Technical Details:
Cell line for ecdysone-inducible expression of Shh.
Looking for Partners:
This cell line can be used to discover compounds that block activation of the Hh response pathway and abnormal cell growth associated with both types of oncogenic mutation.
Publications/Associated Cases:
Taipale et al. 2000 “Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.” Nature. 2000 Aug 31;406(6799):1005-9
