Modulation of systemic Immune Responses by Transplantation of Hemotopoietic Stem Cells Transduced with Genes Encoding Antigens and Antigen Presenting Cell Regulatory Molecules

C03855: Modulation of Systemic Immune Responses by Transplantation of Hemotopoietic Stem Cells Transduced with Genes Encoding Antigens and Antigen Presenting Cell Regulatory Molecules
Technical Details:
The initiation of T cell-dependent immune responses depends on presentation of antigens by bone marrow-derived antigen-presenting cells such as dendritic cells. Tolerance induction depends on expression of antigens by tolerizing antigen presenting cells. Immunotherapy approaches are aimed at introducing antigen into various populations of APCs such as dendritic cells. However, the efficiency with which standard immunotherapy and vaccine approaches introduces antigens into APCs is relatively low. Johns Hopkins University researchers have developed a strategy involving the introduction of genes encoding antigen into hematopoietic stem cells ex vivo followed by transplantation of these transduced cells in vivo. This approach allows for the introduction of genes encoding the signaling portions of molecules that regulated APC differentiation and activation.

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