Tissue-derived Scaffolds for Corneal Reconstruction

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The present invention relates to methods for treating a corneal disease such as, for example, corneal blindness, or the refractive power of a cornea by generating a vitrified decellularized corneal inlay.
Due to donor shortages, corneal blindness remains a significant clinical challenge, although corneal transplantation has a high success. Developing new corneal substitutes which have ideal characteristics, including transparency, proper concave shape, biocompatibility and good integration with host tissue becomes essential to address these challenges of current therapeutic strategies. JHU inventors have developed a new technology to treat animal tissue by decelluarization, vitrification and molding procedures which meets clinical requirements in terms of optical, biomechanical and biological properties for regenerative medicine.  This scaffold is also useful to serve a material to change refractive power of cornea and finally correct refractive error.
(1) A tissue based scaffold was treated by novel decellularizing procedures. 
(2) The scaffold was fabricated through a combined method, a novel drying (vitrification) process in the controlled temperature and humidity, and a conventional riboflavin cross-linking.
(3) The combined process can control mechanical properties and improve transparency of any tissue based scaffolds.
(4) The shape of scaffold could be modified as clinical needs that may be able to correct the refractive power of cornea.
Publications/Associated Cases: WO/2017/024090
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Tissue-derived Scaffolds for Corneal Reconstruction PCT: Patent Cooperation Treaty United States 15/750,689 2/6/2018     Pending
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Sonriza Ford
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