Estrogen Receptor in Normal (ERIN) Cells

C04908: Estrogen Receptor in Normal (ERIN) Cells
Technical Details:
There is no ideal system for studying pre-neoplastic cells that are ERpositive due to the inability to establish an estrogen growth stimulated but non-tumorigenic breast epithelial cell line. Scientists at JHU have developed independently derived clones from the non-cancerous MCF-10A human breast cell line that express ER and are growth stimulated by 17-beta-estradiol (E2) in the absence of epidermal growth factor (EGF), a cytokine normally required for MCF-10A cell proliferation.
Looking for Partners:
The cell lines described above are useful research tools for the study of estrogen and its contribution to neoplastic changes in breast cancer.

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