Search Results - shelby+yuhas

1 Results

Sort By:

Novel selective, covalent inhibitors of DNA polymerase beta, and synthetic lethality in BRCA-deficient cancer

Unmet Need / Invention Novelty: Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors are known synthetic lethal partners for breast cancer gene (BRCA) 1- and 2-deficient cancers. However, not all BRCA-deficient cancers are susceptible to PARP1 inhibitors and others develop resistance. Furthermore, DNA polymerase beta is overexpressed in many cancers, decreasing...

Published: 9/27/2024 | Inventor(s): Marc Greenberg, Shelby Yuhas

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer, Technology Classifications > Therapeutic Modalities > Targets