Method of Fast Imaging of NMR Parameters with Variably-accelerated Sensitivity Encoding (vSENSE)

Case ID:
C14010
Disclosure Date:
3/4/2016
Description:
Unmet Need: Long scan times due to its requirement that multiple saturation-offset image frames be acquired is the underlying reason that widespread clinical use of chemical exchange saturation transfer (CEST) imaging is hampered.

Technology Overview: The invention is a novel method that fully samples one CEST saturation frame, then undersamples the other frames variably. The fully-sampled frame, in conjunction with newly proposed incoherence absorption and artifact suppression strategies, improves the accuracy of sensitivity maps and permits higher acceleration factors for the other undersampled frames than regular SENSE. This technology is validated in a phantom, a normal volunteer and eight brain tumor patients at 3 Tesla. This new method enabled twice the acceleration and generated more accurate images than conventional SENSE.

Stage of Development:  Prototype is currently being tested and provisional patents have been filed.

Publications:  https://www.ncbi.nlm.nih.gov/labs/articles/27364631/
 
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
METHOD OF FAST IMAGING OF NMR PARAMETERS WITH VARIABLY-ACCELERATED SENSITIVITY ENCODING PCT: Patent Cooperation Treaty United States 16/091,785 10/5/2018     Pending
Inventors:
Category(s):
For Information, Contact:
Jon Gottlieb
jgottl10@jhu.edu
410-614-0300
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