Topical Application of TRPM7 Blockers to Treat Sleep Apnea and Hypertension in Obesity

Case ID:
C13841
Disclosure Date:
10/9/2015
Description:

Unmet Need: Obesity is a growing epidemic in the U.S. and leads to cardiovascular morbidity and mortality acting via multiple mechanisms including hypertension and obstructive sleep apnea. High levels of leptin have been associated with both conditions. However, the mechanism by which leptin enhances sympathetic activity is unclear.  Leptin receptors (LEPRs) are expressed in the carotid bodies, the most important arterial chemoreceptors for the cardiovascular-respiratory chemoreflex. However, the mechanism of leptin in CB is unknown. High levels of leptin may increase the CB chemoreflex leading to hypertension.  There is an unmet medical need for agents to therapeutically modulate these signaling mechanisms to reduce obesity, hypertension and sleep apnea JHU inventors found that a key member of the Transient Receptor Potential (TRPM) protein family was highly expressed in the Carotid body channel This work establishes a link between TRPM activity in carotid bodies, as stimulated by leptin signaling, and hypertension/sleep apnea, thus elucidating a novel mechanism of treating these conditions.

Technical Details: JHU inventors found that leptin-induced hypertension was prevented by treatment with a TRPM inhibitor.  Inventors have shown for the first time that stimulation of leptin receptor is capable of activating TRPM channels, and suggest that leptin may exert its physiological effects through modulation of activity of a specific TRPM protein. JHU inventors have identified a novel therapeutic target for obstructive sleep apnea (OSA) and hypertension. JHU inventors have identified that TRP channel inhibitor can potentially be used as new treatment of hypertension and sleep apnea in obesity.

Stage of development/data: proof of concept, pre-clinical

 
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Topical Application of TRPM7 Blockers to Treat Sleep Apnea and Hypertension in Obesity PRO: Provisional United States 62/461,452 2/21/2017     Expired
Topical Application of TRPM7 Blockers to Treat Sleep Apnea and Hypertension in Obesity PCT: Patent Cooperation Treaty PCT PCT/US2018/018667   2/20/2018     Pending
Inventors:
Category(s):
For Information, Contact:
Vera Sampels
vsampel2@jhu.edu
410-614-0300
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