.edu Sample Tracking system for tracking biological samplesJHU REF: [C12601]  Invention novelty: a computerized system for tracking biological samples   Value Proposition Tracking data linked with a specific sample is of critical importance. Thus, laboratory information management systems (LIMS) are needed, which are automated systems to keep a record of samples, make batches and work lists and also club samples through tests or any other common characteristic. LIMS can make schedules to test and track samples in a clinical lab when they are shifted from different departments. They can also keep a ...Fri, 24 Feb 2017 08:08:51 GMTJHTT-Communications@jhu.edu knockdown vectors to inhibit expression of specific nuclear Lamin proteins and variants novelty:JHU researchers have designed and tested several several shRNA knockdown vectors that can inhibit specific isotypes of lamin proteins as well as variants that cause disease.Value Proposition:Many disease arise form aberration in proteins of the nuclear lamina. The researchers have designed and are testing several shRNA knockdown vectors that can inhibit specific isotypes of lamin proteins as well as variants that cause disease.Technical Details:The JHU researchers have demonstrated that they can target Lamin A expression without perturbing the Lmain C isoform, which is derive...Fri, 24 Feb 2017 08:08:49 GMTJHTT-Communications@jhu.edu Tissue Inventory Database Tissue Inventory DatabaseJHU REF: [C12594]  Invention novelty: The invention is Laboratory Information Management System (LIMS) and is used to track pharmacology tissue inventories.  Value Proposition This software includes several novel features compared to existing laboratory information management system. These novel features help to improve the efficiency of laboratory inventory management. Advantages include: l  Track inventory across studies l  Tracks the samples that have or have not been analyzed l  Provide the date of collection of the oldest clinical trial specimen ...Fri, 24 Feb 2017 08:08:48 GMTJHTT-Communications@jhu.edu Mobile Application for the Analysis of Infant Stool Color to Determine Gastrointestinal and Hepatobiliary Disease Color Card Smart Phone ApplicationJHU REF: [C12590]  Invention novelty: Mobile device application (app) for analyzing stool color  Value Proposition Abnormalities in stool color can provide important clues regarding diseases of the gastrointestinal tract and hepatobiliary system. Specifically, red or black stool can suggest gastrointestinal bleeding whereas pale yellow or white stool can suggest obstruction of bile excretion as seen in cholestatic dieases of the liver (e.g., biliary atresia).  This technology is a smartphone app that helps parents identify abnormalities in the color of...Fri, 24 Feb 2017 08:08:47 GMTJHTT-Communications@jhu.edu immunoglobulin purified from NMO-IgG positive patient plasma Human IgG Antibodies from Positive NMO- IgG PatientJHU REF: [C12575]Invention Novelty: This technology provides purified human IgG antibodies isolated from plasma cells from a Neuromyelitis Optica (NMO) positive patient. Value Proposition: NMO or Devic?s disease is a rare inflammatory disease in the optic nerves, and spinal cord where specific disease-related antibodies trigger an autoimmune response in the body. To better understand these mechanisms, purified antibodies samples are needed but difficult to obtain due to the rarity of the disease and processing technique. This technolo...Fri, 24 Feb 2017 08:08:43 GMTJHTT-Communications@jhu.edu of Bacteria, Bacterial Products, and other Immunoregulatory Entities in Combination with Anti-CTLA-4 and/or Anti-PD-1 Antibodies to Treat Solid Tumor Malignancies Therapeutic Method for Solid TumorJHU REF: [C12570]Invention novelty: This technology is a combination therapy method including a tumor-specific bacterium and antibodies that boost tumor immune response.Value PropositionWorldwide cancer affects more than 12 million people each year. This number is expected to increase to 14 million each year by 2015.  Solid tumors generally contain hypoxic tumor cores where a few live tumor cells reside in a quiescent state. These core residing tumor cells are often resistant to standard treatments (e.g. radiotherapy and chemotherapy), survive initial...Fri, 24 Feb 2017 08:08:41 GMTJHTT-Communications@jhu.edu Doppler Optical Coherence Tomography Probe for Real-time Vascular and Lymphaticovenous Anastomosis Guidance and Post Surgical Evaluation surgical evaluation and guidance system for use in extravascular evaluation and guidance of fluid vessel surgeries, includes an optical coherence tomography engine; a vessel probe optically coupled to the optical coherence tomography engine; and a signal processing and display system adapted to communicate with the optical coherence tomography engine to receive imaging signals therefrom. An optical coherence tomography vessel probe for use in extravascular evaluation and guidance of fluid vessel surgeries, includes a probe body having a proximal end and a distal end; an optical relay system ...Fri, 24 Feb 2017 08:08:40 GMTJHTT-Communications@jhu.edu Vectored Immunoprophylaxis Provides High-titer Plasmodium Falciparum Circumsporozoites Antibodies immunoprophylaxis antimalarial therapyJHU REF: [C12545]Invention novelty: an improved antibody-based malarial therapyValue PropositionMalaria remains one of the world?s major causes of death, especially in Africa. Ninety percent of malaria mortalities occur in Africa, where it accounts for about one in five childhood deaths. WHO reported that there were 216 million cases of malaria in 2010, with 655,000 deaths. The majority of cases (65%) occurred in children under 15 years of age. WHO estimates that 3.3 billion people, or approximately half of the world?s population, are at ris...Fri, 24 Feb 2017 08:08:34 GMTJHTT-Communications@jhu.edu Membrane Antigen-targeted Photosensitizers for Photodynamic Therapy photodynamic therapy for prostate and solid-tumorsJHU REF: C12525Invention novelty: This invention is a novel drug composition that can target prostate tumors in vivo for use in photodynamic therapy (PDT).Value Proposition:Currently, prostate cancer treatment often requires invasive surgery or treatment with drugs that may cause adverse side-effects. This current technology is advantageous as it is;?    Minimally invasive?    Unlike other PDT cancer therapeutic drugs it targets the tumor, resulting in fewer side-effects.?    Can compete with immune-based drug treatments as a targeted ...Fri, 24 Feb 2017 08:08:26 GMTJHTT-Communications@jhu.edu Rehabilitation System invention presents methods for using rehabilitation robots and haptic video games to motivate and treat stroke patients. This is done by pairing two or more patients with similar treatment needs, abilities, and interest inside a video game ecosystem where they can support and compete against each other in various virtual scenarios rendered audio-visually as well as haptically.Fri, 24 Feb 2017 08:08:22 GMTJHTT-Communications@jhu.edu Materials for Cryogenic Liquification, 24 Feb 2017 08:08:17 GMTJHTT-Communications@jhu.edu (Biosketch Generation System) Customizable NIH Biosketch Generation SystemJHU REF: [C12495]Invention novelty: A novel web-based cloud computing system for a cost- and time-efficient generation of personalized NIH biosketch files.  Value Proposition: NIH (National institute of Health) grant proposals require submission of a Biosketch, briefly outlining the applicant’s scientific education and accomplishments. Yet, document generation using word processing programs and shared data storage drives is tedious and accompanied by formatting inconsistencies and high administration duties and costs. Hence, this technology...Fri, 24 Feb 2017 08:08:15 GMTJHTT-Communications@jhu.edu Damping Vibration Controller, Primarily for Use with Sunpower Cryotel Coolers cryocooler assembly including a cryocooler housing and a free-piston engine arranged within the housing, an absorber housing and a damper motor arranged within the absorber housing, and a controller housing rigidly coupled between the cryocooler and the active damper such that vibrations may pass through the controller. A controller mounted within the controller housing provides power to the cryocooler and monitors the phase and frequency of the power supplied to the cryocooler. The controller monitors the vibration of the cryocooler assembly and provides a damping signal to the active dampe...Fri, 24 Feb 2017 08:08:04 GMTJHTT-Communications@jhu.edu N-terminal motif mediates Cul5 binding: Novel Target for HIV Therapeutic Intervention Target for HIV Drug DesignJHU REF: [C12416]  Invention novelty: a novel molecular target for HIV drug design   Value Proposition In the United States approximately 1.2 million people are infected with HIV and about 54,000 new infections are reported each year. More than 38 million people are living with the disease worldwide, including more than 3 million children. More than 2.2 million people worldwide are newly infected with HIV according to the UNAIDS data. Human Immunodeficiency Virus Type 1 (HIV-1) Vif has been demonstrated to form a protein complex with cullin 5 (CUL5), which p...Fri, 24 Feb 2017 08:08:03 GMTJHTT-Communications@jhu.edu of Trans Renal HPV DNA in Urine Using a Dual Sequence-capture Approach Proposition:Currently, the primary diagnostic for cervical cancer is a Papanicolaou (Pap) smear. If the Pap smear is positive; HPV genotyping diagnostics, a colposcopy, and/or a biopsy are used as confirmation. All of these diagnostics are highly invasive, and some are very costly. This current technology is advantageous as it is;?       Non-invasive, which reduces the risk of infection or inflammation, and is more culturally acceptable.?       Does not require a well established medical infrastructure unlike that required for Pap smear.?       It is potentially more sensitive than the P...Fri, 24 Feb 2017 08:07:48 GMTJHTT-Communications@jhu.edu - Burden or Mutation Position. A Hybrid Likelihood Model for Sequence-based disease association studies SOLVED In the new ?post-genome? era of personalized medicine, many variants critical to disease susceptibilities and drug sensitivities will be identified and increased numbers of people will undergo genetic testing. The Karchin group is developing algorithms and tools to facilitate this process. These models are being applied to cancer genomics, unclassified variants in Mendelian disease genes, and complex disease genetics. TECHNICAL DETAILS CHASM AND VEST A machine learning method that predicts the functional significance of somatic missense mutations observed in the genomes of ...Fri, 24 Feb 2017 08:07:31 GMTJHTT-Communications@jhu.edu Obscurins: Novel Tumor and Metastasis Suppressors in Breast Cancer with Prognostic and Therapeutic Potentials herein are methods and kits for evaluating potential for invasiveness, metastasis, or recurrence of an epithelial cell cancer. In the methods the expression profile of giant obscurins is detected in a tissue sample of tumor cells or suspected tumor cells and assessed for giant obscuring expression level and distribution therein. Decreased levels or altered distribution of giant obscurins in the cells compared to a control non-invasive standard or to a sample taken at a different point in time is indicative of increased potential of at least one of the invasiveness, metastasis, or recu...Fri, 24 Feb 2017 08:07:27 GMTJHTT-Communications@jhu.edu Gamma 8 pAb Antibody specific for Transmembrane AMPA Receptor Protein (TARP)JHU REF: [C12231]Invention novelty: This technology is an anti-TARP [transmembrane alpha-amino-3-hydroxyl-5-isoxazolepropionate (AMPA) receptor protein] gamma 8 polyclonal antibody.Value Proposition: In many neurological diseases, AMPA receptor function and structure are altered.  This arrangement makes AMPA receptors potential therapeutic targets for clinical intervention.  This technology, by interacting with AMPA receptor complexes, has several advantages:?    Research tool to study modulation of function of receptor...Fri, 24 Feb 2017 08:07:06 GMTJHTT-Communications@jhu.edu of Tetracycline-Regulatable Conditional AIMP2 (Aminoacyl-tRNA Synthetase Complex-interacting Multifunctional Protein 2) Transgenic Mice Mouse Model for Parkinson?s Disease JHU REF: [C12196]  Invention novelty: This tangible material is a transgenic mice model expressing AIMP2 (Aminoacyl-tRNA synthetase complex-interacting multifunctional protein 2), a protein strongly associated with pathogenesis of Parkinson?s disease (PD).   Value Proposition: No animal models overexpressing human AIMP2 exist. These transgenic mice are tools that can facilitate a better understanding of the role of AIMP2 in PD. In addition, interacting proteins may also be identified. Further, these animals can be used to screen therapeutic agen...Fri, 24 Feb 2017 08:06:59 GMTJHTT-Communications@jhu.edu spectral response effects (SRE) compensation method for photon counting detectors (PCDs) Details:Johns Hopkins researchers have developed a new SR compensation method using a forward imaging process, which accurately models the imaging system and the scanned object. The proposed SR compensation uses a sinogram restoration approach and, then, integrates the SR function, or the computational model of the SR, into a forward imaging process. Following forward imaging, the SR compensation method negates the effects of the SR by maximizing the Poisson log-likelihood of measurements. The algorithm was evaluated using a simulated fan-beam x-ray CT scanner and was shown to reduce...Fri, 24 Feb 2017 08:06:46 GMTJHTT-Communications@jhu.edu Speckle De-correlation Based Quantitative Transverse Flow Assessment Details: Johns Hopkins researchers have developed OCT speckle de-correlation based quantitative transverse flow assessment. This method has great potential in many applications that require in vivo, non-invasive, quantitative imaging of microvasculatures The OCT speckle de-correlation based quantitative transverse flow assessment technique calculates cross-correlation coefficient between Ascans from Bscan OCT images. The cross-correlation coefficient (XCC) between adjacent A-scans depends on the displacement. Therefore, flow speed can be derived from the XCC.Looking for Partners: To ...Fri, 24 Feb 2017 08:06:42 GMTJHTT-Communications@jhu.edu Antibodies Against the Barth Syndrome Gene Product, TAZ1, for Research and Diagnostic Applications Antibodies Against the Barth Syndrome Gene Product, TAZ1, for Research and Diagnostic ApplicationsCASE NUMBERC12086Unmet Need: Barth syndrome (BTHS) is an X-linked disease characterized by cardiac and skeletal myopathies, delayed growth until puberty, and cyclic neutropenia; if undiagnosed, affected boys have only a 30% chance of survival to age four. The BTHS gene TAFAZZIN encodes a monolysocardiolipn transacylase that is evolutionarily conserved from yeast to humans. Until now, efforts to characterize TAZ1 and mammalian models of BTHS have been hampered by the absence of comm...Fri, 24 Feb 2017 08:06:25 GMTJHTT-Communications@jhu.edu Drug-Amphiphiles: A New Platform for the Delivery of Anticancer Chemotherapeutics NEEDMany anticancer drug delivery systems suffer from lack of target specificity and drug-loading limitations. Additionally, many drug delivery systems require the use of a nanocarrier, which have certain disadvantages including limitations on the amount of loaded drug and batch to batch variability. This invention is a self-assembled drug-amphiphile that releases anticancer drugs under tumor-relevant conditions.PROBLEM SOLVEDJohns Hopkins researchers have developed a novel, self-assembled amphiphiles for delivery of anticancer therapeutics. This method does not require the addition of n...Fri, 24 Feb 2017 08:06:24 GMTJHTT-Communications@jhu.edu Hopkins Atlas of Pancreatic Pathology iPAD Application Johns Hopkins Atlas of Pancreatic PathologyJHU REF: [C12075]  Invention novelty: The invention is a software app developed for Apple iPad platform as an educational tool for learning about the pathology of human pancreas.   Value Proposition With the advent of improved mobile display and gesture-based user interface, several educational tools are being developed on mobile operating systems such as the iOS and Android. The Johns Hopkins Atlas of Pancreatic Pathology is a one of a kind software app developed on the Apple iPad enhancing learning of medical concepts through interactive expo...Fri, 24 Feb 2017 08:06:21 GMTJHTT-Communications@jhu.edu - A Multi-Petabyte Generic Data Analysis Environment for Science data-intensive computer includes a processing sub-system formed by a plurality of processing servers, a database sub-system formed by a plurality of database servers configured to form a collective database, and a unifying operating system environment. The unifying operating system environment extends across the processing sub-system and the database sub-system to coordinate operation of the plurality of processing servers and the plurality of database servers to act as components in a single data-intensive computer and presents the database sub-system to an application running in the data-i...Fri, 24 Feb 2017 08:06:06 GMTJHTT-Communications@jhu.edu Intensive Computing system and method for operating a data-intensive computer is provided. The data-intensive computer includes a processing sub-system formed by a plurality of processing node servers and a database sub-system formed by a plurality of database servers configured to form a collective database in excess of a petabyte of storage. The data-intensive computer also includes an operating system sub-system formed by a plurality of operating system servers that extend a unifying operating system environment across the processing sub-system, the database sub-system, and the operating system sub-system to...Fri, 24 Feb 2017 08:06:06 GMTJHTT-Communications@jhu.edu Inhibitors of Protein Kinase Signaling that are Neuroprotective and have Potential Applicability for the Treatment of Glaucoma, Optic Nerve Disease, and other Forms of Neurodegeneration is a major cause of visual loss and blindness in elderly Americans and throughout the world. One approach to treatment of glaucoma, and other optic nerve diseases as well as other neurodegenerations, is to develop neuroprotective agents that promote the survival of neurons. We have previously used high-throughput functional genomic screening to identify dual-leucine kinase (DLK) and its homolog, leucine zipper kinase (LZK), as key neuroprotective drug targets in retinal ganglion cells (RGCs)  the neurons in the retina that die in glaucoma and whose loss leads to blindness. We used kin...Fri, 24 Feb 2017 08:06:04 GMTJHTT-Communications@jhu.edu of Quantitative Calibration Phantoms/Systems into Extremity Computed Tomography Scanner embodiment in accordance with the present invention provides a device and method for a quantitatively calibrated computed tomography scanner. The device includes a gentry configured for receiving a patient or part of a patient. The gentry includes an X-ray source and a detector positioned opposite said X-ray source, such that said detector receives the X-rays emitted from the X-ray source. Calibration phantoms are integrated with the gentry and/or a device within the scanner so as to allow for calibration in quantitative CT measurements of Hounsfield units and/or bone mineral density. ...Fri, 24 Feb 2017 08:05:32 GMTJHTT-Communications@jhu.edu the Derivation of Endothelial Cells from Human Pluripotent Stem Cells in a Two-dimensional, Feeder Free Differentiation Scheme defined chemical method for growth of endothelial cells from human stem cellsJHU REF: [C11924]Invention novelty: Development of defined chemical conditions and method for culturing of endothelial cells (ECs) from human embryonic and induced pluripotent stem cells using sequential adherent cell culture method.  Value PropositionThe development of a defined chemical method for the culturing of homogeneous populations of endothelial cells from human stem cells overcomes the following problems faced in the current structural tissue culturing practices: Thrombotic blockage of synthetic polymer ...Fri, 24 Feb 2017 08:05:31 GMTJHTT-Communications@jhu.edu Shield System Designed To: Prevent Cross Contamination from Patient-to-patient Use and is Consistently Available 24/7, Cleaner, Readily-available Radiation ShieldJHU REF: C11919  Invention novelty: This technology is a retractable radiation protection shield that is easily cleaned and sanitized to prevent cross-contamintation from patient to patient.     Value Proposition Radiation shields currently used in procedures are not sanitized between uses, increasing the potential of transmitting germs and diseases from patient to patient. Additionally, radiations shields are often misplaced and not readily available for use when needed. This technology solves these problems by utilizing a single-use disp...Fri, 24 Feb 2017 08:05:30 GMTJHTT-Communications@jhu.edu<![CDATA[Siglec-8 Ig Fusion Protein and Cell Line Secreting It; Transfected HEK & RBL Cell Lines Stably Expressing Siglec-8 on their Surface]]>, 24 Feb 2017 08:05:26 GMTJHTT-Communications@jhu.edu Comprising NDGA Derivatives and Sorafenib and their Use in the Treatment of Cancer NOVELTYJHU investigators have combined the NDGA derivatives M4N and sorafenib to create a pharmaceutical composition that inhibits cancer cell growth. This novel drug combination has increased cytotoxic activity and inhibits growth of HCC human cancer cells in a dose-dependent manner.VALUE PROPOSITIONInvestigators have discovered a drug composition that could be used to inhibit and treat neoplastic diseases such as liver, colon, breast, brain or ovarian cancers.  It was found that M4N, which is nontoxic to normal cells at high concentrations, alters cancer cell metabolism in a way th...Fri, 24 Feb 2017 08:05:14 GMTJHTT-Communications@jhu.edu GridJHU REF: [11834]  Invention novelty: Quantitative method of analyzing medical images for diagnosis and prognosis by defining corresponding anatomical locations across subjects.   Value Proposition: Past biological images can provide valuable diagnostic information, but databases are currently underutilized due to the difficulty of correlating anatomical locations across subjects. Previously, regions-of-interest were painstakingly manually defined. Automatic segmentation requires objects to have clear contrast to define their boundaries. A voxel-by-voxel region-of-interest ima...Fri, 24 Feb 2017 08:05:04 GMTJHTT-Communications@jhu.edu and System for Training Number Sense Video Game for Training Number SenseJHU REF: [C11830]  Invention novelty: an interactive video game to train number sense   Value Proposition Children as young as 3 years old have a “number sense” that may be correlated with mathematical aptitude. “Number sense” is an intuition about the concepts of more and less that does not involve counting. It exists in all people including infants and indigenous peoples who have had no formal education. This technology is a method and system for training number sense through action-packed video games. Advantages of this technology include: ...Fri, 24 Feb 2017 08:05:02 GMTJHTT-Communications@jhu.edu Organic Transistor Sensors electro-chemical sensor includes a first electrode, a second electrode spaced apart from the first electrode, and a semiconductor channel in electrical contact with the first and second electrodes. The semiconductor channel includes a trapping material. The trapping material reduces an ability of the semiconductor channel to conduct a current of charge carriers by trapping at least some of the charge carriers to localized regions within the semiconductor channel. The semiconductor channel includes at least a portion configured to be exposed to an analyte to be detected, and the trapping mat...Fri, 24 Feb 2017 08:05:00 GMTJHTT-Communications@jhu.edu Screening of a Large Library of Biological Samples Through On-demand Droplet Generation and Fusion continuous throughput microfluidic system includes an input system configured to provide a sequential stream of sample plugs; a droplet generator arranged in fluid connection with the input system to receive the sequential stream of sample plugs and configured to provide an output stream of droplets; a droplet treatment system arranged in fluid connection with the droplet generator to receive the output stream of droplets in a sequential order and configured to provide a stream of treated droplets in the sequential order; a detection system arranged to obtain detection signals from the treat...Fri, 24 Feb 2017 08:04:54 GMTJHTT-Communications@jhu.edu Automatic Brain Lesion Incidence and Detection Using Multimodality Longitudinal Magnetic Resonance Imaging develop brain lesions over the natural course of a disease, Thus, there is a need to identify, estimate the size, and track the time course of new lesions as they are being formed and remain in the brain. Currently, this is done by a trained rteuroradiologist using sliceby- slice inspection, this process is very slow, can be prone to human error, and is hard to generalize to large observational studies. Our methods and algorithm provide an automatic solution by incorporating information from multiple imaging modalities., a difficult task even for trained radiologists.Fri, 24 Feb 2017 08:04:45 GMTJHTT-Communications@jhu.edu Integrity Training Module Integrity Training ModuleJHU REF: [C11706] Invention novelty: Johns Hopkins faculty have created an academic integrity module that can be integrated into a course management website. The module would enable incoming students to complete online training for their new institution. Value PropositionIn their undergraduate years, students are frequently confronted with decisions concerning academic integrity. The Center for Academic Integrity defines the concept as, “a commitment, even in the face of adversity, to the five fundamental values: honesty, trust, fairness, respect, and responsi...Fri, 24 Feb 2017 08:04:26 GMTJHTT-Communications@jhu.edu Settling Velocity Based Separation of Synthetic and Biological Particles Microfluidic Blood Fractionation DeviceJHU REF: [C11659]Invention novelty: Separation of components of blood by microfluidic device without damaging its morphology. Value PropositionThe proposed invention possesses several advantages over the current technologies employed for blood fractionation as follows: Reduction in infrastructure costs and tediousness of blood fractionation procedures.Unique design of the device which enables fractionation of blood into different components like RBCs, plasma etc. without the aid of external forces.Minimally invasive technique thereby reducing the da...Fri, 24 Feb 2017 08:04:12 GMTJHTT-Communications@jhu.edu - MultiVariate organization of Combinatorial Alterations Computational Method to Identify Tumor-related GenesJHU REF: C11648Invention novelty: This technology is a novel computational method to identify genes that are potentially important in tumorigenesis, using cancer genomics data. It offers an unbiased and exhaustive search of gene interactions.  Value PropositionThis approach can be useful for identifying genes that participate in cancer progression, networks of genes that promote cancer via combined genetic and transcriptome alterations, druggable cancer-specific genes, and synthetic lethal interactions. The method is generalizable to hi...Fri, 24 Feb 2017 08:04:08 GMTJHTT-Communications@jhu.edu Novel Method for Ultra-low Energy Switching in MRAM for Reducing Power Consumption in MRAMJHU REF: C11627  Invention novelty:   This invention can electrically control the magnetic field surrounding a magnetic tunnel junction by altering the resistance state of the junction.  This occurs at a much lower current density than normal operating conditions.   Value Proposition: ·         Lowers switching current density by approximately 10 times ·         Uses voltage pulses with smaller current densities to achieve reversible switching ·         Compatible with current nonvolatile magnetic random access memories ·         Technolog...Fri, 24 Feb 2017 08:04:01 GMTJHTT-Communications@jhu.edu Mutant DISC1 Mice, Lines 1001 and 1302 Mutant DISCI MiceJHU REF: C11617  Invention Novelty: The disclosed technologies are two tangible materials that are improved homozygous mouse strains with inducible expression of mutant human Disrupted-In-Schizophrenia-1 (hDISC1) using Tet-off system under the control of CAMKII.    Value Proposition: The disclosed materials are improved mouse strains of inducible expression of hDISC1 to facilitate the research in pathogenesis and preclinical therapeutic experiments of schizophrenia.      Technical Details: Johns Hopkins researchers have generated homozygous mouse strains ca...Fri, 24 Feb 2017 08:03:57 GMTJHTT-Communications@jhu.edu Database Interactive 3D Database for Medical DiagnosisJHU REF: C11611  Invention novelty: This invention provides a user bypass of the necessity to review materials that result from keyword inputs.  Instead, this database stores information from scientific publications into a three dimensional atlas, which is immediately activated upon searching with keywords pertaining to that atlas. (I.e. the human brain)  Based on the number of publications that are returned from the search, the 3D atlas changes color and intensity.   Value Proposition: ·         Information can be stored, searched, and retr...Fri, 24 Feb 2017 08:03:55 GMTJHTT-Communications@jhu.edu Integration of Teaching and Patient Care on Rounds and Patient Care on a TabletJHU REF: [C11595]Invention novelty:  Johns Hopkins researchers have created a method and software for the digital integration of trainee doctor education and patient care during rounds. Value Proposition: The Accreditation Council for Graduate Medical education has mandated tighter work hour restrictions. These new restrictions will reduce the amount of time a resident has in a hospital. Therefore, it is vital to ensure that while a resident is in a hospital, they are only performing value added tasks. Unfortunately, processes used in teaching hospitals for...Fri, 24 Feb 2017 08:03:51 GMTJHTT-Communications@jhu.edu Simulation and Permutation Methods for the Determination of Temporal Association between Apnea and Reflux Events of Analysis for Association of Gastroesophageal Reflux and Apnea in Infants  Invention novelty: This invention uses simulation and permutation methods to analyze the temporal association between two types of time series of events, namely gastroesophageal reflux, and apnea due to the blockage of airways.   Value Proposition: ·         Gives a p-value for  the symptom index (SI) and symptom sensitivity index (SSI) ·         Compare the distribution of associated event times to a simulated random distribution. ·         Improves the current model of the SAP (symptom associated pro...Fri, 24 Feb 2017 08:03:18 GMTJHTT-Communications@jhu.edu Enhancement Measurement of Hypervascular Liver Lesions on MRI NOVELTY The proposition of this invention is to provide quantitative assessment of enhancement to the entire tumor volume in Hepatocellular carcinoma cases. This process will remove the subjectivity of treatment response assessment and allow for a more direct comparison of pre- and post-TACE treatment response. Various methods to measure contrast uptake and perfusion of the tumor region in relation to the non-tumorous tissue are conceivable and are outlined in the detailed description. Although these technologies exist separately, until now, there has been no quantitative, volume b...Fri, 24 Feb 2017 08:03:04 GMTJHTT-Communications@jhu.edu Tracking and Cutting: Complex Contextual and Automatic Robotic Primitives for Assistance in Telemanipulation and Telesurgery system for detecting and tracking a curvilinear object in a three-dimensional space includes an image acquisition system including a video camera arranged to acquire a video image of the curvilinear object and output a corresponding video signal, the video image comprising a plurality n of image frames each at a respective time ti, where i=1, 2, . . . , n; and a data processing system adapted to communicate with the image acquisition system to receive the video signal. The data processing system is configured to determine a position, orientation and shape of the curvilinear object in the thr...Fri, 24 Feb 2017 08:02:58 GMTJHTT-Communications@jhu.edu Constructs to Make Papillomavirus Pseudovirions for HPV Types are codon-optimized DNA constructs for the expression of different HPV types major capsid protein, L1 and minor capsid protein, L2, in the vector pVITRO.This Material is also available at Addgene: Publication:■ Vaccine. 2010 Jun 17; 28(28): 4478–4486.  ■Fri, 24 Feb 2017 08:02:42 GMTJHTT-Communications@jhu.edu for Topical Liquid Therapy in Endoscopy and Laparoscopy present invention utilizes a catheter device for targeted delivery of therapeutic molecules in fluids to body cavities. The invention provides a device and method for targeted delivery of fluids to tissue cavities via deployment of a fluid soaked sponge from the catheter to contact surfaces within the body cavity.Fri, 24 Feb 2017 08:02:28 GMTJHTT-Communications@jhu.edu Molecule Free Solution Hydrodynamic Separation Platform method of separating, detecting and determining a size of each of a plurality of particles in a fluid includes compelling the fluid to flow through a fluid channel such that larger particles of the plurality of particles travel through the fluid channel faster than smaller particles of the plurality of particles; illuminating a detection zone of the fluid channel substantially uniformly across an entire cross section of the fluid channel such that each of the plurality of particles passes through illumination light upon passing through the detection zone; detecting each of the plurality of p...Fri, 24 Feb 2017 08:02:10 GMTJHTT-Communications@jhu.edu Abrasion Device, 24 Feb 2017 08:01:54 GMTJHTT-Communications@jhu.edu Online Calibration of Common-Path Fourier-Domain OCT Automatic Online Calibration of Common-Path Fourier-Domain OCTValue Proposition:This technology presents a two stage process. Stage one obtains a series of calibrating polynomial coefficients that describes how the wavenumber in the spectrometer depends on the pixel index. Stage two determines the physical spacing between adjacent A-scan pixels for a particular scanning medium. Spectral data used for calibration is obtained from an arbitrary sample, which may have complicated internal structures, such as a biological specimen. The calibration can be done in real-time during the scannin...Fri, 24 Feb 2017 08:01:38 GMTJHTT-Communications@jhu.edu Sensitization Agents for Prostate Cancer Sensitization Agents for Prostate CancerJHU REF: [C11146]  Invention novelty: A new mechanism to selectively sensitize the prostate to radiation therapy by knocking down DNA repair gene transcripts. Value Proposition: Current dose-escalated radiation therapy for localized prostate cancer treatment has increased the risk of injury of surrounding non-cancerous tissue due to its non-targeting application. Thus, there is a great need for the development of tissue-selective and radiation-sensitizing agents. This technology can solve the problem of broad or non-selective radiation and impr...Fri, 24 Feb 2017 08:01:32 GMTJHTT-Communications@jhu.edu (SMLCs) Derived from Human Embryonic Stem Cells (hESCs) Support Cord-like Structure in vitro invention relates, e.g., to a method for differentiating mammalian (e.g., human) pluripotent stem cells (PSCs) into smooth muscle-like cells (SMLCs) in vitro, comprising a) plating a single-cell suspension of PSCs that are smaller than 50 μm at a seeding concentration of about 5×104 cells/cm2-about 1×105 cells/cm2 onto a suitable surface, and culturing the cells under conditions which prevent the PSCs from aggregating and induce differentiation of the PSCs into vasculogenic progenitor cells; b) harvesting the cultured cells of step a) and separating them into a single cell suspension of c...Fri, 24 Feb 2017 08:00:53 GMTJHTT-Communications@jhu.edu as a Predictor of Human Female Infertility and Responsiveness to Treatment Need:Approximately 48.5 million couples are infertile worldwide.  