Search Results - kenneth+witwer

5 Results

Sort By:

Method of enhancing anti-inflammatory properties of extracellular vesicles

Value Proposition· Promotes adenosine production to inhibit proinflammatory cytokine release· Promotes regulatory T cells expansion· Suppresses effector immune responses· Amplifies a natural, local anti-inflammatory signal, which lowers risk of unintended side effects· Targets specific inflammatory microenvironments to minimize...

Published: 3/13/2026 | Inventor(s): Kenneth Witwer, Matias Ostrowski, Paula Soledad Perez, Tomas Grosso, Martina Fabiano

Keywords(s):

Category(s): Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Inflammation > Chronic Inflammatory Diseases

Gas6-functionalized extracellular vesicles for treatment of inflammatory conditions

Value Proposition· Superior Anti-Inflammatory Potency: This membrane-associated GAS6 demonstrates over 10-fold higher anti-inflammatory activity compared to equivalent amounts of soluble recombinant GAS6 proteins. · Dual Mechanism of Action: Inhibits pro-inflammatory cytokine production and concurrently stimulates anti-inflammatory responses,...

Published: 3/13/2026 | Inventor(s): Kenneth Witwer, Matias Ostrowski, Martina Fabiano, Alan Adamczyk

Keywords(s):

Short Viral RNAs (svRNAs) with Theragnostic Potential in Infection with SARS-CoV-2 and Related Viruses

Value PropositionNovel Biomarkers for Diagnosis & PrognosisInsights into viral immune evasion mechanism Identify key host pathways targeted by svRNAs Novel Therapeutic TargetsIdentified pathways enable the development of immune-modulating therapies. Unmet NeedStudies have show than SARS-CoV-2 employs various mechanisms to evade the host’s innate...

Published: 3/13/2026 | Inventor(s): Kenneth Witwer, Tom Driedonks, Andrey Turchinovich

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > Covid-19, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools > Nucleic Acids, Clinical and Disease Specializations > Infectious Diseases

ExoBLAze Assay: Efficient Quantification of EV Content Delivery

Value Proposition· Specific, FRET-based detection: only quantifies successful EV endosomal escape· Reliable and adaptable: assay works with variety of Evs, target cell types, and fluorescence detection methods· Genetic modification-free: does not require any genetic engineering of target cells· Ground-breaking solution: first proposed...

Published: 3/13/2026 | Inventor(s): Sarah Marquez, Zach Troyer, Kenneth Witwer

Keywords(s):

Category(s): Technology Classifications > Diagnostics

Culture-derived EVs for targeted delivery and treatment of B cell diseases

Value Proposition· Purified EVs with preferential targeting for B cells in both ex-vivo and in-vivo applications.· EVs have half-life between 30-40 minutes, longer than many comparable extracellular vesicles.· EVs purified from cell culture medium to increase throughput, speed, and development of B-cell targeted therapies. Technology...

Published: 3/13/2026 | Inventor(s): Kenneth Witwer, Tom Driedonks, Erin Shirk, Linglei Jiang, Olesia Gololobova

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms