This invention describes biodegradable nanofiber-film composite that forms a conformal coating on medical devices for local, sustained release of multiple antibiotics following implantation. This composite coating comprises of one or more sets of biodegradable polymer fibers embedded in a biodegradable polymer film whereas both the nanofibers and films carry one or more antibiotics, and the loading and release profile of the antibiotics are tunable independently. This invention also describes the process for preparing this composite coating by electrospinning method followed by post spinning annealing. This composite coating is designed to provide superior antimicrobial activity following implantation of medical devices such as those used in orthopedic surgery, intramedullary surgery, internal or external fracture-fixation devices, cardiovascular devices, and implants associated with neurosurgical procedures.
IP status: PCT is pending
Publications/Associated Cases: Ashbauch AG et al (2016) Polymeric nanofiber coating with tunable combinatorial antibiotic delivery prevents biofilm-associated infection in vivo. PNAS. 2016 Oct 24. pii: 201613722