Approximately 15% of couples in the United States are involuntarily infertile. Professional intervention can help about 40% of these couples achieve a pregnant state. A causative factor for the infertility relating to the woman is found in no more than one-half of couples that are evaluated. A complete list of the causes of female infertility is extensive. The following problems that are found most frequently in women include anovulation, tubal or uterine disease, and abnormalities of the cervical mucus. Other possible cau...Fri, 24 Feb 2017 08:00:04 GMTJHTT-Communications@jhu.edu Multispectral Illumination System for Surgery and Visualization of Light-sensitive Tissues observation system for viewing light-sensitive tissue includes an illumination system configured to illuminate the light-sensitive tissue, an imaging system configured to image at least a portion of the light-sensitive tissue upon being illuminated by the illumination system, and an image display system in communication with the imaging system to display an image of the portion of the light-sensitive tissue. The illumination system is configured to illuminate the light-sensitive tissue with a reduced amount of light within a preselected wavelength range compared to multispectral illuminatio...Fri, 24 Feb 2017 07:59:51 GMTJHTT-Communications@jhu.edu Profiling Reveals Dynamic Changes in the Expression of miR-31 During IBD-associated Neoplastic Transformation          Novel MicroRNA Diagnostic for IBD-associated Colorectal CancerCASE NUMBER:    C10775 UNMET NEEDChronic idiopathic inflammatory bowel disease (IBD) predisposes to the development of colorectal carcinoma. Current preventive measures to diminish colorectal cancer mortality in IBD patients consist of periodic surveillance colonoscopies with random biopsies combined with total colectomy if dysplasia or neoplasia are found. However, challenges regarding management and early detection of IBD-associated neoplasia (IBDN) still remain. Precancerous dysplastic lesions still escape detecti...Fri, 24 Feb 2017 07:59:47 GMTJHTT-Communications@jhu.edu Metal Catalysts for Oxygen Reduction porous metal that comprises platinum and has a specific surface area that is greater than 5 m2/g and less than 75 m2/g. A fuel cell includes a first electrode, a second electrode spaced apart from the first electrode, and an electrolyte arranged between the first and the second electrodes. At least one of the first and second electrodes is coated with a porous metal catalyst for oxygen reduction, and the porous metal catalyst comprises platinum and has a specific surface area that is greater than 5 m2/g and less than 75 m2/g. A method of producing a porous metal according to an embodiment of...Fri, 24 Feb 2017 07:59:44 GMTJHTT-Communications@jhu.edu Multilayer 3D Scaffold Consisting of Highly Aligned Electrospun Fibers for Neuronal Regeneration Applications Implantable Multilayer 3D Scaffold for Neuronal Regeneration ApplicationsValue Proposition:The multilayer 3D conduit is a superior candidate for nerve repair and clinical regeneration applications.• The novel wall structure made of double-sided fibers increases the opportunities for cell migration so that more cells populate the regenerating tissue faster in order to restore functional recovery more quickly and facilitate a faster healing response.• This 3D scaffold is composed of one biocompatible, FDA-approved polymer, which makes it considerably easier to fabricate than co-polymer c...Fri, 24 Feb 2017 07:59:31 GMTJHTT-Communications@jhu.edu Workplace Software Application Program 2.0 Workplace Software Application Program 2.0JHU REF: C10683  Invention Novelty: This software is a therapeutic workplace for the treatment of drug addiction using employment-based reinforcement. Value Proposition: Many drug addiction treatment programs are ineffective because they do not provide adequate incentives for the users to stay. This invention is an effective treatment using employment-based reinforcement of therapeutic behavior change. This intervention software has two major phases of treatment: the Therapeutic Learning Center and the Therapeutic Workplace.  Advantages of ...Fri, 24 Feb 2017 07:59:20 GMTJHTT-Communications@jhu.edu Solution for High-throughput, Droplet-based Single Molecule Analysis with Low Reagent Consumption microfluidic device for a confocal fluorescence detection system has an input channel defined by a body of the microfluidic device, a sample concentration section defined by the body of the microfluidic device and in fluid connection with the input channel, a mixing section defined by the body of the microfluidic device and in fluid connection with the concentration section, and a detection region that is at least partially transparent to illumination light of the confocal fluorescence detection system and at least partially transparent to fluorescent light when emitted from a sample under o...Fri, 24 Feb 2017 07:59:14 GMTJHTT-Communications@jhu.edu of Active Purified PiggyBac Transposase Genome Mutagenesis using Active Purified PiggyBac TransposaseJHU REF: C10599  Invention novelty: A novel purified piggyBac transposase active in mammalian cells useful for an accurate, efficient transposon-mediated mutagenesis.  Value Proposition: Transposons have proven a powerful tool for genome engineering by insertional mutagenesis and transgenesis. However, their application is limited by the often-inaccurate cut and paste transposition, resulting in DNA duplications at the excision and target site, and the unavailability of active purified transposases, and there is great demand...Fri, 24 Feb 2017 07:58:56 GMTJHTT-Communications@jhu.edu Method and Applications of Multiply Bent Carbon Nanotubes with Tunable Optical Properties method of producing carbon nanotubes includes directing a flow of a gas over a substrate to provide growth of at least one carbon nanotube in a carbon-nanotube-growth region of the substrate; applying an electric field to the carbon-nanotube-growth region of the substrate after the at least one carbon nanotube has begun to grow in the carbon-nanotube-growth region, the electric field being substantially in a first direction in the carbon-nanotube-growth region; and changing the electric field at a preselected time to be substantially in a second direction in the carbon-nanotube-growth region...Fri, 24 Feb 2017 07:58:29 GMTJHTT-Communications@jhu.edu Submicron CMOS Single-photon Detector Pixel Designs for Large Monolithic Arrays avalanche photodiode is disclosed. The avalanche photodiode includes a substrate of a first conductivity type. A first well of a second conductivity type is formed within the substrate. A second well of the second conductivity type is formed substantially overlying and extending into the first well. A heavily doped region of the first conductivity type is formed substantially overlying and extending into the first well, the junction between the heavily doped region and the second well forming an avalanche multiplication region. A guard ring is formed from a first conductivity material posit...Fri, 24 Feb 2017 07:56:13 GMTJHTT-Communications@jhu.edu Antibodies Against Leukocyte Adhesion Receptor Beta-Chain, Methods of Producing These Antibodies and Use Therefore Antibody for Treatment and Diagnosis of AIDSJHU REF: [C09214]   Invention Novelty: This technology is a novel monoclonal antibody specific against an epitope that suppresses immune response mediated diseases such as AIDS. Value Proposition: Acquired immunodeficiency syndrome (AIDS) is a fatal, incurable disease characterized by profound immunosuppression, opportunistic infection and neuropathies. Current therapies in controlling the AIDS and other immune response mediated diseases are limited in their effectiveness and often times have severe contraindications and side effects. Th...Fri, 24 Feb 2017 07:51:34 GMTJHTT-Communications@jhu.edu Specific Absorption Rate (SAR) Dosimeter for RF Power Deposition in MRI is a dosimeter device that measures SAR deposited by RF power deposition during MRI of a specimen. Such a dosimeter device includes a transducer that is configured to present a load to the MRI scanner in which the transducer is located and to provide an output representative of signals induced in the transducer. The transducer also is configured so that the presented load is substantially equivalent to another load which would be presented by the specimen during MRI of the specimen. Such a transducer also is configured so as to generate an MRI signal that is sufficient to allow the MR...Fri, 24 Feb 2017 07:51:05 GMTJHTT-Communications@jhu.edu Dose-rate Method For Prescribing Radioiodine Treatment In Thyroid Cancer Patients With Lung Metastases NEED Radiopharmaceutical therapy (RPT) is an emerging cancer treatment modality in which tumor-targeting molecules are used to deliver radioactive atoms thereby irradiating tumors preferentially over normal organs. Therefore, precision medicine dosimetry is required so that patients are administered the appropriate amount of the RPT for safe and effective treatment. PROBLEM SOLVED Dosimetry is required by the FDA as part of phase 1 dose escalation studies. Dosimetry data that is trusted by the FDA is essential in securing rapid regulatory approval. This group’s software reduces time t...Fri, 24 Feb 2017 07:50:30 GMTJHTT-Communications@jhu.edu of Stem Cells From Adult Human Pancreas presence of the cell surface marker CD133 or the presence of a glycosylated form of the prominin-1 gene product on adult pancreatic cells is used to identify pancreatic endocrine progenitor cells, and useful in methods of isolation and enrichment. Isolated pancreatic endocrine progenitor cells can be used for cell based therapy for insulin-dependent diabetes and pancreatectomy patients.Fri, 24 Feb 2017 07:50:29 GMTJHTT-Communications@jhu.edu Metastasis-associated Genes As Novel Diagnostic and Prognostic Markers and Therapeutic Targets For Melanoma and prognostic biomarkers and therapeutic targets for melanoma. Technology Overview JHU researchers have identified the protein Neuropilin-2 (NRP2) as a novel biomarker for the early detection of pre-metastatic melanomas allowing the ability to identify and treat the cancer before it enters the metastatic phase. NRP2 is also a therapeutic target that can be used to develop treatments to prevent the transition to metastatic melanoma and reduce mortality rates. ApplicationsThis biomarker can be used to develop assays for detecting pre-metastatic melanoma and developing new therap...Fri, 24 Feb 2017 07:50:25 GMTJHTT-Communications@jhu.edu for the Passage of Human Embryonic Stem Cells, devices and kits are provided for isolating or enriching multicellular embryonic stem (ES) cell colonies from a mixture of multicellular ES cell colonies and single ES cells present in a cellular suspension, by utilizing a filtration matrix that selectively excludes passage of multicellular ES cell colonies. Isolated or enriched multicellular ES cell colonies can be used for propagating pluripotent ES cells.Fri, 24 Feb 2017 07:50:18 GMTJHTT-Communications@jhu.edu Novel Diagnostic and Prognostic Markers and Therapeutic Targets for Melanoma present invention relates to methods of determining melanoma status in a subject. The invention also relates to kits for determining melanoma status in a subject. The invention further relates to methods of identifying biomarkers and correlating biomarker expression to melanoma status or stage in a subject.Fri, 24 Feb 2017 07:50:05 GMTJHTT-Communications@jhu.edu Proteins from Human Embryonic Germ (EG) Cell Derivatives for deriving and cultivating human embryonic stem (ES) cells and maintaining their pluripotency in culture is provided by utilizing secreted products obtained from the culture medium of human embryonic gem (EG) cell derivatives, such as embryoid body-derived cells. Substrates include compounds such as collagen I, fibronectin, or superfibronectin, or extracellular matrix, typically human derived.Fri, 24 Feb 2017 07:50:04 GMTJHTT-Communications@jhu.edu Bacteria with Light-emitting Substrates of Thymidine Kinase instant invention provides a method for diagnosing an infection in a subject by administering to the subject a compound suitable for imaging which binds to a thymidine kinase present in the infecting organism, and obtaining an image of the subject to determine the presence and location of the compound, wherein a localization of the compound is indicative that the subject has an infection.Fri, 24 Feb 2017 07:47:44 GMTJHTT-Communications@jhu.edu Packaging Cell Line For Diphtheria Toxin Expressing Non-replicating Adenovirus invention provides a packaging cell line for production of diphtheria toxin (DT) expressing, non-replicating adenovirus for use in suicide gene therapy of cancer cells, as well as production of immunotoxins. Also provided are methods for producing diphtheria toxin (DT) expressing, non-replicating adenovirus, methods for producing immunotoxins, and adenovirus and immunotoxins produced by those methods. Further provided are methods for making a cell resistant to diphtheria toxin.   Fri, 24 Feb 2017 07:45:40 GMTJHTT-Communications@jhu.edu Responsible for Stargardt-like Dominant Macular Dystrophy gene responsible for Stargardt-like macular dystrophy has been identified, along with its normal allelic form. The mutant gene encodes a mutant protein containing a frameshift mutation, resulting in abnormal fatty acid synthesis and transport in the retina. Also disclosed are assays for Stargardt-like macular dystrophy and therapies.Fri, 24 Feb 2017 07:44:08 GMTJHTT-Communications@jhu.edu as a Target of c-MYC prototypic oncogene c-MYC encodes a transcription factor, which can drive proliferation by promoting cell cycle re-entry. However, the mechanisms through which c-MYC achieves these effects have been unclear. Using serial analysis of gene expression (SAGE), we have identified the cyclin dependent kinase 4 (CDK4) gene as a transcriptional target of c-MYC. c-MYC induced a rapid increase in CDK4 mRNA levels through four highly conserved c-Myc binding sites (MBS) within the CDK4 promoter. Cell cycle progression is delayed in c-MYC-deficient RAT1 cells, and this delay was associated with a defec...Fri, 24 Feb 2017 07:43:40 GMTJHTT-Communications@jhu.edu CDX2, a homeobox gene, has been identified as a downstream effector of tumor suppressor APC. APC induces the transcription of CDX2. This newly found relationship permits specific drug screening assays as well as therapeutic and diagnostic methods.Fri, 24 Feb 2017 07:43:17 GMTJHTT-Communications@jhu.edu Roles of Cholesterol in Hedgehog Protein Biogenesis and Signaling present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport in a cell comprising contacting a cell with an effective amount of a compound that affects hedgehog, thereby affecting cholesterol biosynthesis or transport. The effect may be inhibition or stimulation of cholesterol biosynthesis or transport. ...Fri, 24 Feb 2017 07:42:41 GMTJHTT-Communications@jhu.edu Authenticated Dictionaries with Skip Lists and Commutative Hashing efficient and practical method for dynamically maintaining an authenticated dictionary uses a skip list data structure and communicative hash functions to provide a dictionary database (201) that stores information objects so that any individual object can be authenticated as belonging or not belonging to the dictionary. The authentication consists of a short sequence of vales that begin with an element and a sequence of values that, when hashed in order using a cryptographic associative hash function, create the same value as the hashed digest of the entire dictionary. Rather than hashing ...Fri, 24 Feb 2017 07:40:00 GMTJHTT-Communications@jhu.edu Domains in Flavobacterium Okeanokoites (FOKI) Restriction Endonuclease present inventors have identified the recognition and cleavage domains of the FokI restriction endonuclease. Accordingly, the present invention relates to the DNA segments encoding the recognition and cleavage domains of the Fold restriction endonuclease, respectively. The 41 kDa N-terminal fragment constitutes the FokI recognition domain while the 25 kDa C-terminal fragment constitutes the FokI cleavage nuclease domain. The present invention also relates to hybrid restriction enzymes comprising the nuclease domain of the FokI restriction endonuclease linked to a recognition domain of anot...Fri, 24 Feb 2017 07:39:14 GMTJHTT-Communications@jhu.edu of Endogenous Anti-tumor Autoantibodies to Target Surface Tumor Antigens via Low-dose P4N NOVELTYThis invention provides a novel mechanism of improving the immune response to cancer by increasing the production of endogenous anti-tumor antibodies via treatment with the nordihydroguaiaretic acid (NDGA) derivative P4N. VALUE PROPOSITIONGenetic events involved in cancer development lead to the generation of tumor-specific antigens, against which patients develop anti-tumor antibodies. At endogenous levels, the efficacy of these antibodies in tumor elimination are generally minimal.  This technology utilizes low-dose P4N, a derivative of nordihydroguaiaretic acid (NDGA), as a...Fri, 24 Feb 2017 07:27:51 GMTJHTT-Communications@jhu.edu of Blood Volume using Velocity-Selective Pulse Trains on MRI NOVELTY A novel velocity-selective inversion pulse sequence that can be used for MR angiography applications. VALUE PROPOSITION There is a growing demand for high–performance imaging that is beneficial in cases where 1.5 Tesla does not work well enough, such as scanning for developmental abnormalities or performing high–resolution MR angiography, diffusion or perfusion imaging. There is a need for techniques to work with higher signal to noise ratio (SNR). With a three– to four–fold higher SNR, 3–tesla MRI more precisely localizes areas of activation, enabling accurate mapping of ...Fri, 24 Feb 2017 07:27:50 GMTJHTT-Communications@jhu.edu Augmented Reality for Medical Interventions NEED The standard techniques for many orthopedic surgical operations often become a high risk, expensive procedure that rely on the ability of a surgeon to mentally reconstruct computed tomography (CT) images and co-register these images with the patient’s 3-D anatomy intraoperatively. This typically requires multiple X-ray images at several orientations of the CT mounted C-arm; subjecting the patient to significant radiation exposure, extended time under anesthesia, and increased operating room costs. TECHNICAL DESCRIPTION 3-D augmented reality technology allows intuitive real-time o...Fri, 24 Feb 2017 07:27:49 GMTJHTT-Communications@jhu.edu AND DEVICE FOR SELECTIVE TREATMENT INSIDE BODY LUMEN NOVELTY A flexible renal denervation ablation device with sensitive multi-electrode system to selectively regulate electrical delivery to nerves, minimize vessel damage, and treat complex hypertensive patients VALUE PROPOSTITION The unwanted side effects of antihypertensive medications have stimulated exploration of alternative treatment modalities, in particular for the growing number of patients with resistant hypertension. Renal denervation serves as a solution due to reported significant decreases in blood pressure observed in patients; however this procedure may not be a solu...Fri, 24 Feb 2017 07:27:48 GMTJHTT-Communications@jhu.edu Inhibitor Discovery and Nanoparticle-Enhanced Delivery for Cancer Therapy Inhibitor Discovery and Nanoparticle-Enhanced Delivery for cancer therapyJHU REF: C13142 Invention novelty: An improved glutaminase (GLS) inhibitors delivery system to enhance efficacy and prolong glutaminase inhibitor drug levels in tumor for improve treatment of pancreatic cancer. Value Proposition: Currently available glutaminase inhibitors are generally poorly soluble, metabolically unstable, and/or require high doses, which together reduce their efficacy and therapeutic index. Johns Hopkins researchers have developed more potent inhibitors and tumor-penetrating stealth nanopar...Fri, 24 Feb 2017 07:27:33 GMTJHTT-Communications@jhu.edu - Hopkins Policies Online, 24 Feb 2017 07:27:30 GMTJHTT-Communications@jhu.edu of Murine Ovarian Cancer Cell Line Suitable for Non-Invasive Imaging Murine Ovarian Cancer Cell LineJHU REF: [C12340]Invention novelty: This tangible material is a transgenic murine ovarian cancer cell line expressing luciferase for non-invasive monitoring of tumor load in a mouse bearing this cell line.  Value Proposition: There is a need for cancer cell lines that can be monitored/detected non-invasively. This cell line provides such a tool that can be used to develop and evaluate treatment strategies for ovarian cancer. These cell lines can be used to test effectiveness of DNA vaccines and drugs that target ovarian cancer. Other advantages include:...Fri, 24 Feb 2017 07:27:24 GMTJHTT-Communications@jhu.edu Assays For a Polymorphism in the SCARB1 Gene That Affects Expression and Function of the Receptor, 24 Feb 2017 07:27:05 GMTJHTT-Communications@jhu.edu Diagnosis in Urine invention relates to assays for a Plasmodium analyte in a liquid sample such as a body fluid. More particularly, the invention relates to a method and apparatus for the detection of a ligand in a body fluid such as urine or blood, which can diagnose malarial infection.Fri, 24 Feb 2017 07:27:00 GMTJHTT-Communications@jhu.edu Novel Rapid Quantitative Assay for the Simultaneous Detection of Microbial Infection and Speciation    An adaptation of the real-time PCR assay allows for highly sensitive detection of any eubacterial species with simultaneous speciation. The assay relies on a ?multiprobe? design in which a single set of highly conserved sequences encoded by the 16S rRNA gene serves as the primer pair, and it is used in combination with both an internal highly conserved sequence, the universal probe, and an internal variable region, the species-specific probe. A pre-PCR ultrafiltration step can be used to effectively decontaminate or remove background DNA. The real-time system reliably identifies 14 com...Fri, 24 Feb 2017 07:26:54 GMTJHTT-Communications@jhu.edu Complexes Mediate APC-Tumor Suppression, 24 Feb 2017 07:26:51 GMTJHTT-Communications@jhu.edu Inhibitor of Programmed Cell Death is the fundamental cellular process for the self-destruction of cells. Modulation of cell survival is essential to tissue development and homeostasis with aberrations of this process accounting for many pathological conditions such as cancer. Apoptosis is a complex, multi-step event involving proteins that both inhibit and initiate cell death. Inhibition of apoptosis primarily has been attributed to proteins of the Bcl-2 family; however, the exact mechanisms by which these proteins inhibit cell death remain unknown. Recently, a new class of anti-apoptotic factors has been identified....Fri, 24 Feb 2017 07:26:49 GMTJHTT-Communications@jhu.edu DNA Methylation Markers To Create a Molecular Staging Paradigm for Solid Malignancies and To Predict Cancer Recurrence and Patient Survival  Currently, cancer recurrence in solid malignancies occurs in many patients after complete curative surgery despite no additional histological evidence of remaining cancer outside the area of resection, especially in the surrounding lymph nodes.  It is believed that in patients with recurrent disease, micrometastases reside that are undetectable upon microscopic examination.  To address these shortfalls in cancer staging, scientists at The Johns Hopkins University devised a novel paradigm of molecular tumor grading using hypermethylation markers.  The methodology utilizes methylati...Sat, 18 Feb 2017 17:06:31 GMTJHTT-Communications@jhu.edu Non-invasive Cancer Diagnostic Using Mitochondrial Mutations mutations occur as a product of contact of a person with an environmental pollutant. Mitochondrial mutations are readily detectable in body fluids. Measurement of mitochondrial mutations in body fluids can be used as a dosimeter to monitor exposure to the environmental pollutant. Mitochondrial mutations can also be detected in cancer patients. Probes and primers containing mutant mitochondrial sequences can be used to monitor patient condition.Sat, 18 Feb 2017 16:54:03 GMTJHTT-Communications@jhu.edu Nanomaterials for Directed Energy Transport disclose a peptide-based nanomaterial platform that is capable of supporting energy transport processes broadly defined, where such energy transport can be photonic or electrical in nature, and where such excitation can perturb or stimulate material associated with the nanomaterial.  We have developed heterostructure nanomaterials with energy donor and energy acceptor units that show the photonic transfer of energy to the acceptor units or the photo-induced separation of charge, thus serving as a way to funnel excitation energy to specific sites or otherwise create localized electric fields...Fri, 17 Feb 2017 10:13:20 GMTJHTT-Communications@jhu.edu Clone 299-2 HRPII 3A4 Producing Monoclonal Antibody to Pfalciparum Histidine Rich Protein 2 or Monoclonal Antibody Purified from same Hybridoma, 17 Feb 2017 08:42:20 GMTJHTT-Communications@jhu.edu Method for Late Introduction of the (8R)-Hydroxyl Group in Carbapenem beta-Lactam Antibiotic Synthesis Enzymes and Methods for Improved Syntheses of Carbapenem Beta-Lactam AntibioticsValue Proposition:• Regio- and stereospecific introduction of the (8R)-hydroxyl group late in a chemoenzymatic production process• Simpler, more chemically robust starting materials can be used from the outset allowing more vigorous reaction conditions in subsequent steps• Simpler, cheaper, and more robust routs of syntheses of carbapenem Beta-lactam antibiotics.Technical Details:BackgroundCarbapenem antibiotics are highly potent, broad spectrum compounds that are resistant to most Beta-lactamases. Their sa...Fri, 17 Feb 2017 08:03:52 GMTJHTT-Communications@jhu.edu and Amorphous pi-electron-dense Conjugated Organic Polymers for Energy and Electronic Applications disclose a novel approach to achieve solubility of pi-conjugated organic electronic materials in commonly used processing solvents without the need for electronically inert substituents commonly used to render these materials soluble.  Furthermore, the materials in the solid-state are completely amorphous and will thus minimize crystallinity within the semiconductor active layer, which is clearly beneficial for some technologies, and is emerging as an important aspect in others.  Our design is based upon an unusual pi-electron building block that we have shown previously to be comparable in...Fri, 17 Feb 2017 07:10:02 GMTJHTT-Communications@jhu.edu Neo Mouse Line (also called Pkd2cond mutant) Mouse Model of Polycystic Kidney Disease (PKD2Cond)JHU REF: C11721Material available at Jackson Laboratory ( No: 017292 - B6.129X1(Cg)-Pkd2tm1.1Tjwt/JInvention novelty:  This tangible material is a transgenic mouse strain with a mutant Pkd2 (Polycystic Kidney Disease 2) gene.  This Pkd2 conditional mouse model may be used to investigate the role and function of the Pkd2 gene which is responsible for many cases of autosomal dominant polycystic kidney disease cases.Value Proposition:  Autosomal Dominant Polycystic kidney disease (ADPKD) is the most common of all the ...Fri, 17 Feb 2017 06:43:56 GMTJHTT-Communications@jhu.edu Engineered Mice researchers have constructed a wide variety of genetically engineered mice that are useful for research. FEATURESThe collection includes gene knockout mice and a variety of fluorescent reporter mice. It allows an investigator to monitor the effect of gene knock out or the results of selective expression of reporters in defined cells/tissues. STAGE OF DEVELOPMENTThe mouse are at Jackson labs for distribution. They are: 023841 B6;129-Iis1tm9(CAG-Bgeo,-Fzd3)Nat/J 023842 STOCK Fzd3tm2.1Nat/J 023843 B6;129-Gt(ROSA)26Sortm6(Fzd6)Nat/J 023844 B6;129-Lis1tm10(Fzd6)Nat/J DISEASE IND...Wed, 15 Feb 2017 09:42:40 GMTJHTT-Communications@jhu.edu REDUCE SICKLE HEMOGLOBIN POLYMERIZATION RED CELLS, IRON, AND ERYTHROPOIESIS pathophysiology of sickle cell disease (SCD) is dependent on the polymerization of deoxygenated sickle hemoglobin (HbS), leading to erythrocyte deformation (sickling) and vaso-occlusion within the microvasculature.  Following deoxygenation, there is a delay time before polymerization is initiated, during which nucleation of HbS monomers occurs.  An agent with the ability to extend this delay time or slow polymerization would therefore hold therapeutic, possibly curative, potential.  We used the SELEX method to screen for HbS-binding RNA aptamers modified with nuclease-resistant 2’-fluoro p...Wed, 15 Feb 2017 08:20:59 GMTJHTT-Communications@jhu.edu Triazole Compounds to Treat Nav1.6-related Brain Disorders NeedAbnormal behavior of sodium (Nav) channels is linked to a variety of epilepsy syndromes, movement disorders, and neuropathic pain. While researchers continue to elucidate the roles of different Nav channel isoforms within a variety of neurological disorders, current therapeutics influence numerous Nav channel isoforms, resulting in off-target side effects. Development of therapeutic compounds capable of targeting specific Nav channel isoforms is important for treatment of Nav-associated disorders. Technology OverviewThis inventor identified strongly anti-epileptic triazole-derived co...Wed, 15 Feb 2017 08:19:25 GMTJHTT-Communications@jhu.edu Triazole Compounds to Treat Brain Disorders NeedAbnormal behavior of sodium (Nav) channels is linked to a variety of epilepsy syndromes, movement disorders, and neuropathic pain. While researchers continue to elucidate the roles of different Nav channel isoforms within a variety of neurological disorders, current therapeutics influence numerous Nav channel isoforms, resulting in off-target side effects. Development of therapeutic compounds capable of targeting specific Nav channel isoforms is important for treatment of Nav-associated disorders. Technology OverviewThis inventor identified strongly anti-epileptic triazole-derived co...Wed, 15 Feb 2017 08:19:25 GMTJHTT-Communications@jhu.edu of the 6-Diazo-5-oxo-L-norleucine (DON) and other glutamine antagonists is a glutamine antagonist that is actively used in preclinical models of immunology, cancer and neurodegenerative disease.  There have been several clinical trials using DON to treat a variety of cancers. Currently there is a possibility DON, DON prodrug or analogs could be used again in the clinic. Unfortunately, DON is a polar unstable molecule which has made quantification in biological matrices challenging. We have developed and characterized a bioanalytical method to quantify DON in tissue samples that could be implemented for use in both preclinical and clinical work.  