A Novel Method for Quantitatively Analyzing Multiple Genes for the Presence of Methylation in Biological Samples

Case ID:
Disclosure Date:
C04348: Detection of Aberrantly Methylated Genes in Human Samples as Markers of Malignancy

Technical Details:
Inventors have identified novel genes that may be aberrantly methylated in cancer cells. A method for quantification and diagnosing such methylation has also been developed called quantitative multiplex-methylation specific PCR (QM-MSP).

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• This technology can be used to detect aberrant methylation in various body tissues including: blood, plasma, duct cells lymph, ductal lavage fluid, nipple aspiration fluid, breast tissue, lymph nodes, bone marrow, etc.
• Aberrent methylation can be detected in tissue containing as little as 50 – 1000 tumor cells resulting is a highly sensitive test.
• May allow for quick detection of cancer leading to rapid and aggressive cancer treatment which may increase chances of patient survival.
• This technology may also be used for disease staging and/or detecting therapy response.
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Quantitative Multiplex Methylation-Specific PCR ORD: Ordinary Utility United States 10/976,932 8,062,849 10/28/2004 11/22/2011 10/28/2024 Granted
Quantitative Multiplex Methylation-Specific PCR CON: Continuation United States 13/224,024 8,822,155 9/1/2011 9/2/2014 10/28/2024 Granted
Quantitative Multiplex Methylation-Specific PCR DIV: Divisional United States 14/469,009 9,416,404 8/26/2014 8/16/2016 10/28/2024 Granted
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For Information, Contact:
Nakisha Holder
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