A Miniature Microscope for Multi-contrast Optical Imaging in Animals

Case ID:
C14532
Disclosure Date:
1/10/2017
Description:
Unmet Need
Imaging has taken leaps and bounds during the past two decades with the advent of a multitude of imaging modalities. Specifically, brain imaging has grown as well with the development of multiple contrast mechanisms. This allows for multiple physiological variable to be studied concurrently, allowing for a more comprehensive study of the brain or any other organ. This study allows for in-depth investigation of the brain or other organs relating to dysfunction and disease, allowing for assisting in finding cures. The biggest current issue is the combination of multiple image contrast mechanisms requires a sophisticated custom-built set up with many costly components. This bulkiness requires them to be stationary and limits the number of contrast mechanisms that can be combined as the location limits the number of possible images that can be taken. This causes this mechanism to rarely be used. There is a need to develop a sophisticated portable device that allows for multi-contrast images to realize while also being cost-effective, size conscious, and accuracy to continue to be high.
 
Technological Overview
The inventors have developed a miniature microscope for multi-contrast optical imaging that is portable, used as a ‘plug and play’ device, and requires minimal technical expertise to operate. Furthermore, it costs just a fraction of what is needed to build a bench-top multi-contrast imaging system that is bulky and currently infrequently used. This technology is founded on the recent advances in miniaturized opto-electronics and 3D printing technology. The microscope is 5 centimeters and weighs less than 10 grams. This microscope captures neural activity through incorporating a fluorescence channel in addition to three different forms of hemodynamic imaging. Furthermore, the inventors envision three major applications of this portable device. The first is utilizing the technology to distinguish between vessel compliance and flow dynamics during arousal from anesthesia. The second is using a synchronization channel enabling simultaneous neuroimaging and EEG recording. The third is creating functional multi-contrast brain imaging and wide-area mapping analogous to functional MRI.
 
Stage of Development
The inventors of developed a design and prototype are currently developing plans to test the device.
 
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
A Miniature Microscope for Multi-contrast Optical Imaging in Animals PRO: Provisional United States 62/529,100 7/6/2017   7/6/2018 Expired
A MINIATURE MICROSCOPE FOR MULTI-CONTRAST OPTICAL IMAGING IN ANIMALS PCT: Patent Cooperation Treaty PCT PCT/US2018/040979   7/6/2018     Pending
Inventors:
Category(s):
For Information, Contact:
Jon Gottlieb
jgottl10@jhu.edu
410-614-0300
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