Novel Therapeutic Target for Neural Regeneration, Stroke and Anti-depressants

Case ID:
C10583
Disclosure Date:
12/11/2008
Description:
Unmet need
Current anti-depressants in the market have various limitations including lack of broad-spectrum drugs, unexpected side effects, toxicity and low efficacy for certain patients. New generation of anti-depressants based on most recent biomedical discoveries concerning depression are urgently needed.

Technology overview
Johns Hopkins researchers have identified novel function of Gadd45b in regulating chromatin and epigenetic DNA methylation levels of promoters for specific types of neuronal genes, including those essential for neuronal plasticity and cell survival. Gadd45b is a member of a family of proteins with roles in modulating cell response to both genotoxic stress and physiological stress. Few of the key Gadd45b-dependent targets include BDNF and FGF. The researchers further found that effects of antidepressant methods (such as electroconvulsive treatment or voluntary exercise) in adult hippocampus are due to Gadd45b up-regulation in neurons. The most effective anti-depressant electroconvulsive treatment induces a robust expression of Gadd45b. Augmentation of Gadd45b and its associated pathways can potentially be used as a novel means to modulate cellular epigenetic status and for treating depression and anxiety as well as enhancing learning and memory.
 
Stage of development
Discovery
 
Publications
Ma DK et al. Science 323(5917), 1074–7, 2009
 
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Compositions for Promoting Epigenetic DNA Demethylation and Methods of Use Therefore PCT: Patent Cooperation Treaty Japan     6/24/2011     Abandoned
Compositions for Promoting Epigenetic DNA Demethylation and Methods of Use Therefore PCT: Patent Cooperation Treaty United States 13/142,134 8,735,071 12/14/2011 5/27/2014 12/23/2029 Granted
Inventors:
Category(s):
For Information, Contact:
Nakisha Holder
nickki@jhu.edu
410-614-0300
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