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PHARMACEUTICAL AGENTS TARGETING CANCER STEM CELLS

UNMET NEEDChronic environmental exposure induces cancer stem cells (CSCs) with SOX2 overexpression, one of the most important CSC factor for urothelial cancer (UC). COX2 and YAP1 coordinately regulate SOX2 expression, and mutually compensate for the reduction of expression of SOX2 to maintain CSCs. Thus targeting the COX2/YAP/SOX2 signaling axis eliminates...

Published: 9/11/2025 | Inventor(s): Mohammad Hoque, David Sidransky, Akira Oki

Keywords(s): Antagonists/Inhibitors, Bladder Cancer, Cancers, Combination, Disease Indication, Non-novel, Predicted Novelty, Small Molecules, Targeted Therapy/Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Urothelial Carcinoma

Category(s): Clinical and Disease Specializations > Oncology > Bladder Cancer, Clinical and Disease Specializations > Oncology > Urothelial Carcinoma, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Urology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets