Search Results - macular+degeneration

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An ex vivo Model for Rapid Evaluation of Choroidal Mast Cell Degranulation

Unmet NeedAlmost 11 million people in the United States have symptoms of age-related macular degeneration (AMD). AMD is a multifactorial disease distinguished by progressive degeneration in the macular region of the eye, resulting in irreversible central vision loss among the elderly population. Current evidence suggests that inflammation plays a vital...

Published: 6/27/2024 | Inventor(s): Gerard Lutty, Shuntaro Ogura

Keywords(s): Discovery/Research Tools, Disease Indication, Eye Disorders, In Vitro Research Tool, In Vivo Research Tool, Macular Degeneration, Rat Model, Target-based Screening Tool

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Assays, Clinical and Disease Specializations > Ophthalmology > Macular Degeneration, Clinical and Disease Specializations > Ophthalmology > Dry Age-Related Macular Degeneration

External and internal intraoperative optical coherence tomography imaging for subretinal material delivery

Unmet NeedCompared to intravitreal injection, subretinal injection is a more direct approach for targeting cells in the subretinal space. This novel device and described methodology will provide a new therapeutic technique for treating vitreo-retinal diseases, especially when gene therapy and/or cell therapy are involved. To date, subretinal delivery...

Published: 6/28/2024 | Inventor(s): Jin Kang, Mandeep Singh, Kevin Wolfe, Kathleen Perrino

Keywords(s): Disease Indication, Eye Disorders, Imaging and Sensing Systems, In Vivo Medical Imaging, Integrated Imaging System, Interventional and Surgical Systems, Macular Degeneration, Other, Surgical Intervention Method, Therapeutic Devices, Therapeutics

Category(s): Clinical and Disease Specializations > Ophthalmology > Age-Related Macular Degeneration, Clinical and Disease Specializations > Ophthalmology > Stargardt's Disease, Technology Classifications > Medical Devices > Imaging

Retinal Implantation Device

Unmet NeedMillions of people around the world suffer from retinal degenerative diseases at varying degrees of vision loss. Common to all retinal degenerative diseases is the damage to photoreceptor cells of the retina, which malfunction and disappear. Current treatments can begin with trying to “rescue” remaining photoreceptors. Unfortunately this strategy...

Published: 6/27/2024 | Inventor(s): Mandeep Singh, Kevin Wolfe, Jin Kang, Kathleen Perrino, Andrea Timm

Keywords(s): Disease Indication, Eye Disorders, Implanted Device, Implants, Macular Degeneration, Retinal Degeneration, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices

Category(s): Clinical and Disease Specializations > Ophthalmology > Macular Degeneration, Clinical and Disease Specializations > Ophthalmology > Retinal Degeneration, Technology Classifications > Medical Devices > Regenerative Medicine

Metipranolol for Treatment of Retinitis Pigmentosa

Unmet NeedRetinitis pigmentosa (RP) is a genetic disorder with a prevalence of 1 in 4000 people worldwide. RP can be the result of a number of mutations that all result in severe rod photoreceptor degeneration and death, causing excess oxygen in the outer retina and subsequent oxidative damage to cone photoreceptors. Symptom onset begins in childhood...

Published: 6/27/2024 | Inventor(s): Peter Campochiaro, Yogita Kanan, Ken Green

Keywords(s): Antagonists/Inhibitors, Disease Indication, Eye Disorders, Macular Degeneration, Non-novel, Predicted Novelty, Repurposed, Retinitis pigmentosa, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations > Ophthalmology > Retinitis Pigmentosa, Clinical and Disease Specializations > Ophthalmology > Macular Degeneration, Technology Classifications > Therapeutic Modalities > Small Molecules

A Highly Accurate Fundus Classification Method and Apparatus for Grading of the Advance of Age Related Macular Degeneration

A method of detecting, and classifying severity of, a retinal disease using retinal images includes at least one of receiving, retrieving or generating reference data that includes information concerning occurrences of key image features for each of a plurality of retinal disease and disease severity conditions; receiving a retinal image of an individual;...

Published: 6/27/2024 | Inventor(s): Srihari Kankanahalli, David Freund, Philippe Burlina, Neil Bressler

Keywords(s): Clinical Diagnostics, Diagnostic Tool, Disease Indication, Eye Disorders, Macular Degeneration, Measurement Tool, Neurodegeneration

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Ophthalmology > Macular Degeneration, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Ophthalmology, Clinical and Disease Specializations > Ophthalmology > Retinal Degeneration, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Diagnostics > Diagnostic Imaging

ABCA4 Cell Lines

TITLE: ABC4A cell linesCASE NUMBER: C13886ABSTRACTStargardt disease is the most common form of early onset macular degeneration. Mutations in ABCA4, a member of the ATP-binding cassette (ABC) family, are associated with Stargardt disease. JHU researchers have examined two disease-causing mutations in the NBD1 region of ABCA4, R1108C and...

Published: 6/27/2024 | Inventor(s): Liudmila Cebotaru

Keywords(s): Cell Lines, Discovery/Research Tools, Disease Indication, Eye Disorders, Human Cell Lines, In Vitro Research Tool, Macular Degeneration, Neurodegeneration

Itraconazole Analogs and Use Thereof

C11669: Novel Compounds for Cancer and Macular Degeneration TreatmentNovelty: This invention is a series of novel and potent itraconazole derivative that have showed strong activity against tumor growth and macular degeneration.Value Proposition: The novel compounds effectively inhibit angiogenesis, which is critical for tumor growth and macular degeneration....

Published: 6/27/2024 | Inventor(s): Jun Liu, Wei Shi, Kalyan Kumar Pasunooti, Wukun Liu, Ruojing Li, Sarah Head, Yingjun Li

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Eye Disorders, Macular Degeneration, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Ophthalmology > Macular Degeneration