Search Results - ranjan+perera

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A microRNA for treatment of childhood medulloblastoma

Value PropositionTargets specifically to medulloblastomaReduces tumorigenicity in vitro and in vivoNanoparticle encapsulation is capable of enhanced miRNA deliveryUnmet Need:Medulloblastoma is a malignant embryonal tumor of the cerebellum and brainstem that accounts for roughly 15–20% of pediatric brain tumors and is the most common solid tumor in children...

Published: 4/24/2026 | Inventor(s): Ranjan Perera, Sudipta Seal, Justin Hanes, Kannan Rangaramanujam

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology > Medulloblastoma, Technology Classifications > Therapeutic Modalities > Gene Therapies

Novel long-coding RNA as a marker and therapeutic target for medulloblastomas

Unmet Need / Invention Novelty: Current strategies to provide personalized treatment based on molecular profiles for patients suffering from MB lack efficiency and are accompanied by severe side effects and high mortality rates. There is an unmet need to understand the molecular mechanisms of group 3 MBs to drive precision medicine.Technical Details:...

Published: 4/24/2026 | Inventor(s): Ranjan Perera, Sudipta Seal, Keisuke Katsushima

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

Long Noncoding RNAs as Therapeutic and Diagnostic Markers for Childhood Cancer Medulloblastoma

Unmet NeedMedulloblastoma (MB) is the most common pediatric brain tumor and requires aggressive therapy in high-risk cases. MB is frequently resistant to treatment and is associated with high morbidity and mortality in affected individuals. There are four distinct molecular subgroups of MB (WNT, SHH, Group 3, and Group 4), which are characterized by...

Published: 4/24/2026 | Inventor(s): Ranjan Perera, Keisuke Katsushima

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, In Vitro Diagnostics (Old), Novel, Predicted Novelty, Target, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Oncology > Medulloblastoma, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Therapeutic Modalities > Targets