Stat3 Antagonists and Their Uses as Vaccines Against Cancer

Case ID:

C04271

Disclosure Date:

6/20/2003

C04271: Stat3 Antagonists and Their Uses as Vaccines Against Cancer
Technical Details:
The present invention relates to methods for treating and/or preventing cancer. In particular the present invention relates to ex vivo immunotherapeutic methods. The methods comprise decreasing Stat3 (signal transducer and activator of transcription3) expression and/or function in tumor cells and the administration of such cells to a subject in need of treatment and/or prevention. Other methods of the invention comprise activating T-cells by co-culturing the T-cells with the tumor cells with decreased Stat3 expression or function. The invention further encompasses methods comprising decreasing Stat3 expression or function in antigen-presenting cells and co-administering tumor cells and the antigen-presenting cells with decreased Stat3 function to a patient. The invention further relates to methods for stimulating dendritic cell differentiation.

Direct Link:

https://jhu.technologypublisher.com/technology/16292

Inventors:

Category(s):

Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Vaccines,

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For Information, Contact:

Jeanine Pennington

jpennin5@jhmi.edu

410-614-0300

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