Early Cancer Detection by Single-molecule Imaging of Nucleocytoplasmic Tumor-specific Proteins in the Peripheral Circulation

Case ID:
C13781
Disclosure Date:
8/13/2015
Description:
We report a platform technology for the ultra-sensitive detection and digital quantification of proteins. Our technology?which we term SMAC, for single-molecule analysis and counting?integrates microfluidics with single-molecule imaging. With SMAC, we discover the potential for nucleocytoplasmic proteins to serve as a novel class of exquisitely tumor-specific biomarkers for early cancer detection and diagnosis. As proof-of-principle, we demonstrate in multiple preclinical models that SMAC can identify early-stage cancer with 100% specificity and sensitivity.
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Early Cancer Detection by Single-molecule Imaging of Nucleocytoplasmic Tumor-specific Proteins in the Peripheral Circulation PCT: Patent Cooperation Treaty PCT PCT/US2017/053354   9/26/2017     Pending
Inventors:
Category(s):
For Information, Contact:
Vera Sampels
vsampel2@jhu.edu
410-614-0300
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