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Preventing Myocardial Loss and Sudden Death in Patients with Arrhythmogenic Cardiomyopathy via Rescuing of AIF/thioredoxin-2 Signaling

Unmet NeedAbout 400,000 to 460,000 people die each year from sudden cardiac death (SCD). Patients with Arrhythmogenic Cardiomyopathy (ACM) are at increased risk for heart failure and SCD triggered by exercise. Common ACM driver mutations occur in about 1 out of every 10,000 people. However, the physiological mechanisms that drive myocardial loss and...

Published: 3/14/2025 | Inventor(s): Stephen Chelko, Nazareno Paolocci, Gizem Keceli, Daniel Judge, Nunzianna Doti, Menotti Ruvo, Alessandra Monti, Nuria Amat, Peter Andersen

Keywords(s): Cardiac Arrest, Cardiovascular Diseases, Disease Indication, Small Molecules, Target, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations > Cardiovascular > Cardiac Arrest, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities > Small Molecules