Method of Fast Imaging of NMR Parameters with Variably-accelerated Sensitivity Encoding (vSENSE)

Case ID:

C14010

Disclosure Date:

3/4/2016

Unmet Need: Long scan times due to its requirement that multiple saturation-offset image frames be acquired is the underlying reason that widespread clinical use of chemical exchange saturation transfer (CEST) imaging is hampered.

Technology Overview: The invention is a novel method that fully samples one CEST saturation frame, then undersamples the other frames variably. The fully-sampled frame, in conjunction with newly proposed incoherence absorption and artifact suppression strategies, improves the accuracy of sensitivity maps and permits higher acceleration factors for the other undersampled frames than regular SENSE. This technology is validated in a phantom, a normal volunteer and eight brain tumor patients at 3 Tesla. This new method enabled twice the acceleration and generated more accurate images than conventional SENSE.

Stage of Development: Prototype is currently being tested and provisional patents have been filed.

Publications: https://www.ncbi.nlm.nih.gov/labs/articles/27364631/

Patent Information:

Title	App Type	Country	Serial No.	Patent No.	File Date	Issued Date	Expire Date	Patent Status
METHOD OF FAST IMAGING OF NMR PARAMETERS WITH VARIABLY-ACCELERATED SENSITIVITY ENCODING	PCT: Patent Cooperation Treaty	United States	16/091,785	10,908,235	10/5/2018	2/2/2021	8/3/2037	Granted

Direct Link:

https://jhu.technologypublisher.com/technology/24886

Inventors:

Category(s):

Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices,

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For Information, Contact:

Louis Mari

lmari3@jhu.edu

410-614-0300

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