The bioanalysi...Wed, 15 Feb 2017 08:18:36 GMTJHTT-Communications@jhu.edu Surface Plasmon Resonance Approach to Monitor Animal Toxin Interactions with Isolated Voltage-gated Sodium Channel Paddle Motifs and the Use Thereof toxins that inhibit voltage-gated sodium (Nav) channel fast inactivation can do so through an interaction with the S3b-S4 helix-turn-helix motif, or paddle motif, located in the domain IV voltage sensor. Here, we show that the domain IV paddle can be lifted out of the Nav channel and immobilized on sensor chips. Subsequent Surface Plasmon Resonance (SPR) experiments suggest that this motif retains its susceptibility to animal toxins that target the domain IV voltage sensor. As such, our results reveal the inherent pharmacological sensitivities of the isolated paddle motif which may be e...Wed, 15 Feb 2017 08:17:35 GMTJHTT-Communications@jhu.edu and Knock-in Mouse Lines, 08 Feb 2017 11:33:25 GMTJHTT-Communications@jhu.edu REFERENCING METHOD FOR CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) MRI. Need: Chemical exchange saturation transfer (CEST) imaging is a relatively new contrast mechanism for MRI exploiting exchange-based magnetization transfer (MT) between solute and water protons. Although it has huge potential for developing noninvasive agents for cell labeling and other applications, when applying the method in vivo or even in phantoms, often results in regions of artifactual intensities. This is due to the fact that CEST images depend on exact knowledge of the water resonance frequency in each image volume element (voxel) and are extremely sensitive to magnetic inhomogen...Fri, 27 Jan 2017 13:12:32 GMTJHTT-Communications@jhu.edu Nanoparticles as Cancer Vaccines and Biomimetic Delivery Systems Proposition: Nanoparticles (NPs) have gained increasing attention and popularity for their ability to deliver pharmaceutical or imaging agents to the tumor site for targeted cancer treatment and therapeutic monitoring. Yet, toxicity and reproducibility of the NPs remain challenges that limit their clinical utility. Disclosed herein is a novel approach of generating cancer cell plasma membrane-coated polymeric NPs and their use as personalized cancer vaccines and biomimetic delivery systems. Advantages include: Replicates the complex surface of cancer cell surface plasma membrane profile...Thu, 26 Jan 2017 08:57:11 GMTJHTT-Communications@jhu.edu Mice, 24 Jan 2017 05:56:14 GMTJHTT-Communications@jhu.edu Polymerase Beta Inhibitors, 23 Jan 2017 20:47:47 GMTJHTT-Communications@jhu.edu hprt-null, NOG hprt-null mice, 18 Jan 2017 12:03:06 GMTJHTT-Communications@jhu.edu for Inhibition of Human Cytomegalovirus (HCMV) NEED: Infection with human cytomegalovirus (HCMV) continues to be a major threat for pregnant women and immunocompromised hosts. Although anti-HCMV therapies are available, development of new agents are desired because of the limited drugs approved for HCMV, the side effects associated with them, and the emergence of resistant viral mutants during therapy. TECHNICAL DETAILS: Through screening of the LOPAC library, we identified emetine as HCMV inhibitor. Studies in the JHU researchers lab revealed that the EC50 of Emetine is 40 nM and its CC50 is 8 uM, resulting is selectivity index of 2...Wed, 11 Jan 2017 10:48:31 GMTJHTT-Communications@jhu.edu microgenerator using recycled 227Ac from a 225Ac cyclotron-produced source, 05 Jan 2017 13:04:20 GMTJHTT-Communications@jhu.edu A Mouse Model of Hemophilia A, 21 Dec 2016 08:17:49 GMTJHTT-Communications@jhu.edu of Human Cell Lines with Inactivated GLUT1 Genes, 21 Dec 2016 05:33:33 GMTJHTT-Communications@jhu.edu to Screen for Small Molecules that Suppress CUG RNA-induced Neurotoxicity, 21 Dec 2016 05:20:27 GMTJHTT-Communications@jhu.edu (MY-31) Hybridoma (MY-31) CASE NUMBER C09194 DESCRIPTION CD56, clone MY31, is derived by immunizing (C57BL/6 x BALB/c) F1 mice with the KG1a cell line and fusing the immune splenocytes with the SP2/0 myeloma cell line. CD56 recognizes an antigen present on natural killer (NK) lymphocytes. PUBLICATION Lanier, L.L., Le, A.M., Civin, C.I., Loken, M.R., Phillips, J.H. The Relationship of CD16 (Leu 11) and Leu 19 (NKH–1) Antigen Expression on Human Peripheral Blood NK Cells and Cytotoxic T Lymphocytes. J Immunol 136:4480–4486, 1986Mon, 19 Dec 2016 13:17:15 GMTJHTT-Communications@jhu.edu and Immune Cell Imaging based on PD-L1 Expression, 05 Dec 2016 11:32:35 GMTJHTT-Communications@jhu.edu Cell Lines, 05 Dec 2016 10:10:22 GMTJHTT-Communications@jhu.edu of a Novel Antibody to the Estrogen Receptor Beta (ERbeta), 05 Dec 2016 09:29:01 GMTJHTT-Communications@jhu.edu Adduct-specific Anti-thymidylate Synthase Antibody for Monitoring Fluorouracil Anticancer Therapy, 05 Dec 2016 08:44:30 GMTJHTT-Communications@jhu.edu AGENTS TARGETING CANCER STEM CELLS, 13 Nov 2016 17:00:15 GMTJHTT-Communications@jhu.edu B6129(SJL)-Grip1-tm1Rlh, 024415 B6.129S6(Cg)-Wwc1-tm1.1Rlh, 024417 B6.129S6(SJL)-Prkcz-tm1.1Rlh, 024418 B6.129S6-Gria1-tm7Rlh, 024419 B6.129(Cg)-Gria2-tm2Rlh, 024420 B6.129(Cg)-Gria1-tm4Rlh, 08 Nov 2016 07:08:56 GMTJHTT-Communications@jhu.edu Lines Carrying Mutations in Genes of Interest, 08 Nov 2016 06:29:04 GMTJHTT-Communications@jhu.edu Plasmids for Mutating Genes, 08 Nov 2016 06:00:43 GMTJHTT-Communications@jhu.edu plasmid (Chimeric MLV/HIV-Gag) aka pSR389, 08 Nov 2016 05:48:13 GMTJHTT-Communications@jhu.edu 1 Mutant Mice (W1572C Mutant Strain) and (D1545E Mutant Strain), 08 Nov 2016 05:12:39 GMTJHTT-Communications@jhu.edu Papillomavirus Virus-like-participle Protein, 07 Nov 2016 08:32:31 GMTJHTT-Communications@jhu.edu, RL1, RL13, RL2 Monoclonal Antibodies, 07 Nov 2016 08:06:25 GMTJHTT-Communications@jhu.edu 20 Wildtype Control Knock in MCF-10A Cells Exon 20 Wildtype Control Knock in MCF-10A Cells DESCRIPTION A human breast epithelial cell line (MCF-10A) with gene targeting resulting in no change in the PIK3CA gene after homologous recombination, (wildtype control). TANGIBLE MATERIAL: Human PIK3CA (H1047R/+) MCF10A Cell Line ASSOCIATED INSTITUTION Oncology, School of Medicine PI: Ben Ho Park, MD, PhD ASSOCIATED PUBLICATION: Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8): 2835–2840  Mon, 07 Nov 2016 07:50:45 GMTJHTT-Communications@jhu.edu Enteroids Novelty: This invention establishes human enteroids as nontransformed cell culture models to understand human intestinal physiology and pathophysiology and the epithelial response, including host restriction, cell type restriction, and virus-induced fluid secretion.   Value Proposition: Johns Hopkins researchers have developed novel, cellularly diverse, and physiologically relevant epithelial cell cultures that recapitulate in vivo properties of gastrointestinal infections and allow the study of early molecular events during gastrointestinal infections. Additionally, drug the...Mon, 07 Nov 2016 06:19:43 GMTJHTT-Communications@jhu.edu Mesothelin Expressing ID8-Defb29 Vegf /luc (ID8-Defb29 Vegf-luc/Hmeso) immunotherapy targeting mesothelin represents a potentially plausible approach for the control of ovarian cancer as most ovarian cancers express high levels of mesothelin. In the current study, JHU researchers created a mesothelin-positive luciferase-expressing ovarian cancer model, ID8-Defb29 Vegf /luc. ID8-Defb29 Vegf ?luc was infected by retrovirus encoding human mesothelin. ID8-Defb29 Vegf-luc/Hmeso was isolated by preparative flow cytometry of stained cells with human mesothelin antibody. FEATURESThe ID8-Defb29 Vegf -luc cell line is generated by infecting the ID8-Defb29 Ve...Mon, 07 Nov 2016 06:11:34 GMTJHTT-Communications@jhu.edu TC-1 Tumor Cells (TC-1/luc) Cell Line of the major limitations to ovarian cancer immunotherapy is the difficulty of generating ovarian cancer mouse models. Without suitable ovarian cancer models in immune intact mice, it will be difficult to test new therapies for ovarian cancers.Firefly luciferase-expressing TC-1 cells (TC-1-Luc) was generated by JHU researchers with retrovirus carrying the luciferase gene. The retrovirus was produced with a pLuci-thy1.1construct expressing both luciferase and thy1.1. pLuci-thy1.1 was transfected into the Phoenix packaging cell line and the virion-containing supernatant was immediatel...Mon, 07 Nov 2016 06:06:39 GMTJHTT-Communications@jhu.edu Signaling Mice, 04 Nov 2016 10:18:17 GMTJHTT-Communications@jhu.edu Analysis of Non-amplified/overexpressed HER2 L869R Heterozygous in Human Somatic Breast Cells, 04 Nov 2016 06:57:34 GMTJHTT-Communications@jhu.edu Diagnostic Method for Retinal Examinations in Children, 31 Oct 2016 09:41:54 GMTJHTT-Communications@jhu.edu retinal-based eye tracking technology, 31 Oct 2016 09:39:26 GMTJHTT-Communications@jhu.edu Device and Method to Detect Strabismus and Lazy Eye in Children, 31 Oct 2016 09:37:18 GMTJHTT-Communications@jhu.edu Alignment Monitor and Method, 31 Oct 2016 08:49:55 GMTJHTT-Communications@jhu.edu THERAPY TARGETING NOVEL TARGET, 28 Oct 2016 12:45:09 GMTJHTT-Communications@jhu.edu inhibitors of DXP synthase as anti-infective drugs novelty:  novel class of chemical inhibitors targeting DXP synthase with increased selectivity to pathogens Value Proposition: Development of anti-infectives has direct impact on infectious diseases such as malaria and tuberculosis. The long term goal is to develop novel, potent and broad-based anti-microbial agents that also exhibit limited toxicity to the human host. This technology is focused on a novel class of chemical inhibitors, which exhibit chemistry that is unique to DXP synthase, a potentially promising yet insufficiently explored drug target. The group of inhibitors synth...Fri, 28 Oct 2016 12:43:39 GMTJHTT-Communications@jhu.edu Microarray for Diagnosis of Cancer, 28 Oct 2016 12:40:04 GMTJHTT-Communications@jhu.edu rRNA Amplicon Sequences Associated with Oral Cancer and HPV Infection, 28 Oct 2016 12:34:47 GMTJHTT-Communications@jhu.edu silencing technology for the treatment of triple negative breast cancer Novelty: The given invention proposes an efficient technology for the treatment of triple negative breast cancer Value Proposition: Often associated with rapid progression and poor outcomes, Triple Negative Breast Cancer (TNBC) refers to any breast cancer that does not express the genes for estrogen receptor (ER), progesterone receptor (PR) and Her2/neu and accounts for about 15-20% of all breast cancer cases. Moreover, TNBC patients have a higher rate if distant recurrence and a poorer prognosis than women with other breast cancer subtypes. Currently immunotherapy, radiation therapy...Fri, 28 Oct 2016 12:28:39 GMTJHTT-Communications@jhu.edu of DNA Vaccines with DNA Encoding Ii-PADRE Generates Potent PADRE-specific CD4+ T-cell Immune Responses and Enhances Vaccine Potency Administration of DNA Vaccines with DNA Encoding Ii-PADRE Generates Potent PADRE-specific CD4+ T-cell Immune Responses and Enhances Vaccine Potency Technical Details: Various strategies have been developed for enhancing DNA vaccine potency by modifying the properties of Antigen Presenting Cells (APCs). These strategies include increasing the number of antigen-expressing Dendritic Cells (DCs); improving antigen expression, processing, and presentation in DCs; promoting DC activation and function; and enhancing DC and T cell interaction to augment vaccine-elicited T cell immune respons...Fri, 28 Oct 2016 07:20:05 GMTJHTT-Communications@jhu.edu to Detect Small Molecules that Suppress Expression of the Mutant Huntington Disease Gene, 27 Oct 2016 21:12:55 GMTJHTT-Communications@jhu.edu A Cystic Fibrosis Bronchial Epithelial Cell Line with a Single Integration Site for the Stable Expression of any Gene of Interest, 21 Oct 2016 09:40:11 GMTJHTT-Communications@jhu.edu lines Derived from Huntington’s Disease Induced Pluripotent Stem Cells, and their Use for Identification of Novel Therapeutics, 21 Oct 2016 07:41:01 GMTJHTT-Communications@jhu.edu Instructional Guide – Fostering Longterm Charitable Donations by Distributed Publication(s), 21 Oct 2016 07:30:05 GMTJHTT-Communications@jhu.edu of ntrk1 cDNA in the Nontumorgenic Breast Epithelial Cell Line MCF-10A, 21 Oct 2016 07:20:05 GMTJHTT-Communications@jhu.edu Reporter and Conditional Knockout Mice, 21 Oct 2016 07:11:14 GMTJHTT-Communications@jhu.edu Conditional Forebrain Knockout Mouse Model of Human Psychiatric Disorders, 21 Oct 2016 06:09:30 GMTJHTT-Communications@jhu.edu LOW-COST REPORTER GENE ASSAY, 20 Oct 2016 09:05:52 GMTJHTT-Communications@jhu.edu Combinations for the Reversal of HIV-1 Latency Need: HIV-1 persists in a latent reservoir despite suppressive antiretroviral therapy (ART). Resting CD4+ T cells (rCD4s) that harbor latent proviruses allow little to no HIV-1 gene expression, thereby rendering the virus imperceptible to the host immune response. However, cellular activation reverses this latent state, allowing HIV-1 transcription and subsequent production of replication-competent virus. This small but stable latent reservoir necessitates life-long ART and is a major barrier to curing HIV-1 infection. One proposed strategy for eliminating the latent reservoir is to phar...Tue, 18 Oct 2016 22:13:20 GMTJHTT-Communications@jhu.edu Form of Activin Type IIB Receptor (ACVR2B/Fc), 18 Oct 2016 22:13:12 GMTJHTT-Communications@jhu.edu of Kelch-like ECH-associated Protein 1 (Keap1) in Kidney Epithelial Cells Causes Hydronephrosis in Mice, 18 Oct 2016 18:24:52 GMTJHTT-Communications@jhu.edu Pulmonary Hypertension Biomarker, 18 Oct 2016 18:17:43 GMTJHTT-Communications@jhu.edu Placed Markers for Post-surgical Imaging, 18 Oct 2016 15:52:59 GMTJHTT-Communications@jhu.edu Mutant Glioma Xenograft (JHH-273), 18 Oct 2016 15:32:34 GMTJHTT-Communications@jhu.edu Footprint Green Roof Optimized for Climbing Plants, 18 Oct 2016 15:16:10 GMTJHTT-Communications@jhu.edu Formation to Define Risk for Colon Cancer, 18 Oct 2016 13:52:30 GMTJHTT-Communications@jhu.edu Activity of proPSA, 18 Oct 2016 12:49:48 GMTJHTT-Communications@jhu.edu brain tumor patient prognosis, 17 Oct 2016 09:58:52 GMTJHTT-Communications@jhu.edu Chemoembolization Guidance based on Tumor Viability Mapping and Feed Blood Vessel Geometry, 17 Oct 2016 08:45:45 GMTJHTT-Communications@jhu.edu for Preview of Low-dose X-ray Projection and Tomographic Images from a Previous Volumetric Image, 17 Oct 2016 08:43:02 GMTJHTT-Communications@jhu.edu Quantitative Evaluation of Uterine Fibroids after Loco-regional Therapy, 17 Oct 2016 08:41:52 GMTJHTT-Communications@jhu.edu for Preview of Low-dose X-ray Projection and Tomographic Images, 17 Oct 2016 08:39:49 GMTJHTT-Communications@jhu.edu Tissue Property Mapping for Real-time Tumor Detection and Interventional Guidance, 17 Oct 2016 08:38:20 GMTJHTT-Communications@jhu.edu of Assessing Tissue Vascular Permeability Using Non-labeled Dextran Detected by MRI, 17 Oct 2016 08:36:55 GMTJHTT-Communications@jhu.edu of non-labeled antimetabolites and analogs thereof as theranostic agents, 17 Oct 2016 08:35:31 GMTJHTT-Communications@jhu.edu Device and Method to Measure Ventricular Arterial Coupling and Vascular Performance, 17 Oct 2016 08:34:05 GMTJHTT-Communications@jhu.edu Assemblies for Detecting Muscle Signals in a Prosthetic Liner, 17 Oct 2016 08:32:42 GMTJHTT-Communications@jhu.edu Photoacoustic Imaging for Guiding Skull Base Surgeries, 17 Oct 2016 08:30:37 GMTJHTT-Communications@jhu.edu for Coating Stents with a Conformal Hydrogel with Embedded Stem Cells for Cardiac Therapy, 17 Oct 2016 08:28:48 GMTJHTT-Communications@jhu.edu Monitor Emulator for CPR Feedback, 17 Oct 2016 08:25:49 GMTJHTT-Communications@jhu.edu Osteoporosis Using Photoacoustic Spectroscopy, 17 Oct 2016 08:23:26 GMTJHTT-Communications@jhu.edu Selective Pulses with Arbitrary Shape, 17 Oct 2016 08:21:33 GMTJHTT-Communications@jhu.edu for Color Corrected OCT Imaging Endoscope/Catheter to Achieve High-resolution, 17 Oct 2016 08:14:48 GMTJHTT-Communications@jhu.edu Tomographic Reconstruction with Correlated Measurement Noise, 17 Oct 2016 08:03:48 GMTJHTT-Communications@jhu.edu Assay for the Determination of Tumor Cell Metastatic Propensity NEEDCancer mortality is largely due to metastasis where cells from a tumor spread and invade additional organs. Current techniques in pathology identify cancerous tissue and can in some cases provide qualitative estimates of tumor aggressiveness.  Genetic testing is providing clues to tumor prognosis, but clinical data can be misleading due to large variations in the response of individuals to treatment. Developing personalized precision treatment strategies is difficult because no rapid, quantitative tests are available to evaluate the aggressiveness and metastatic potential of tumors. ...Mon, 17 Oct 2016 08:01:57 GMTJHTT-Communications@jhu.edu Beam Shaping using Sequential Deformable Mirrors, 17 Oct 2016 07:36:58 GMTJHTT-Communications@jhu.edu Art Development of Stable Eyes Rehabilitation Device, 17 Oct 2016 07:34:32 GMTJHTT-Communications@jhu.edu Ball Lens-based Optical Fiber Probe for Optical Coherence Tomography, 17 Oct 2016 07:30:04 GMTJHTT-Communications@jhu.edu Tracker Configuration within Patient Support Table, 17 Oct 2016 07:05:17 GMTJHTT-Communications@jhu.edu to Measure Wall Motion and Wall Thickness Using Contrast Enhanced Fluoroscopy, 17 Oct 2016 06:57:02 GMTJHTT-Communications@jhu.edu Bioreactor for Delivery of Paracrine Factors, 17 Oct 2016 06:44:44 GMTJHTT-Communications@jhu.edu Imaging for Skin Cancer Detection, 16 Oct 2016 17:41:10 GMTJHTT-Communications@jhu.edu Monitoring, 14 Oct 2016 13:39:59 GMTJHTT-Communications@jhu.edu for High-throughput Stimulation, Immunostaining, and Visualization of Single Cells, 14 Oct 2016 13:33:39 GMTJHTT-Communications@jhu.edu HCT116 and DLD-1 Cells, 14 Oct 2016 12:12:15 GMTJHTT-Communications@jhu.edu Nanoporous Metal Nanoparticle Catalysts, 14 Oct 2016 11:24:08 GMTJHTT-Communications@jhu.edu Motion Distortion Correction in Manually Scanned Hand-held Optical Coherence Tomography System, 14 Oct 2016 11:20:33 GMTJHTT-Communications@jhu.edu Physician Workload Safety and Quality Survey, 14 Oct 2016 10:48:39 GMTJHTT-Communications@jhu.edu Chicken and Rabbit Antibodies, Termed Anti-CC, Generated Using Denatured C-terminal 199 Amino Acid Fragment of Mouse Polycystin-1 Protein as Immunogen, 14 Oct 2016 10:34:44 GMTJHTT-Communications@jhu.edu Single Mode Fiber Probe with Optimized Reference Reflectivity, 14 Oct 2016 10:17:02 GMTJHTT-Communications@jhu.edu 3D and 4D Fourier Domain Doppler Optical Coherence Tomography Based on Dual Graphics Processing Units, 14 Oct 2016 10:14:01 GMTJHTT-Communications@jhu.edu Free-hand Scanning Common-path Fourier Domain Optical Coherence Tomography Probe for Image-guided Intervention, 14 Oct 2016 10:11:47 GMTJHTT-Communications@jhu.edu Resistance and Aberrant Autophagic Cascades in Mental Illness, 14 Oct 2016 08:09:24 GMTJHTT-Communications@jhu.edu Knockout Mouse, 14 Oct 2016 06:40:03 GMTJHTT-Communications@jhu.edu compounds for Hedgehog pathway blockade in proliferative disorders, including hematopoietic malignancies, 14 Oct 2016 05:29:49 GMTJHTT-Communications@jhu.edu DNA Methylation Using Bifurcated M.Sssl, 13 Oct 2016 13:40:03 GMTJHTT-Communications@jhu.edu, Free-hand OCT Imaging, 13 Oct 2016 12:52:54 GMTJHTT-Communications@jhu.edu for Skill Assessment and Feedback to Trainee Surgeons OVERVIEW JHU scientists have developed methods for skill assessment and feedback to trainee surgeons. Increased research attention has been paid to the training of novice surgeons by providing objective skill assessment. Robotic surgery is one training tool that has gained widespread use across surgical disciplines in both real and simulated environments. The current performance metric in robotic surgery tasks is instrument tip distance, measured in a fixed reference frame. This standard has trouble distinguishing between novice and proficient motions. This disclosed invention addre...Thu, 13 Oct 2016 12:40:58 GMTJHTT-Communications@jhu.edu Platform for Creating an Artificial Blood Brain Barrier, 13 Oct 2016 12:17:41 GMTJHTT-Communications@jhu.edu B6.129S6(Cg)-Ntrk2tm2.1Ddg; 025417 STOCK Megf8tm1.2Ddg; 025418 C3;B6-Megf8m687Ddg; 025615 STOCK Islr2tm2.1Ddg; 027214 B6.129S6(Cg)-Ntrk2tm3.1(cre/ERT2)Ddg, 12 Oct 2016 10:14:51 GMTJHTT-Communications@jhu.edu Mutations of Sema3a, Sec24b, and Megf8 in Mouse, 11 Oct 2016 08:11:41 GMTJHTT-Communications@jhu.edu Gfp Knock-in to the Islr2 (aka Linx) Locus, 11 Oct 2016 06:51:48 GMTJHTT-Communications@jhu.edu Mutations of B3gnt1 and Ispd in Mouse, 11 Oct 2016 06:43:40 GMTJHTT-Communications@jhu.edu Cartridge and Methods for Integrated Biochemical Assay at the Point-of-care report a self-contained, miniaturized biochemical assay platform for nucleic acid testing of infectious agents from biological fluids. Our work utilizes a sealed plastic cartridge with patterned surfaces for reagent storage and fluidic processing. Biochemical reactions including nucleic acid amplification tests are performed with a colorimetric readout. Device actuation is automated by a USB controlled servo motor compatible with control via laptop or handheld devices. We describe the fabrication and assembly process for the plastic cartridges, in addition to the workflow for single stream ...Mon, 12 Sep 2016 10:45:10 GMTJHTT-Communications@jhu.edu rabbit antibody against human recombinant Atox1 is a 7.6 kDa cytosolic protein that plays an important role in human copper metabolism. The recombinant intein-fusion of Atox1 was expressed in E.coli, intein tag was cleaved during purification and purified Atox1 was used for immunization of rabbits. Serum containing anti-Atox1 antibodies was tested using mouse liver homogenates and purified Atox1.  The anti-Atox1 antibody detects endogenous Atox1 and recombinant Atox1; it shows some cross reactivity in cell lysates with a non-specific 14 kDa band. Dilution 1:1000-1:2000.FEATURESCompared to the mouse monoclonal anti-Atox1 antibo...Fri, 26 Aug 2016 11:50:08 GMTJHTT-Communications@jhu.edu Plasmid pUC19-PPase for E. coli Pyrophosphatase, 11 Aug 2016 10:38:40 GMTJHTT-Communications@jhu.edu – Serologically Determine Parasite Burden of Chronic Toxoplasma Infection, 09 Aug 2016 19:03:05 GMTJHTT-Communications@jhu.edu Peptides as Cancer Vaccines, 05 Aug 2016 12:01:07 GMTJHTT-Communications@jhu.edu integrity assay (DIA) for cancer diagnostics, using confocal fluorescence spectroscopy Proposition: Traditional DNA integrity testing relies on real time PCR to amplify a limited number of chromosomal loci and determine the relative proportions of segments. This suffers from biased amplification that will skew the distribution of DNA lengths and make accurate determination of concentrations difficult. In addition, PCR based methods are cost prohibitive in clinical environments since they require expensive reagents, are laborious to perform, and require specialized equipment. Cylindrical Illumination Confocal Spectroscopy (CICS), an implementation of single molecule confoca...Fri, 05 Aug 2016 10:12:23 GMTJHTT-Communications@jhu.edu Glucose Tolerance Test for Mild Cognitive Impairment/Alzheimer's Disease Biomarker Development NEEDAlzheimer’s disease is an irreversible, progressive brain disorder that slowly destroys memory and thinking skills, and eventually the ability to carry out the simplest tasks. Treatment of Alzheimer’s disease (AD) is significantly hampered by the lack of easily accessible biomarkers that can detect disease presence and predict disease risk reliably. Early detection biomarkers are necessary not only for the prediction of cognitive decline, but also for patient selection in clinical trials. Often, patients are included in clinical trials whose disease has progressed far beyond modifica...Tue, 02 Aug 2016 20:26:07 GMTJHTT-Communications@jhu.edu of Myocardial Injury, 02 Aug 2016 19:56:34 GMTJHTT-Communications@jhu.edu V600E and TERT Promoter Mutations Cooperatively Identify the Most Aggressive Papillary Thyroid Cancer with Highest Recurrence, 22 Jul 2016 10:50:41 GMTJHTT-Communications@jhu.edu Promoter Mutations in Thyroid Cancer, 22 Jul 2016 10:46:35 GMTJHTT-Communications@jhu.edu Analogues to Promote Skin Regeneration, 19 Jul 2016 15:11:14 GMTJHTT-Communications@jhu.edu Mutant for Next-Gen Sequencing Library Preparation, 18 Jul 2016 13:16:38 GMTJHTT-Communications@jhu.edu Diagnostic Assay for PML Risk Stratification, 07 Jul 2016 14:32:31 GMTJHTT-Communications@jhu.edu of Injury or Neurodegenerative Disorders of the Enteric Nervous System (ENS) that cause Gastrointestinal Dysfunctions for which There is No Effective Therapy, 30 Jun 2016 08:49:04 GMTJHTT-Communications@jhu.edu OSTEOTOMY SAW GUIDE need: En bloc resections of tumors in the spine require multiple osteotomies to free the specimen from the spinal column. Osteotomies through a vertebral segment can be performed in many different ways, such as using osteotomes, drills, reciprocating saws, and wire saws. Yet, existing techniques are prone to unintentional cutting of adjacent critical soft tissue structures like the spinal cord. Hence, researchers innovated a novel Vertebral Osteotomy Saw Guide that enables producing a reliable, planned osteotomy while minimizing damages to other structures for an improved patient safety ...Wed, 15 Jun 2016 08:18:16 GMTJHTT-Communications@jhu.edu Ketogenic Diet Rescues Neurogenesis Defects in a Mouse Model of Kabuki Syndrome, 03 Jun 2016 07:19:17 GMTJHTT-Communications@jhu.edu and Methods for Treating Solid Tumors NEEDCancers are now recognized as being driven by widespread changes in the epigenome including changes in DNA methylation and chromatin packaging. Changes in DNA methylation include global loss of methylation and focal gain of methylation at promoter regions of tumor suppressor genes leading to transcriptional silencing. DNA methylation, the covalent modification of DNA, is mediated by a family of DNA methyltransferases (DNMTs). In recent years, inhibitors of DNMTs (DNMTis) have emerged as therapeutic targets for treatment of myeloid malignancies as well as cutaneous T cell lymphoma. In...Fri, 03 Jun 2016 07:11:49 GMTJHTT-Communications@jhu.edu Bacterial Cyclic Dinucleotide Activates the Cytosolic Surveillance Pathway and Mediates Innate Resistance to Tuberculosis NEED Detection of cyclic-di-adenosine monophosphate (c-di-AMP), a bacterial second messenger, by the host cytoplasmic surveillance pathway (CSP) is known to elicit Type I interferon responses critical for antimicrobial defense. However, the mechanisms and role of c-di-AMP signaling in Mycobacterium tuberculosis virulence remain unclear. Here, JHU researchers report that c-di-AMP, not cytosolic DNA alone, is a critical ligand for CSP activation leading to induction of Type I IFNs and autophagy during M. tuberculosis infection.  TECHNICAL DESCRIPTION Johns Hopkins researchers generated a ...Fri, 03 Jun 2016 06:52:50 GMTJHTT-Communications@jhu.edu System for the Capture of Mycobacteria, 03 Jun 2016 06:43:11 GMTJHTT-Communications@jhu.edu of "MANAbodies" Specific to HLA-restricted Epitopes Encoded by Somatically Mutated Genes, 03 Jun 2016 06:00:50 GMTJHTT-Communications@jhu.edu 2 Collagen VIII (Col8a2) L450W Knock-in Mouse Model of Fuchs Endothelial Corneal Dystrophy, 02 Jun 2016 12:22:17 GMTJHTT-Communications@jhu.edu as Anti-cancer Therapeutic Agents, 12 May 2016 06:26:50 GMTJHTT-Communications@jhu.edu Verteporfin Amphiphiles (SAVA) for Local Cancer Therapy, 12 May 2016 06:15:56 GMTJHTT-Communications@jhu.edu Water Fixture for Increased Hand Hygiene, 11 May 2016 12:13:49 GMTJHTT-Communications@jhu.edu Artificial Cells: Anisotropic Supported Lipid Bilayers on Biodegradable Micro and Nanoparticles for Spatially Dynamic Surface Protein Presentation, 21 Apr 2016 05:53:18 GMTJHTT-Communications@jhu.edu of Preventing Organ Transplant Rejection, 18 Apr 2016 07:28:11 GMTJHTT-Communications@jhu.edu YAP Activity in Combination with Immunomodulation to Alter Regulatory T Cell-mediated Immune Regulation in order to Treat Cancer, 18 Apr 2016 07:18:16 GMTJHTT-Communications@jhu.edu profile signature and potential biomarkers associated with a lack of therapeutic response to anti-PD-1 blockade therapy for Renal Cell Carcinoma (RCC), 06 Apr 2016 09:11:55 GMTJHTT-Communications@jhu.edu tauLacZ/+) Knock-in Mice, 22 Mar 2016 11:21:39 GMTJHTT-Communications@jhu.edu creERT2/+) Knock-in Mice, 22 Mar 2016 11:15:24 GMTJHTT-Communications@jhu.edu cre/+) Knock-in Mice, 22 Mar 2016 11:08:46 GMTJHTT-Communications@jhu.edu Transgenic Mouse Line for Ablating Cells Positive for Opn4 Expression, 22 Mar 2016 10:42:28 GMTJHTT-Communications@jhu.edu Antibody, 21 Mar 2016 07:19:40 GMTJHTT-Communications@jhu.edu ILLUMINATION CONFOCAL SPECTROSCOPY Need: Single molecule detection (SMD) allows the study of molecular properties without the bias of ensemble averaging. Although in principle, SMD can be highly quantitative, its current implementations limit its accuracy, throughput, and practical applicability. The minute size of the SMD observation volume enables high signal/noise ratio detection of even single fluorescent molecules due to highly suppressed background levels. However, the diffraction-limited observation volume that enables SMD also significantly hampers its application in quantification and burst parameter determinatio...Thu, 17 Mar 2016 11:28:23 GMTJHTT-Communications@jhu.edu Oxazolidinone for Treatment of Infections with Mycobacterium Tuberculosis and Gram Positive Bacteria, 10 Mar 2016 06:14:51 GMTJHTT-Communications@jhu.edu 34x208 Base Pair Repeat Array Containing the 601 Nucleosome Positioning Sequence, 09 Mar 2016 09:38:59 GMTJHTT-Communications@jhu.edu BH4 domain-induced gene expression profiles, 09 Mar 2016 08:50:20 GMTJHTT-Communications@jhu.edu Ehrlichia Phagocytophila Major Surface Protein (MSP) From Clone p20H13 Recombinant Ehrlichia Phagocytophila Major Surface Protein (MSP) From Clone p20H13 Technical Details: Recombinant E. phagocytophilia MSP is a major immunodominant protein antigen derived from the human E. phagocytophilia (HE agent) strain BDS. The clone was initially selected based upon reactivity with monoclonal antibody to the major 44kDa surface antigen and the gene sequenced and subcloned into the pCAL vector (Stratagene) and expressed in E. coli BL21. Looking for Partners: The recombinant protein is a fusion with calmodulin binding protein and may be used for serologic stu...Wed, 09 Mar 2016 08:15:32 GMTJHTT-Communications@jhu.edu - A Novel Method to Reduce H3T3 Phosphorylation in Rapidly Dividing Cells, 07 Mar 2016 07:21:03 GMTJHTT-Communications@jhu.edu Two-carbon Linked Artemisinin-Derived Trioxane Dimers: Antimalarial and Anticancer Activities, 19 Feb 2016 11:49:38 GMTJHTT-Communications@jhu.edu plasmid, PAN-1 TAP pEG(KT), and BJ2168 yeast strain, 19 Feb 2016 08:27:58 GMTJHTT-Communications@jhu.edu Markers in Pancreatic Cancer, 16 Feb 2016 11:14:18 GMTJHTT-Communications@jhu.edu Biomarker for Improved Survival Prediction, 16 Feb 2016 10:30:05 GMTJHTT-Communications@jhu.edu Novel System for Transfascial Suture Placement Through Mesh for Hernia Surgery, 08 Feb 2016 05:47:40 GMTJHTT-Communications@jhu.edu Acid -Conjugated Dendrimers as a Tunable, High-Performance CEST MRI NanoPlatform for Diagnostic Imaging Proposition: Brain tumors have poor survival rates and treatment options are limited due to the requirement of therapeutics to cross the blood-brain-barrier to reach the tumor site. Convection-enhanced delivery (CED) of nanoformulations is gaining increasing attention to overcome this challenge. However, there is an unmet need for imaging modalities to effectively monitor the micro-distribution of drugs to ensure optimal treatment efficacy. This invention describes novel dendrimer-conjugated nanoformulations that exhibit strong CEST-MRI contrast and presents a powerful platform for drug ...Mon, 08 Feb 2016 05:45:57 GMTJHTT-Communications@jhu.edu Indole-2-carboxyamide Derivative Compounds for Treatment of TB NeedAlthough effective therapy exists for TB caused by drug-susceptible mycobacterium tuberculosis, this therapy requires daily administration of multiple drugs for a minimum of 6 months. The consequence of noncompliance with the existing TB treatment leads to the development of drug-resistant TB in which case both first-line and second-line drug for treating fail. However, a series of compounds just discovered indicates translational potential of novel chemical entities for treatment of both drug-susceptible and drug resistant TB by showing positive lab results in vitro and in vivo expe...Fri, 05 Feb 2016 07:32:17 GMTJHTT-Communications@jhu.edu Mouse Endothelial Cell Line that Retains the Functional Characteristics of Lymph Node Endothelium, 29 Jan 2016 13:38:43 GMTJHTT-Communications@jhu.edu Conditional Transgenic Mice, 29 Jan 2016 09:54:52 GMTJHTT-Communications@jhu.edu Line Stably Expressing the Rat TRPV1 cDNA, 29 Jan 2016 08:53:08 GMTJHTT-Communications@jhu.edu - ymphocyte Specific Activation of Nrf2 Protects from Acute Kidney Injury, 22 Dec 2015 14:54:18 GMTJHTT-Communications@jhu.edu brain stimulation method for improvement of motor symptoms in Parkinsons Disease, 18 Dec 2015 08:17:14 GMTJHTT-Communications@jhu.edu is a Major Tumor Suppressor Gene in Thyroid Cancer, 02 Dec 2015 12:27:49 GMTJHTT-Communications@jhu.edu Inhibitors of Bacterial Growth, 30 Nov 2015 10:09:59 GMTJHTT-Communications@jhu.edu, 27 Nov 2015 21:28:33 GMTJHTT-Communications@jhu.edu Novel Obesity Model: Human Synphilin-1 Transgenic Mouse, 27 Nov 2015 21:00:08 GMTJHTT-Communications@jhu.edu regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers, 11 Nov 2015 10:13:34 GMTJHTT-Communications@jhu.edu Blockade together with Vaccine Therapy Facilitates Effector T Cell Infiltration into Pancreatic Tumors, 11 Nov 2015 08:35:09 GMTJHTT-Communications@jhu.edu novel Malaria vaccine candidate, 11 Nov 2015 08:29:41 GMTJHTT-Communications@jhu.edu test to isolate high numbers of CTCs in Patients w/ Advanced Prostate Cancer Need:Prostate cancer (PC) is the second most common cancer in American men; about one-in-seven will be diagnosed with prostate cancer during his lifetime. The American Cancer Society estimates that there will be 161,000 new cases and 27,000 deaths from prostate cancer, making it the third leading cause of cancer death in American men.  In patients with advanced disease, prostate cancer cells upregulate and mutate many genes including the androgen receptor (AR), which allows them to thrive even following androgen deprivation therapy (ADT).  Chemotherapeutics which inhibit the AR have been...Tue, 10 Nov 2015 13:40:29 GMTJHTT-Communications@jhu.edu Novel Approach to Enhance Specific Immunity by Constraining Antibodies on Nanoparticles have exquisite specificity for their antigen.  Thus antibodies have great therapeutic potential in terms of selectively targeting receptors to either promote or inhibit receptor activity.  Likewise, antibodies can target infected or tumor cells by recognizing their antigen on the cell of interest.  However, the exquisite specificity imparted by the antibody-antigen interaction can be abrogated by the expression of the target receptor on off target cells.  For example soluble anti-CD3 will activate all T cells not just the T cells of interest but on all T cells.  Likewise, anti-CTLA-...Tue, 10 Nov 2015 12:50:31 GMTJHTT-Communications@jhu.edu Approaches for Monospecific Mouse Antibody Validation: IP/WB, ICoW and Flip, 10 Nov 2015 11:30:22 GMTJHTT-Communications@jhu.edu Based Sickle Cell Anemia Therapeutic NOVELTY: This technology is a set of RNA aptamers capable of reducing sickle hemoglobin (HbS) polymerization, which has therapeutic potential in reducing vaso-occlusion and ischemia in sickle cell disease patients. VALUE PROPOSITION: Sickle cell anemia is a genetically inherited disease affecting 1 in 400 African American and up to 2% of the population in some areas of Africa. It results in malformed sickle-shaped red blood cells. HbS polymerize and adhere to the vascular endothelium, resulting in reduce blood flow and blokage. The symptoms and severity of the disease varies between ...Tue, 10 Nov 2015 10:58:09 GMTJHTT-Communications@jhu.edu Reporter Alleles: Tools for in vitro and in vivo Epigenetic Therapeutic Development - Treatment Method, 10 Nov 2015 10:48:09 GMTJHTT-Communications@jhu.edu and Application of a Llama-derived Single Domain Antibody Binding to Glycoprotein D of HSV-2, 10 Nov 2015 08:50:13 GMTJHTT-Communications@jhu.edu REF: C12865 - Novel Biomarkers for Tumor Response to Anti-Cancer Therapy, 10 Nov 2015 08:29:24 GMTJHTT-Communications@jhu.edu Novel and Unique Set of Human Antibodies to Human Resistin and to Human Resitin-like Molecule Beta (RELMB) that can be used to Target these Proteins in Human Disease NeedDiseases resulting from pulmonary remodeling, such as Pulmonary Arterial Hypertension (PAH), Hypertrophic Cardiomyopathy (HCM), Pulmonary Fibrosis (PF) and Chronic Obstructive Pulmonary Disease (COPD) are fatal diseases for which the standards of care are palliative therapies that treat the symptoms of the disease as the patient progresses toward heart failure and death.  