Methods for Treatment of Brain Injury in the Presence of Anesthesia

Case ID:
Disclosure Date:
Unmet Need:
Brain injury (e.g. traumatic brain injury) is a devastating health problem in the US and beyond. Often, anesthesia is used during the acute and chronic phase of the treatment. Thus far, there is no treatment taking advantage of the direct effects of anesthesia on a patient to administer therapy for brain injury.
Technology Overview:
Johns Hopkins researchers develop a novel method of delivering neuroprotective agents to the brain in the presence of an anesthetic used commonly following brain injury. The invention is based on the finding that in the presence of anesthesia, glial cells become activated. The glial cell activation has negative consequences on the glymphatic system, which plays a key role in clearing waste/edema from the injured brain. They also discovered that in the presence of anesthesia, glial uptake of nanoparticles is significantly increased. Therefore, administering nanoparticles containing drugs may enable them to get to target areas and trigger the brain?s own mechanisms to help heal itself. The Invention identifies:
  1. A potential method of treatment using nanoparticles to deliver drugs specifically to the glia to restore glia?s normal functions.
  2. Decreases amount of edema and attenuation of the injured glia cells which would allow for improve recovery from traumatic brain injury (TBI).
  3. Nanoparticles and anesthesia in tandem could provide effective and novel ways to treat traumatic brain injury and other brain injuries.
Stage of Development:
The inventors performed in vitro studies with the mouse microglial cells (BV2 cell line) treated with pentobarbital and the dendrimer nanoparticle-Cy5 conjugates (D-Cy5) in cell uptake imaging studies.
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Methods for Treatment of Brain Injury in the Presence of Anesthesia PRO: Provisional United States 62/433,309 12/13/2016     Expired
For Information, Contact:
Carole Burns
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