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Solid-phase Synthesis of Oligonucleotides Containing N6-(2-Deoxy-alpha,beta-D-erythropentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine (Fapy•dG)

Unmet Need: Study of the common DNA damage oxidative lesion Fapy∙dG has been extremely limited due to the lack of tools available to synthesize oligonucleotides containing this lesion. Technical Details: Johns Hopkins researchers have developed a solid-phase synthetic method to prepare oligonucleotides containing N6-(2-Deoxy-α,β-D-erythropentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine...

Published: 9/27/2024 | Inventor(s): Marc Greenberg, Haozhe Yang

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Category(s): Technology Classifications > Research Tools > Nucleic Acids