A safe and effective therapy to treat these conditions has yet to be discovered.Technology OverviewJH researchers have identified two proteins, Resistin and Resistin Like Molecule Beta (RELMβ), that are central to t...Thu, 15 Oct 2015 10:39:42 GMTJHTT-Communications@jhu.edu Molecular-genetic Reporter System, 01 Oct 2015 12:44:13 GMTJHTT-Communications@jhu.edu Counting by Next Generation Sequencing for Ultrasensitive Human DNA Detection, 01 Oct 2015 12:00:18 GMTJHTT-Communications@jhu.edu Designed for Sterile Liquid Nitrogen Freezing, Quick Thawing and Injection of Cellular Slurries, 01 Oct 2015 11:44:42 GMTJHTT-Communications@jhu.edu to Direct hiPSC to Form Three-dimensional Human Retinal Tissue in vitro, 01 Oct 2015 10:41:04 GMTJHTT-Communications@jhu.edu Function of Six Transmembrane GDE Proteins, 01 Oct 2015 10:29:54 GMTJHTT-Communications@jhu.edu the Cancer Cells with Epigenetic Therapy (DNA Demethylating Agents and Histone Deacetylase Inhibitors) Sensitizes Multiple Cancers to PARP Inhibitors, 01 Oct 2015 06:50:49 GMTJHTT-Communications@jhu.edu Iron Oxide Nanoparticles for MR Theranostics, 28 Sep 2015 13:01:25 GMTJHTT-Communications@jhu.edu Promoter Methylation and Somatic Mutation Analyses Reveal Alterations in PAX, NOTCH, and TP53 Pathways Associated with Poor Survival in Head and Neck Cancer, 28 Sep 2015 12:16:53 GMTJHTT-Communications@jhu.edu REF: C12704 - NOVEL STRATEGIES TO OVERCOME MELANOMA DRUG RESISTANCE, 28 Sep 2015 09:37:39 GMTJHTT-Communications@jhu.edu Suppression of Non-conserved Cryptic Exons is Compromised in Human Neurodegenerative Diseases, 28 Sep 2015 07:26:39 GMTJHTT-Communications@jhu.edu Promoter Mutations for the Early Detection and Monitoring of Ubladder Cancers, 24 Sep 2015 13:10:37 GMTJHTT-Communications@jhu.edu DNA methylation and genotype specific biomarker of suicide attempt, 24 Sep 2015 12:32:58 GMTJHTT-Communications@jhu.edu Cost Regulated Genetic Switch for Saccharomyces Cerevisiae, 23 Sep 2015 08:33:59 GMTJHTT-Communications@jhu.edu Surface Conjugation Approach to Formulate Nano-carriers for Magnetic Resonance Imaging (MRI) Tracking, 23 Sep 2015 08:24:18 GMTJHTT-Communications@jhu.edu for highly efficient conversion of human stem cells to lineage-specific neurons., 23 Sep 2015 06:42:28 GMTJHTT-Communications@jhu.edu Heart Slices, 23 Sep 2015 06:24:02 GMTJHTT-Communications@jhu.edu to Use Viral and Host Methylation Markers for Cervical Cancer Screening and Triage in Liquid Prep, Serum/plasma, and Urine: PCR and Sequencing Based Process Methods, 22 Sep 2015 08:43:48 GMTJHTT-Communications@jhu.edu of the Albumin-bound Protein/peptide Complex (ABPPC) is Biomarker for Disease, 10 Sep 2015 07:02:24 GMTJHTT-Communications@jhu.edu Kisspeptin Secretion Impairs Insulin Secretion from Pancreatic Bets Cell. Kisspeptin Receptor GPR54 Antagonist for Treatment of Prediabetes and Diabetes Mellitus in Humans., 02 Sep 2015 06:06:14 GMTJHTT-Communications@jhu.edu of Targets for Catheter Ablation of Persistent Atrial Fibrillation based on Analysis of Patient-specific Fibrosis Patterns, 27 Aug 2015 12:29:17 GMTJHTT-Communications@jhu.edu for Forming Refractory Carbide, Nitride and Boride Coatings with Controlled Porosity, 03 Aug 2015 11:11:27 GMTJHTT-Communications@jhu.edu Molecule Inhibitors Targeting PBX1-DNA Binding to Treat Drug Resistant Cancers, 28 Jul 2015 12:59:52 GMTJHTT-Communications@jhu.edu of Membranes with Polydopamine and Silver Nanoparticles formed in situ to Mitigate Biofouling, 28 Jul 2015 11:18:18 GMTJHTT-Communications@jhu.edu outer nuclear membrane Bcl-2 Transgenic Bcl2 Cells and ProPSA Panel for Prostate Cancer Drug DiscoveryNovelty: Recombinant proPSA panel and transgenic Bcl2 prostate cancer cell lines, enabling the detailed mechanistic analysis of prostate tumorigenesis and development of novel anti-cancer treatment strategies.Value Proposition: Due to the lack of early clinical manifestations prostate cancer is often not detected until the disease has spread, resulting in poor patient prognosis. Elevated levels of anti-apoptotic cell death regulator Bcl2 (B-cell lymphoma-2) in the outer nuclear membrane (ONM) as well as free PSA (...Tue, 24 Mar 2015 12:43:27 GMTJHTT-Communications@jhu.edu Smart Screw-driver to Prevent Inadvertent Screw Stripping in Bone A Smart Screwdriver to Prevent Inadvertent Screw StrippingNovelty: This invention uses torque and angular rotation sensors to determine optimum screw tightening in bone.Value Proposition: The current method for judging screw tightening in orthopedic surgery involves manual torque feedback (i.e. the surgeon tightens the screw until it is “two-fingers tight”). This method, however, leads to screw stripping 20% of the time. The proposed device uses torque and angle sensors to implement the “turn-of-the-nut”, rotation based method of screw tightening. The device senses when the screw is se...Tue, 24 Mar 2015 12:42:46 GMTJHTT-Communications@jhu.edu Flox Mice, 24 Mar 2015 12:40:54 GMTJHTT-Communications@jhu.edu, targeted mutant mouse line B6.129S6(Cg)-Ntrk1 ::superscript-tm2Ddg::/J (aka B6.Cg-Ntrk1::superscript-tm2DdG::/J) Mouse strain for studying TrkA in neurons.Mice is stored at The Jackson Laboratory ( Stock No. 013059 C3.B6-Erbb3m3329Ddg/J Technical Details: Mouse models can make essential contributions to our understanding of the cause, prevention and treatment of disease. Inventor has disclosed a knock-in mutant mouse line that expresses a FLAG-TrkA fusion protein. TrkA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family.Looking for Partners: The mouse strain is potentially commercializable as a research tool which may be useful for visualization of expression, tr...Tue, 24 Mar 2015 12:38:52 GMTJHTT-Communications@jhu.edu mutant mouse line C3.B6-Erbb3::superscript-m3329Ddg::/J (aka C3.B6-Erbb3::superscript-I449S::/DdgJ ) Mouse strain with Erbb3 mutation to study nervous system development.Mice is stored at The Jackson Laboratory ( Stock No. 013720 - B6.l29S6(Cg)-Ntrkltm2Ddg/J Technical Details: Erbb3 encodes a protein that belongs to the Epidermal Growth Factor Receptor (EGFR) family of receptor tyrosine kinases. ERBB3 is known to interact with Neuregulin 1 which is thought to be essential for the normal development of the nervous system and the heart. Inventor has disclosed a mouse line developed via N-ethyl-N-nitrosourea mutagenesis. This mouse strain is called C3.B6-Erbb3m3329Ddg/J (a...Tue, 24 Mar 2015 12:38:51 GMTJHTT-Communications@jhu.edu Analytics on Large File and Storage Systems Just-In-Time Analytics on Large File and Storage Systems Technical Details: As file systems reach the petabytes scale, users and administrators are increasingly interested in acquiring highlevel analytical information for file management and analysis. Two particularly important tasks are the processing of aggregate and top-k queries which, unfortunately, cannot be quickly answered by hierarchical file systems such as ext3 and NTFS. Existing pre-processing based solutions, e.g., file system crawling and index building, consume a significant amount of time, energy and space (for ge...Tue, 24 Mar 2015 12:38:51 GMTJHTT-Communications@jhu.edu Mouse Mouse line with a TrkB mutation with Lox P sites.Value Proposition: Mouse lines can make essential contributions to our understanding of the cause, prevention and treatment of various diseases and conditions. This invention provides a mouse line harboring a TrkB mutation with Lox P sites useful for Cre-mediated recombination to generate a null allele. Tue, 24 Mar 2015 12:38:33 GMTJHTT-Communications@jhu.edu Pkd2(tm1Tjw) Mouse line 2. Pkd2(tm1.1Tjw) 3. Pkd2(tm1.2Tjw) 4. Pkd2(tm1.3Tjw) 5. Pkd2(tm1.4Tjw) Mouse Model to study Human Autosomal Dominant Polycystic Kidney Disease.Value Proposition: Inventors disclose five mouse lines with loxP sites introduced into introns 10 and 13 of the mouse Pkd2 gene that allow its regulated inactivation using inducible Cre-recombinases. This mouse model can mimic the features of human autosomal dominant polycystic kidney disease and may be used to further our understanding of this condition and to test and screen potential therapies for this disease.Mouse lines:- Pkd2tm1Tjw mouse line; it also is known as Pkd2flox11-13. This line was generated by intr...Tue, 24 Mar 2015 12:38:31 GMTJHTT-Communications@jhu.edu Mouse line with mutation in TrkB receptor.Value Proposition: The TrkB receptor is part of the large family of receptor tyrosine kinases. The present technology is a mouse line harboring a Phenylalanine to Alanine mutation in the TrkB receptor at F616 without Lox P sites. Tue, 24 Mar 2015 12:38:23 GMTJHTT-Communications@jhu.edu Scalable, Cable Driven Morphable Manipulator with Unique Fabrication Method A Scalable, Cable Driven Morphable Manipulator with Unique Fabrication MethodValue Proposition: The invention is much stiffer than comparable morphable surgical manipulators, resulting in an increased ability to apply normal forces at the tip. In addition, the unique construction method leaves the lumen unobstructed for the passage of other tools, including a smaller version of the same style manipulator. As a result, this technology can be used as both a steerable guide cannula and or a dexterous manipulator, depending on the exact application.Technical Details: The new cable driven m...Tue, 24 Mar 2015 12:38:07 GMTJHTT-Communications@jhu.edu Guided Cooperative Control for Surgical Manipulation of Delicate Tissue Micro-force Guided Cooperative Control for Surgical Manipulation of Delicate TissueValue Proposition: This technology reduces the time and associated complications of retinal microsurgery, thereby reducing cost of procedure and cost and time of recovery.Technical Details: Microsurgical manipulation requires surgeons to perform micron scale maneuvers while safely applying forces to the retinal tissue that are beneath sensory perception. Precise manipulation of this delicate tissue has thus far been hindered by human limits on tool control. Contemporary robotic methods are unable to hand...Tue, 24 Mar 2015 12:38:01 GMTJHTT-Communications@jhu.edu Architectures for Organic Electronic Sensors Circuit Architectures for Organic Electronic SensorsValue Proposition: Logic gate device architectures consist of p-type and n-type transistors. Incorporating p- and n- type transistors that are sensitive to an analyte into logic gate structures can increase sensitivity and selectivity. In addition, incorporation can make data measuring, collecting, and interpretation much simpler and easier. In the case where both transistors work in synergy and are electrically sensitive to an analyte, the inverter is also sensitive and can provide greater sensitivity and/or selectivity. An example...Tue, 24 Mar 2015 12:37:59 GMTJHTT-Communications@jhu.edu for Presenting Force Sensor Information Using Cooperative Robot Control and Audio Feedback Method for Presenting Force Sensor Information Using Cooperative Robot Control and Audio FeedbackValue Proposition: Technical Details: In the case of a micromanipulation task like vitreoretinal surgery, the surgeons indirectly assess the relative stress applied to the tissue via visual interpretation of changing light reflections from deforming tissue. This type of visual sensory substitution requires significant experience and concentration, common only to the expert surgeons. Johns Hopkins University inventors provide a clearer and more objective feedback mechanism that measures thes...Tue, 24 Mar 2015 12:37:58 GMTJHTT-Communications@jhu.edu Exchange Interface and Control Algorithm for Cooperative Surgical Robots Tool Exchange Interface and Control Algorithm for Cooperative Surgical RobotsValue Proposition: In the hand-on cooperative robot control paradigm both the operator and the robot hold the tool while the forces exerted by the operator on the tool are sensed with a force/torque sensor and the robot moves to minimize these forces, effectively rendering the operator's desired motion. For surgical applications, quick tool changes are desirable and often required for timing and safety reasons.Technical Details: Johns Hopkins University inventors propose a tool exchange and interaction mechani...Tue, 24 Mar 2015 12:37:58 GMTJHTT-Communications@jhu.edu Force Sensor for Microsurgical Instruments Interferometric Force Sensor for Microsurgical InstrumentsValue Proposition: Many clinical procedures involve intervention and manipulation of extremely small, delicate tissue structures where the interaction forces are usually below the threshold of human perception. Retinal microsurgery is an example of the requirement for micron-level maneuvers. The manipulation of vitreoretinal structures inside the eye poses enormous challenges, due to tissue delicacy, surgical inaccessibility, suboptimal visualization, and the potential for irreversible tissue damage resulting from unintentional ...Tue, 24 Mar 2015 12:37:56 GMTJHTT-Communications@jhu.edu Surface Tracking and Motion Compensation Hand-held Microsurgical Tool System Based on Dynamic Common-Path Optical Coherence Tomography Sensor 1-D Surface Tracking and Motion Compensation Hand-held Microsurgical Tool System Based on Dynamic Common-Path Optical Coherence Tomography SensorValue Proposition: A CP-OCT distance sensing probe coupled with a piezoelectric micro linear motor is used on 1-D microsurgical tool tips for tactical feedback. A predictor algorithm uses the OCT signal to ensure precise and efficient targeting in this system in order to mitigate surgical error.Technical Details: Johns Hopkins University inventors have developed a highly effective, real-time 1-D surface tracking and motion compensation system ...Tue, 24 Mar 2015 12:37:56 GMTJHTT-Communications@jhu.edu of Registered Subsurface Anatomy Visualization of Registered Subsurface Anatomy Value Proposition: This technology uses a near-infrared imager, suitable for use in pre-clinical trials and a system capable of providing real-time fused visualizations of the urinary tract in robotic surgery. Technical Details: Johns Hopkins University inventors disclose details for real-time registration methods for integrating near infrared imaging and visual imaging, in displays suitable for use in robotic and other minimally invasive surgery. Looking for Partners: This technology could be used for surgery activate...Tue, 24 Mar 2015 12:37:55 GMTJHTT-Communications@jhu.edu for Comparative Longitudinal Analysis and Methods for Feedback to Trainee Surgeons Metrics for Comparative Longitudinal Analysis and Methods for Feedback to Trainee SurgeonsValue Proposition: Methods for training new robotic surgeons and evaluating robotic surgery skill are now actively being developed. However, existing art is limited by a) lack of distinction between surgical skill, and robotic system operation skills, and b) lack of the ability to track development of these skills. Compared to skill quantification reported in the literature, we investigate skill development and longitudinal assessment. Such assessment will be key for developing feedback methods to...Tue, 24 Mar 2015 12:37:54 GMTJHTT-Communications@jhu.edu for Localizing Radiation Implants from Limited X-ray Data Method for Localizing Radiation Implants from Limited X-ray DataValue Proposition: Johns Hopkins University inventors consider the 3-D implant localization as a seed-matching problem and a combinatorial optimization algorithm was formulated. It resolves the correspondence of identified seeds in every image even when a significant number of seeds overlap one another on one or more observed images. In order to solve the optimization problem within near real time, a dimensionality reduction is performed with pruning algorithm that enables a systematic rejection of infeasible combinations ...Tue, 24 Mar 2015 12:37:52 GMTJHTT-Communications@jhu.edu Dimensional Microwell Array Three Dimensional Microwell ArrayValue Proposition: Parallel encapsulation of living cargo in an array format while enabling interaction with the surrounding in all three dimensions. Increased surface to volume ratios allow preventing cell death related to hypoxia and in general to lack of nutrients resulting in increased efficiency of bioartificial devices.Technical Details: Traditional microwell arrays are inherently two dimensional allowing encapsulated living cargo e.g. cells to access the surroundings from only one opening (a 2D interface). We describe and realize the concept of 3...Tue, 24 Mar 2015 12:37:52 GMTJHTT-Communications@jhu.edu<![CDATA[12612 B6.129-Gria1<tm5R1h>/J; 12613 B6.129-Gria1<tm6R1h>/J; 12614 B6.129-Gria1<tm2R1h>/J; 12615 B6.129-Gria2<tm1R1h>/J; 12616 B6.129-Gria3<tm1R1h>/J; 12617 B6.129-Gria3tm2R1h/J; 12618 B6.129-Gria4<tm2R1h>/J; 12619 B6.129-Gria4tm1R1h/J]]>, 24 Mar 2015 12:37:31 GMTJHTT-Communications@jhu.edu dimers as potent anti-cytomegalovirus (CMV) agents NEED: Infection with cytomegalovirus (CMV) is common in humans and is usually asymptomatic; yet, in immunocompromised hosts, such as transplant recipients and patients with AIDS, CMV infection is associated with significant morbidity and mortality. Cytomegalovirus infection also is the most common congenitally-acquired infection and the leading infectious agent causing mental retardation and deafness in congenitally infected children. CMV treatments exist, but are associated with considerable side effects. Hence, new treatment options for CMV are urgently needed, in particular for infant...Tue, 24 Mar 2015 12:36:54 GMTJHTT-Communications@jhu.edu Detection on Dependent Data: Application to Seizure Prediction in Epilepsy Patients Quickest Detection on Dependent Data: Application to Seizure Prediction in Epilepsy Patients Technical Details: Quickest detection is the problem of detecting, with as little delay as possible, a change in the probability distribution of a sequence of random measurements. This problem arises in a great variety of applications, such as speech and image processing, biomedical signal processing, machinery monitoring and finance. The design of quickest detection procedures typically involves the optimization of a trade-off between two types of performance indices. Our first invention is...Tue, 24 Mar 2015 12:36:53 GMTJHTT-Communications@jhu.edu Plasmid, 24 Mar 2015 12:36:45 GMTJHTT-Communications@jhu.edu Instrument with Integrated Forward Looking Optical Coherence Tomography Surgical Instrument with Integrated Forward Looking Optical Coherence TomographyValue Proposition: This technology presents a new class of microsurgical instruments incorporating common path optical coherence tomography (CPOCT) capabilities. These instruments may be used freehand or with robotic assistance. An example prototype uses 25-gauge microsurgical pick incorporating a single 125 um diameter optical fiber interfaced to a Fourier Domain CP-OCT system developed at Johns Hopkins University. The device provides end point sensing at the surgical site allowing for real time feedback ...Tue, 24 Mar 2015 12:36:41 GMTJHTT-Communications@jhu.edu Target of Mycobacterium Tuberculosis for Development of Drug and Vaccine, 24 Mar 2015 12:36:40 GMTJHTT-Communications@jhu.edu Method for Non-invasive Cerebral and Systemic Cooling and Neuroprotection A Method for Non-invasive Cerebral and Systemic Cooling and Neuroprotection Technical Details: A method for achieving cerebral cooling by expansion of a gas delivered into the patients’ nasopharynx is described. The gas is compressed and delivered via a nasal catheter in to the nasopharnx. The gas is allowed to exit via several openings in the catheter inside the nasal cavity. Expanding gas cools the nasopharynx and the air in the para nasal sinuses and convective cooling of the brain stem is achieved. The gas may be an anesthetic (eg., N20, Xenon etc) that additionally may have ne...Tue, 24 Mar 2015 12:35:09 GMTJHTT-Communications@jhu.edu and Chemically Triggered Assembly of Untethered 3D Structures, 24 Mar 2015 12:33:59 GMTJHTT-Communications@jhu.edu and Selective Control of Specific Biological Activities with Partially Acylated and Mixed SCFA-derivatized Monosaccharide-SCFA Hybrid Molecules Proposition: This invention solves two problems inherent with the use of Short Chain Fatty Acid (SCFA)-monosaccharide hybrid molecules to modulate cellular activity. The first problem is the toxicity of former versions of these compounds. The current invention uses structure activity relationships as it has been discovered to either enhance or avoid toxicity (depending on the intended application). A second problem is that these compounds have a diverse set of biological activities and the current invention allows specific activities to be deconvoluted and selectively controlled; as a co...Tue, 24 Mar 2015 12:32:53 GMTJHTT-Communications@jhu.edu a High-throughput Screening Method for Identification and Validation of T Cell Epitopes Based Upon the Mass Spectral Analysis of Antigens Bound to Class II HLA-DR Constructs High throughput method to identify physiologically relevant epitopes Technical Details: All currently established methods for the identification of immunogenic epitopes are extremely tedious, time consuming and frequently unsuccessful. The identification of high throughput methods to isolate most likely candidates derived from natural processing of protein antigens is a most desirable goal. Scientists at JHU have invented a high throughput method to identify physiologically relevant epitopes presented by MHC class II for helper T-cell activation.Looking for Partners: The assay can ...Tue, 24 Mar 2015 12:27:47 GMTJHTT-Communications@jhu.edu Chain Fatty Acid (SCFA) - Carbohydrate Bifunctional Hybrid Molecules with Novel Anti-cancer Properties Short Chain Fatty Acid (SCFA) - Carbohydrate Bifunctional Hybrid Molecules with Novel Anti-cancer Properties Value Proposition: Butyrate, a natural short chain fatty acid (SCFA), is well-established to have anti-cancer properties via its ability to induce cell cycle arrest and apoptosis in cancer cells. Currently, several clinical trials are underway for treatment of cancer (leukemia, prostate, sickle cell ulcers and liver disorder) with butyrate and its analogs. In this invention JHU inventors have developed a panel of novel sugar-based butyrate carrying small-molecules that facilitat...Tue, 24 Mar 2015 12:26:57 GMTJHTT-Communications@jhu.edu Digital Mouse Whole Body (MOBY) Phantom 4D Digital Mouse Whole Body (MOBY) PhantomNovelty: The 4D digital mouse whole body (MOBY) phantom is a realistic and flexible model of the mouse anatomy and cardiac and respiratory motions for use in molecular imaging research.Value Proposition: Currently, there is a lack of realistic computer generated phantoms modeling the mouse anatomy and physiological functions for use in molecular imaging research. With the rise of small animal imaging, new instrumentation, data acquisition strategies, and image processing and reconstruction techniques are being developed and researched. One meth...Tue, 24 Mar 2015 12:25:33 GMTJHTT-Communications@jhu.edu is a Frequent Target for Aberrant Methylation in Pancreatic Adenocarcinoma SPARC/osteonectin is a Frequent Target for Aberrant Methylation in Pancreatic Adenocarcinoma Technical Details: Deregulated expression of SPARC/osteonectin, a secreted glycoprotein with multiple biological functions, has been associated with the progression of various cancers. Using microarrays, we previously identified SPARC as one of the genes induced by treatment with a DNA methylation inhibitor in pancreatic cancer cells. We therefore analysed the expression pattern and methylation status of the SPARC gene in pancreatic cancer. Gene expression profiling by oligonucleotide microar...Tue, 24 Mar 2015 12:24:48 GMTJHTT-Communications@jhu.edu of Novel Targets for Aberrant Methylation in Pancreatic Carcinoma Using High-throughput Microarrays Discovery of Novel Targets for Aberrant Methylation in Pancreatic Carcinoma Using High-throughput Microarrays Technical Details: In order to identify potential targets for aberrant methylation in pancreatic cancer, we analyzed global changes in gene expression profiles of 4 pancreatic cancer cell lines after treatment with the demethylating agent 5-aza-2?-deoxycytidine (5Aza-dC) and/or the histone deacetylase inhibitor trichostatin A (TSA). A substantial number of genes were induced 5-fold or greater by 5Aza-dC alone, TSA alone, and by treatment with both agents. The methylation st...Tue, 24 Mar 2015 12:24:32 GMTJHTT-Communications@jhu.edu monoclonal antibody CTD110.6 monoclonal antibody Technical Details: O-linked N-acetylglucosamine (O-GlcNAc) is a newly described but ubiquitous dynamic modification of key regulatory proteins in side virtually all multi-cellular eukaryotic cells. Recently, this sugar modification has been shown to be as abundant as protein phosphorylation, often competing with this key regulatory switch in the cell?s regulatory pathways. O-GlcNAc is now implicated to play an important role in diabetes, cancer and neurodegenerative diseases, such as Alzheimer?s Disease. The monoclonal antibody CTD110.6 is a valuable to...Tue, 24 Mar 2015 12:22:43 GMTJHTT-Communications@jhu.edu HIF-1aDP, A Constitutively-Expressed form of Hypoxia-Inducible Factor 1a HIF-1aDP, A Constitutively-Expressed form of Hypoxia-Inducible Factor 1a Technical Details: It has previously been demonstrated that a truncation of HIF-1alpha after amino acid residue 390 results in a constitutively expressed form of the protein. The purpose of this work was to identify mechanisms by which the half-life of the HIF1alpha protein is modulated as a function of cellular O2 concentration, such that the stability of the protein is greater under hypoxic, relative to non-hypoxic conditions. The strategy employed was to introduce mutations into the protein-coding DNA seque...Tue, 24 Mar 2015 12:21:13 GMTJHTT-Communications@jhu.edu of an Immortalized Cell Line, ASC-17D, from Adult Rat Sertoli Cells, 18 Mar 2015 08:49:43 GMTJHTT-Communications@jhu.edu Activity Program for People with Dementia Tailored Activity Program (TAP) for Improved Lifestyle with DementiaNovelty: An individualized home-based intervention program to reduce behavioral challenges, improve engagement for dementia patients and to improve quality of life of both the patient and the caregiver.Value Proposition: Approximately one third of people over 80 years of age will develop some form of dementia. Standard care typically involves pharmacologic agents, but these are only modestly effective, carry serious risks, including mortality, and do not address behavioral symptoms families consider most distressful; a...Tue, 07 Oct 2014 10:27:11 GMTJHTT-Communications@jhu.edu Craniomaxillofacial Surgery Computer-Assisted Craniomaxillofacial SurgeryNovelty: A novel computer-assisted surgical planning and intra-operative navigation system for use in complex craniomaxillofacial (CMF) surgical procedures such as Le Fort-based, maxillofacial transplantation.Value Proposition: Le Fort-based, maxillofacial transplantation accompanying a single jaw with teeth is an emerging therapeutic option for patients presenting with complex CMF deformities, resulting from etiologies such as gunshot wounds, burns and trauma. To date, eight patients have undergone single jaw maxillofacial transplantation a...Tue, 07 Oct 2014 10:27:05 GMTJHTT-Communications@jhu.edu Ventilation Feedback Sensor for Use in Clinical and Training Settings Novel Low-Cost Ventilation Feedback SensorNovelty: Manual ventilation feedback sensor for use in clinical and training settings.Value Proposition: Survival rates of cardiac arrest remain below 15%, causing nearly 450,000 American deaths annually. Experimental data recently suggested that rescue breathing, or ventilations, during resuscitation may actually worsen patient outcome. Ventilation rates observed during clinical resuscitations varied from 21 to 30 breaths per minute, which is significantly faster than the American Heart Association recommendation for continuous ventilations at...Tue, 07 Oct 2014 10:27:03 GMTJHTT-Communications@jhu.edu Dynamics Computer Model of Community Functioning in Disasters (CoPE-WELL) CoPE-WELL Computer Model of Community Functioning in DisastersNovelty: A software program to predict and simulate the time-course of community functioning and well-being resilience during and after a disaster, for every county in the nation.Value Proposition: Research shows that many people and communities believe they are significantly more prepared for emergencies and natural disasters than they actually are. This gap in conceptual preparedness leaves many communities completely unprepared for catastrophic events, such as Hurricane Katrina and the recent tornado in Moore, OK. Predi...Tue, 07 Oct 2014 10:27:02 GMTJHTT-Communications@jhu.edu Molecule Malarial Aldolase-trap Enhancers and Glideosome Inhibitors Novel Anti-Malarial Compounds and CompositionsNovelty: This technology provides new classes of anti-malarial compounds and a method to identify such compounds.Value Proposition: Nearly half the worlds population is at risk of acquiring malaria, which is caused by the Plasmodium family of protozoan parasites. Common drugs used to treat malaria very effectively inhibit or kill Plasmodium by interfering with metabolic pathways or other critical intracellular processes, but are not highly specific and may cause potentially severe side effects. In addition, resistance to these drugs is beco...Tue, 07 Oct 2014 10:27:01 GMTJHTT-Communications@jhu.edu A software environment for the analysis of relaxation data acquired with accordion spectroscopy SOFTWARE SOLUTION FOR ACCORDION SPECTROSCOPIC DATA ANALYSIS Value Proposition: Try our Express Licensing site: Johns Hopkins Express Licensing for SARA Accordion spectroscopy can be used to measure NMR relaxation rates in much less time than traditional methods. Until now, there have been no unified software packages available for the analysis of relaxation rates obtained by accordion spectroscopy, and applications have been limited despite its advantages. SARA offers a selection of analysis protocols that can be used for spectroscopic analysis and it has a number of advantage...Tue, 07 Oct 2014 10:27:01 GMTJHTT-Communications@jhu.edu P3 (A15) cell line comprising the TC-1 P3 subclone to serve as an immune resistant tumor model for cancer immunotherapy research.Value Proposition:Many human tumors demonstrate downregulation of MHC class I molecule expression as a means of immune evasion. Thus, the development of a suitable tumor model with downregulated MHC class I expression is critical for designing vaccines and immunotherapeutic strategies to control such tumors. This invention is a cell line containing the TC-1 P3 (A15) subclone that has downregulated MHC class I expression for testing immunotherapeutic strategies. Othe...Tue, 07 Oct 2014 10:27:01 GMTJHTT-Communications@jhu.edu and Validation of a Novel Method for More Accurate Estimation of Low-Density Lipoprotein Cholesterol from the Standard Lipid Profile Derivation and Validation of a Novel Method for More Accurate Estimation of Low-Density Lipoprotein Cholesterol from the Standard Lipid ProfileNovelty: A novel, accurate method for LDL-C estimation from the standard lipid profile using an adjustable factor for the triglycerides to very low-density lipoprotein cholesterol (TG:VLDL-C) ratioValue Proposition: Low-density lipoprotein cholesterol (LDL-C) is of longstanding clinical and research interest and the primary target in national and international clinical practice guidelines. Conventionally, LDL-C is estimated by the Friedewald equ...Tue, 07 Oct 2014 10:27:00 GMTJHTT-Communications@jhu.edu microarray for in vitro cell spheroids Tissue Microarray for Histological Analysis of In Vitro Cell SpheroidsNovelty: A simple method of sorting and embedding in vitro cell spheroids to significantly improve throughput of histological analysis.Value Proposition: Culturing cells in three-dimensional spheroids results in cell behaviors that are dramatically different from two-dimensional cultures and that more closely recapitulate the in vivo environment. Currently cell spheroids are cultured to study the behavior of many different cellular systems, such as cancer cells and stem cells, and to do preliminary testing of new dru...Tue, 07 Oct 2014 10:27:00 GMTJHTT-Communications@jhu.edu Computational Modeling of Atrial Fibrosis to Guide Catheter Ablation of Atrial Fibrillation Computational Modeling Tool to Guide Catheter Ablation of Atrial FibrillationNovelty: A method for predicting the optimal ablation sites in atrial fibrillation patients with atrial fibrosis.Value Proposition: Atrial fibrillation (AF) is the most common arrhythmia in humans. Catheter ablation is an established treatment modality for AF. The procedure of catheter ablation relies on identifying the target atrial regions responsible for maintaining the arrhythmia using electrophysiological mapping. However, electrophysiological mapping is a time-consuming and invasive approach. Additionall...Tue, 07 Oct 2014 10:26:58 GMTJHTT-Communications@jhu.edu Releasing Factor (HRF) Inducible Mice Transgenic HFR Mouse Model for Asthma and Allergy Drug DiscoveryNovelty: A mouse strain harboring lung epithelial cell-targeted inducible HRF, permitting the site-specific, regulatable HRF over-expression to study its use as a drug target for asthma and allergies.Value Proposition: Asthma is a prevalent chronic lung disorder characterized by inflammation and narrowing of the airways that can be efficiently controlled, yet, to date is incurable. Histamine releasing factor (HRF) has been suggested as a potential therapeutic target for asthma and other allergic reactions; however, detaile...Tue, 07 Oct 2014 10:26:56 GMTJHTT-Communications@jhu.edu System and Method for 3D-2D Image Registration Multiple Source / Single Detector System for 3D-2D Image RegistrationNovelty: The technology is a system and method for registration of 3D volumetric images to 2D images using a single X-ray detector for multiple emitters.Value Proposition: Surgical procedures depend on pre-operative registration for being successful. The accuracy of registration depends on how well the system can infer data from 3D image and identify the parts to be operated on a 2D image. The inventors have developed this technology to achieve accurate 3D-2D registration as well as reducing exposure of the patient to...Tue, 07 Oct 2014 10:26:56 GMTJHTT-Communications@jhu.edu applications of tissue extracellular matrix particles Extracellular Matrix Fabrication and ApplicationsNovelty: A novel method of fabricating extracellular matrix (ECM) solutions and structures.Value Proposition: ECM derived from human or animal tissue provides complex architectural and biological features to support in vivo tissue regeneration and in vitro biomedical research. Existing methods for the fabrication of ECM particles produce ECM particles with a heterogeneous mixture of particle size, making it difficult to standardize research for the effects of cell-ECM interactions and limiting options for in vivo ECM delivery. This novel...Tue, 07 Oct 2014 10:26:56 GMTJHTT-Communications@jhu.edu Automated Pipeline MriStudio Automated Pipeline AlgorithmsNovelty: Novel algorithms for the automated analysis and tagging of magnetic resonance (MR) images.Value Proposition: Transferring the clinical identification of MR image regions of interest from manual to automatic techniques would likely reduce time required for analysis and increase reliability; however, current methods of automated brain mapping techniques actually reduce accuracy due to over-simplified processes. These novel algorithms have been combined in series to create a tool for the automated anatomical labeling of brain structures (JHU...Tue, 07 Oct 2014 10:26:55 GMTJHTT-Communications@jhu.edu Anatomical Labeling by Multi-Contrast Differmorphic Probability Fusion Automated Anatomical Labeling of Brain StructuresNovelty: A novel method to automatically label brain tissue types and structures based on imaged tissue characteristics.Value Proposition: Identification of brain structures or regions of interest (ROIs) is an essential step in image-based neurological analysis. For example, medical MR imaging of the brain