Passive Hyperspectral Sensing Reliably Identifies Colorectal Cancer in Intraoperative Colon Specimens

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Unmet Need: Surgical management of colorectal cancer relies on accurate intraoperative identification of tumor and resection to negative margins. Hyperspectral (HS) imaging is a passive, non-ionizing diagnostic method that has garnered increased interest for its ability to detect multiple tumor types and even neoplastic biomarkers. We sought to explore the ability to use HS spectroscopy for transluminal identification of tumor specimens during surgical resection of colorectal cancers.
Technology Overview:  The accuracy of HS measurements to identify colorectal cancer was high during both transluminal and direct tumor imaging. Signal fidelity does not appear to degrade within the first 30 minutes following resection. High-resolution optical spectroscopy is a potentially useful diagnostic tool in the operative management of colorectal cancer.
Stage of Development:  Eleven patient specimens were successfully analyzed. In 2 patients, histologic evaluation revealed inflammatory disease only, and HS spectroscopy accurately predicted an absence of tumor specimen in these samples. For patients with pathology confirmed colorectal cancer, HS spectroscopy was able to detect 86% of extraluminal tumor specimens with a 0% false positive rate (sensitivity 86%, specificity 100%). For intraluminal specimens, HS spectroscopy had a tumor detection rate of 100% with no false positives (sensitivity 100%, specificity 100%).
“Passive hyperspectral sensing reliably identifies colorectal cancer in intraoperative colon specimens.” Journal of the American College of Surgeons Volume 223, Issue 4, Supplement 1, October 2016, Pages S34
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
HYPERSPECTRAL IMAGING FOR PASSIVE DETECTION OF COLORECTAL CANCERS PCT: Patent Cooperation Treaty United States 16/342,805 4/17/2019     Pending
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Jon Gottlieb
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