Search Results - richard+johnson

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Multicolor SYNGAP1 Alternative Splice Reporters

Value Proposition· High sensitivity: detection of specific splicing events · High throughput: can assess multiple splicing scenarios due to tri-chromatic and tetra-chromatic reporter plasmids · Improved SYNGAP1 treatment research· Reduced time to assess candidate treatments Technology DescriptionResearchers at Johns Hopkins...

Published: 3/14/2025 | Inventor(s): Ingie Hong, Richard Huganir, Yoichi Araki, Richard Johnson

Keywords(s):

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Clinical and Disease Specializations > Psychiatry > Autism Spectrum Disorder, Clinical and Disease Specializations > Psychiatry > Schizophrenia

SYNGAP1 splice-switching antisense oligonucleotide as therapy for human cognitive disorders

Unmet Need: SYNGAP1-related Intellectual Disability (SRID, MRD5) is a severe neurodevelopmental disorder (NDD) characterized by encephalopathy, intellectual disability (ID), autism spectrum disorder (ASD), and epilepsy and accounts for 0.5-1% of all NDDs and ~1% of the ~200 million ID cases worldwide (SYNGAP Research Fund, 2020). Supportive management...

Published: 3/14/2025 | Inventor(s): Richard Huganir, Yoichi Araki, Ingie Hong, Richard Johnson, Yinuo Han

Keywords(s):

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids

Gene therapy for SYNGAP1 encephalopathy and SYNGAP1-related disorders

Published: 3/14/2025 | Inventor(s): Richard Huganir, Ingie Hong, Yoichi Araki, Richard Johnson

Keywords(s):

Category(s): Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Gene Therapies