LuSIV Cells: A Highly Sensitive Detection System for Infectious HIV and Related Retroviruses

C03712: LuSIV Cells: A Highly Sensitive Detection System for Infectious HIV and Related Retroviruses
Technical Details:
JHU researchers constructed a reporter cell line, derived from human CEMx174 cells, that can be used to readily identify cells that are infected with HIV and related retroviruses. This cell line, designated LuSIV, contains a reporter construct comprising the firefly luciferase reporter gene under the control of a minimal SIV long terminal repeat (LTR) and infection is detected through a straightforward, quantitative luciferase assay. This cell line is highly sensitive to infection by a broad range of primary and laboratory strains of HIV/SIV and is capable of detecting a single round of HIV/SIV infection in 24 hours or less.
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This cell line provides a highly sensitive and quantitative detection system for infectious HIV and related retroviruses, and can be used for high throughput assays to screen for anti-virals and other inhibitors of infection.

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