Scaffold design and process for developing tissue-engineered organs with hollow structures

Case ID:
C13509
Disclosure Date:
4/6/2015
Description:
Collagen is a commonly used biomaterial for tissue engineering applications given its compositional proximity to physiological tissues. Despite much progress in recent years, clinical application of collagen-based scaffolds has been limited by constraints in its biomanufacturing process. Recently, the JHU scientists developed an innovative process to manufacture seamless and biomechanically tunable collagen scaffolds with unprecedented flexibilities of incorporating a variety of design features in both longitudinal and radial or cross-sectional directions relevant to genitourinary and gastrointestinal tissues. Specifically, the JHU scientists developed hollow and tubular collagen scaffolds ranging from ureter-like micro-sized tubings to tubes with highly customized lumens that resemble intestinal villi, fluid bladders, and alveolar sacs that together with stem cells can potentially be used in pre-clinical and clinical settings. This biomanufacturing process can be also used to create collagen scaffolds for small intestine, blood vessels and nerve conduits.
 
Published material: Singh et al (2017) Biomanufacturing Seamless Tubular and Hollow Collagen Scaffolds with Unique Design Features and Biomechanical Properties. Adv. Healthcare Mater. 6(5): 1601136
 
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Scaffold design and process for developing tissue-engineered organs with hollow structures PRO: Provisional United States 62/448,973 1/21/2017     Expired
Scaffold design and process for developing tissue-engineered organs with hollow structures PCT: Patent Cooperation Treaty PCT PCT/US2018/014426   1/19/2018     Pending
Inventors:
Category(s):
For Information, Contact:
Mitchell Harris
mharr145@jhu.edu
410-614-0300
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