A New Index Utilizing Myocardial Scar and Myocardial Interstitial Fibrosis Volume to Assess Left Ventricular Function

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Unmet Need:  Assessing the condition of the heart after a heart attack in key to determining effective treatment for heart muscle damage, and to predict future heart failure. Monitoring the function of the left ventricle of the heart is an important way to diagnose cardiac function after heart attack. In current methods, physicians examine elements of heart function such as blood ejection fraction to make clinical diagnoses and predictions. Left ventricle ejection fraction (LVEF) is the most prevalent variable used to evaluate global function of the left ventricle. However, significant myocardial damage can occur before the LVEF indicates a pathological change. There is an unmet need for a more accurate indicator of heart damage. Index can be used for improved outcome assessment in clinical research studies assessing efficacy of new treatments. Index accounts for functional changes in myocardial tissue which have not previously been included for better characterization of heart function. Measurement can be done with MRI to more robustly predict cardiac failure.
Technology Overview:  JHU scientists previously reported a LV global function index (LVGFI) which combines the LV volumes with anatomical parameters to better characterize LV dysfunction. Now the scientists have improved the LVGFI with modified algorithms and software to account for changes in cardiac function due to previous myocardial damage such as infarction or fibrosis. An adjusted LVGFI will particularly will help to assess the efficacy of new treatments in the context of clinical trials more accurately and sensitively.
Stage of Development:  Pre-clinical
Publications:  Background Hypertension. 2013 Apr;61(4):770-8
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Jon Gottlieb
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