3D-printed Bone Extracellular Matrix Scaffold

Case ID:

C13515

Decellularized bone particulates are mixed with polycaprolactone (PCL) or another thermoplastic material. The material, when heated above a specific temperature, becomes a viscous liquid PCL suspension with bone particulates that can be extruded from an extrusion-based three-dimensional printer. This allows for the construction of anatomically shaped, porous, and patient-matched scaffolds with innate bioactivity that can be used to regenerate bone.

This technology is the development of anatomically-shaped, porous scaffolds comprised primarily of bone extracellular matrix. The gross geometry can be extracted from computerized tomography images and made in the shape of the patient’s bone. The pore sizes and geometry can be controlled to optimize tissue in growth and bone regeneration. Most importantly: it combines manufacturability of synthetic materials with bioactivity of native materials.

Patent Information:

Title	App Type	Country	Serial No.	Patent No.	File Date	Issued Date	Expire Date	Patent Status
EXTRACELLULAR MATRIX (ECM) MIXTURE AND ECM SCAFFOLDS MADE WITH SAME	PCT: Patent Cooperation Treaty	United States	15/739,946	11,925,725	12/26/2017	3/12/2024	6/24/2036	Granted
EXTRACELLULAR MATRIX (ECM) MIXTURE AND ECM SCAFFOLDS MADE WITH SAME	CON: Continuation	United States	18/431,366		2/2/2024			Pending

Direct Link:

https://jhu.technologypublisher.com/technology/24943

Inventors:

Category(s):

Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices,

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For Information, Contact:

Lisa Schwier

lschwie2@jhu.edu

410-614-0300

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