requires identification of key anatomical structures. Manual definition of structures is often used as the gold standard and its time-consuming and often provides poor reproducibility. Automated brain mapping techniques that chart unde...Tue, 07 Oct 2014 10:26:55 GMTJHTT-Communications@jhu.edu Visual Acuity Testing Vision Test SoftwareNovelty: An automated software platform for examiner-independent assessment of patient visual acuity.Value Proposition: The CDC estimates that approximately 11 million Americans aged 12 years and older could improve their vision through proper refractive correction, and more than 3.3 million Americans aged 40 years and older require this correction to perform daily functions. This technology is an automated software platform to test visual acuity. In this software, a customized algorithm is used to identify the minimal character size that is reliably recognized by t...Tue, 07 Oct 2014 10:26:55 GMTJHTT-Communications@jhu.edu monoclonal antibody Monoclonal PICK1 Antibody for Characterization of AMPAR in Synaptic PlasticityNovelty: A novel monoclonal anti-PICK1 antibody, permitting researchers to unravel the mechanisms and significance of AMPAR trafficking for synaptic plasticity.Value Proposition: AMPA receptors (AMPARs) are tetrameric glutamate-gated ion channels, which mediate fast excitatory synaptic transmission in the brain. Dynamic regulation of AMPAR plays a critical role in synaptic plasticity underlying learning and memory. Protein kinase C-binding protein PICK1 is a binding partner and essential regulator of AMPAR in...Tue, 07 Oct 2014 10:26:54 GMTJHTT-Communications@jhu.edu monoclonal antibody Monoclonal GluR3 Antibody for Characterization of AMPAR in Synaptic PlasticityNovelty: A novel monoclonal anti-GluR3 antibody, permitting researchers to unravel the mechanisms and significance of AMPAR trafficking for synaptic plasticity.Value Proposition: AMPA receptors (AMPARs) are glutamate-gated ion channels that mediate fast excitatory synaptic transmission in the brain. Functional AMPARs are tetramers assembled from 4 subunits, GluR1-4, that operate as modulators of synaptic strength underlying learning and memory; yet, the precise physiological role of individual subunit composi...Tue, 07 Oct 2014 10:26:54 GMTJHTT-Communications@jhu.edu monoclonal antibody Monoclonal GluR2 Antibody for Characterization of AMPAR in Synaptic PlasticityNovelty: A novel monoclonal anti-GluR2 antibody, permitting researchers to unravel the mechanisms and significance of AMPAR trafficking for synaptic plasticity.Value Proposition: Glutamate is the primary excitatory neurotransmitter in the brain, mediating fast synaptic transmission predominantly via AMPA receptors (AMPARs). AMPAR trafficking and insertion into the neuronal surface is critical for synaptic scaling, integral to learning and memory. This technology provides a monoclonal antibody against AMPAR su...Tue, 07 Oct 2014 10:26:54 GMTJHTT-Communications@jhu.edu monoclonal antibody. Monoclonal GluR1 Antibody for Characterization of AMPAR in Synaptic PlasticityNovelty: A novel monoclonal anti-GluR1 antibody, permitting researchers to unravel the mechanisms and significance of AMPAR trafficking for synaptic plasticity.Value Proposition: Most excitatory synaptic transmission in the brain is mediated by AMPA receptors (AMPARs), ionotropic glutamate receptors believed to be integral to synaptic plasticity underlying learning and memory. AMPAR dysregulation has been associated with various neuropathologies; therefore, the herein disclosed monoclonal antibody against AMP...Tue, 07 Oct 2014 10:26:54 GMTJHTT-Communications@jhu.edu method for computationally predicting electrically optimal placement sites for internal defibrillators in pediatric and congenital heart disease patients Method to Predict Optimal ICD PlacementNovelty: A method for computationally predicting electrically optimal placement sites for implantable cardioverter- defibrillators (ICDs), specifically in pediatric and congenital heart defect patients.Value Proposition: Standard procedures for implantation of ICDs typically cannot be used in pediatric and congenital heart defect (CHD) patients because of small heart size and congenitally altered anatomy. ICD implantation in this population is often individualized, and there are no standardized protocols for healthcare providers to follow. This va...Tue, 07 Oct 2014 10:26:53 GMTJHTT-Communications@jhu.edu Polyclonal Antibody Directed Against a Peptide Corresponding to Mouse and Human Acyl Coenzyme A Thioesterase 7 (ACOT7) ACOT7 Antibody for Neurometabolic Profiling and Drug DiscoveryNovelty: A polyclonal antibody against ACOT7, permitting unraveling the regulation of neuronal lipid balance for the discovery of novel therapeutics for neurological diseases.Value Proposition: Dysregulated lipid metabolism has been implicated in a multitude of inborn neuropathologies and neurodegenerative diseases, including Alzheimers and Parkinsons disease. Yet, to date the basic metabolic control of fatty acid metabolism in neurons remains enigmatic. This technology provides a polyclonal antibody against (acyl-CoA thioes...Tue, 07 Oct 2014 10:26:53 GMTJHTT-Communications@jhu.edu Suicidality and Impulsivity in Children and Adolescents when Initiating Antidepressant Therapy Treating Suicidal Symptoms Derived from Anti-depressant TherapyNovelty: This technology has identified two novel preventative methods to address increased suicidal behaviors observed in children and young adults suffering from depression and panic disorders starting treatment on anti-depressant drugsValue Proposition: The time delay before patient experience the effective benefits of Anti-depressants or SSRIs (Selective Serotonin Reuptake Inhibitors) therapies has become an accepted fact among the medical community. Additionally, studies show there is an increased risk of suicidality (...Tue, 07 Oct 2014 10:26:53 GMTJHTT-Communications@jhu.edu Bayesian Inference Model to Predict Phenotype from Personal Variation Bayesian Inference Model to Predict Phenotype from Personal VariationNovelty: An inference model that predicts the probability of medically relevant phenotypes from an individuals genomic information.Value Proposition: Genetic testing is increasingly used as a diagnosis, linking genomic data to specific phenotypic characteristics; however, due to patient variability, it is challenging to develop a model to predict the association between genetic information and phenotype on an individual level, for personalized testing. This model can be used to predict individual phenotypes based on a...Tue, 07 Oct 2014 10:26:52 GMTJHTT-Communications@jhu.edu Vena Cava (IVC) Shunt, Double-balloon Catheter for Occlusion as a Surgical Tool Readily Adjustable Dual-Balloon Catheter for Cardiovascular SurgeryNovelty: This technology implements an adjustable dual-balloon system within an intravascular catheter to allow finer control and better fit for a variety of blood vessel dimensions.Value Proposition: Current balloon catheters for the Inferior Vena Cava (IVC), the major vein that returns blood to the heart, have fixed balloon sizes which make it harder to control blood loss due to the vessels irregular dimensions and can cause further damage by overstretching it. This enhanced catheter invention uses two adjustable ball...Tue, 07 Oct 2014 10:26:51 GMTJHTT-Communications@jhu.edu Milestone Achievement (LCMA) system Learner-Centered Milestone Achievement (LCMA) SystemNovelty: An electronic education tool for continuous improvement of medical education interactions through the monitoring and reporting of milestone-performance outcomes.Value Proposition: The readiness of surgical residency graduates is not always guaranteed in todays healthcare systems. As the complexity in the healthcare system grows, more effective and efficient strategies are demanded to develop competent professionals. The LCMA system applies adult learning strategies to maximize individual achievement of milestone outcomes in o...Tue, 07 Oct 2014 10:26:50 GMTJHTT-Communications@jhu.edu Interface Between Pre-existing CPR Performance Measurement Devices and CPR Performance Assessment and Visualization Applications Interface between CPR performance measurement devices and performance assessment and visualization applicationsNovelty: A computer software platform with accompanying hardware to provide accurate and clinically realistic quality CPR (QCPR) feedback.Value Proposition: The American Heart Association CPR guidelines include metrics that place importance on the quality of the resuscitative effort. QCPR metrics, which include chest compression depth, rate, and recoil, are measured in practice by QCPR-capable clinical monitors to provide real-time and post-event performance feedback. Presentl...Tue, 07 Oct 2014 10:26:50 GMTJHTT-Communications@jhu.edu Sensor Signal Generator to be Used with Interfacing Clinical Monitors/devices Anatomic/Physiological Sensor Signal Generator for Clinical Monitoring DevicesNovelty: A tool to generate and send simulated clinical sensor outputs to clinical monitoring devices.Value Proposition: Despite the advances in healthcare simulation technologies, many simulators still do not interface with clinical devices realistically. A realistic training environment, including clinically-relevant population of monitoring device screens, offers a better simulation-based model with which to train and complete research. There is currently no known device that allows for generated signals t...Tue, 07 Oct 2014 10:26:50 GMTJHTT-Communications@jhu.edu Add-on Device to Allow Anterior-posterior and/or Anterior-lateral Defibrillation Simulation Add-On Device for DefibrillationNovelty: A device to enable realistic defibrillation of healthcare simulators and simulator substitutes in the AP and AL positions.Value Proposition: Cardiac arrest causes more than 300,000 deaths in the United States annually. Rapid defibrillation and high quality chest compressions have been shown to significantly reduce patient morbidity and mortality. Defibrillation training is vital, as it has been demonstrated that pediatric providers with hands-on experience with a defibrillator are 87% more likely to successfully defibrillate in a give...Tue, 07 Oct 2014 10:26:50 GMTJHTT-Communications@jhu.edu of T2-preparation and motion tracking in Magnetic Resonance Integration of T2-Preparation and Motion Tracking in MRINovelty: A method for improving T2-weighted magnetic resonance imaging (MRI) in the presence of patient motion.Value Proposition: MRI is an indispensible medical imaging modality, primarily because of its ability to distinguish among a wide variety of human tissues and tissue pathologies. However, MRI is a relatively slow imaging technique and therefore motion artifact in images is inevitable. This technology allows for the concurrent measurement of motion during T2-weighted imaging without increasing total imaging time. Additiona...Tue, 07 Oct 2014 10:26:49 GMTJHTT-Communications@jhu.edu Sensing of Free Metal Ions Using iCEST MRI-based Non-Invasive Metal Ion Detection SystemNovelty: Novel method combining chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) with 19F fluorinated chelators to detect free metal ions with high sensitivity and specificity.Value Proposition: Although metal ions are involved in a myriad of biological processes, non-invasive detection of free metal ions in deep tissue remains a formidable challenge. This invention presents an approach for specific sensing of the presence of metal ions in which the amplification strategy of CEST is combined with the broad ra...Tue, 07 Oct 2014 10:26:49 GMTJHTT-Communications@jhu.edu Augmented Reality Multimodal Operation Neural Integration Environment (HARMONIE) HARMONIE System: Hybrid Augmented Reality Multimodal Operation Neural Integration EnvironmentNovelty: A device to improve upper-extremity prosthetics with integrated eye tracking and machine vision, volitional control, and voice command feedback capabilities.Value Proposition: Approximately 55,500 arm-related amputations are recorded in US Hospitals annually. Upper-extremity prosthetic devices have advanced to enable patients to complete simple manipulatory functions; however many of these prosthetics limit tactile control due to inadequate prosthetic feedback systems regarding the var...Tue, 07 Oct 2014 10:26:49 GMTJHTT-Communications@jhu.edu Substrates New Reporter System for CEST MRINovelty: Novel reporter system for chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) without paramagnetic metal substrates.Value Proposition: Among the clinically applied 3D imaging modalities, MRI has the highest resolution and is therefore the preferred method for detection of cellular gene expression. However, because of the low sensitivity of MRI, few reporter gene systems exist. This invention comprises a new class of reporter genes for MRI that does not employ paramagnetic metal substrates but rather relies on the contra...Tue, 07 Oct 2014 10:26:48 GMTJHTT-Communications@jhu.edu Analysis by Glycoprotein Immobilization for Glycan Extraction and Liquid Chromatography on Microfluidic Chip High-Throughput Glycan Profiling via Solid-Phase Extraction and MicroCHIP-LCNovelty: Novel solid phase glycan extraction microfluidics chip for high-throughput glycan analysis, useful for disease diagnostic and drug development.Value Proposition: Mass spectrometry (MS) has become of increasing interest to quantitatively monitor aberrant glycosylation, implicated in a variety of diseases, including inflammation, HIV and cancer; yet, current glycan analysis procedures require time-consuming multi-step sample preparation, resulting in low yield and poor reproducibility. Therefore, this in...Tue, 07 Oct 2014 10:26:48 GMTJHTT-Communications@jhu.edu Cardiac Glycoside Analogs as Anti-Human Cytomegalovirus (HCMV) Agents Novel group of cardiac glycosides shown to have effective anti-HCMV properties for HCMV infection treatment. Value Proposition: HCMV infection is a serious problem in organ transplant patients and congenitally-infected babies. The currently available systemic therapies for HCMV targeting the viral DNA polymerase are associated with significant side effects and emergence of resistant viral strains. This invention identifies a class of cardiac glycosides as host-targeted therapeutics for HCMV. Additional advantages include: Circumvents the problem of resistant viral strainsNo side effec...Tue, 07 Oct 2014 10:26:48 GMTJHTT-Communications@jhu.edu Heterocycles for MRI Contrast and pH Sensing, 07 Oct 2014 10:26:48 GMTJHTT-Communications@jhu.edu Acid and Its Analogs for MRI Contrast, 07 Oct 2014 10:26:48 GMTJHTT-Communications@jhu.edu ya Mtungi - Secrets of the Gourd Siri ya Mtungi Educational Docudrama for Improved Health Care in TanzaniaNovelty: An educational television drama featuring everyday life and challenges in Tanzania, aiming to introduce societal and behavioral changes for an improved health outcome.Value Proposition: Tanzania is facing a generalized HIV epidemic, with an estimated adult prevalence of 5.6%. Yet, poverty and inadequate human resources to deliver quality health services to the population exacerbate an efficient disease management. Hence, the here-disclosed educational television drama set in Dar es Salaam comprising stor...Tue, 07 Oct 2014 10:26:47 GMTJHTT-Communications@jhu.edu Actuators for Controlled Release of Drugs Mechanical-Chemical Controlled-Release Microtools for Targeted Drug DeliveryNovelty: Novel mechanical-chemical drug-loaded micro-devices capable of anchoring to diseased tissue followed by sustained drug release.Value Proposition: There is an unmet need for improved drug delivery systems enabling the non-invasive, patient-accepted administration of therapeutics for gastrointestinal disorders. Recent progress in matrix materials has led to the development of proficient time-release technologies allowing the prolonged drug release over several days; yet, the current limitation is a targe...Tue, 07 Oct 2014 10:26:47 GMTJHTT-Communications@jhu.edu, Non-invasive, Non-contact, and Real-time Tumor Detection Using Ultra-WideBand (UWB) Radar Tumor Detection Using Radar-based Medical ImagingNovelty: A novel tumor-detection technique using Ultra-Wideband (UWB) radar.Value Proposition: UWB is a new technology used in military and commercial remote sensing applications for through-the-wall imaging, identifying hidden features obstructed by walls, concrete, or ground surfaces. This invention transfers and modifies existing UWB technology to provide lower-cost, more effective, and safer radiation oncology imaging. It is particularly valuable to real-time lung tumor imaging and position detection, as existing modes of imaging, su...Tue, 07 Oct 2014 10:26:46 GMTJHTT-Communications@jhu.edu therapeutic target for Human Cytomegalovirus (HCMV) infection Identification of Nucleotide-binding Oligomerization Domain-containing protein 2 (NOD2) as a key protein expressed and involved in HCMV infections and diseases.Value Proposition: HCMV is a major pathogen in immunocompromised hosts and pregnant women. The currently available therapies for HCMV are associated with significant side effects and emergence of resistant viral strains. Apart from safety and resistance, drug efficacy is also a major concern with these HCMV drugs. This invention introduces a new protein, NOD2, which plays a key role in HCMV infection regulation and therefore, i...Tue, 07 Oct 2014 10:26:46 GMTJHTT-Communications@jhu.edu and Therapeutic Applications Thereof RNA Polymerase I Inhibitors to Treat CancersNovelty: Novel small molecules that inhibit RNA polymerase I-driven cancers by promoting proteasome-mediated degradation of the catalytic subunitValue Proposition: Given that aberrant RNA polymerase I transcription is a hallmark of cancer, targeting components of the Pol I machinery should be a promising approach for developing anti-cancer medicines. Actinomycin D is the sole representative of specific RNA polymerase I inhibitors in current clinical use. Despite its high efficiency, its applications have been limited by its high toxicity. Eve...Tue, 07 Oct 2014 10:26:46 GMTJHTT-Communications@jhu.edu Regulates HER2/EGFR Activity in HER2-positive Breast Cancer, 07 Oct 2014 10:26:45 GMTJHTT-Communications@jhu.edu Keyword Search System using Bayesian Point Process Models Phonetic Keyword Search System Using Bayesian Point Process ModelsNovelty: An efficient system architecture for keyword search based on the phonetic timing characteristics of speech.Value Proposition: Methods for identifying keywords or keyphrases in continuous speech are implemented in a growing number of technologies. In battery-powered mobile devices, such as smartphones, laptops, and tablets, these speech retrieval systems must be increasingly efficient, as the majority of these devices still do not match the computing power of desktop computers. Although keyword search technologie...Tue, 07 Oct 2014 10:26:45 GMTJHTT-Communications@jhu.edu Localization and Navigation (BLN) Bioelectric Localization and NavigationNovelty: A novel system for localization, tracking, and navigation of interventional devices, such as catheters and endoscopes, without using external imaging.Value Proposition: Guidance of interventional devices generally relies on external imaging such as fluoroscopy, CT, or MRI. These techniques often subject patients to dangerous and unnecessary levels of radiation, putting patients at risk for cancer and other injuries. The proposed system utilizes extremely low-voltage signals generated and/or measured by an array of electrodes on the medica...Tue, 07 Oct 2014 10:26:44 GMTJHTT-Communications@jhu.edu Resonance Pulse Sequence for Detecting the Buildup of the Transfer of Changes in Magnetization from Nuclei in Mobile Solute Molecules in Tissue Method to Improve CEST MRI AcquisitionsNovelty: Magnetic resonance imaging (MRI) pulse sequence for detecting the buildup of the transfer of magnetization changes from nuclei in mobile solute molecules in tissue.Value Proposition: Chemical Exchange Saturation Transfer (CEST) imaging is a new MR imaging approach that allows for the detection of low concentration endogenous cellular proteins and metabolites indirectly through their exchangeable protons. In addition exogenous agents can be detected. Because of the increased imaging sensitivity specific to CEST techniques, the concentratio...Tue, 07 Oct 2014 10:26:44 GMTJHTT-Communications@jhu.edu to Accelerate Healing of Injured Tissues via Stem Cells in Nanofiber Patches Stem Cell Developed Patches for Accelerated AngiogenesisNovelty: This technology describes compositions and methods of use of certain patches, with infused stem cells and/or derived growth factors, used for accelerated healing of tissue injuries.Value Proposition: Existing therapeutic angiogenesis techniques that employ individual growth factors and other stem cell delivery methods to tissue injuries are non-optimal due to unknown factors associated with the correct sequence, concentration and combination of injecting the growth factors and stem cells. This technology exploits the pote...Tue, 07 Oct 2014 10:26:44 GMTJHTT-Communications@jhu.edu Ear Implant Sensor Middle Ear Implant SensorNovelty: A piezoelectric sensor for monitoring compressive load and verifying proper sound conduction in middle ear implants to provide surgeons with real-time feedback regarding implant fit and positioning during surgery.Value Proposition: According to the World Health Organization, global incidence of middle ear-related hearing disorders amount to 4.76 cases per 1000 individuals. It has been reported that over 20% of ear implant surgeries require revision surgery after initial implant installation due to improper placement, as there are currently no intraoper...Tue, 07 Oct 2014 10:26:43 GMTJHTT-Communications@jhu.edu Stimulation Electrode Vestibular Stimulation ElectrodeNovelty: A novel vestibular stimulation electrode lead to be used with an implanted stimulation module in patients with impaired vestibular function.Value Proposition: Over one-third of all Americans over the age of 40 have vestibular dysfunction. Damaged or impaired vestibular systems can cause balance problems, such as unsteadiness, vertigo, and vision difficulties. A number of vestibular stimulation approaches have been developed to replace the natural mechanisms of balance sensation in patients with impaired vestibular systems; however existing elect...Tue, 07 Oct 2014 10:26:43 GMTJHTT-Communications@jhu.edu Source-detector Trajectories for Tomographic Imaging Task-based Trajectories for Tomographic ImagingNovelty: A method that can integrate a patients prior intervention image knowledge into the new image acquisition process. A customized scan orbit will be applied to maximize image acquisition performance.Value Proposition: Traditional tomographic imaging approaches tend to neglect the utilization of previous imaging scans or use them in only a very coarse manner. Robotic C-arms have the capacity for general CT trajectories, but the use of arbitrary orbits has been very limited. Similarly, the data from these arbitrary orbits can be more d...Tue, 07 Oct 2014 10:26:43 GMTJHTT-Communications@jhu.edu Force/Toque Sensor with Fiber Bragg Gratings MRI-Compatible Force and Torque SensorNovelty: A MRI-compatible tool to remotely measure axial force and torque interactions between a device, such as a surgical needle, and a substrate, such as patient tissue and, then, relay this information to the user.Value Proposition: Prostate needle insertion is a technique used in medical procedures, such as brachytherapy seed implantation, biopsies, and treatment injections; during prostate needle insertion, the gland rotates and displaces and the surrounding soft tissues deform, resulting in needle placement inaccuracy. Needle placement error...Tue, 07 Oct 2014 10:26:43 GMTJHTT-Communications@jhu.edu for Registration and Enhanced Visualization in X-ray Radiographs Method for Registration and Enhanced Visualization in X-Ray RadiographsNovelty: This invention enables 9 degrees of freedom (DoF) for 3D-2D image registration for radiographic X-ray based medical imaging devices. It enables registration in scenarios where position of X-ray is unconstrained to the detector.Value Proposition: Conventional methods for solving the 3D-2D registration problem during X-ray detection are limited in their ability to solve higher-order Degrees of Freedom (DoF) systems. This poses a problem when the position of X-ray source can be unconstrained with respect to th...Tue, 07 Oct 2014 10:26:42 GMTJHTT-Communications@jhu.edu Novel Method for Magnetometer and Accelerometer Calibration from Angular Rate Gyroscopes Method for Magnetometer and Accelerometer CalibrationNovelty: A novel technique for estimating sensor bias in magnetometers and accelerometers using angular rate data obtained from a gyroscope.Value Proposition: Magnetometers, accelerometers, and gyroscopes are used together in a number of applications, including vehicle navigation systems and personal electronics devices, such as smart phones and tablet devices. The combination of these sensors allows for the estimation of the full attitude (heading, pitch, and roll) of a device; however, all of these sensors are affected by biases, s...Tue, 07 Oct 2014 10:26:42 GMTJHTT-Communications@jhu.edu derivatives as novel drugs against epilepsy syndromes caused by aberrant sodium channel behavior Epilepsy Therapy via Sodium Channel Modulation using Rufinamide AnalogsNovelty: Identification of rufinamide and its analogs as promising new therapeutics for epileptic diseases and seizure disorders.Value Proposition: Lennox-Gastaut Syndrome (LGS) is rare and severe form of childhood-onset epilepsy associated with various types of seizures and cognitive dysfunction that persist into adulthood; yet, to date, LGS management is challenged by the lack of reliable diagnostic tests and potentially grave side-effects of available therapeutics. Rufinamide is a promising new compound with broa...Tue, 07 Oct 2014 10:26:41 GMTJHTT-Communications@jhu.edu Guiding Indication System for Monitoring Vascular Flow and Patency under Ultrasound Ultrasound-Based Anastomosis Detection and Assessment ToolNovelty: An implantable, resorbable marker and associated detection software to improve effectiveness of postoperative ultrasound-based detection of vascular complications following reconstructive surgery.Value Proposition: Thousands of patients undergo cancer- and trauma-related reconstructive surgery annually; however, many procedures fail due to inadequate revascularization of implanted tissue. This is generally in the location of the surgical connection between existing blood vessels and the ones in the implanted tissue, kno...Tue, 07 Oct 2014 10:26:41 GMTJHTT-Communications@jhu.edu methylation markers for metastatic prostate cancer Novel Biomarkers for Metastatic Prostate Cancer Diagnosis/PrognosisNovelty: Epigenetic biomarkers for the diagnosis and risk assessment of metastatic prostate cancer based on DNA hyper/hypo-methylation patterns from metastatic tissue of patients.Value Proposition: Current prostate cancers tests show low specificity and moderate sensitivity leading to many false diagnoses. There is also an unmet clinical need for biomarkers that can diagnose prostate cancer in the early stage. This invention comprises of biomarkers that display DNA methylation patterns in metastatic prostate cancer for ...Tue, 07 Oct 2014 10:26:40 GMTJHTT-Communications@jhu.edu Conditional Knockout Mouse Viable vangl2 Conditional Knockout Transgenic MouseNovelty: This invention is a viable vangl2 conditional knockout transgenic mouse. VANGL planar cell polarity protein 2 (VANGL2) is a membrane protein involved in specialized directional shape development of cell types key for hearing, balance and neural tube development. Mutations in vangl2 result in misalignment of tissues that require highly aligned polarity for proper function.Value Proposition: A recognized challenge to vangl2 functional studies is that currently available vangl2 transgenic mice disrupt vangl2 in the entire embry...Tue, 07 Oct 2014 10:26:40 GMTJHTT-Communications@jhu.edu IMPLANT SYSTEM WITH LOW BATTERY ALERT Vestibular Implant System with Low Battery AlertNovelty: This technology is a vestibular implant system with a low battery alert. The system includes an implantable stimulator which provides a signal to electrically stimulate target neural tissue for vestibular sensation.Value Proposition: One significant challenge for vestibular implant system is supplying and maintaining the amount of power demanded by such a system to function continuously. The relatively high power consumption requires a large battery placed within the system. Changes in the battery levels and power status can a...Tue, 07 Oct 2014 10:26:39 GMTJHTT-Communications@jhu.edu magnetic resonance imaging (fMRI) methodology using transverse relaxation preparation and non- echo-planar-imaging (EPI) pulse sequences Enhanced Whole Brain fMRINovelty: This invention is a method to mitigate geometric distortion and signal dropout when performing whole brain imaging by blood-oxygenation-level-dependent fMRI.Value Proposition: Current approaches to blood-oxygenation-level-dependent (BOLD) fMRI rely on 2D gradient echo (GRE) echo-planar-imaging (EPI), and are limited by geometric distortions and signal dropouts in regions near air cavities such as in the orbitofrontal cortex and temporal lobes. This method addresses these limitations. It relies on inducing BOLD contrast with a T2 or T2* preparation modu...Tue, 07 Oct 2014 10:26:39 GMTJHTT-Communications@jhu.edu Telomerator a new tool for chromosome engineering (Circular to Linear DNA Converter) Novel Circular to Linear DNA ConverterNovelty: Novel in vivo method to inducible convert circular DNA molecules in yeast into stably maintained linear chromosomes.Value Proposition: Currently, circular artificial chromosomes are the mainstay in chromosome engineering. This invention comprises a technology by which DNA can be linearized at any position in a circular molecule to produce a stable, fully functional, synthetic chromosome in yeast. Other advantages include: - Useful in creating disease models in engineered yeast cells - Critical component of a neochromosome - Can be potentia...Tue, 07 Oct 2014 10:26:39 GMTJHTT-Communications@jhu.edu technology for epigenetic drug development, 07 Oct 2014 10:26:38 GMTJHTT-Communications@jhu.edu for Tracking Microsurgical Instrumentation System for Tracking Microsurgical InstrumentationNovelty: A device that provides real-time 3D tracking of the eye and surgical instruments relative to each other during surgical procedures.Value Proposition: A number of unaddressed problems are regularly encountered in eye surgery, such as poor visualization, lack of force sensing, and hand tremor. Computer- and robot-assisted ocular surgical systems offer solutions to many of these problems; however, many existing systems interfere with existing workflow, obstruct the visual path, and can be inaccurate. Using depth- and position-sensi...Tue, 07 Oct 2014 10:26:37 GMTJHTT-Communications@jhu.edu - A Webtool for Patient Report Outcome (PRO) Data Collection in Clinical Practice A Web Tool for Patient Report Outcomes (PRO) Data Collection in Clinical PracticeNovelty: The invention is a prototype website to collect PROs in outpatient clinical oncology and link the data with the Electronic Medical Record (EMR). It can indicate patients problems, provide recommendations, and connect the result with electronic health records.Value Proposition: Preliminary reports from clinicians and patients suggest that a website to collect PROs and link them with the EMR could help improve the quality of cancer care. Therefore, there is a need to centralize the PRO data and repo...Tue, 07 Oct 2014 10:26:37 GMTJHTT-Communications@jhu.edu of Diagnostic Biomarkers and Therapeutic Targets for Pancreatic Cancer Diagnostic Protein Biomarkers For Pancreatic CancerNovelty: This technology comprises the identification of three protein biomarkers, highly expressed in pancreatic cancer compared to normal pancreatic cells.Value Proposition: Pancreatic ductal adenocarcinoma is the fourth leading cause of cancer-related death in the US. Thus there is an unmet need for diagnostic markers in pancreatic cancer. Current markers are not very reliable. This invention provides three biomarkers strongly expressed in pancreatic cancer where as weakly or not expressed at all in pancreatic normal duct cells. The...Tue, 07 Oct 2014 10:26:37 GMTJHTT-Communications@jhu.edu Therapeutic Strategy for Human Cytomegalovirus (HCMV) Infection A novel therapeutic strategy for HCMV infection by modulation of the Wnt signaling pathway. Value Proposition: HMCV infection is a serious threat for pregnant women and the immunocompromised, such as HIV/AIDS patients or solid organ transplant recipients. Currently, the main HCMV treatment is a six-week cycle of intravenous administration of ganciclovir (GCV), a viral DNA polymerase inhibitor. Given the long treatment cycle, side-effects, toxicity and GCV resistant viral strains, alternative treatments are highly desirable. This technology identifies a novel therapeutic approach for b...Tue, 07 Oct 2014 10:26:36 GMTJHTT-Communications@jhu.edu ShhN, 07 Oct 2014 10:26:36 GMTJHTT-Communications@jhu.edu Large Frequency Moments with Pick-and-Drop Sampling Big Data Algorithm using Large Frequency MomentsNovelty: An algorithm that uses approximating large frequency moments with pick-and-drop sampling to analyze big data.Value Proposition: As the volume of data grows the ability to analyze the data becomes compromised. In some cases the data is generated by a single event and stored for analysis, such as from a large simulation. In others, the data is generated by singular concurrent events, such as daily sales data from Amazon. While each day's data may be efficiently analyzed, the size the aggregate data may be too big for practical anal...Tue, 07 Oct 2014 10:26:36 GMTJHTT-Communications@jhu.edu Poly(beta-amino ester)s for siRNA Delivery Efficient Delivery Vehicle for Controlled Gene KnockdownNovelty: This technology comprises the use of bioreducible polymer based nanoparticle system that can release siRNA cargo to the cytoplasm of cells to knockdown target gene expression in tissues.Value Proposition: Gene therapy is a developing medical field and there is a need for systems that can rapidly and efficiently deliver therapeutic products to the site of action. siRNA based gene therapy is one such approach and its ability to efficiently target expression of specific genes is well known. But systems that can deliver siRNA...Tue, 07 Oct 2014 10:26:34 GMTJHTT-Communications@jhu.edu Position Imaging Toolbox (muPIT) Interactive: Webserver for mapping variant positions to annotated, interactive 3D structures Mutation Position Imaging Toolbox (muPIT) InteractiveNovelty: The current invention