Detection of Tumor-Derived DNA in Cerebrospinal Fluid of Patients with Primary Tumors of the Brain and Spinal Cord

Case ID:
C13728
Disclosure Date:
6/15/2015
Description:
Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-specific biomarkers. As cell-free DNA from brain and spinal cord tumors cannot usually be detected in the blood, we studied whether the cerebrospinal fluid (CSF) that bathes the CNS is enriched for tumor DNA, here termed CSF-tDNA. We analyzed 35 primary CNS malignancies and found at least one mutation in each tumor using targeted or genome-wide sequencing. These results suggest that CSF-tDNA could be useful for the management of patients with primary tumors of the brain or spinal cord.
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Detection of Tumor-Derived DNA in Cerebrospinal Fluid of Patients with Primary Tumors of the Brain and Spinal Cord PCT: Patent Cooperation Treaty PCT PCT/US2016/041862 7/12/2016     Expired
Detection of Tumor-Derived DNA in Cerebrospinal Fluid of Patients with Primary Tumors of the Brain and Spinal Cord PCT: Patent Cooperation Treaty United States 15/744,299 1/12/2018     Pending
Inventors:
Category(s):
For Information, Contact:
Nakisha Holder
nickki@jhu.edu
410-614-0300
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