Technical Details:
The invention describes novel mutations in serine-threonine kinase genes within the Phosphatidylinositol-3-OH Kinase (PI(3)K) pathway in patients with colorectal cancer. Details are described in the paper by Parsons et al., 2005 (see below).
Looking for Partners:
The discovery of novel mutations in PI(3)K pathway genes provide a basis for the development of new therapeutic and diagnostic approaches for such patients.
Publications:
Parsons D et al. (2005) “Colorectal cancer: mutations in a signaling pathway”. Nature. 436:792
