Molecular Switches and Methods for Making and Using the Same Involving the Circular Permutation of DNA

Case ID:
C04399
Disclosure Date:
1/28/2004
Description:
Technical Details: The invention provides molecular switches which couple external signals to functionality and to methods of making and using the same. The switches according to the invention can be used, for example, to regulate gene transcription, target drug delivery to specific cells, transport drugs intracellularly, control drug release, provide conditionally active proteins, perform metabolic engineering, create molecular sensors, and modulate cell signaling pathways. Libraries comprising the switches and expression vectors and host cells for expressing the switches are also provided. These libraries involve the circular permutation of DNA.
 
Looking for Partners: Protein molecular switches engineered by the methods of this invention have a wide variety of potential applications in, for example, (a) the regulation of gene transcription, (b) the modulation of cell signaling pathways, (c) targeted drug delivery, (d) drug transport, (e) the creation of conditionally active toxic proteins, (f) metabolic engineering, and (g) the creation of novel biosensors.
 
Inventors: Marc Ostermeier, Gurkan Guntas
 
Patent Status: Granted US Patents 8,338,138, 8,679,753, and 9,290,544
 
Publications/Associated Cases: Chem Biol. 2004 Nov;11(11):1483-7; also see JHU Ref C01706
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Methods for Making and Using Molecular Switches Involving Circular Permutation PCT: Patent Cooperation Treaty European Patent Office 05722592.2   1/28/2005     Pending
Methods for Making and Using Molecular Switches Involving Circular Permutation PCT: Patent Cooperation Treaty United States 10/588,114 8,338,138 8/1/2007 12/25/2012 1/28/2025 Granted
Methods for Making and Using Molecular Switches Involving Circular Permutation DIV: Divisional United States 13/680,751 8,679,753 11/19/2012 3/25/2014 1/28/2025 Granted
Methods for Making and Using Molecular Switches Involving Circular Permutation DIV: Divisional United States 14/165,064 9,290,544 1/27/2014 3/22/2016 1/28/2025 Granted
Inventors:
Category(s):
For Information, Contact:
Vera Sampels
vsampel2@jhu.edu
410-614-0300
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