3D-printed Bone Extracellular Matrix Scaffold

Case ID:
C13515
Disclosure Date:
4/5/2015
Description:
Decellularized bone particulates are mixed with polycaprolactone (PCL) or another thermoplastic material. The material, when heated above a specific temperature, becomes a viscous liquid PCL suspension with bone particulates that can be extruded from an extrusion-based three-dimensional printer. This allows for the construction of anatomically shaped, porous, and patient-matched scaffolds with innate bioactivity that can be used to regenerate bone.

This technology is the development of anatomically-shaped, porous scaffolds comprised primarily of bone extracellular matrix.  The gross geometry can be extracted from computerized tomography images and made in the shape of the patient’s bone. The pore sizes and geometry can be controlled to optimize tissue in growth and bone regeneration. Most importantly: it combines manufacturability of synthetic materials with bioactivity of native materials.
 
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
3D-printed Bone Extracellular Matrix Scaffold PCT: Patent Cooperation Treaty United States 15/739,946 12/26/2017     Pending
Inventors:
Category(s):
For Information, Contact:
Jon Gottlieb
jgottl10@jhu.edu
410-614-0300
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