A Method to Improve Nanoparticle Distribution Within the Brain Interstitium by Enabling their Escape from Perivascular Spaces

Case ID:
C13711
Disclosure Date:
6/22/2015
Description:
Johns Hopkins inventors have developed a combination strategy that improves the overall homogeneity and volume of distribution of an administered nanoparticle when infused into the brain. This strategy comprises 1) developing a non-adhesive nanoparticle and 2) administering this nanoparticle in a hyperosmolar solution into the brain using convection enhanced delivery (CED). We demonstrate that a 60 nm, non-adhesive nanoparticle administered into the striatum via CED in a 3% hyperosmolar solution achieves higher and more homogeneous volumes of distribution throughout the brain interstitium. This can be attributed to the nanoparticle’s ability to travel through and escape from perivascular spaces (PVS) and back into the brain interstitium.
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
A Method to Improve Nanoparticle Distribution Within the Brain Interstitium by Enabling their Escape from Perivascular Spaces PCT: Patent Cooperation Treaty Japan 2018-512554   9/9/2016     Pending
A Method to Improve Nanoparticle Distribution Within the Brain Interstitium by Enabling their Escape from Perivascular Spaces PCT: Patent Cooperation Treaty United States 15/759,465 3/12/2018     Pending
Inventors:
Category(s):
For Information, Contact:
Sonriza Ford
sford23@jhu.edu
410-614-0300
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