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P75 Neurotrophin Receptor Antagonist for the Treatment of Acute and Chronic Cardiac Disease

Unmet Need / Invention Novelty: Hemodynamic stress during heart disease results in adverse remodeling and loss of function of the myocardial tissue. One mechanism that underlies this pathology is activation of the p75 neurotrophin receptors (p75NTR) in the heart. There is an unmet need for a therapeutic which blocks the p75 neurotrophin receptor in...

Published: 3/13/2025 | Inventor(s): Nazareno Paolocci, Ning Feng, Carlo Tocchetti, Cyrus Takahashi, Bruce Carter

Keywords(s): Antagonists/Inhibitors, Biologics, Cardiovascular Diseases, Disease Indication, Myocardial Infarction (MI), Non-novel, Peptide, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Cardiovascular > Acute Heart Failure