Search Results - paul+kuhn

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A Thermosensitive and Biodegradable Hydrogel as a Delivery System for the Local and Controlled Release of a Blood Pressure Drug (Valsartan) Combined with Senolytics (Dasatinib and Quercetin) to Treat Chronic Diabetic Wounds

JHU Ref #: C16199 Value Proposition:Provides a slow, sustained release of a combination therapy to reverse cellular senescence and enhance collagen production in proliferating and senescent primary dermal fibroblasts.Utilizes a thermosensitive and biodegradable hydrogel for sustained release of nanoparticles and drugs. Requires fewer applications compared...

Published: 3/14/2025 | Inventor(s): Efrosini Kokkoli, Peter Abadir, Jeremy Walston, Paul Kuhn

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Hydrogel-Nanoparticle System for Localized Therapeutic Cocktail Delivery in Invasive Ductal Carcinoma (IDC)

Unmet Need: Systemic delivery of drugs often leads to faster clearance, off-target effects, and system-wide unintended toxicity. Current therapeutics designed to specifically target invasive ductal carcinoma (IDC) have a narrow therapeutic index, lack predictive biomarkers, and have serious side effects due to off-target toxicity. This lack of efficacy...

Published: 3/14/2025 | Inventor(s): Efrosini Kokkoli, Denis Wirtz, Gabriella Russo, Paul Kuhn

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Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer