Technical Details:
HAUSP (also known as USP7) deubiquitinase gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Cummins et al., 2004a (see below)
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The cell lines described in this invention can be used in screens for novel molecules that target the p53 pathway in human cancer cells or to confirm the specificity of p53-targeted drugs discovered through other approaches.
