Search Results - paul+kuhn

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Thermosensitive Hydrogel-Nanoparticle System to Reverse Cellular Senescence and Enhance Collagen Production

Value Proposition:Provides a slow, sustained release of a combination therapy to reverse cellular senescence and enhance collagen production in proliferating and senescent primary dermal fibroblasts.Utilizes a thermosensitive and biodegradable hydrogel for sustained release of nanoparticles and drugs.Requires fewer applications compared to traditional...

Published: 1/22/2026 | Inventor(s): Efrosini Kokkoli, Peter Abadir, Jeremy Walston, Paul Kuhn

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies, Clinical and Disease Specializations > Diabetes, Clinical and Disease Specializations > Wound Healing

Hydrogel-Nanoparticle System for Localized Therapeutic Cocktail Delivery in Invasive Ductal Carcinoma (IDC)

Unmet Need: Systemic delivery of drugs often leads to faster clearance, off-target effects, and system-wide unintended toxicity. Current therapeutics designed to specifically target invasive ductal carcinoma (IDC) have a narrow therapeutic index, lack predictive biomarkers, and have serious side effects due to off-target toxicity. This lack of efficacy...

Published: 1/22/2026 | Inventor(s): Efrosini Kokkoli, Denis Wirtz, Gabriella Russo, Paul Kuhn

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer