Carcinogen-specific Induction of Genetic Instability

Case ID:

C03921

Disclosure Date:

7/25/2001

C03921: Carcinogen-specific Induction of Genetic Instability
Technical Details:
The researchers created two H3 colorectal cancer cell lines. One cell line has chromosomal instability (CIN) and resistance to 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP). The other cell line has microsatelite instability (MIN) and resistance to methylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). For details see Bardelli et al., 2001.
Looking for Partners:
This invention provides the basis for a new drug screen to identify compounds that specifically kill aneuploid cancer cells of the CIN or MIN type.

Direct Link:

https://jhu.technologypublisher.com/technology/16222

Inventors:

Category(s):

Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools,

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For Information, Contact:

Jeanine Pennington

jpennin5@jhmi.edu

410-614-0300

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