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Potent, Simplified Derivatives of Immunosuppressive Agents
Case ID:
C04420
Report of Invention:
3/16/2004
Web Published:
10/7/2014
C04420: Potent, Simplified Derivatives of Immunosuppressive Agents
Technical Details:
Pateamine A (PatA), a metabolite from the marine sponge Mycale, is a potent inhibitor of the intracellular signal transduction pathway that emanates from the T-cell receptor and leads to the transcription of cytokines such as interleukin-2 (IL-2). Researchers at Johns Hopkins and Texas A&M have identified distinct binding and scaffolding domains in the PatA structure with respect to interactions with its putative cellular receptor(s). Based on these domains, a simplified PatA derivative (DMDAPatA) was generated that can be prepared in fewer synthetic steps relative to PatA and was found to exhibit greater potency in inhibition of IL-2 production relative to PatA. In addition, several other PatA derivatives were synthesized that displayed lower potency but marked stability relative to the natural product.
Looking for Partners:
These compounds may provide new pharmaceutical compounds for treating immune mediated disease and conditions.
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
POTENT, SIMPLIFIED DERIVATIVES OF PATEAMINE A
ORD: Ordinary Utility
United States
10/388,257
7,230,021
3/13/2003
6/12/2007
2/9/2024
Granted
Direct Link:
https://jhu.technologypublisher.com/technology/16332
Inventors:
Category(s):
Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities,
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For Information, Contact:
Jeanine Pennington
jpennin5@jhmi.edu
410-614-0300
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