Glutamine Antagonists for the Treatment of Cognitive Deficits, including NeuroAIDs

Case ID:

C13696

Disclosure Date:

6/15/2015

Some glutamine antagonists have been shown to have anti-cancer activities in multiple preclinical and clinical studies. However the toxicity of the glutamine antagonists at doses necessary for their anticancer effects have hampered their clinical development. Herein we describe a completely novel use for the glutamine antagonists. Using a prototype glutamine antagonist, we show for the first time, at doses significantly less that that used for its anticancer efficacy, that it can selectively abrogate cognitive deficits in the EcoHIV model of neuroAIDs. We show supporting PK and biomarker data. These data predict the use of glutamine antagonists (or their prodrugs or analogs) for the treatment of cognitive deficits in general, and specifically for NeuroAIDs.

Patent Information:

Title	App Type	Country	Serial No.	Patent No.	File Date	Issued Date	Expire Date	Patent Status
GLUTAMINE ANTAGONISTS FOR THE TREATMENT OF COGNITIVE DEFICITS	CIP: Continuation-in-part	United States	15/884,974	11,110,104	1/31/2018	9/7/2021	7/29/2036	Granted
GLUTAMINE ANTAGONISTS FOR THE TREATMENT OF COGNITIVE DEFICITS	CON: Continuation	United States	18/479,357		10/2/2023			Pending

Direct Link:

https://jhu.technologypublisher.com/technology/24837

Inventors:

Category(s):

Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Neurology > Cognitive Impairment, Clinical and Disease Specializations > Neurology > HIV-Associated Neurocognitive Disorders, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities,

Get custom alerts for techs in these categories/from these inventors:

Subscribe for JHTV Updates

For Information, Contact:

Nakisha Holder

nickki@jhu.edu

410-614-0300

Save This Technology:

Bookmark this page

Download as PDF