is a browser-based application for single nucleotide variants and mutations, designed to map genomic positions onto 3D protein structures.Value Proposition: The vast amount of available sequencing data is evidence that the limiting factor of research is shifting from data acquisition towards data analysis. As part of this effort, computational methods have been developed to identify putatively relevant genetic variants, but results are sometimes difficult to interpret. For example, many popular methods ...Tue, 07 Oct 2014 10:26:34 GMTJHTT-Communications@jhu.edu of DNA from the Papanicolaou Test to Detect Ovarian and Endometrial Cancers PapGene TestNovelty: This invention provides a diagnostic for ovarian and endometrial cancers using Pap smear samples.Value Proposition: The incidence and mortality of ovarian and endometrial cancers have remained high due to the lack of effective screening tests for early detection. Recently, the liquid-based Pap test replaced traditional Pap smear in screening tests for cervical cancer. The new Pap test enables cytological evaluation and collection of DNA for molecular diagnostics. This invention provides a new screening method for ovarian and endometrial cancers by detecting DNA mut...Tue, 07 Oct 2014 10:26:33 GMTJHTT-Communications@jhu.edu Peptide Hydrogels Generating Chemical Exchange Saturation Transfer MRI Contrast and Uses Thereof, 07 Oct 2014 10:26:33 GMTJHTT-Communications@jhu.edu wild type and AKT1 E17K and PIK3CA H1047R knock-in MCF-7 cells PIK3CA Wild Type and AKT1 E17K and PIK3CA H1047R Knock-in MCF-7 CellsNovelty: MCF-7 derivatives with different mutations in the phosphatidylinositol-3-kinase (PI3-kinase) pathway gene PIK3CA and AKT1.Value Proposition: MCF-7 is the most widely used human breast cancer cell line, and it serves as a valuable model for preclinical investigations of breast cancer biology and therapy. The most commonly used techniques to study gene function in human cell lines include transgene expression or gene knockdown using short interfering RNA technology. These methods do not allow physiologic expres...Tue, 07 Oct 2014 10:26:33 GMTJHTT-Communications@jhu.edu Multi-echo Length and Offset VARied Saturation (Me-LOVARS) Method for Chemical Exchange Saturation Transfer (CEST) MR Imaging High Temporal Resolution CEST ImagingNovelty: This invention allows for a higher temporal resolution for Chemical Exchange Saturation Transfer (CEST) imaging while preserving high contrast ratios.Value Proposition: CEST imaging allows for the detection of low concentrations of solutes. However, in order to do this type of imaging, a long saturation pulse is required. This new invention divides the long saturation pulse into 3-5 smaller pulses, after which an image can be acquired. The temporal resolution is increased over previous methods, and tumor contrast values are improved by 3-5%...Tue, 07 Oct 2014 10:26:32 GMTJHTT-Communications@jhu.edu Inducible Reconstitution and Real-time Quantitative Kinetic System for the Analysis of Catalysis and Inhibition in Membranes An assay to evaluate membrane-immersed enzyme kinetics in real time.Novelty: This technology is an inducible and real-time quantitative kinetic assay for the analysis of intra-membrane proteolysis.Value Proposition: Intra-membrane proteases can catalyze hydrolysis immersed within membranes. These enzymes are implicated in diseases such as Alzheimers disease, Parkinsons disease, Malaria and Tuberculosis. No assay is currently available to quantitatively monitor catalysis occurring within a cells natural membrane setting in real-time. This invention provides a novel assay for the analysi...Tue, 07 Oct 2014 10:26:32 GMTJHTT-Communications@jhu.edu, Projection-based MRI Endoscopy Method Motion Insensitive MRI EndoscopyNovelty: This technology enables MRI endoscopy to capture clear images despite any patient/endoscope movement.Value Proposition: Patient movement during traditional MRI can dramatically decrease the quality of the resulting images. MRI endoscopy adds yet another moving part. This invention facilitates the use of MRI endoscopy by reducing its sensitivity to movement. This novel technology reduces the amount of time required to take one image from 0.5 seconds to up to 2 milliseconds, which lowers the dependence of image quality on patient/endoscope movem...Tue, 07 Oct 2014 10:26:32 GMTJHTT-Communications@jhu.edu Fluorescent Aldehyde Dehydrogenase (ALDH) Substrate Red-Fluorescent Aldehyde Dehydrogenase Substrate for Stem Cell IsolationNovelty: A novel red-fluorescent ALDH substrate facilitating the imaging and purification of viable stem cells for different therapeutic applications.Value Proposition: A hallmark of normal and cancer stem cells (CSC) is an enhanced activity of aldehyde dehydrogenases (ALDH), oxidoreductases involved in many cell metabolic, differentiation and detoxification processes. Thus, ALDH presents a functional marker to identify and isolate these rare cell types; yet, green-fluorescent ALDH substrates currently used to stai...Tue, 07 Oct 2014 10:26:31 GMTJHTT-Communications@jhu.edu Genetic Assay to Determine Prognosis in Polycythemia vera Patients Genetic Biomarker Prognostic Screen for Polycythemia Vera PatientsNovelty: The technology is a PCR-based screening assay based on identified genetic biomarkers to determine prognosis in polycythemia vera patients.Value Proposition: Polycythemia vera (PV) is a blood cell disorder complicated by the risk of disease progression into acute myeloid leukemia and myelofibrosis. Predictive assays which can inform physicians about individual patient transformation risk are currently unavailable. However, information about patient transformation risk is important to avoid prescribing unnecessary...Tue, 07 Oct 2014 10:26:31 GMTJHTT-Communications@jhu.edu Classifiers for Non-invasive Identification of High Grade Prostate Cancer with Metastatic Potential Genomic Classifiers for Non-Invasive Identification of Prostate CancerNovelty: This technology comprises the identification of a genomic expression signature that is unique to high grade prostate cancer with metastatic potential which can be used as a non-invasive diagnostic assay.Value Proposition: This technology provides an alternative to the currently offered prostate cancer screening methods PSA testing and clinical staging by digital rectal exam (DRE) which leads to overuse of invasive diagnostic procedures, over/false-diagnosis and over treatment of prostate cancer. The genomic ...Tue, 07 Oct 2014 10:26:31 GMTJHTT-Communications@jhu.edu for Quantitative Analysis of Glycans and Glycosylation Sites on Glycoproteins Using Solid-phase Extraction of Glycopeptides and Glycans (SPEGAG) Quantitative High-Throughput Glycan AnalysisNovelty: This technology comprises the development of a method for quantitative analysis of glycans conjugated to proteins using mass spectrometry (Mass Spec).Value Proposition: Glycosylation is one of the most common protein modifications. Aberrant glycosylation is associated with disease development. Abnormal protein glycosylation may serve as diagnostic biomarkers and/or therapeutic targets for various disases. However, studies on protein glycosylation have been complicated by the diverse structure of protein glycans and the lack of effect...Tue, 07 Oct 2014 10:26:30 GMTJHTT-Communications@jhu.edu Assay Measurement of Amyloid Precursor Protein in Healthy and Alzheimers Disease Cerebrospinal Fluids, 07 Oct 2014 10:26:30 GMTJHTT-Communications@jhu.edu Test for Sturge-Weber Syndrome (SWS), Klippel-Trenaunay-Weber Syndrome, and Port-Wine Stains (PWSs) Based on Analysis of Gene Mutations and Biological Consequences of the Mutation A Molecular Diagnostic Test for Sturge-Weber Syndrome Value Proposition:SWS is a neurovascular disorder that is often associated with a capillary malformation of the face (PWS) and is phenotypically related to KTWS. Although SWS is a congenital disorder usually presenting in infancy, most affected individuals survive into adulthood with varying degrees of neurological impairments. Early presymptomatic diagnosis of SWS brain involvement is difficult because standard MRI and CT imaging have low sensitivity in the newborn period and early infancy. This invention provides a molecular diagn...Tue, 07 Oct 2014 10:26:28 GMTJHTT-Communications@jhu.edu Patient Flow Management (RTDC and PTM Dashboard) Real-Time Patient Flow Management (RTDC and PTM Dashboard)Novelty: This invention provides a real-time dashboard that provides the patient’s stakeholders immediate access to patient flow information.Value Proposition: Current patient flow management at hospitals remains disjointed, inconsistent and inefficient, leading to severe delays, break downs, bottlenecks, and ultimately, higher costs. By using current advances in information and communication technology (ICT), this technology monitors patient flow on a real time basis and distributes patient data to all stakeholders involved. Th...Tue, 07 Oct 2014 10:26:27 GMTJHTT-Communications@jhu.edu Robot for Transrectal Prostate Biopsy MRI-Safe Targeted Prostate Biopsy RobotNovelty: A new apparatus for accessing and sampling specific tissue in the prostate.Value Proposition: Prostate cancer diagnoses are estimated to exceed 240,000 in the US alone for 2012. Within this figure there are a large number of cases of tumors that do not threaten the lifespan of the patient. While there appears to be overtreatment of this disease, there are still roughly 28,000 deaths yearly due to prostate cancer. Poor diagnostic accuracy is largely attributed to the difficulty in obtaining the proper tissue during a biopsy. While MRI is k...Tue, 07 Oct 2014 10:26:27 GMTJHTT-Communications@jhu.edu of Drug Abuse by Preventing GAPDH Nitrosylation, 07 Oct 2014 10:26:27 GMTJHTT-Communications@jhu.edu Methylation Biomarkers of Post Partum Depression Risk, 07 Oct 2014 10:26:27 GMTJHTT-Communications@jhu.edu Temperature Mapping Using Temperature-responsive Water Saturation Shift Referencing (T-WASSR) MRI MRI Thermal ImagingNovelty: This technology is a novel, non-invasive procedure for temperature mapping of tissues regardless of fat content.Value Proposition: The use of hyperthermia devices and treatments is becoming increasingly popular for the purpose of treating cancer without radiation, chemotherapy drugs, or invasive surgery. These technologies depend highly on the ability to monitor and regulate patient temperature in the tissue to assure therapy is being properly applied. Temperature sensors, while accurate and small, only offer a single-point measurement of temperature, which ...Tue, 07 Oct 2014 10:26:26 GMTJHTT-Communications@jhu.edu Like-particles for Diagnostics and Antibody Development This tangible material is polyomavirus virus like-particles that can be used to measure human antibodies to polyomaviruses in diagnostic assays and to introduce polyomavirus capsid specific antibodies by immunization.Value Proposition: Merkel cell polyomavirus (MCPyV) is a recently discovered polyomavirus in Merkel Cell Carcinoma, a rare and aggressive skin tumor. Currently, little is known about MCPyV infection in human populations. This technology is polyomavirus virus like-particles, employed to study this disease by developing virus-like particle (VLP)-based enzyme-linked immunoso...Tue, 07 Oct 2014 10:26:25 GMTJHTT-Communications@jhu.edu Antibodies: A Novel Biomarker Associated with RA Severity Cross-reacts with and Enhances PAD4 Enzymatic Activity Novel Biomarker for Rheumatoid Arthritis SeverityNovelty: This technology is a novel biomarker that is used to diagnose and determine disease severity in patients with rheumatoid arthritis (RA).Value Proposition: Rheumatoid arthritis is a chronic autoimmune inflammatory disorder that causes inflammation and permanent damage in joints and surrounding tissues. Identifying biomarkers that could lead to earlier implementation or modification of the optimal therapy for patients are clearly needed. This invention identifies a novel biomarker that diagnoses patients with rheumatoid arthritis ...Tue, 07 Oct 2014 10:26:25 GMTJHTT-Communications@jhu.edu software for Goldmann Visual Fields Need:  Kinetic visual fields provide an important quantitative measure of peripheral retinal function and are commonly used as an outcome measure in clinical trials, especially in those for outer retinal and neuro-ophthalmic disorders.  Traditionally were collected manually, but now these maps of retinal sensitivity can n be collected by automated perimeters as well.  However, quantitative analysis of the results is often limited to area calculations of seeing areas in the visual field map.  Even if expressed as solid angles (in degrees squared or steradians) this analysis ignores the ge...Tue, 07 Oct 2014 10:26:25 GMTJHTT-Communications@jhu.edu Quality Closed-Loop Ultrasound Imaging System Closed-Loop Ultrasound Imaging SystemNovelty: Ultrasound imaging system for tracking clinical outcomes.Value Proposition: Tool tracking/guidance is pivotal to determining operation success and guaranteeing clinical outcome. The proposed invention consists of modified tools that can be incorporated into most commercial ultrasonic imaging systems. Expensive ultrasound systems do not need to be replaced. A one-time addition of external electronics to the system coupled with tools containing the proposed enhancements is all that will be needed to make use of the proposed invention. The pr...Tue, 07 Oct 2014 10:26:24 GMTJHTT-Communications@jhu.edu Rapid Interactive Mobile Messaging (TRIMM) for Weight Management mHealth Weight Management ProgramNovelty: Tailored Rapid Interactive Mobile Messaging (TRIMM) is a mHealth program for personalized weight management intervention.Value Proposition: Existing obesity interventions are costly and often intrusive, and their adoption and effectiveness have not kept up with the rising prevalence of obesity. Recent studies have demonstrated the ability of remotely delivered behavioral interventions to achieve and sustain clinically significant weight loss. This invention is the remotely delivered fully automated weight management program using the user-frien...Tue, 07 Oct 2014 10:26:24 GMTJHTT-Communications@jhu.edu Measurement of Fractional Flow Reserve from Medical Imaging Quantitative Measurement of Fractional Flow Reserve from Medical ImagingNovelty: This invention is a new way to quantify Fractional flow reserve (FFR) from medical imaging.Value Proposition: FFR is a quantitative index of the physiologic significance of coronary artery stenosis. It has become the most frequently used assessment method and is being increasingly applied in cardiac catheterization laboratory. Current methods of determining coronary artery health from blood flow involve either an invasive medical procedure or computer-aided methods that are less precise and require signifi...Tue, 07 Oct 2014 10:26:24 GMTJHTT-Communications@jhu.edu high-resolution intracranial vessel wall imaging technique 3-D Imaging Technique for Brain Blood VesselsNovelty: A 3-D high resolution imaging technique for intracranial blood vessels to optimize medical imaging.Value Proposition: The original technique has been described for imaging the wall of the extracranial arteries but not for intracranial vessels. Hopkins researchers have optimized an imaging technique for walls of small, inherently curved vessels of the intracranial circulation. Other attempts at imaging intracranial arteries have been 2-D approaches, which are subject to considerable signal and resolution constraints. This technique e...Tue, 07 Oct 2014 10:26:23 GMTJHTT-Communications@jhu.edu - LAPC4-CR a Castration Resistant Human Prostate Cancer Cell Line, 07 Oct 2014 10:26:22 GMTJHTT-Communications@jhu.edu - VCaP-CR a Castration Resistant Human Prostate Cancer Cell Line, 07 Oct 2014 10:26:22 GMTJHTT-Communications@jhu.edu Diagnostic ELISA Assay for Perinatal Brain Injury, 07 Oct 2014 10:26:22 GMTJHTT-Communications@jhu.edu Relaxation Index of Left Ventricular Diastolic Function, 07 Oct 2014 10:26:22 GMTJHTT-Communications@jhu.edu Spirit Program: Family Strengthening for Native American Communities Family Spirit Program: Family Strengthening for Native American CommunitiesNovelty: The invention is a method designed in the form of home visiting intervention program to support young Native American Indian women during pregnancy and 3 years post-partum.Value Proposition: The Family Spirit Program is an evidence-based and culturally tailored home visiting intervention program for educating both American Indian mothers and infants. The home visit based training is carried out by Native American Indian paraprofessionals, who are well-versed with the culture and traditions of Native Ame...Tue, 07 Oct 2014 10:26:21 GMTJHTT-Communications@jhu.edu, Passive Spinal Cord Monitor Neural Blockade Monitor for Spinal TraumaNovelty: The Neural Blockade Monitor is a device that uses passive EMG to monitor the effects of local anesthetics to report the location and density of blockade.Value Proposition: Trauma to the spinal cord can cause serious consequences like paralysis. The current clinical standard for assessing the viability of the spinal cord involves the use of invasive probes to actively stimulate the cord and monitor for response. The technology is a non-invasive passive monitor for determining continuity and health of nerves of the spinal cord. The monit...Tue, 07 Oct 2014 10:26:20 GMTJHTT-Communications@jhu.edu Solutions eMOCHA Solutions: A New Smart mHealth PlatformNovelty: Multipurpose mHealth application that efficiently collects, analyzes, and delivers in real-time data using diverse mobile platforms.Value Proposition: eMOCHA Solutions is a fully-featured health-related client-to-server software application that allows end-users to directly communicate in real-time using smartphones and tablets. Similar solutions tend to be designed by software programmers that fail to properly address the needs of healthcare providers and researchers. eMOCHA was designed by healthcare and research professionals w...Tue, 07 Oct 2014 10:26:20 GMTJHTT-Communications@jhu.edu A Wearable Integrated System for Real-Time Anomaly Tracking MOVA: A Wearable Integrated System for Real-Time Anomaly TrackingNovelty: The current invention is a novel algorithmic framework for detection of anomalies in images from both real time stationary and non-stationary data sources.Value Proposition: The method for detection of Movement Anomalies, MovA, is an unsupervised and automatic method for anomaly object detection from stationary and/or non-stationary sensors (e.g., cameras, etc) that can be generalized to cover many scenarios. We have developed a real-time manifold distance learning (MDL) system that can track, distinguish, and co...Tue, 07 Oct 2014 10:26:20 GMTJHTT-Communications@jhu.edu Entropy Based on Dynamic Nonlinear Comparison of Intervals of Ventricular Activation (RR) with Intervals of Ventricular Repolarization (QT) Novel Method for Detection of Cardiac Rhythms Using Cardiac EntropyNovelty: This invention is a method for the analysis of heart rhythms based on entropy of electrocardiographic ventricular activation (RR) and repolarization (QT) for detecting risk of heart arrhythmia.Value Proposition: Despite several medical advancements, congestive heart failure is a lethal disease with a high mortality rate ranging between 30-50% among the aging populations. The onset and mechanism of heart failure is complex which causes deleterious remodeling of the physical structure and functioning of the heart...Tue, 07 Oct 2014 10:26:20 GMTJHTT-Communications@jhu.edu Autologous Adult Stem Cell Therapy for Prevention of Pre-Term Birth birth affects 12% of obstetrical outcomes and is associated with significant short term and long term public health ramifications for the children born in that setting. Majority of spontaneous preterm birth cases occur in a setting of inflammation, even in the absence of infection. Human stem cells have been shown to exhibit immunomodularary effect in treatment of inflammatory diseases. We conducted rodent experiments, utilizing a mouse model of intrauterine inflammation and preterm birth to determine whether maternal treatment with human stem cells would decrease the rate of preterm b...Tue, 07 Oct 2014 10:26:19 GMTJHTT-Communications@jhu.edu Key Image and Case Log Application High-Efficiency Radiology Software SuiteNovelty: A new web-based environment for managing radiology cases. Also allows for easy sharing of information with colleagues.Value Proposition: The workflow of radiologists is demanding, requiring the selection of appropriate images that accompany their reports. These images are critical in recording an accurate history of any important findings. Radiologists also need to be able to easily access cases of images to be shared at conferences or in publications. Unfortunately, current tools are not well suited to accomplish all these tasks in the ...Tue, 07 Oct 2014 10:26:19 GMTJHTT-Communications@jhu.edu of Human Cell Lines with Genetic Inactivation of PDPK1, 07 Oct 2014 10:26:19 GMTJHTT-Communications@jhu.edu method for cardiac low-voltage defibrillation by converting cardiac fibrillation to cardiac tachycardia followed by termination of cardiac tachycardia Method for Cardiac Low-Voltage Defibrillation Value Proposition: Defibrillation by strong electric shock remains the only clinically proven method to terminate ventricular fibrillation (VF) and to prevent sudden cardiac death. The defibrillation of atrial fibrillation (AF) on the other hand is hindered by the possibility of inducing a rapid heartbeat, called ventricular tachycardias (VTs). The use of shocks to treat malignant cardiac arrhythmias is associated with a host of adverse effects that include cellular injury from electroporation, cardiac conduction disturbances, mechanical...Tue, 07 Oct 2014 10:26:18 GMTJHTT-Communications@jhu.edu of drug loaded microfiber sutures for ophthalmic application Drug-Loaded Microfiber SuturesNovelty: The technology is an ultrafine, drug-loaded microfiber suture in various surgical applications including ophthalmic surgery.Value Proposition: This technology provides a means of improving surgical outcomes by using sutures that can be loaded with various drugs, including antibiotics and immunosuppressants. These novel sutures act as drug delivery systems, showing drug release for more than three months during in vitro trials. The sutures are made of Poly (l lactic acid) (PLLA), which is a biocompatible polymer. There are currently no PLLA sutu...Tue, 07 Oct 2014 10:26:18 GMTJHTT-Communications@jhu.edu Source Mapping in Prior-Image-Based Reconstruction Information Source Mapping in Prior-Image-Based ReconstructionNovelty: The current invention is a method to quantify contributions from prior and current images during image reconstruction, giving increased control over image parameters and higher quality images from less information.Value Proposition: Advanced reconstruction methods for computed tomography typically treat each data acquisition as an isolated event and disregard valuable patient-specific prior information; some reconstruction methods can incorporate prior images into a reconstruction objective function. Inclusion of su...Tue, 07 Oct 2014 10:26:17 GMTJHTT-Communications@jhu.edu Monoclonal Antibody (Hybridoma Clone 028.9.4.A) Anti-KIBRA Monoclonal Antibody and Hybridoma Clone 028.9.4.ANovelty: This tangible material is a monoclonal antibody specific for KIBRA and Hybridoma Clone 028.9.4.A.Value Proposition: Anti-KIBRA monoclonal antibodyTechnical Details: Johns Hopkins researchers have produced a Hybridoma clone 028.9.4.A that produces an anti-KIBRA monoclonal antibody. KIBRA is a protein encoded by a gene linked with human memory performance. It is highly expressed in kidney and in memory-related brain regions. KIBRA has various roles in distinct contexts and cell types. In podocytes, KIBRA interacts with ...Tue, 07 Oct 2014 10:26:16 GMTJHTT-Communications@jhu.edu Therapeutic Hypothermia Device Neonatal Hypothermic Therapy for Developing CountriesNovelty: A device and method for providing hypothermic therapy without using electricity.Value Proposition: Hypoxic ischemia-encephalopathy (HIE) is a life threatening condition in which there is a lack of oxygen to the brain. It occurs in 5 of every 1000 births of which 10-60% result in death, while 25% of survivors are left disabled. Furthermore, asphyxia accounts 23% of newborn deaths each year. Both of these conditions can be treated with hypothermic therapies, where the body and brain are cooled to slow metabolic rates. However,...Tue, 07 Oct 2014 10:26:16 GMTJHTT-Communications@jhu.edu A Mobile Based Non-invasive Hemoglobin Meter Aimed at the Developing WorldNovelty: The current invention is a simple, low cost hemoglobin detection system aimed at the developing world.Value Proposition: Anemia affects between 53% and 90% of pregnant women in developing countries, according to the World Health Organization. Currently, blood based hemoglobin assays are only performed at equipped laboratories and hospitals, out of reach of the average citizen of a developing nation. As a result, few screenings occur, and those that do are not sufficiently objective. Tests results vary de...Tue, 07 Oct 2014 10:26:14 GMTJHTT-Communications@jhu.edu Stretched Micro Fibers and Methods of Use Improved Stretched Microfiber ProductionNovelty: This technology is a new method for producing stretched microfibers with smaller, more consistent diameters.Value Proposition: While there are numerous known applications for microfibers, current fabrication methods lack a significant amount of control. These primarily consist of using a high voltage electrode to initiate the creation of material. However, it is very difficult to control the speed at which the fiber is extruded, yielding inconsistent and often wide thickness. Mechanical properties, are therefore, very inconsistent. This ...Tue, 07 Oct 2014 10:26:14 GMTJHTT-Communications@jhu.edu Aneuploidy Testing through Compressed Genome Sequencing of Maternal Plasma, 07 Oct 2014 10:26:13 GMTJHTT-Communications@jhu.edu Therapy via a Combination of Epigenetic Modulation and Immune Modulation addition to the conventional forms of cancer therapy (chemotherapy, surgery, radiation), newer forms of therapy, including epigenetic modulation with DNA demethylating agents and HDAC inhibitors and therapies targeted at the immune system, are being investigated. We have discovered that epigenetic modulation alters tumor gene expression so as to induce an immune signature. Based on this finding and the known ability of demethylating agents to induce de novo expression of tumor-specific antigens, as well as a discovery that tumors induce immune checkpoint ligands to protect themselves from a...Tue, 07 Oct 2014 10:26:13 GMTJHTT-Communications@jhu.edu A inbred mouse, 07 Oct 2014 10:26:13 GMTJHTT-Communications@jhu.edu Parallel Reduction and Applications Fast Data Reduction via Multi-Processor FrameworkNovelty: The current invention is an improved framework for reducing the size of input data that utilizes multiple processors running simultaneously (in parallel).Value Proposition: The amount of data available is growing exponentially. There are steepening requirements to process this data. In parallel computing (multiple processors executing instructions simultaneously), a reduction algorithm (used to reduce the size of input data) often requires more time than the theoretic ideal. Furthermore, it suffers from the unbalance of workload...Tue, 07 Oct 2014 10:26:13 GMTJHTT-Communications@jhu.edu Method for Directing Catheter Movement to Target Arrhythmia Ablation Using the Cardiac Activation Sequence Cardiac Ablation(Heart) Guidance SystemNovelty: A method that automatically guides electrodes to the origin of an arrhythmia for more accurate ablation(heartbeat) therapy.Value Proposition: Ablation is an effective method in treating cardiac arrhythmias; however both its usage and success rate are inhibited by a lack of tools that can effectively find the source of the arrhythmia. Current methods include placing probes on the heart to find an exact signal match, or using external analysis software that maps the progression of activation during a heartbeat. While these do give some indi...Tue, 07 Oct 2014 10:26:13 GMTJHTT-Communications@jhu.edu Automated Brain Lesion Detection Using Cross Sectional Multimodality Magnetic Resonance Imaging Automated System for Analysis of MRI Data for Neurological AbnormalitiesNovelty: OASIS (Automated Statistical Inference for Segmentation) is a statistically principled, fast, and accurate tool for the analysis of multi-sequence MRI data that provides a segmentation identifying how much lesion load a subject has, and where in the brain these lesions exist, from a single cross-sectional imaging study. This analysis is effective in determining etiologies and clinical management of many neurological diseases, including but not limited to, multiple sclerosis (MS).Value Proposition: While t...Tue, 07 Oct 2014 10:26:12 GMTJHTT-Communications@jhu.edu Air Postpartum Tamponade (ADAPT) Automatically-Deflating Air Postpartum Tamponade (ADAPT)Novelty: ADAPT is the first air-inflated tamponade which applies a pressure greater than the woman’s blood pressure to the birth canal and uterine sinuses to cease blood flow.Value Proposition: Postpartum hemorrhage (PPH) is the leading cause of maternal mortality worldwide. The ADAPT increases time for transportation to a higher care facility so treatment can be administered. The pressure and compression mechanisms utilized to stop blood flow and compress the uterine sinuses are the same as those traditionally employed to stop e...Tue, 07 Oct 2014 10:26:12 GMTJHTT-Communications@jhu.edu Radiotracers for Imaging and Classification of Bacterial Infections This technology identifies a series of small molecular metabolic tracers to increase imaging and diagnosis capabilities for infectious disease, especially at deep sites of infection. These biomarkers are useful in localizing, differentiating, and quantifying infectious disease.Value Proposition: Current methods for diagnosing infections, such as microscopy and microbiologic culture, are hindered by excessive time consumption and low accuracy. This invention proposes several radiolabeled molecular probes for accurate imaging and diagnosis of infection sites. This technology is critical...Tue, 07 Oct 2014 10:26:12 GMTJHTT-Communications@jhu.edu Tracking and Registration in Interventional Ultrasound, 07 Oct 2014 10:26:12 GMTJHTT-Communications@jhu.edu Robot-ultrasound Probe for Prostate Biopsy, 07 Oct 2014 10:26:11 GMTJHTT-Communications@jhu.edu Screen Identifies Neuroprotective Drug Targets and Biomarkers in Glaucoma and other Forms of Neurodegeneration NeedCurrently, glaucoma and retinal degenerative diseases are often not diagnosed until they enter advanced stages and the process cannot be reversed. This technology provides an effective method of identifying biomarkers associated with the optic nerve damage caused by these conditions, leading to development of diagnostic biomarkers. Other advantages include:• Early diagnosis of glaucoma and neurodegenerative provides patients with additional treatment options.• Growing unmet need for glaucoma diagnosis as average global population age increases.