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Neuropilin-1 Sema Mice
Case ID:
C04679
Report of Invention:
4/8/2005
Web Published:
10/7/2014
C04679: Neuropilin-1 Sema Mice
Technical Details:
Neuropilin-1 (Npn-1) is a receptor that binds ligands from structurally distinct families like semaphorins (Sema) and vascular endothelial growth factors (VEGF). Npn-1 is a type I transmembrane protein with a small cytoplasmic domain and multiple extracellular domains capable of mediating a variety of protein/protein interactions. Studies using transgenic and knock-out mice of NPN-1 indicate that this molecule is important for vascular and neuronal development. Gene replacement strategy was used to generate a knockout mouse called npn-1Sema-, that expresses a variant of the Npn-1 protein. Interestingly, unlike npn-1 null mice, which die around E12.5, homozygous npn-1Sema- mice survive until birth.
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These mice allow investigation of the role of Npn-1 and semaphorins in development.
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Direct Link:
https://jhu.technologypublisher.com/technology/16389
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Category(s):
Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools,
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For Information, Contact:
Christine Joseph
cjoseph6@jhmi.edu
410-614-0300
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