Technical Details:
The researchers created two H3 colorectal cancer cell lines. One cell line has chromosomal instability (CIN) and resistance to 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP). The other cell line has microsatelite instability (MIN) and resistance to methylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). For details see Bardelli et al., 2001.
Looking for Partners:
This invention provides the basis for a new drug screen to identify compounds that specifically kill aneuploid cancer cells of the CIN or MIN type.