• Potential to develop several glaucoma ...Tue, 07 Oct 2014 10:26:11 GMTJHTT-Communications@jhu.edu Human Metastatic Breast Cancer Cell Line (RBC3) Novel Human Metastatic Breast Cancer Cell Line (RBC3) Value Proposition: Johns Hopkins researchers developed a human breast cancer cell line (RBC3) to study spinal metastasis. Specifically, the cell line was isolated from a spinal metastatic lesion, and was tagged with GFP and luciferase. When RBC3 is injected into the left ventricle of athymic female rats, it increases the fraction of animals affected with spinal metastasis, leading to paralysis in all animals demonstrating bioluminescence positive signal. The result shows that RBC3 generates metastases to the spine at a higher fre...Tue, 07 Oct 2014 10:26:11 GMTJHTT-Communications@jhu.edu Reactive Particles with Controlled Geometries, Energies and Ignition Thresholds and Methods for Making the Same Method for Fabricating Reactive Particles and Foils with Controllable GeometriesNovelty: The invention is a method to make multi-layered reactive particles, or foils with highly controllable geometries. By being able to specify the geometry, and packing of these particles, very specific traits can be controlled with regards to ignition thresholds and reaction propagation rates in particle compacts.Value Proposition: In the application of reactive foils and particles, it is often desirable that they have specific external geometries that enable easy handling and low packing fractions. ...Tue, 07 Oct 2014 10:26:10 GMTJHTT-Communications@jhu.edu Dimensional (4D) Tracking System Using Orthogonal Dynamic 2D MRI 4D Tumor Tracking for Radiation TherapyNovelty: A new way for tracking tumor movement to improve safety in radiation therapy deliveryValue Proposition: Radiation therapy is a widely used cancer treatment method, although there are still issues with this procedure. Ideally, the therapy is applied only to the cancerous tissue, while healthy tissue is left unaffected. In many cases, however, the tumor moves due to patient breathing, making this a difficult goal to achieve. One of the most common methods to address tumor movement is to apply radiation to a region of possible positions, bas...Tue, 07 Oct 2014 10:26:10 GMTJHTT-Communications@jhu.edu Hypermethylation of ZNF516 and FKBP6 are Molecular Candidates for Screening and Triage of HPV-positive and Inconclusive-Pap Women Clarifying an Inconclusive Cervical Cancer ScreeningNovelty: This technology is biomarkers identified for diagnostic testing of cervical cancer in HPV-positive and Inconclusive-Pap Women.Value Proposition: Currently, no tests exist to further diagnose cervical cancer after an inconclusive initial result. This leads to abnormal/inconclusive Pap test results and ultimately over-diagnosis/over-treatment of affected patients. This technology provides diagnostic biomarkers capable of testing for cervical cancer in patients when HPV tests are positive and Pap tests are inconclusive. Other a...Tue, 07 Oct 2014 10:26:09 GMTJHTT-Communications@jhu.edu Cryoprobe for Flexible Bronchoscopic Sampling of Lung Parenchyma Cryoprobe Capsule to Protect Tissue SamplesNovelty: The current invention is a device for protecting the integrity of tissue samples taken during transbronchial biopsies.Value Proposition: Transbronchial biopsies (TBBx) taken with standard biopsy forceps are well known to suffer from a lack of sufficient quality due to crush artifact and are often found to be insufficient for the diagnosis of diffuse lung disease. In the last 3 years, the use of flexible cryoprobes for TBBx has been shown to improve the diagnostic yield in the diagnosis of lung cancer when compared to standard TBBx for...Tue, 07 Oct 2014 10:26:09 GMTJHTT-Communications@jhu.edu N-Terminus FLAG tag on DNMT1 Details: DNA methyldtransferase1 (DNMT1) is a maintenance methyltransferase enzyme; additional roles for DNMT1 in gene expression are not understood clearly. DNMT1 is shown to have repressive activity, and deletion of its catalytic domain does not abolish this activity. In this study Johns Hopkins researchers examine the repressor function of catalytically inactive DNMT1 by generating this technology consisting of wtDNMT1 and catalytically inactive DNMT1 constructs with N-terminal FLAG tag inserts cloned into a pEF1á IRES-puro vector. Looking for Partners: To develop and comme...Tue, 07 Oct 2014 10:26:08 GMTJHTT-Communications@jhu.edu Imaging from Visible Light Endoscopic Images 3D Imaging Endoscope Method and SoftwareNovelty: Inventors at Hopkins have developed a safer method for determining the diameter of an airway, specifically for stenosis, the abnormal narrowing of the airway.Value Proposition: The problem of stenosis, or abnormal narrowing of the airway is an upper airway anomaly that presents frequently in children and has significant associated morbidity. Current methods use Computed Tomography and Endotracial tubes for sizing has associated negative effects. This method and software system, called quantitative endoscopy (QE) is designed to replace cu...Tue, 07 Oct 2014 10:26:08 GMTJHTT-Communications@jhu.edu Measures of IFN(alpha) and IFN(gamma) Activity, 07 Oct 2014 10:26:07 GMTJHTT-Communications@jhu.edu Tube and External Interface for Saline or Drug Delivery to the Paranasal Sinuses Nasal Implant for Efficient Treatment of SinusitisNovelty: Implant improves drug delivery for the treatment of sinusitis.Value Proposition: In the United States, about 3 to 10 million people suffer from chronic sinusitis, caused by inflammation of the paranasal sinus tissue. Common treatment methods include saline irrigation and steroids, used to alleviate symptoms, but current delivery solutions are unable to treat areas that are inaccessible due to local inflammation. This invention provides a means to easily and directly apply therapies to the sinuses. The device, which is an implan...Tue, 07 Oct 2014 10:26:06 GMTJHTT-Communications@jhu.edu Novel Method to Visualize Cells that Undergo Apoptosis Reversal Proposition: This biosensor may be used to identify anastasis events in animals or cells, in screens to identify genes/protein/RNAs that modulate anastasis or in screens for small molecules that potentiate or inhibit anastasis. Technology advantages: - This biosensor can be used to label cells in vivo or in vitro. - This technology permanently labels cells that experience transient caspase activation but survive and are able to reverse apoptosis. - This technology may also be used to label cells that experience apoptosis-independent caspase activation. - Specific embodiment to study anas...Tue, 07 Oct 2014 10:26:06 GMTJHTT-Communications@jhu.edu Center Educational Exhibits Safety Center Educational Exhibits Novelty: Safety Center Exhibit Value Proposition: This work is comprised of 21 (or 23) interactive and engaging educational exhibits that bring to life injury prevention information, advice and recommendations for parents of young children. Technical Details: Johns Hopkins researchers created these exhibits to highlight the common hazards found in everyday items in and around our homes. Because these hazards are so commonplace, we needed a way to bring special attention to them and have adults and children think about safety in a different...Tue, 07 Oct 2014 10:26:06 GMTJHTT-Communications@jhu.edu Fronto-orbital Titanium Mesh 3D Facial Reconstruction Pre-Form MeshNovelty: A 3D titanium surgical mesh for frontal-orbital implantation to perform facial reconstruction after injury, cancer, or infection.Value Proposition: High energy impacts can cause trauma to the upper third of the face resulting in fracture of the frontal bone, frontal sinus and the superior orbital roof. Cranialization is the treatment of choice for such injuries and a titanium mesh is used to reconstruct the anterior table of the frontal sinus. Hopkins has developed a 3D titanium surgical mesh for frontal-orbital implantation to perform fac...Tue, 07 Oct 2014 10:26:05 GMTJHTT-Communications@jhu.edu Thioacetal Trioxanes in the Artemisinin Family Novel Artemisinin Analog Antimalarial DrugsNovelty: The inventors have created several semisynthetic analogs of artemisinin with antimalarial properties.Value Proposition: In 2010, malaria affected over 216 million people, and while treatments for malaria exist, malaria parasites have grown resistant to several of the commonly used, quinoline-based drugs. Artemisinin is known for its antimalarial properties and is currently used as a component in the common antimalaria combination therapy (ACT). This invention is several semisynthetic analogs of artemisinin for use in novel antimalaria...Tue, 07 Oct 2014 10:26:05 GMTJHTT-Communications@jhu.edu Angiogenic Factors as Prognostic Biomarkers in Prostate Cancer of two diagnostic and prognostic biomarkers whose levels in serum were associated with the presence of aggressive prostate cancer. Value Proposition:Currently, no clear test exists to accurately determine the aggressiveness of prostate cancer. This technology is capable of identifying the aggressiveness of a prostate cancer, leading to more tailored treatment options. Other advantages include: Non-invasive test can be developed by testing serum levels of biomarkers.Accurate diagnosis of aggressiveness reduces over-treatment, minimizing harmful side-effects and costs.Grow...Tue, 07 Oct 2014 10:26:05 GMTJHTT-Communications@jhu.edu of Pancreatic Fibroblasts Including Pancreatic Cancer Associated Fibroblasts and Immortalization of these into Cell Lines, 07 Oct 2014 10:26:04 GMTJHTT-Communications@jhu.edu (CTRP15), a Novel Myokine that Links Skeletal Muscle to Systemic Lipid Homeostasis Novel Protein Therapeutic for Diabetes and ObesityNovelty: This technology identifies a novel myonectin protein, which links skeletal muscle to metabolic regulation. Myonectin was found to lower circulating free fatty acid levels by promoting lipid uptake.Value Proposition: Type-2 diabetes, obesity, and metabolic syndrome are diseases that dramatically reduce patient quality of life and lead to other ailments. This discovery helps shed light on responses to energy states and mediation of metabolism that can be applied to understand and treat metabolic diseases. The specific novel my...Tue, 07 Oct 2014 10:26:04 GMTJHTT-Communications@jhu.edu Signatures of Invasive Cancer Subpopulations Assay and molecular signature to identify invasive cancer cell population in tumorsNovelty: This invention is an assay for evaluating the metastatic potential of epithelial cancers, and a molecular signature linked to aggressive and invasive cancer subpopulations.Value Proposition: Inventors have developed an assay to enable stratification of cancer cells based on their invasive behavior. Inventors have also identified a molecular signature of a cancer cell subpopulation that is highly invasive and resistant to therapy. This signature has been confirmed in more than 3 mouse mammary car...Tue, 07 Oct 2014 10:26:04 GMTJHTT-Communications@jhu.edu Rabbit Polyclonal Antiserum (identified as JH6038), 07 Oct 2014 10:26:04 GMTJHTT-Communications@jhu.edu CHUMONovelty: Motion Picture/Audio Visual WorkValue Proposition: Motion Picture/Audio Visual WorkTechnical Details: Juma is a poor fisherman who loves telling tales. Amina is the girl who loves to hear his stories. They long to be together, but Amina?s father, Ali, wants a better life for her. Ali finds this in yustus, a rich but self-serving young suitor. Juma must put everything on the line to save their love, but he must sacrifice more than he bargained for in order succeed. Produced in and around Dar es Salaam by Media for Development International (Tanzania) and funded by the John...Tue, 07 Oct 2014 10:26:04 GMTJHTT-Communications@jhu.edu for Tomographic Reconstruction Using Prior Images and a Statistical Measurement Model, 07 Oct 2014 10:26:03 GMTJHTT-Communications@jhu.edu Efficient Conversion of Human Stem Cells to Dopaminergic Neurons by Proneural Transcription Factor Atoh1, 07 Oct 2014 10:26:03 GMTJHTT-Communications@jhu.edu KO Cells: 130-2 and 10-7 (and PALB2 Heterozygotes: 55-7) PALB2 Knockout Cell Line for Anti-cancer Drug ScreeningNovelty: Genetically modified human colon cancer cell lines in which either one or both copies of the PALB2 (Partner and Localizer of BRCA2) gene is deleted. These cell lines serve as great cancer drug screening tool.Value Proposition: PALB2 is essential for repairing damaged DNA and is commonly mutated in a subset of cancers, such as ovary, breast, and pancreas. This technology comprises of human cancer cell lines where the PALB2 gene has been knocked out. This cell line may serve as the basis of a simple and efficient system for ...Tue, 07 Oct 2014 10:26:03 GMTJHTT-Communications@jhu.edu Arthroscopic Treatment of Pincer-type Femoroacetabular Impingement with Precise 3D Planning Hip Surgery Planning, Guidance, and Assessment SystemNovelty: A new method to perform arthroscopic hip surgeries with improved accuracy.Value Proposition: Femoroacetabular impingement (FAI) is characterized by poor interaction between femur and acetabulum that limits range of hip motion and can lead to early osteoarthritis for young and active patients. Surgical treatment involves removing sections of bone that are responsible for the early contact; however, there are a number of challenges with this procedure. Firstly, surgical planning is often difficult due to the limitations of ava...Tue, 07 Oct 2014 10:26:02 GMTJHTT-Communications@jhu.edu to Use Autologous Fibroblasts to Alter Skin Identity, 07 Oct 2014 10:26:02 GMTJHTT-Communications@jhu.edu and Blood-derived Adhesives, 07 Oct 2014 10:26:02 GMTJHTT-Communications@jhu.edu and Application of Novel IRDye Conjugated-DPA-713 Analogs for Imaging Inflammation Novel Small Molecule for Inflammation and Cancer ImagingNovelty: The technology is a novel small synthetic molecule that binds to TSPO (Translocator Protein) for inflammation and cancer imaging.Value Proposition: Imaging of tumor sites and areas of inflammation presents the opportunity to improve both diagnosis and treatment of cancer and other diseases. This technology uses the elevated expression of TSPO found in activated leukocytes and some malignant tumors as the molecule target. There are several small molecules identified as TSPO binding ligands, which can be used for targeti...Tue, 07 Oct 2014 10:26:02 GMTJHTT-Communications@jhu.edu Control and Miniaturization of the Safe DC Stimulator for Neural Prostheses Safe DC Stimulators for Neural ProsthesesNovelty: The invention consists of two Safe DC Stimulators (SDCS 2) working in tandem for improved flow of direct current to target tissue for the treatment of sensory and motor impairments. This neural prosthetic is scalable and is safe for the patient.Value Proposition: Common methods for neural prostheses must use AC current because of biologically unsafe conditions that DC current creates at the electrode-tissue interface and the inability of DC current to flow without interruption. Further, neural prostheses with AC current produce incons...Tue, 07 Oct 2014 10:26:02 GMTJHTT-Communications@jhu.edu Stealth Nanoparticles Prepared by a Novel Self-assembly Emulsification Method Novel Nanoparticle Vehicle for Hydrophobic and Hydrophilic TherapeuticsNovelty: A self-assembly emulsification method that generates novel, stealth nanoparticles capable of rapid drug penetration through mucosal membranes while avoiding adhesion to mucin for both hydrophobic and hydrophilic therapeutics.Value Proposition: Current therapeutic delivery vehicles involving mucous penetrating nanoparticles are very limited in the therapeutics they are capable of encapsulating. The emulsion composition described by this invention is capable of encapsulating both hydrophilic and hydrophobic ...Tue, 07 Oct 2014 10:26:01 GMTJHTT-Communications@jhu.edu Cells of Defined and Dynamic Size and Shape, 07 Oct 2014 10:26:00 GMTJHTT-Communications@jhu.edu of Pulmonary Hypertension Blood Test Biomarkers for Pulmonary Arterial HypertensionNovelty: This invention is a novel set of circulating biomarkers found in serum and plasma which can be used for diagnostic and prognostic testing of Pulmonary Arterial Hypertension (PAH).Value Proposition: Currently, the first line of treatment for PAH is prescribing vasodilators, which are not effective in up to 30% of patients causing poor prognosis and eventual lung transplant. This technology employs specific prognostic and diagnostic markers that are capable of identifying whether or not the patient either has the condition...Tue, 07 Oct 2014 10:26:00 GMTJHTT-Communications@jhu.edu for Measuring Substances in Circulating Blood Unique Biosensor for Continuous Monitoring of Circulating BiomarkersNovelty: The technology presents a novel transistor-based biosensor design for continuous monitoring of circulating biomarkers in blood or urine that can be used for clinical diagnosis, point of care (POC) assays, and patient monitoring.Value Proposition: There is currently no method to measure proteins, molecules, and drugs in bodily fluids with immediate feedback. The technology involves a novel biosensor design for continuously monitoring body fluids to detect and quantify proteins, molecules, metabolites, drugs, e...Tue, 07 Oct 2014 10:25:59 GMTJHTT-Communications@jhu.edu of ALMS1 Gene Expression or Inhibition of Alstrom Protein to Induce Cardiomyocyte Proliferation Stem Cell Free Cardiac Tissue GrowthNovelty: This invention is a novel method of inducing cardiomyocyte proliferation without the use of stem cells.Value Proposition: This technology can be developed to repair heart size or function, repair injuries such as myocardial infarctions and congenital defects such as hypoplastic left heart syndrome or septal defects.Technical Details: Johns Hopkins researchers have identified a pair of infant siblings with persistent postnatal cardiomyocyte replication and applied whole exome sequencing to determine the cause of their condition. They identifi...Tue, 07 Oct 2014 10:25:59 GMTJHTT-Communications@jhu.edu for Identifying Required Molecular Components of Twist-1 Mediated Invasion, Dissemination, and Metastasis Platform to Study TWIST-1 Mediated Cancer Metastasis Value Proposition: This assay may be used to identify small molecule compounds, biologics or druggable targets to antagonize Twist-1 induced EMT and cell migration. Technology Features and Benefits: ? This platform can enable rapid, cost and time efficient high throughput screening of compounds. ? Assay uses primary, normal epithelial tissues without any mutations that may interact with experimental manipulation. ? Assay has been optimized for a multiwell plate format. ? Media conditions in this assay are chemically ...Tue, 07 Oct 2014 10:25:59 GMTJHTT-Communications@jhu.edu Inducible Dimerization System Using Gibberellin Analogs and their Binding Proteins, 07 Oct 2014 10:25:58 GMTJHTT-Communications@jhu.edu 1 HCV Pseudoparticle Library, 07 Oct 2014 10:25:58 GMTJHTT-Communications@jhu.edu of RNF43 Mutations in Pancreatic Cysts, 07 Oct 2014 10:25:57 GMTJHTT-Communications@jhu.edu for the Treatment of Autism Sulforaphane for the Treatment of AutismNovelty: This technology is a novel, mechanism-based treatment for autism using a phytochemical compound derived from cruciferous vegetables.Value Proposition: Currently, the only available drugs for the treatment of autism are symptomatic. These drugs aim to modulate behavior, but do not target the underlying cause of the symptoms. This invention uses a chemical derived from broccoli to simulate the effects of a fever, which has been shown to alleviate behavioral symptoms in children with autism. This method of treatment could increase cognit...Tue, 07 Oct 2014 10:25:57 GMTJHTT-Communications@jhu.edu Unit Clinical Situational Awareness Command and Control System, 07 Oct 2014 10:25:56 GMTJHTT-Communications@jhu.edu Method to Increase Availability of Specific Membrane Lipids (termed "lipid liberation"), 07 Oct 2014 10:25:56 GMTJHTT-Communications@jhu.edu Collagen Strands for Imaging and Therapy Novel Collagen Targeting for Imaging and Therapeutic ApplicationsNovelty: This technology employs collagen mimetic peptides to target denatured collagen in vivo for imaging and treatment of cancer and other diseases affecting the collagen matrix.Value Proposition: There are currently no available means of targeting a denatured collagen matrix in vivo for imaging or therapeutic purposes. The ability to view the collagen matrix in diseased tissue could lead to important discoveries for the treatment of cancer and other tissue degenerative diseases, as well as for tissue remodeling proce...Tue, 07 Oct 2014 10:25:56 GMTJHTT-Communications@jhu.edu A Method for the Quantitative Assessment of Disease Response using Medical Image Data. Medical Image Analysis and Diagnosis Improvement ToolsNovelty: This technology bundle is a set of processing tools for medical image analysis.Value Proposition: The current invention is a suite of tools for improving diagnoses from medical images, involving three separate technologies. Currently, there is a need for precise, quantitative medical image assessment. Methods currently used leave much to be desired in terms of assessment over time, precision, and sensitivity. Current methods are not well-personalized for each patient, and may lead to incorrect diagnosis. The disclosed inven...Tue, 07 Oct 2014 10:25:55 GMTJHTT-Communications@jhu.edu High-efficiency Inducible Cell-cell Fusion Culture System High-efficiency Inducible Cell Fusion Culture SystemNovelty: This invention embodies a new culture system that induces cell-cell fusion in transfected cells with high efficiency. In addition to the newfound ability to fuse normally non-fusing Drosophila S2R+ cells, this system provides insight into the mechanisms and interactions involved in cell-cell fusion.Value Proposition: Cell-cell fusion is critical for the conception, development and physiology of multicellular organisms and is involved in processes as diverse as fertilization, formation of bone, muscle and placenta, and immune ...Tue, 07 Oct 2014 10:25:54 GMTJHTT-Communications@jhu.edu for Healthcare Workshop Process Improvement in Healthcare Using LeanNovelty: This is a two day interactive training session that equips representatives with Lean for Healthcare tools and techniques they can use to teach the Lean course at their home institution.Value Proposition: The ability to eliminate waste in healthcare delivery presents the opportunity for professionals to streamline their business. Further, the identification and elimination of wasteful practices would decrease expenses, allowing funds, as well as time, to be redistributed to other areas as needed. The Lean for Healthcare course is uniq...Tue, 07 Oct 2014 10:25:54 GMTJHTT-Communications@jhu.edu of Alcohol Toxicity Drug to Prevent Alcohol ToxicityNovelty: The technology involves the use of dietary chemicals to reduce the unpleasant symptoms associated with alcohol consumption and reduce the risk of serious diseases.Value Proposition: Alcohol toxicity from the consumption of a large amount of alcohol in a short period of time can lead to many adverse symptoms and health problems. This technology is one-of-a-kind therapeutic that detoxifies alcohol and metabolizes acetaldehyde faster causing less damage to cells. This is particularly useful in certain populations in which ALDH2 polymorphisms, causi...Tue, 07 Oct 2014 10:25:54 GMTJHTT-Communications@jhu.edu Gene 1 (BARX1) in Gastric Carcinogenesis, 07 Oct 2014 10:25:54 GMTJHTT-Communications@jhu.edu of Gold and Polymers Novel Surface-Modified Gold Nanocomposite Drug Delivery FormulationNovelty: Layered assembly of cationic polymers carrying siRNA strands on gold nanoparticles (AuNPs) for enhanced target cell specificity and novel therapeutic/diagnostic applications.Value Proposition: Currently available non-viral gene delivery polymers have several shortcomings in the form of low transfection efficiency and poor dispersion and release. This technology overcomes the above stated shortcomings of the current drug delivery systems developed for gene therapy and tissue-targeted drug delivery. Other advanta...Tue, 07 Oct 2014 10:25:53 GMTJHTT-Communications@jhu.edu Rickttsia Amblyommii in Cell Culture, 07 Oct 2014 10:25:53 GMTJHTT-Communications@jhu.edu for Evaluating Regional Cardiac Function and Dyssynchrony from a Dynamic Imaging Modality Using Endocardial Motion SQUEEZ – New Technique for Cardiac Function MeasurementNovelty: The current invention is a new quantitative method for measuring regional cardiac function and dyssynchrony from cardiac CT images acquired during routine angiography and myocardial perfusion scans.Value Proposition: Current methods to measure cardiac function rely on cardiac wall thickness, thickening, or myocardial strain measurements and need segmentation of both endocardium and epicardium. Numerous algorithms claim to be able to segment epicardium automatically; however the state of the art clinical cardiac segmentatio...Tue, 07 Oct 2014 10:25:52 GMTJHTT-Communications@jhu.edu Hand Micromanipulation Robot Small Steady Hand Micromanipulation Surgical RobotNovelty: A new type of bi-manual robot surgical tool that allows for steady manipulation of surgical instruments by hand with a focus on low-cost, compact, simple, and reliable hardware.Value Proposition: Many surgical disciplines such as ear, nose, and throat (ENT) cosmetic and reconstructive surgery as well as nonsurgical fields such as bio-medical research and micro assembly, have a micro manipulation component that pushes human sensory-motor limits. Current robotic systems are far too big, cumbersome, and costly, and require signifi...Tue, 07 Oct 2014 10:25:52 GMTJHTT-Communications@jhu.edu Anti-LAG3 Monoclonal Antibody (4-10-C9) Mouse LAG-3 Monoclonal AntibodyNovelty: A mouse monoclonal antibody (mAb) against LAG-3 (Lymphocyte Activation Gene 3).Value Proposition: LAG-3 is expressed on the cell surface of activated T-cells and is known to be an important global regulatory molecule that controls many aspects of T-cell proliferation and homeostasis. This invention is an effective mouse LAG-3 monoclonal antibody that can easily identify and locate the LAG-3 protein in the cell. This antibody may be useful in the study of T-cell activation or suppression in many diseases.Technical Details: Johns Hopkins and St. Ju...Tue, 07 Oct 2014 10:25:52 GMTJHTT-Communications@jhu.edu Rapamycin Conjugates for Spatiotemporal Control of Small GTPase Activity, 07 Oct 2014 10:25:51 GMTJHTT-Communications@jhu.edu mouse B6. CG-TG (ACTB-UPF1*R844C) 581Hed/J Transgenic Mouse Line with Mutated Rent1/UFP1 GeneNovelty: A transgenic mouse strain with deactivated Nonsense-Mediated Decay (NMD) pathway by the expression of mutated Regulator of Nonsense Transcript (Rent1)/UFP1 protein.Value Proposition: The wild-type protein Rent1/UFP1 acts as a trans-effector of the cellular surveillance mechanism called the NMD, which is responsible for eliminating faulty mRNA transcripts before deleterious effects. Therefore, studying the effect of a mutation that deactivates the NMD pathway can open new ways to prevent the condition. This invention comprises o...Tue, 07 Oct 2014 10:25:51 GMTJHTT-Communications@jhu.edu and Other Intracellular pH Acidifiers for the Treatment and Prevention of Cancer. Novel Therapeutics for Glioblastoma and Other CancersNovelty: This invention uses 5-Nonloxytryptamine (5-NOTO) and other intracellular pH acidifiers for the treatment of glioblastoma (GBM). It can serve as a platform for using PH acidifiers to treat other cancers as well.Value Proposition: GBM is the most common form of primary brain cancer, accounting for more than 50% intracranial cancers worldwide. Nearly 100% Patients with GMB die within 1-2 years of diagnosis. The improvement in treatment of GBM has been slow for decades. The proposed approach could be developed as an effective tr...Tue, 07 Oct 2014 10:25:51 GMTJHTT-Communications@jhu.edu mice Transgenic Mouse Line with Inducible Diphtheria Toxin GeneNovelty: A novel line of transgenic mice expressing stable inducible diphtheria toxin gene under the control of an NG-2 promoter. This mouse line can be used in neuroscience studies to induce a model state of chronic demyelination.Value Proposition: Neuronal cell studies are an important tool in deciphering the pathophysiology of disorders affecting the central nervous system (CNS). This invention presents genetically modified mice that contain an inducible diphtheria toxin gene which in the presence of Cre/Cre-ER in the oligona...Tue, 07 Oct 2014 10:25:51 GMTJHTT-Communications@jhu.edu mice, 07 Oct 2014 10:25:51 GMTJHTT-Communications@jhu.edu mice PDGF Receptor Transgenic Mouse Line with Inducible Cre RecombinaseNovelty: Transgenic mouse line containing inducible Cre recombinase expressed under the control of platelet derived growth factor alpha receptor (PDGF\R) promoter. This PDGFR-CreER mouse model is a useful resource for studying cell specific genetic regulation of oligodendrocytes in vivo.Value Proposition: Oligodendrocytes and pericytes in the central nervous system (CNS) express NG-2 and PDGFR. NG-2 promoters are commonly used to label NG2+ cells in transgenic models, but using a PDGFR promoter better restricts the trans...Tue, 07 Oct 2014 10:25:51 GMTJHTT-Communications@jhu.edu Mice NG2-lck-EGFP Transgenic Mouse LineNovelty: Transgenic mouse line expressing the eGFP reporter that is controlled by an NG2 promoter. This mouse model is a useful resource for in vivo as well as in vitro study of neuronal development and function.Value Proposition: Neuroglial cells like pericytes and oligodendrocytes express NG-2 proteoglycans in progenitor cells but the gene expression is down-regulated as the cells mature. Therefore, NG-2 expression marks the development and functionality of these neuronal cells. This invention is a transgenic mouse line expressing the eGFP reporter u...Tue, 07 Oct 2014 10:25:50 GMTJHTT-Communications@jhu.edu Affinity Beta Lactamase Inhibitors, 07 Oct 2014 10:25:50 GMTJHTT-Communications@jhu.edu Analogs and Use Thereof, 07 Oct 2014 10:25:50 GMTJHTT-Communications@jhu.edu in Human Cancers, 07 Oct 2014 10:25:49 GMTJHTT-Communications@jhu.edu mutations in HOXB13 are associated with prostate cancer risk HOXB13 Biomarkers Associated with Increased Prostate Cancer RiskNovelty: Five HOXB13 markers (G84E, L144P, Y88D, G216C, R229G) for identifying men with high risk of developing early-onset and hereditary prostate cancer.Value Proposition: Currently, there are no reliable genetic markers to assess risk for prostate cancer and the PSA test is known to lead to over-diagnosis of men with prostate cancer. To address this issue we have identified and validated markers that are associated with a 5 to 6 fold increase in prostate cancer risk. Studies were performed in a large international sampl...Tue, 07 Oct 2014 10:25:49 GMTJHTT-Communications@jhu.edu Gastrointestinal Tissue Sampling with Tetherless Microdevices Relatively Non-Invasive Biopsy Sampling Device of TissueNovelty: The micro-tools uses a tetherless design which is relatively non-invasive, non-toxic, and collects using a magnetic probe, which allows for a large number of samples to be extracted by covering more surface area for randomized statistical sampling.Value Proposition: It is difficult and invasive to obtain diagnostically relevant samples from certain organs, such as the gastrointestinal tract, the airways and lungs, urinary tract and bladder. In ex-vivo proof-of-principle experiments, porcine gastrointestinal tissue sample...Tue, 07 Oct 2014 10:25:48 GMTJHTT-Communications@jhu.edu Reference Spectrum Subtraction without Prior Measurement Using Graphics Processing Unit for Fourier-domain Optical Coherence Tomography A Real-Time Noise Subtraction for FD-OCT using the GPUNovelty: The invention is a method to perform real-time reference spectrum (noise) subtraction from Fourier-Domain Optical Coherence Tomography (FD-OCT) without an initial reference measurement.Value Proposition: Fourier-domain optical coherence tomography (FD-OCT) is used in a number of medical applications including Dental imaging devices. FD-OCT, however, is inhibited by the presence of noise that typically appears as horizontal streaks on the image. To eliminate this noise a measurement is made without a sample present, and is ...Tue, 07 Oct 2014 10:25:48 GMTJHTT-Communications@jhu.edu Binaural Rendering of Complex Acoustic Scenes, 07 Oct 2014 10:25:48 GMTJHTT-Communications@jhu.edu Filtered Quasi-monochromatic Talbot-lau Interferometers for High Sensitivity and Contrast Phase-contrast Imaging with Hard X-rays Next-Generation Imaging SystemNovelty: This technology is an imaging system that uses X-rays for high sensitivity differential phase contrast imaging, producing high contrast images with excellent spatial resolution.Value Proposition: Current imaging technologies, such as MRI, suffer from poor spatial resolution but are able to image soft tissue. Additionally, while X-ray imaging has good resolution it offers poor soft tissue contrast. This invention is novel in its arrangement and combination of different types of reflectors to achieve high resolution images of biological tissue. Ot...Tue, 07 Oct 2014 10:25:48 GMTJHTT-Communications@jhu.edu Affinity Chymase Inhibitors, 07 Oct 2014 10:25:47 GMTJHTT-Communications@jhu.edu Hopkins Safety Reports On Demand (JHS-ROD), 07 Oct 2014 10:25:47 GMTJHTT-Communications@jhu.edu New Peptide-based Algorithm for Comparative Protein Detection-levels in Shotgun Proteomics, 07 Oct 2014 10:25:47 GMTJHTT-Communications@jhu.edu Care Caregiver Assessment Form Guided Care Caregiver Assessment Form for Improved Chronic CareNovelty: Novel survey to unravel the specific care-related challenges of family caregivers for improved caregiver support and chronic disease management.Value Proposition: Family care-giving has proven valuable for the high-quality care of the rising numbers of chronic elderly patients; however, caregivers, due to the long-term, high-intensity care-giving, experience great strains and burden, and new strategies to better support caregivers are urgently needed. Hence, the Guided Care Caregiver Assessment Form presents a valu...Tue, 07 Oct 2014 10:25:47 GMTJHTT-Communications@jhu.edu Care Caregiver Interview Guided Care Caregiver Interview for Improved Chronic Disease ManagementNovelty: A new approach to improve chronic care by providing systematic support to family caregivers.Value Proposition: Population ageing is accompanied by rising numbers of elderly people with multimorbidity requiring high-quality chronic care; however, the long-term, high-intensity care-giving evidentially imposes an immense burden on the family caregivers, and there is great demand for improved chronic care models. Hence, the Guided Care Caregiver Interview encompasses a 125-question survey for the detailed inter...Tue, 07 Oct 2014 10:25:47 GMTJHTT-Communications@jhu.edu Transgenic Mice, 07 Oct 2014 10:25:46 GMTJHTT-Communications@jhu.edu markers for stratifying breast cancer, for prognosis, for predicting disease recurrence and response to treatment Markers to Differentiate between ER Subtypes, Predict Treatment Outcome and Risk of Reoccurrence in Breast Cancer Value Proposition: - 40 loci have been validated in an independent dataset. - This technology may reveal important biological differences in the epigenome between breast cancer subtypes. - These markers may provide ancillary clinical diagnostic, prognostic and predictive tools. - This technology may be developed to detect methylated genes in various human samples obtained from serum, tissue, plasma, nipple aspirate fluid, fine needle aspirates, ductal lavage, ductoscopy, et...Tue, 07 Oct 2014 10:25:46 GMTJHTT-Communications@jhu.edu Trocar with Lens Cleaner Time-saving Laparoscopic Lens Cleaning ToolNovelty: This technology is a multipurpose laparoscopic trocar that allows a surgeon to clean the stained lens of a scope without removing it from the trocar, resulting in increased procedure efficiency, increased patient safety, and decreased operating room costs.Value Proposition: Laparascopic surgery is less invasive than traditional large incision procedures, yet typically lasts longer. During a laparoscopic procedure, the scope lens will inevitably become stained by fluid, tissue, or condensation. Currently, surgeons must remove the lens...Tue, 07 Oct 2014 10:25:46 GMTJHTT-Communications@jhu.edu Novel Treatment for Heart Attack, 07 Oct 2014 10:25:46 GMTJHTT-Communications@jhu.edu of Chromosome 1 and Chromosome 19 Genes Contributing to Oligodendrogliomagenesis, 07 Oct 2014 10:25:45 GMTJHTT-Communications@jhu.edu of ATRX in Brain Tumors, 07 Oct 2014 10:25:45 GMTJHTT-Communications@jhu.edu Targeted Coating of Tumor Cells with Foreign Antigenic Peptide Renders Tumor Cells Susceptible to Antigen-specific CD8+ T Cell-mediated Killing, 07 Oct 2014 10:25:45 GMTJHTT-Communications@jhu.edu and Derivatives for Treatment of Peripheral Neuropathies and Other Neurodegenerative Disorders neuropathies are a group of neurodegenerative disorders affecting the peripheral nerves. Currently there is no effective therapy that prevents nerve degeneration except in cases of autoimmune peripheral neuropathies. Wehave now identified a compound, ethoxyquin (EQ), that prevents nerve degeneration in chemotherapy-induced peripheral neuropathy (CIPN), diabetic peripheral neuropathy (DPN) and human immunodeficiency associated sensory neuropathy (HIV-SN). Novel derivatives of ethoxyquin retain their neuroprotective efficacy in models of both CIPN and HIV-SN. Evaluation of efficacy of...Tue, 07 Oct 2014 10:25:44 GMTJHTT-Communications@jhu.edu Novel Adjuvant Based Approach to Enhance Cancer Immunotherapy, 07 Oct 2014 10:25:44 GMTJHTT-Communications@jhu.edu Cytomegalovirus (CMV) for High-throughput Drug Screening Luciferase-tagged CMV strains for rapid sensitive anti-CMV drug screening.Value Proposition: To date, the identification of anti-viral agents for cytomegalovirus (CMV), a major threat in immunocompromised people and congenitally-infected children, relies on evaluation of viral replication via plaque assays and real-time PCR. However, these assays are laborious, time-consuming and often not conclusive. New drug screening methods, such as the one described below, are urgently needed. This new technology provides CMV strains expressing luciferase under control of the CMV-DNA polymerase (...Tue, 07 Oct 2014 10:25:44 GMTJHTT-Communications@jhu.edu Capture and Release Using Reversible Hydrazone-based Coupling Method Novel Method to Capture and Release GlycansNovelty: The outlined technology takes advantage of