Alternative Pathway of complement assay to diagnose atypical HUS and other disorders of complement activation

Case ID:
C13381
Disclosure Date:
12/30/2014
Description:
Atypical hemolytic uremic syndrome (aHUS) is a rare microangiopathic hemolytic anemia (MAHA) that often leads to renal failure, stroke and premature death(1). In most cases the disease is caused by genetic mutation in one of more than 6 genes that leads to increased activation of the alternative pathway of complement. Currently there is no good diagnostic assay for aHUS; thus, the disease is often confused with other MAHAs such as thombotic thrombocytopenic purpura (TTP), malignant hypertension, pre-eclampsia, disseminated intravascular coagulation, and catastrophic anticardiolipid syndrome. Making a prompt diagnosis is critical because aHUS is effectively treated by eculizumab, a drug that costs more than $20,000 dollars a dose(2). Thus, physicians and hospitals are understandably reluctant to release the drug without a more certain diagnosis. We have developed a simple, rapid, and inexpensive assay to reliably distinguish aHUS from other MAHAs within 1-2 days of clinical presentation.

Publication: Exp Hematol. 2016 May;44(5):390-8
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Alternative Pathway of complement assay to diagnose atypical HUS and other disorders of complement activation PCT: Patent Cooperation Treaty Canada 2,977,981   2/29/2016     Pending
Alternative Pathway of complement assay to diagnose atypical HUS and other disorders of complement activation PCT: Patent Cooperation Treaty European Patent Office 16756542.3   2/29/2016     Pending
Alternative Pathway of complement assay to diagnose atypical HUS and other disorders of complement activation PCT: Patent Cooperation Treaty Australia 2016224962   2/29/2016     Pending
Alternative Pathway of complement assay to diagnose atypical HUS and other disorders of complement activation PCT: Patent Cooperation Treaty United States 15/553,826 8/25/2017     Pending
Inventors:
Category(s):
For Information, Contact:
Christine Joseph
cjoseph6@jhmi.edu
410-614-0300
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