Particulate Drug Delivery System to Enable Targeted Ultrasound-gated Release of Neuromodulatory Agents

Case ID:
C13913
Disclosure Date:
12/10/2015
Description:

Targeted, noninvasive neuromodulation of the brain of an otherwise awake subject could revolutionize both basic and clinical neuroscience. Towards this goal, the JHU scientists have developed nanoparticles that allow noninvasive uncaging of a neuromodulatory drug upon the application of focused ultrasound. These nanoparticles are composed of biodegradable and biocompatible constituents and are activated using sonication parameters that are readily achievable by current clinical transcranial focused ultrasound systems. These particles are potent enough that their activation can silence seizures in an acute rat seizure model. Notably, there is no evidence of brain parenchymal damage or blood-brain barrier opening with their use. Further development of these particles promises noninvasive, focal, and image-guided clinical neuromodulation along a variety of pharmacological axes.

 

Published material: Airan et al (2017) Noninvasive Targeted Transcranial Neuromodulation via Focused Ultrasound Gated Drug Release from Nanoemulsions. Nano Lett. 17(2): 652-659
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Particulate Drug Delivery System to Enable Targeted Ultrasound-gated Release of Neuromodulatory Agents PCT: Patent Cooperation Treaty PCT PCT/US2017/033226   5/18/2017     Pending
Inventors:
Category(s):
For Information, Contact:
Sonriza Ford
sford23@jhu.edu
410-614-0300
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