hydrazone chemistry to devise a novel method to capture and release glycans from glycoproteins without destroying integrity of sugar structures.Value Proposition: Existing glycopeptide/glycan separation technologies required for analysis of glycoproteins and associated glycans result in low yields of glycans due to the multiple purification processes. The disclosed technology allows direct capture of glycans from complex biological samples and their reversible release without disturbing their...Tue, 07 Oct 2014 10:25:43 GMTJHTT-Communications@jhu.edu Three-way Diaphragm Valve Implantable Three-way Diaphragm ValveNovelty: Biocompatible three-way valve features three points of access where only two of the three conduits are open at any given time. The invention facilitates permanent vascular access and allows cleaning of the device without exposure of the bloodstream.Value Proposition: About 300,000 patients undergo hemodialysis each year in the United States. The current options for permanent hemodialysis access (grafts and fistulas) require multiple surgeries and can lead to the loss of access site, stenosis development, or death. The invention has a nov...Tue, 07 Oct 2014 10:25:43 GMTJHTT-Communications@jhu.edu Management Database, 07 Oct 2014 10:25:43 GMTJHTT-Communications@jhu.edu Receptor as a Therapeutic Target for Autism Disorder, 07 Oct 2014 10:25:42 GMTJHTT-Communications@jhu.edu Novel Target for Anti-cancer Drug Development, 07 Oct 2014 10:25:41 GMTJHTT-Communications@jhu.edu of SGK-1 as a Novel Means to Treat Autoimmune Disease and Enhance Anti-pathogen and Anti-tumor Immunity Novel Target for Treatment of Autoimmune DiseasesNovelty: Inhibition of this novel target has the potential to treat autoimmune diseases, as well as enhancing immunity against pathogen infections and tumor formation.Value Proposition: Currently, most immunosuppressive therapies non-specifically inhibit the immune system and leave the body susceptible to infection. Inhibition of this novel target addresses this perilous side effect by directly targeting the effectors responsible for human immune response and promotion of autoimmune diseases, while leaving the rest of the immune system i...Tue, 07 Oct 2014 10:25:40 GMTJHTT-Communications@jhu.edu Component that will Fragment into Particles of Selected Geometry and Reactivity Solid Structural Component with Controllable Fragmentation and ReactivityNovelty: This technology features the ability to control the size and reactivity of fragments that result from the ignition of munitions and is useful in a variety of defense and military applications.Value Proposition: Solid metal structures in most munitions do no fragment in a controlled manner. Often, very small particles are obtained. One can pattern the solid structure to improve fragmentation but this may be challenging for reactive structures. This technology allows one to control the mechanical strength ...Tue, 07 Oct 2014 10:25:40 GMTJHTT-Communications@jhu.edu of GNAS Mutations in Pancreatic Cystic Lesions 3% of the population of the US harbors a pancreatic cyst and these cysts often pose a difficult management problem. One of the most common cystic neoplasms of the pancreas, and a bona fide precursor to invasive adenocarcinoma, is called Intraductal Papillary Mucinous Neoplasm (IPMN). To help reveal the pathogenesis of these lesions, we purified the DNA from IPMN cyst fluids of 19 patients and searched for mutations in 169 genes commonly altered in human cancers. In addition to theexpected KRAS mutations, we identified recurrent mutations at codon 201 of GNAS. A larger number (N = 113) o...Tue, 07 Oct 2014 10:25:40 GMTJHTT-Communications@jhu.edu Process for Assessing Cardiac Filling Pressure Noninvasively Automated Process for Assessing Cardiac Filling Pressure Non-invasivelyNovelty: This algorithm creates an automated process for interfacing with the Noninvasive System for Assessing Cardiac Filling Pressure previously developed by Dr. Harry A. Silber.Value Proposition: Congestive heart failure is linked to the left ventricle filing pressure, currently measured by invasive catheters or insensitive radiographic methods. Precision and repeatability both require the user to follow an optimal protocol. By coding these steps into the present invention, the Noninvasive System addresses these ...Tue, 07 Oct 2014 10:25:38 GMTJHTT-Communications@jhu.edu for Deformable Image Registration Accommodating Missing Tissue Accurate Image Registration Method for Anatomy Changes Between ScansNovelty: Fast deformable image registration that can accurately account for tissues and materials excised or introduced between image acquisitionValue Proposition: Deformable image registration plays critical role in image-guided surgery by linking images taken at various time intervals. However, current methods do not account for tissues and materials removed (or introduced) between image scans, resulting in inaccurate images. This invention features “extra-dimensional” deformations, enabling fast and precise image re...Tue, 07 Oct 2014 10:25:38 GMTJHTT-Communications@jhu.edu for Automatic Localization/Identification of Structures in Projection Images, 07 Oct 2014 10:25:38 GMTJHTT-Communications@jhu.edu Endoscopic Device and Method to Retrieve Tetherless Microtools Improved Colon Biopsy Devices: Tetherless Microtools and Magnetic Deployment/ Retrieval EndoscopeNovelty: The device and method is used to retrieve tissue with minimally invasive and collects large numbers of samples.Value Proposition: Current colon biopsy methods include collection of many, relatively large samples from multiple areas in the colon resulting in significant damage to the colonic mucosa over time, and increasing the chance of side effects for the patient. There is a clear unmet medical need for a system for more efficient biopsy tissue sampling. - Allows collection of mu...Tue, 07 Oct 2014 10:25:37 GMTJHTT-Communications@jhu.edu Pig-passaged H37Rv rel Mtb Mutant, rel Complement Strain, rel Tetracycline-inducible Knock-in Strain, rel Tetracycline-inducible Knock-down Strain Transgenic rel Tubercle Bacilli for Anti-Tuberculosis Drug ScreeningNovelty: Transgenic guinea pig-passaged tubercle bacilli with modified rel expression levels useful for the identification of novel anti-tuberculosis therapeutics.Value Proposition: To date, tuberculosis (TB) infections are often unrecognized due to the ability of tubercle bacilli to develop asymptomatic latent infection; however; under circumstances when the immune response is perturbed, infections can reactivate and recrudesce into clinically active contagious tuberculosis. Hence, there is great interest in elucidati...Tue, 07 Oct 2014 10:25:37 GMTJHTT-Communications@jhu.edu computational approach for generating representative hepatitis C virus genomic sequences, 07 Oct 2014 10:25:37 GMTJHTT-Communications@jhu.edu (and Offset) VARied Saturation (LOVARS) Method for Chemical Exchange Saturation Transfer (CEST) MRI Method for Obtaining Multi-probe Magnetic Resonance Images (MRI)Novelty: A novel method of obtaining simultaneous detection of multiple probes within an MRI, allowing for a visual representation of the data that can be separated based on probes.Value Proposition: Current MRI technology would significantly benefit from having the ability to discriminate probes during data acquisition, creating an opportunity for the separation of these probes based on a variety of MRI data characteristics. This technology creates this capability by incorporating an additional step of performing a chemic...Tue, 07 Oct 2014 10:25:36 GMTJHTT-Communications@jhu.edu resonance methodology for imaging of exchange-relayed intramolecular nuclear overhauser enhancement (NOE) effects in mobile solutes., 07 Oct 2014 10:25:36 GMTJHTT-Communications@jhu.edu Peptide Stimulator of NHE3, the Brush Border Epithelial Na/H Exchanger Effective Treatment of Acute Diarrhea Using a Novel Peptide ModificationNovelty: A peptide derived from the Sodium-Hydrogen Exchanger-3 (NHE-3) protein that increases sodium absorption in the intestine, aiding rehydration and can be used as a therapeutic for acute diarrhea.Value Proposition: The Center for Disease Control recommends that currently marketed medications for diarrhea should not be used in cases of acute diarrhea. The peptide therapy described in this invention fills a critical gap in treatment options, particularly for pediatric patients who are most susceptible to acute ...Tue, 07 Oct 2014 10:25:36 GMTJHTT-Communications@jhu.edu to Enhance Interventional Image-guided Thermo-radiotherapy and Thermo-chemotherapy Treatment of Solid Tumor Cancers, and Methods Related Thereto Targeted radiation- and chemo-enhancing heat therapy for cancerNovelty: The proposed technology is a device and platform for treating local and metastatic cancer using multifunctionalized iron oxide nanoparticles in conjunction with radiation and chemotherapeutic agents.Value Proposition: Metastatic cancer is persistent and difficult to treat, but studies have shown that heat between 39 C and 49 C sensitizes metastatic cells to radiation and chemotherapy. This invention uses coated iron oxide nanoparticles capable of localizing in cancer cells to induce hyperthermia when exposed to lo...Tue, 07 Oct 2014 10:25:35 GMTJHTT-Communications@jhu.edu Automatic External Defibrillators for ICD Patients Undergoing Procedures Involving Electromagnetic Interference Automatic External Defibrillator for ICD PatientsNovelty: This technology is an automatic external defibrillator for patients with implantable cardioverter defibrillators (ICDs) to avoid electromagnetic interference during the post-procedural period after surgical and endoscopic procedures.Value Proposition: Many surgical procedures require deactivation of ICDs if a patient requires one. During this time, the patient’s heart can suddenly stop and, therefore, these procedures must be carried out in specialized operating rooms with staff trained in advanced cardio life support. This in...Tue, 07 Oct 2014 10:25:35 GMTJHTT-Communications@jhu.edu - Lightweight Java Image Analysis and Processing A novel software for imaging analysis of Individual carbon nanotubesNovelty: Less computing intensive software with novel algorithms that can identify and size individual carbon nanotubes in atomic force microscopy imaging.Value Proposition: Johns Hopkins researchers have created a novel data processing and analysis software for atomic force microscopy (AFM). AFM is commonly used to characterize carbon nanotubes (CNTs), but its current capability is limited to measuring gross topographical features. This invention contains novel algorithms that can locate and measure individual CNTs. I...Tue, 07 Oct 2014 10:25:35 GMTJHTT-Communications@jhu.edu Trioxane Amide Sulfur Compounds Oral Single Dose Therapeutic for MalariaNovelty: The combination of a novel oral drug with Mefloquine administered as a single oral dose demonstrates anti-malarial activity.Value Proposition: Malaria is responsible for a million deaths each year and some treatments are not very effective, as the malarial parasite has developed resistance to them. Moreover, the effective treatment options are often multi-dose regimens which are not patient friendly and further encourage development of resistance. This technology is a novel oral drug which when taken in combination with mefloquine as a s...Tue, 07 Oct 2014 10:25:34 GMTJHTT-Communications@jhu.edu Theranostic Imaging of Metastatic Cancer PSMA-based Theranostic Imaging of Metastatic CancerNovelty: This invention is a pharmaceutical composition and method for the effective imaging, targeting, and treatment of metastatic tumor cells.Value Proposition: In the United States, prostate cancer (PCa) is the second leading cause of cancer-related death among men. There is a compelling need to find effective treatments for metastatic cancers, including PCa. The technology described here enables the systemic delivery of drugs to diseased cells while leaving healthy cells intact and confirms its therapeutic efficacy using non-inva...Tue, 07 Oct 2014 10:25:34 GMTJHTT-Communications@jhu.edu Novel Cell Line TMA Approach for Tissue Biomarker Development and Validation, 07 Oct 2014 10:25:34 GMTJHTT-Communications@jhu.edu miRNA Microarray Analysis in Barrett's Esophagus and Esophageal Adenocarcinoma MicroRNA Diagnostic for Early Stage Esophageal CancerNovelty: MicroRNA (miR) biomarker panel useful for a high sensitivity, specificity and non-invasive diagnostic assay for the detection of Barrett?s Esophagus and early stage esophageal cancer.Value Proposition: Diagnoses of early stage of esophageal cancer are often missed by currently endoscopic biopsy and histopathological examination. These techniques are very invasive, unpleasant and have low patient compliance. MicroRNA (miR) biomarkers are potentially sensitive enough for the detection of the earliest stages of esophageal cance...Tue, 07 Oct 2014 10:25:33 GMTJHTT-Communications@jhu.edu Expressing tg Mice, 07 Oct 2014 10:25:33 GMTJHTT-Communications@jhu.edu for Aggressive Prostate Cancer, 07 Oct 2014 10:25:33 GMTJHTT-Communications@jhu.edu Magnetic Resonance Methods of Measuring Transverse Relaxation Time (T2), T2 Imaging, and Enhancing T2 Contrast in MRI One-Step MRI Method to Increase Image ContrastNovelty: A new method of measuring transverse relaxation time (T2), T2 imaging and T2 contrast in MRI.Value Proposition: T2-contrast is essential to diagnostic MRI in a multitude of disorders. Prior methods utilize the spin-echo (SE) method to measure T2 and to generate T2contrast. The SE method involves multiple MRI pulse applications that contribute to RF power deposition, and confound other MRI properties of interest. The current invention provides a new method that avoids SE, that can preserve other MRI sequence properties, and which is...Tue, 07 Oct 2014 10:25:32 GMTJHTT-Communications@jhu.edu, High-dynamic Range RF Power Monitor for MRI/MRS Real-Time High Dynamic Range RF Power MonitorNovelty: This device is a reduced-to-practice 6-channel MRI-compatible RF monitor that can operate up to 400MHz and accurately measure RF power over the full dynamic range and duty cycles of clinical and research MRI scanners, NMR instruments, and RF transmitters.Value Proposition: Measurement of RF power delivery, and deposition in the body (the specific absorption rate, SAR) during human MRI scanning is critical in complying with FDA regulations and ensuring patient safety. Accurate RF power measurements are also required for testing the s...Tue, 07 Oct 2014 10:25:32 GMTJHTT-Communications@jhu.edu of Spatially-encoded MRS Using Preselected Compartments an Linear Algebraic Modeling Novel Method of Performing Localized Magnetic Resonance SpectroscopyNovelty: This is a reduced-to practice method for optimizing both scan time and signal-to-noise (SNR) ratio in Magnetic Resonance Spectroscopy metabolic studies.Value Proposition: Scan time and SNR are major problems for magnetic resonance spectroscopy (MRS) of low-concentration metabolites. Model-based MRS reconstruction methods, which can reduce scan time, have not been realized in humans. Matching voxels to anatomical features prior to acquisition yields intrinsically higher signal to noise ratio (SNR) than summing...Tue, 07 Oct 2014 10:25:32 GMTJHTT-Communications@jhu.edu Detection of Misaligned Eyes in Young Children, 07 Oct 2014 10:25:31 GMTJHTT-Communications@jhu.edu coli K12 Proteome Microarray E.coli Proteome Microarray ChipNovelty: A protein microarray chip containing 4,176 proteins encoded by the E.coli K12 strain for proteomics studies in prokaryotes.Value Proposition: Proteome chips comprising of individually purified proteins are not common due to the complexity and difficulty of high-throughput protein purification. However for this invention, researchers have developed a high-throughput protein purification protocol that allowed them to purify 4,176 proteins encoded by the E.coli K12 strain. These proteins were then used to create E.coli proteome chips for analyzing b...Tue, 07 Oct 2014 10:25:31 GMTJHTT-Communications@jhu.edu for Cancellation of Large Magnetic Susceptibility Artifacts in MRI with Specific Application to MR Imaging Patients with Pacemaker and ICDs Device for Cancellation of Large Magnetic Susceptibility Artifacts in MRINovelty: A device to maximize cancellation of the magnetic field distortion created when objects with high variations in magnetic susceptibility are placed in a uniform magnetic field; specifically, this device facilitates the reduction of MR imaging artifact produced by pacemakers and ICDs in order to maximize the diagnostic image quality in the region surrounding to these devices.Value Proposition: MRI is the gold-standard modality for localizing myocardial scar; however, significant MR image distortion and sign...Tue, 07 Oct 2014 10:25:30 GMTJHTT-Communications@jhu.edu Use of Clq/TNF-Related Protein 12 (CTRP12) as a Treatment for Type 2 Diabetes Anti-Diabetic Actions of Novel Recombinant ProteinNovelty: This technology comprises the identification of a novel hormone CTRP12 for its use as a treatment against type 2 diabetes.Value Proposition: The current technology discloses a method to treat Type 2 Diabetes Mellitus (T2DM) and reduce obesity associated with T2DM. The technology involves the identification, function and application of a novel recombinant protein CTRP12 with anti-diabetic actions. CTRP12 may be an effective treatment for complications associated with obesity, Type 2 Diabetes, and Metabolic syndrome. The advantag...Tue, 07 Oct 2014 10:25:30 GMTJHTT-Communications@jhu.edu DNA Hypomethylation as Biomarker for Clinical Detection, Inflammation Severity, and Disease Progression in Gastric Cancer, 07 Oct 2014 10:25:30 GMTJHTT-Communications@jhu.edu Computer-Aided-Detection (CAD) system for personalized disease detection, assessment, and tracking, in medical imaging based on user selectable criteria. Personalized Disease Tracking Imaging SystemNovelty: A novel personalized disease tracking imaging system to identify, measure, classify, and track diseases in the body over time (past, present, and future).Value Proposition: Advances in computers have greatly advanced the science of disease state imaging in individuals. Despite these advances, interpretation of these images, considered both difficult and time-consuming, is still mainly done by humans. To aid in these tasks, Computer-Aided-Detection (CAD) have been developed to assist in the interpretation of medical images. This inven...Tue, 07 Oct 2014 10:25:29 GMTJHTT-Communications@jhu.edu 3D Registration of Radiological Images A Novel 3D Pre-clinical Imaging SoftwareNovelty: A novel 3-D pre-clinical imaging software which uses re-slicing of different modalities to improve medical imaging registration.Value Proposition: Currently pre-clinical imaging is processed in 2D images which are crucial to the researcher in observing changes, either at the organ, tissue, cell, or molecular level. Image registration is the process of finding a transformation that aligns one image to another. The importance of medical image registration is due in part to the many clinical applications including diagnosis and surgical pla...Tue, 07 Oct 2014 10:25:28 GMTJHTT-Communications@jhu.edu Synthetic Sputum-penetrating Gene Carriers Synthetic Sputum-penetrating Gene CarriersNovelty: The technology provides novel compositions and methods to deliver gene therapy to cystic fibrosis (CF) patients.Value Proposition: CF is one of the most common genetic disorders. Currently, there are no aerosol gene delivery methods to efficiently penetrate the hyperviscoelestic sputum in the lungs that is a result of CF. This creates a barrier for the treatment of CF and other obstructive airway diseases. This invention consists of synthetic gene carriers to more efficiently deliver the gene therapy necessary to treat CF. By tunin...Tue, 07 Oct 2014 10:25:28 GMTJHTT-Communications@jhu.edu CT Reconstruction of Objects Containing Known Components, 07 Oct 2014 10:25:27 GMTJHTT-Communications@jhu.edu of non-invasive voltage maps prior to catheter ablation of VT, 07 Oct 2014 10:25:26 GMTJHTT-Communications@jhu.edu kinase activity biosensors Novel Luminescent Biosensors to Visualize In Vivo Kinase ActivityNovelty: Novel reporters designed to enable sensitive and robust real time visualization of protein kinase activity in vivo in either a population of cells or in a single cell.Value Proposition: Currently available, fluorescence resonance energy transfer (FRET)-based kinase activity reporters (KARs) are insensitive to important baseline variations in kinase activity. This technology consists of novel reporters that enable more sensitive and more robust detection of real time kinase activity in vivo. Other advantages inclu...Tue, 07 Oct 2014 10:25:26 GMTJHTT-Communications@jhu.edu in Autism Hydroxyurea for the Treatment of AutismNovelty: This technology employs hydroxyurea (HU), a common treatment for sickle cell disease, to reduce core symptoms, like social responsiveness, in patients of all ages with autism.Value Proposition: Currently, the only available drugs for the treatment of autism are symptomatic. These drugs aim to modulate behavior, but do not target the underlying cause. This invention uses HU or similar compounds to simulate the effects of a fever, which has been shown to alleviate behavioral symptoms in children with autism. This treatment of autism coul...Tue, 07 Oct 2014 10:25:26 GMTJHTT-Communications@jhu.edu Field Illuminated Reflectance Fiber Bundle Endoscopic Microscope Fiber Bundle Based Endoscopic Microscope SystemNovelty: A fiber bundle based endoscopic microscope system (illumination and image acquisition configuration, in which only one fiber bundle is used for medical imaging and diagnostics.Value Proposition: Endoscopic systems are instruments used to examine the interior of a hollow organ or cavity of the body. Current medical imaging diagnostic endoscopic microscope systems are large and costly. This system uses one fiber bundle for illumination and image acquisition, which can help further miniaturize the endoscopic probe and reduce the syst...Tue, 07 Oct 2014 10:25:25 GMTJHTT-Communications@jhu.edu Profiles as Methods for Diagnosis and Prognosis of Irritable Bowel Syndrome Markers for Diagnosis and/or Prognosis of Irritable Bowel Disease and Syndrome Value Proposition: - The identified markers may be combined to optimize sensitivity and specificity. - These markers may be used in ELISA or Chip format. - Markers have been validated using colonic tissue biopsy samples. - Predicate technology and CPT codes already exist. - This technology is predicted to be priced lower than current tests which will likely allow faster acceptance by doctors and patients. - A diagnostic test may be developed to detect these markers in patient blood, serum, plasma or tissue. ...Tue, 07 Oct 2014 10:25:25 GMTJHTT-Communications@jhu.edu activation of a transcription factor by proteolytic cleavage Novel Method for Real Time Monitoring of Gene ExpressionNovelty: The invention is a novel method which allows the targeted activation and characterization of a protein molecule of interest in a living cell without disrupting its natural state or functionality.Value Proposition: Currently, protein expression can be followed using translation fusion, however this risks disrupting the function of the protein. Another approach is using a reporter molecule on the same transcript or same promoter; however inaccuracy in counting undermines this approach. This technology addresses both of thes...Tue, 07 Oct 2014 10:25:25 GMTJHTT-Communications@jhu.edu to achieve rapid and uniform drug distribution at a mucosal surface Rapid and Uniform Drug Delivery through Mucosal SurfacesNovelty: A novel nanoparticle drug delivery formulation that is capable of rapidly diffusing through mucus while creating a uniform distribution at the mucosal surface, including regions of highly folded epithelium.Value Proposition: Drug delivery systems that utilize transmucosal delivery are subject to becoming trapped within mucosal secretions, limiting drug uptake and ultimately being mechanically cleared away from the mucosal surface. The nanoparticle composition described in this invention is capable of quickly diffusing th...Tue, 07 Oct 2014 10:25:25 GMTJHTT-Communications@jhu.edu post-translational processing for native-like BChE production in CHO cells Novel Biological Countermeasure Against Toxic Nerve AgentsNovelty: The technology comprises a novel recombinant butyrlcholinesterase (BChE) protein that is long lived and has the same properties as those of plasma derived natural BChE protein.Value Proposition: Currently, the short lived recombinant BChE protein and its other inferior properties limit the use of existing recombinant gene expression systems in the war against toxic organophosphorus (OP) nerve agents. This technology allows the production of a novel recombinant protein with equivalent physical, chemical and biological pr...Tue, 07 Oct 2014 10:25:25 GMTJHTT-Communications@jhu.edu GN11 cells: gonadotropin-releasing hormone (GnRH) expressing cell lines. Value Proposition: This technology involves GN11 cells obtained from a tumor in mice containing a transgene consisting of a human GnRH promoter fused to the SV40 Large TAntigen oncogene (Tag). GN11 cells are immortalized, gonadotropin-releasing hormone (GnRH) expressing cell lines. Publications/Associated Cases: Novaira HJ, et. al. Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines. Mol Cell Endocrinol. 2009 Nov 13;311(1-2):126-34. PUBMED ID: 19576263.Tue, 07 Oct 2014 10:25:24 GMTJHTT-Communications@jhu.edu inhibitors of protein kinase signaling that are neuroprotective and have potential applicability for the treatment of glaucoma, optic nerve disease, and other forms of neurodegeneration - #2 is a major cause of visual loss and blindness in elderly Americans and throughout the world. One approach to treatment of glaucoma, and other optic nerve diseases as well as other neurodegenerations, is to develop neuroprotective agents that promote the survival of neurons. Through a high content screen of libraries of small molecule compounds, we have identified a protein kinase inhibitor that can promote the survival and/or neurite outgrowth of retinal ganglion cells (RGCs), the cells in the retina that die in glaucoma and whose loss leads to vision loss. Based on the activity of th...Tue, 07 Oct 2014 10:25:23 GMTJHTT-Communications@jhu.edu from Schizophrenia patents with a DISC1 mutation Schizophrenia Associated Induced Pluripotent Stem Cell LinesNovelty: Induced Pluripotent Stem Cell (iPSC) lines derived from somatic cells from members of an American family with schizophrenia and without a schizophrenia diagnosisValue Proposition: Mutations in the Disrupted-in-Schizophrenia 1 (DISC1) gene have been shown to predispose individuals to psychiatric disorders like schizophrenia. This technology is the establishment of multiple iPS cell lines with or without the DISC1 mutation associated with schizophrenia to screen for drugs against schizophrenia and other psychiatric diso...Tue, 07 Oct 2014 10:25:23 GMTJHTT-Communications@jhu.edu Method of Identifying Key Residues in Multiple Protein-Protein Interactions (Improved Reverse Two-Hybrid Methods) This invention is a method for identifying key residues in protein-protein interactions in a complex system.Value Proposition: Currently, it is not possible to rapidly and simultaneously identify protein residues that selectively disrupt interactions with multiple partner proteins. This technology utilizes an improved yeast reverse two-hybrid screen to discover amino acid residues that are critical for multiple protein interactions. Other advantages include:Identification of specific disruptions of protein interaction interfaces (Improved Reverse Two Hybrid Screen);Simultaneous identi...Tue, 07 Oct 2014 10:25:23 GMTJHTT-Communications@jhu.edu Therapeutic Alleviating Cognitive Impairment from Multiple Sclerosis (MS) technology is a first of its kind, potential therapeutic in alleviating cognitive impairment (CI) as a result of Multiple Sclerosis (MS) and related central nervous system (CNS) autoimmune diseases.Value Proposition:CI is a debilitating outcome of many CNS disorders, including MS. Currently, the high prevalence of CI and the extremely negative functional impact it causes remain unabated, causing many patients and their families to suffer unnecessarily. In fact, the minority of patients with MS are even screened by their treating neurologists for CI because of the widespread belief...Tue, 07 Oct 2014 10:25:22 GMTJHTT-Communications@jhu.edu TRX genes provide prognostic information in cancers, 07 Oct 2014 10:25:21 GMTJHTT-Communications@jhu.edu and Multimodality Non-Linear Reduction method for segmentation and classification of radiological imaging A Method for the Classification and Segmentation of MRI ImagesNovelty: A novel method for segmentation and classification which also combines multi-parametric MRI and/or other radiological imaging into a single dataset for increased specificity of diagnosis.Value Proposition: Early detection is the key to survival for cancer patients. Currently, there is limited technology with computer aided diagnosis (CAD) systems that integrate multi-parametric MRI and/or other radiological imaging procedures into highly specific datasets. Moreover, the CAD systems use only small portions of the dat...Tue, 07 Oct 2014 10:25:21 GMTJHTT-Communications@jhu.edu and System to Digitize Pathology Specimens in a Stepwise Fashion for Review System for Improved Pathology Specimen EvaluationNovelty: This technology is a system to dramatically improve the ease and efficiency of evaluation of pathology slide specimens.Value Proposition: The current navigation paradigm in digital microscopy relies on a computer mouse or other input device to "drag" the displayed image from one location to another. The drawbacks associated with current methods indicate a need for quicker, more robust automated methods to review pathologic samples for the diagnosis of disease. The system will re-orient tissue from any angle into a single linear ...Tue, 07 Oct 2014 10:25:20 GMTJHTT-Communications@jhu.edu Hybrid Cyclic Libraries and Screens Thereof Generation and Proteome-Wide Screening of Novel Hybrid LibrariesNovelty: This technology embodies the design and method of developing novel hybrid cyclic libraries and screening of such libraries against entire human proteome using protein chip technology.Value Proposition: A major challenge for the biologists today in elucidating the functions of human proteins is to discover new molecules that specifically bind to proteins. The disclosed technology provides a novel method to generate a new structural class of molecular ligands that can be used as probes of protein functions. The adva...Tue, 07 Oct 2014 10:25:20 GMTJHTT-Communications@jhu.edu Airway Opening Device for Obstructive Sleep Apnea Treatment Nasal Catheter for Obstructive Sleep ApneaNovelty: A medical device that mechanically prevents the collapsing of soft tissue on the mouth palate thereby restoring normal breathing during an episode of sleep apnea.Value Proposition: Obstructive Sleep Apnea (OSA) is the common type of apnea where the soft tissue lining the airway in the throat collapses and restricts airflow causing sudden pauses in breathing during sleep. Commonly used methods to treat sleep apnea require repeated self administration of devices, lifestyle changes or invasive surgical procedures. This invention is a mini...Tue, 07 Oct 2014 10:25:20 GMTJHTT-Communications@jhu.edu of Non-labeled Infusion of Natural Sugars and Detection by MRI for Assessing Tissue Perfusion and Metabolism, 07 Oct 2014 10:25:19 GMTJHTT-Communications@jhu.edu Center of Motion Robot for Medical Image Scanning and Image-guided Targeting Remote Center of Motion Robot for Medical Image Scanning and Image-guided TargetingNovelty: A robot which uses a Remote Center of Motion to operate ultrasound probes with maneuverability similar to manual handling. It allows 3-D image rendering from 2-D ultrasound and enables a variety of robot-assisted image-guided procedures.Value Proposition: Since ultrasound probes are typically operated manually, position information required for 3-D reconstruction is lost. Because robots intrinsically measure their joint coordinates, this information is now readily available for imaging. This inv...Tue, 07 Oct 2014 10:25:19 GMTJHTT-Communications@jhu.edu Telesurgery System for Teaching and Guidance During Complex Procedures, 07 Oct 2014 10:25:18 GMTJHTT-Communications@jhu.edu Processing Method for Fluoroperfusion Image Processing Method for FluoroperfusionNovelty: The current invention is a novel method to enhance Fluoroperfusion imaging contrast.Value Proposition: Evaluation of myocardial perfusion using Fluoroscopy is important for guiding invasive therapies for obstructive coronary artery disease. Conventional simple baseline subtraction that determines the level of signal intensity does not work well in quantitative analysis. One possible factor is accumulated huge amount of contrast agent that is injected many times from the beginning of coronary intervention. This new image processing met...Tue, 07 Oct 2014 10:25:18 GMTJHTT-Communications@jhu.edu Sponge Device for Weight Loss Minimally Invasive Weight Loss Device.Novelty: Minimally invasive introduction of a sponge device capable of modulating satiety by constricting gastric capacity leading to lower food intake related weight loss.Value Proposition: Life style changes and pharmaceutical intervention have not been very successful in inducing weight loss in patients with obesity and gastric disorders. Bariatric surgery although effective initially is risky and leads to eventual weight gain. This technology is an endoscopically placed sponge device which when soaked with liquid inflates causing constriction o...Tue, 07 Oct 2014 10:25:17 GMTJHTT-Communications@jhu.edu to Improve Heart Failure by Restoration of Synchronous Contraction after Period of Dyssynchrony, 07 Oct 2014 10:25:17 GMTJHTT-Communications@jhu.edu and Flexible Microfluidics, 07 Oct 2014 10:25:16 GMTJHTT-Communications@jhu.edu Transgenic Mouse Model of Atopic Dermatitis, Skin Remodeling, and Atopic March Transgenic Mouse Model of Atopic Dermatitis and Skin RemodelingValue Proposition: JHU scientists have developed an inducible transgenic model in which IL-13 can be expressed in the skin to define the resulting dermal and systemic phenotypes and mechanisms involved. The mice display increased susceptibilty to allergen stimulation in the airways even though the original pathology is in the skin. - Published as: Zheng T, Oh MH, Oh SY, Schroeder JT, Glick AB, Zhu Z. 2009. Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodeling. J Invest Dermato...Tue, 07 Oct 2014 10:25:16 GMTJHTT-Communications@jhu.edu Encoded Cell-based Sensor for Fatty Acid Metabolites, 07 Oct 2014 10:25:16 GMT