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A Multi-modal Deep Learning Method for Ventricular Arrhythmia Risk Stratification

Unmet NeedHypertrophic cardiomyopathy (HCM) is a rare genetic condition (prevalence in adults: 0.2-0.5%) that causes pathologic enlargement of the left ventricle (1). While many HCM patients live normal lives, some are at risk for severe cardiac complications, including sudden cardiac death due to ventricular arrhythmia (VA). VA risk is currently evaluated...

Published: 3/14/2025 | Inventor(s): Natalia Trayanova, Minglang Yin, Changxin Lai

Keywords(s):

OPtimal Target Identification via Modeling of Arrhythmogenesis

Unmet Need· Atrial fibrillation affects millions of patients worldwide, with the number expected to grow 2.5-fold in the next 40 years. (Boyle et al., 2016) Ablation of cardiac tissue around the pulmonary veins is a standard treatment, but fails 20-40% of the time in patients with a type of atrial fibrillation called persistent atrial fibrillation....

Published: 3/14/2025 | Inventor(s): Natalia Trayanova, Adityo Prakosa, Ryan Bradley, Eugene Kholmovski, Syed Yusuf Ali, Carolyna Yamamoto

Keywords(s):

Category(s): Clinical and Disease Specializations > Cardiovascular > Arrhythmias, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools

Arrhythmic Sudden Death Survival Prediction using Deep Learning Analysis of Scarring in the Heart

Unmet Need:Sudden cardiac death (SCD) is a leading cause of death in western countries, accounting for 15 – 20% of deaths (Kumar, et al. 2021). Currently, the standard for estimating risk for SCD is based on a left ventricular ejection fraction (LVEF) lower than 30-35% (Russo et al, 2013) which captures only 20% of arrhythmic sudden cardiac deaths (SCDA)...

Published: 3/14/2025 | Inventor(s): Natalia Trayanova, Dan Popescu, Mauro Maggioni, Julie Shade

Keywords(s):

Category(s): Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Cardiovascular > Arrhythmia, Clinical and Disease Specializations > Cardiovascular > Arrhythmias, Clinical and Disease Specializations > Cardiovascular > Cardiac Arrest, Clinical and Disease Specializations > Cardiovascular > Ventricular Tachycardia, Clinical and Disease Specializations > Cardiovascular > Ventricular Fibrillation, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Computers, Electronics & Software > Machine Learning

System and Method for Personalized Arrhythmia Risk Assessment by Simulating Arrhythmia Inducibility

Unmet NeedEach year over 300,000 people die of sudden cardiac death (SCD) in the US alone. Implanted cardioverter-defibrillators (ICDs) are considered the best defense against SCD. However, the processes for determining good candidates for ICDs remains vague and overly inclusive. Current tests that provide better pictures of a patient’s SCD risk are...

Published: 3/13/2025 | Inventor(s): Natalia Trayanova, Katherine Wu, Hermenegild Arevalo, Fijoy Vadakkumpadan

Keywords(s): Arrhythmias, Cardiovascular Diseases, Computing; Calculating; Counting, Disease Indication, Image Analysis, Image Data Processing or Generation, Physics

Category(s): Clinical and Disease Specializations, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Cardiovascular > Arrhythmias

Using Patient-Specific Modeling of the Heart for Risk Stratification for Ventricular Arrhythmia in Patients with Repaired Tetralogy of Fallot (TOF) via Image-Based Computational Simulations

The JHU inventors previous invention (C11304) provides a non-invasive method to identify the optimal ablation sites for infarct-related ventricular tachycardia (VT) by using 3D electrophysiological heart simulations with a model reconstructed from the patient’s late gadolinium-enhanced (LGE) MRI image. In this application, the inventors extend that...

Published: 3/13/2025 | Inventor(s): Natalia Trayanova, Adityo Prakosa, Mark Cartoski, Patrick Boyle

Keywords(s): Arrhythmias, Cardiovascular Diseases, Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Disease Indication, Physics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular > Arrhythmias, Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Cardiovascular

Automatable Method for Directing Catheter Movement to Target Arrhythmia Ablation Using the Cardiac Activation Sequence

C11948: Cardiac Ablation(Heart) Guidance SystemNovelty: A method that automatically guides electrodes to the origin of an arrhythmia for more accurate ablation(heartbeat) therapy.Value Proposition: Ablation is an effective method in treating cardiac arrhythmias; however both its usage and success rate are inhibited by a lack of tools that can effectively...

Published: 3/13/2025 | Inventor(s): Aravindan Kolandaivelu

Keywords(s): Arrhythmias, Cardiovascular Diseases, Disease Indication, Interventional and Surgical Systems, Surgical Navigation

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular > Arrhythmias, Technology Classifications > Medical Devices > Surgical, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Medical Devices

Method for determining risk of ventricular arrhythmia based on an analysis of brief recording of ECG

C10996: Method for Determining Ventricular Arrhythmia Risk Based on Analysis of ECG RecordingNovelty: The novel analytics could potentially be used to distinguish those patients with cardiac conditions that could be helped by an ICD from those that are not likely to benefit from an ICD.Value Proposition: Sudden cardiac death (SCD) from abnormal heart...

Published: 3/13/2025 | Inventor(s): Ronald Berger, Larisa Tereshchenko

Keywords(s): Arrhythmias, Cardiovascular Diseases, Clinical Diagnostics, Diagnostic Tool, Disease Indication, Measurement Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular > Arrhythmias, Technology Classifications > Diagnostics > In Vivo Diagnostics, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Diagnostics

Method for Termination of Cardiac Fibrillation and Tachycardia

C10844: Gentler Method for Termination of Cardiac ArrhythmiasNovelty: A method to prevent cardiac sudden death by delivering a high frequency current or electric field to the myocardium, with less associated damage to the heart.Value Proposition: Currently the only reliable way to terminate fibrillation is by delivering a high voltage DC shock to cause...

Published: 3/13/2025 | Inventor(s): Harikrishna Tandri, Ronald Berger, Leslie Tung, Henry Halperin, David Hunter, Seth Weinberg

Keywords(s): Arrhythmias, Cardiovascular Diseases, Disease Indication, Electrical Stimulation Device, Implanted Device, Implants, Therapeutic Devices, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular > Arrhythmias, Technology Classifications > Medical Devices > Therapeutic Devices, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Medical Devices

Cardiac Sock Electrode and Implantable Defibrillator System

C03552: Cardiac Sock Electrode and Implantable Defibrillator System Technical Details: An object of this invention is to provide an implantable cardioverter defibrillator (ICD) system and/or method that is less painful to a patient than one or more conventional ICD systems/methods. Another object of this invention is to provide a flexible array including...

Published: 3/13/2025 | Inventor(s): Ronald Berger

Keywords(s): Arrhythmias, Cardiovascular Diseases, Disease Indication, Implanted Device, Implants, Therapeutic Devices, Therapeutics