Molecular Switches and Methods for Making and Using the Same Involving the Circular Permutation of DNA
Report of Invention:
1/28/2004
Technical Details: The invention provides molecular switches which couple external signals to functionality and to methods of making and using the same. The switches according to the invention can be used, for example, to regulate gene transcription, target drug delivery to specific cells, transport drugs intracellularly, control drug release, provide conditionally active proteins, perform metabolic engineering, create molecular sensors, and modulate cell signaling pathways. Libraries comprising the switches and expression vectors and host cells for expressing the switches are also provided. These libraries involve the circular permutation of DNA. Looking for Partners: Protein molecular switches engineered by the methods of this invention have a wide variety of potential applications in, for example, (a) the regulation of gene transcription, (b) the modulation of cell signaling pathways, (c) targeted drug delivery, (d) drug transport, (e) the creation of conditionally active toxic proteins, (f) metabolic engineering, and (g) the creation of novel biosensors. Inventors: Marc Ostermeier, Gurkan Guntas Patent Status: Granted US Patents 8,338,138, 8,679,753, and 9,290,544 Publications/Associated Cases: Chem Biol. 2004 Nov;11(11):1483-7; also see JHU Ref C01706
Patent Information:
| Title |
App Type |
Country |
Serial No. |
Patent No. |
File Date |
Issued Date |
Expire Date |
Patent Status |
| Methods for Making and Using Molecular Switches Involving Circular Permutation |
PCT: Patent Cooperation Treaty |
United States |
10/588,114 |
8,338,138 |
8/1/2007 |
12/25/2012 |
1/28/2025 |
Granted |
| Methods for Making and Using Molecular Switches Involving Circular Permutation |
DIV: Divisional |
United States |
13/680,751 |
8,679,753 |
11/19/2012 |
3/25/2014 |
1/28/2025 |
Granted |
| Methods for Making and Using Molecular Switches Involving Circular Permutation |
DIV: Divisional |
United States |
14/165,064 |
9,290,544 |
1/27/2014 |
3/22/2016 |
1/28/2025 |
Granted |
|
|
Inventors:
Category(s):
Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Gene Therapies,
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