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LuSIV Cells: A Highly Sensitive Detection System for Infectious HIV and Related Retroviruses
Case ID:
C03712
Report of Invention:
6/5/2000
Web Published:
10/7/2014
C03712: LuSIV Cells: A Highly Sensitive Detection System for Infectious HIV and Related Retroviruses
Technical Details:
JHU researchers constructed a reporter cell line, derived from human CEMx174 cells, that can be used to readily identify cells that are infected with HIV and related retroviruses. This cell line, designated LuSIV, contains a reporter construct comprising the firefly luciferase reporter gene under the control of a minimal SIV long terminal repeat (LTR) and infection is detected through a straightforward, quantitative luciferase assay. This cell line is highly sensitive to infection by a broad range of primary and laboratory strains of HIV/SIV and is capable of detecting a single round of HIV/SIV infection in 24 hours or less.
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This cell line provides a highly sensitive and quantitative detection system for infectious HIV and related retroviruses, and can be used for high throughput assays to screen for anti-virals and other inhibitors of infection.
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Direct Link:
https://jhu.technologypublisher.com/technology/16179
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Category(s):
Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools,
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For Information, Contact:
Christine Joseph
cjoseph6@jhmi.edu
410-614-0300
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