Ankyrin-G and Ion Channel Pathway Cell Model for Testing Psychiatric Therapeutics

Case ID:
C13171
Disclosure Date:
7/23/2014
Description:

TITLE                                                 

Ankyrin-G and Ion Channel Pathway Cell Model for Testing Psychiatric Therapeutics

 

CASE NUMBER

C13171

 

ABSTRACT

L-Type calcium channel loci and the Ankyrin-G locus have emerged from Genome-Wide Association Studies as among the major risk factors for human psychiatric disorders, and Johns Hopkins researchers have developed a cell model that may be useful to screen for new small molecule therapeutics for psychiatric disorders. They have hypothesized, based on past and current data that these gene product are linked in a signaling pathway in the cerebral cortex and other forebrain structures relevant to psychiatric disorders.

 

FEATURES

Johns Hopkins researchers have developed a cell model that may be useful to screen for new small molecule therapeutics for psychiatric disorders base on the hypothesis is that calcium entry into voltage-gated calcium channels downregulates Ankyrin-G. Using primary cortical or hippocampal mouse or rat neurons, the voltage-gated calcium channels are stimulated with KCl-induced depolarization, or channel opening drugs with levels of Ankyrin-G by immunofluorescence as the readout. They found:

approximately 50% decrease in Ankyrin-G, which has been replicated.

Alternative readouts could be the voltage-gated sodium or potassium channels.

Potentially use the interaction between Ankyrin-G and these voltage-gated channels as readout

This assay could be used to screen for novel small molecules therapeutics that could block the alteration in these readouts

 

STAGE OF DEVELOPMENT

Tangible material, Ankyrin-G and Ion Channel Pathway cell model.

 

DISEASE INDICATION

Psychiatric Disorders

 

ASSOCIATED PUBLICATIONS

- None -

 

TECHNOLOGY CLASSIFICATION

Primary Category: Discovery/Research Tools

Primary Subcategory: Research Reagent

 

 

Patent Information:
Inventors:
Category(s):
For Information, Contact:
Christine Joseph
cjoseph6@jhmi.edu
410-614-0300
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