ESR1 Mutations in Human Breast Cancer Cells

TITLE                                                 
ESR1 mutations in human breast cancer cells

CASE NUMBER
C13950

ABSTRACT
Newly discovered mutations in the estrogen receptor alpha gene, ESR1, are thought to predict for resistance to certain endocrine therapies in breast cancers that express hormone receptors.

FEATURES
Johns Hopkins researchers used AAV gene targeting to introduce wild type (controls), Y537S and D538G ESR1 mutations into the human breast cancer cell line MCF-7.

STAGE OF DEVELOPMENT
Tangible material

DISEASE INDICATION
Breast Cancer

ASSOCIATED PUBLICATIONS
■ Oncotarget. 2016 Oct 18;8(48):83432-83445. ■
 

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