Simulation and Database-guided Antimicrobial Peptide Evolution

Case ID:
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Unmet Need 
Antimicrobial peptides (AMPs) are typically amphiphilic peptides that have selectively to target and kill bacteria at low micromolar concentrations, often without harming mammalian cells and are thus an excellent candidate for drug development.

Technology Overview
The  new methodology combines molecular dynamic simulations and database-guided high-throughput screening to rationally design membrane-active peptides.  This methodology is able to design a range of structural and functional properties such as pore size and selectively targeting membranes with specific lipid compositions, essentially creating designer membrane active peptides MAPs for a wide range of biomedical applications.

Stage of Development
New MAPs have been efficiently produced by JHU researchers using this technology demonstrating its effectiveness.
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
ANTIMICROBIAL PEPTIDES AND METHODS OF MAKING AND USING SAME PCT: Patent Cooperation Treaty PCT PCT/US2018/021985   3/12/2018     Pending
For Information, Contact:
Benjamin Saeks
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