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ATR-Seckel Cancer Cells for Drug Discovery
Case ID:
C04993
Report of Invention:
5/31/2006
Web Published:
10/7/2014
C04993: ATR-Seckel Cancer Cells for Drug Discovery
Technical Details:
Advanced gene targeting methods were used to generate biallelic knock-in point mutations in human colorectal cancer cells that cause a loss of ATR function, but retain enough activity to permit viability. JHU researchers determined that progression of the cancer cell cycle after radiation treatment requires the ATR kinase.
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As ATR strongly contributed to clonogenic survival after radiation treatment, these data suggest that blocking ATR activity or activating p38 SAPK pathways might be useful strategies for the radiosensitization of check-point deficient cancer cells. This invention suggests ATR kinase is an anti-cancer target and provides a tool for novel drug discovery. These drugs could then be widely useful in combination therapy
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Direct Link:
https://jhu.technologypublisher.com/technology/16467
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Category(s):
Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines,
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For Information, Contact:
Sahil Aggarwal
sahil.aggarwal@jhu.edu
410-614-0300
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