ATR-Seckel Cancer Cells for Drug Discovery

C04993: ATR-Seckel Cancer Cells for Drug Discovery
Technical Details:
Advanced gene targeting methods were used to generate biallelic knock-in point mutations in human colorectal cancer cells that cause a loss of ATR function, but retain enough activity to permit viability. JHU researchers determined that progression of the cancer cell cycle after radiation treatment requires the ATR kinase.
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As ATR strongly contributed to clonogenic survival after radiation treatment, these data suggest that blocking ATR activity or activating p38 SAPK pathways might be useful strategies for the radiosensitization of check-point deficient cancer cells. This invention suggests ATR kinase is an anti-cancer target and provides a tool for novel drug discovery. These drugs could then be widely useful in combination therapy

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