A Cell Line with Targeted Deletions of both Bax and p21

Case ID:

C04312

Disclosure Date:

8/20/2003

C04312: A Cell Line with Targeted Deletions of both Bax and p21
Technical Details:
A Bax and p21 knock out cell line in human colorectal cancer cells. Details are described in the papers by Zhang et al. (2000) and Yu et al. (2003).
Looking for Partners:
Cells that lack both a functional BAX and p21 gene are relatively resistant to apoptosis. This cell line can be used for testing the specificity of drugs that affect apoptosis. Such drugs can potentially be used as chemotherapeutic or chemopreventive agents.

Direct Link:

https://jhu.technologypublisher.com/technology/16304

Inventors:

Category(s):

Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools,

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For Information, Contact:

Jeanine Pennington

jpennin5@jhmi.edu

410-614-0300

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