CADENCE Balloon Shunt

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CADENCE is a novel, patented treatment platform that functions to alter cerebrospinal fluid (CSF) flow, increase cerebral blood flow (CBF), and modulate the intracranial pressure (ICP) wave through natural cardiac-induced dynamics.  CADENCE can be visualized as an intra-aortic balloon pump for the brain and therefore functionally very distinct from a CSF shunt.  For patients with hydrocephalus, the current method of passive shunting drains CSF and reduces ICP, but it does not directly address CBF. CADENCE’s ability to alter CSF flow, increase CBF, and modulate ICP addresses clinical unmet needs that passive shunting cannot address. As an entry point for potentially treating a vast array of diseases associated with increased levels of CSF the inventors have shown preliminary proof-of-concept that the CADENCE system can actively and controllably improve CSF pressure pulsation and CBF in NPH animal models and normal brains.
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
SYSTEMS AND METHODS FOR FLUID REMOVAL FROM A PORTION OF A PATIENT'S BODY PCT: Patent Cooperation Treaty United States 15/999,842 8/20/2018     Pending
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Seth Zonies
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