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N-Hydroxysulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors

Case ID:
C04917
Disclosure Date:
2/22/2006

Technology Overview


The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.


Compound CXL-1427 used in the following studies is covered by the patents.


Publications

Intravenous Infusion of the Novel HNO Donor BMS-986231 Is Associated With Beneficial Inotropic, Lusitropic, and Vasodilatory Properties in 2 Canine Models of Heart Failure - PMC (nih.gov)


A Study of Continuous Infusions of HNO (Nitroxyl) Donor in Patients With Heart Failure and Impaired Systolic Function - Study Results - ClinicalTrials.gov


Evaluate the Safety and Efficacy of 48-Hour Infusions of HNO (Nitroxyl) Donor in Hospitalized Patients With Heart Failure - Full Text View - ClinicalTrials.gov


A Dose Ranging Phase IIa Study of 6 Hour Intravenous Dosages of CXL-1427 in Patients Hospitalized With Heart Failure - Full Text View - ClinicalTrials.gov


Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
N-Hydroxysulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors DIV: Divisional European Patent Office 12195118.0 2586434 3/16/2007 4/27/2016 3/16/2027 Granted
N-Hydroxysulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors PCT: Patent Cooperation Treaty Israel 193839 193839 3/16/2007 7/31/2015 3/16/2027 Granted
N-Hydroxysulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors ORD: Ordinary Utility United States 11/724,792 8,030,356 3/16/2007 10/4/2011 8/1/2030 Granted
N-Hydroxysulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors DIV: Divisional Israel 217739 217739 3/16/2007 12/30/2016 3/16/2027 Granted
N-Hydroxysulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors DIV: Divisional European Patent Office 12155608.8 2489350 3/16/2007 12/4/2013 3/16/2027 Granted
N-Hydroxysulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors DIV: Divisional European Patent Office 12195124.8 2586435 3/16/2007 9/14/2016 3/16/2027 Granted
N-Hydroxysulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors DIV: Divisional Japan 2013-032658 5764590 3/16/2007 8/9/2015 3/16/2027 Granted
N-Hydroxysulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors DIV: Divisional Mexico MX/a/2013/001662 342895 3/16/2007 10/18/2016 3/16/2027 Granted
N-Hydroxysulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors DIV: Divisional Korea (South) 10-2016-7029907 10-1878816 3/16/2007 7/10/2018 3/16/2027 Granted
N-Hydroxysulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors DIV: Divisional Israel 238271 238271 3/16/2007 8/30/2017 3/16/2027 Granted
N-Hydroxysulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors DIV: Divisional European Patent Office 16181496.7 3124471 3/16/2007 6/3/2020 3/16/2027 Granted
N-Hydroxysulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors CON: Continuation United States 14/857,308 9,487,498 9/17/2015 11/8/2016 3/16/2027 Granted
N-Hydroxysulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors CON: Continuation United States 15/286,145 9,725,410 10/5/2016 8/8/2017 3/16/2027 Granted
N-Hydroxysulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors CON: Continuation United States 15/640,342 9,969,684 6/30/2017 5/15/2018 3/16/2027 Granted
N-Hydroxysulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors CON: Continuation United States 15/961,441 10,179,765 4/24/2018 1/15/2019 3/17/2037 Granted
N-Hydroxysulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors CON: Continuation United States 16/685,534 10,829,445 11/15/2019 11/10/2020 3/16/2027 Granted
N-Hydroxysulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors CON: Continuation United States 17/093,506 11,306,056 11/9/2020 4/19/2022 3/16/2027 Granted
Direct Link:
https://jhu.technologypublisher.com/technology/50276
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For Information, Contact:
Mohit Ganguly
mgangul1@jh.edu
410-614-0300
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